Michael Morcos

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study
    M Morcos
    Department of Internal Medicine I, University of Heidelberg, Bergheimerstr 58, 69115 Heidelberg, Germany
    Diabetes Res Clin Pract 52:175-83. 2001
  2. doi request reprint Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cells
    M Morcos
    Department of Internal Medicine 1 Endocrinology, Metabolism and Clinical Chemistry, University of Heidelberg, Germany
    Horm Metab Res 40:752-9. 2008
  3. doi request reprint The model Caenorhabditis elegans in diabetes mellitus and Alzheimer's disease
    Michael Morcos
    Department of Internal Medicine 1, Endocrinology and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    J Alzheimers Dis 16:897-908. 2009
  4. ncbi request reprint Long-term treatment of central Cushing's syndrome with rosiglitazone
    M Morcos
    University of Heidelberg, Department of Internal Medicine, Endocrinology, Metabolism and Clinical Chemistry Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 115:292-7. 2007
  5. ncbi request reprint Activation of tubular epithelial cells in diabetic nephropathy
    Michael Morcos
    Department of Internal Medicine 1, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
    Diabetes 51:3532-44. 2002
  6. pmc Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes
    Per M Humpert
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany
    Cardiovasc Diabetol 6:9. 2007
  7. pmc Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily
    Angelika Bierhaus
    University of Heidelberg, Department of Medicine I, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Clin Invest 114:1741-51. 2004
  8. doi request reprint Association of homozygous SDF-1 3'A genotype with proliferative diabetic retinopathy
    Zdenka Djuric
    Department of Internal Medicine I and Clinical Chemistry, Ruprecht Karls University, Heidelberg, Germany
    Acta Diabetol 47:79-82. 2010
  9. pmc C. elegans as model for the study of high glucose- mediated life span reduction
    Andreas Schlotterer
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Diabetes 58:2450-6. 2009
  10. doi request reprint Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans
    Andreas Schlotterer
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany
    Aging Cell 9:420-32. 2010

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study
    M Morcos
    Department of Internal Medicine I, University of Heidelberg, Bergheimerstr 58, 69115 Heidelberg, Germany
    Diabetes Res Clin Pract 52:175-83. 2001
    ..Furthermore, progression of the disease might be inhibited by antioxidant drugs. A placebo-controlled study is needed...
  2. doi request reprint Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cells
    M Morcos
    Department of Internal Medicine 1 Endocrinology, Metabolism and Clinical Chemistry, University of Heidelberg, Germany
    Horm Metab Res 40:752-9. 2008
    ..Most importantly, rosiglitazone effects on NFkappaB activation were maximal at later time points, indicating that rosiglitazone treatment confers long lasting renoprotective effects...
  3. doi request reprint The model Caenorhabditis elegans in diabetes mellitus and Alzheimer's disease
    Michael Morcos
    Department of Internal Medicine 1, Endocrinology and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    J Alzheimers Dis 16:897-908. 2009
    ..elegans. So far, C. elegans research has contributed to a better understanding of the function of AD-related genes and the development of this disease...
  4. ncbi request reprint Long-term treatment of central Cushing's syndrome with rosiglitazone
    M Morcos
    University of Heidelberg, Department of Internal Medicine, Endocrinology, Metabolism and Clinical Chemistry Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 115:292-7. 2007
    ..Some studies revealed beneficial effects of the PPARgamma (Peroxisome-Proliferator-Activator- Receptor-gamma)-agonist rosiglitazone (RG) in in vitro studies, animal models and short term clinical studies...
  5. ncbi request reprint Activation of tubular epithelial cells in diabetic nephropathy
    Michael Morcos
    Department of Internal Medicine 1, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
    Diabetes 51:3532-44. 2002
    ....
  6. pmc Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes
    Per M Humpert
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany
    Cardiovasc Diabetol 6:9. 2007
    ..Since previous data were partly divergent, the aim of this study was to compare sRAGE and esRAGE in a head-to-head analysis in patients with type 2 diabetes (T2DM) with albuminuria...
  7. pmc Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily
    Angelika Bierhaus
    University of Heidelberg, Department of Medicine I, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Clin Invest 114:1741-51. 2004
    ..These data demonstrate, for the first time to our knowledge, that the RAGE-NF-kappaB axis operates in diabetic neuropathy, by mediating functional sensory deficits, and that its inhibition may provide new therapeutic approaches...
  8. doi request reprint Association of homozygous SDF-1 3'A genotype with proliferative diabetic retinopathy
    Zdenka Djuric
    Department of Internal Medicine I and Clinical Chemistry, Ruprecht Karls University, Heidelberg, Germany
    Acta Diabetol 47:79-82. 2010
    ..The finding that homozygous carriers of the SDF-1 3'A genotype are more frequent in diabetes patients with proliferative retinopathy suggests a possible role of this genotype in the development of sight-threatening diabetic retinopathy...
  9. pmc C. elegans as model for the study of high glucose- mediated life span reduction
    Andreas Schlotterer
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Diabetes 58:2450-6. 2009
    ..Establishing Caenorhabditis elegans as a model for glucose toxicity-mediated life span reduction...
  10. doi request reprint Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans
    Andreas Schlotterer
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany
    Aging Cell 9:420-32. 2010
    ..These results show that APE1/EXO-3, p53/CEP-1, and thioredoxin affect each other and that these interactions determine aging as well as neuronal structure and function...
  11. pmc Posttranslationally modified proteins as mediators of sustained intestinal inflammation
    Martin Andrassy
    Department of Medicine I, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Am J Pathol 169:1223-37. 2006
    ..Thus, CML-mps generated in inflammatory lesions have the capacity to elicit a RAGE-dependent intestinal inflammatory response...
  12. doi request reprint Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population
    Christoph Oberlinner
    Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, 69120, Germany
    Acta Diabetol 47:161-5. 2010
    ..These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied...
  13. ncbi request reprint Plasma sRAGE is independently associated with urinary albumin excretion in type 2 diabetes
    Per M Humpert
    Department of Medicine 1, University of Heidelberg, Heidelberg, Germany
    Diabetes Care 29:1111-3. 2006
  14. ncbi request reprint No association of the 94T/G polymorphism in the adiponectin gene with diabetic complications
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Heidelberg, Germany
    Diabetes Obes Metab 7:455-9. 2005
    ..This study examined a possible association of the T/G polymorphism at nucleotide 94 in the adiponectin gene with the prevalence of diabetic complications...
  15. ncbi request reprint SDF-1 genotype influences insulin-dependent mobilization of adult progenitor cells in type 2 diabetes
    Per M Humpert
    Medizinische Klinik 1, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Diabetes Care 28:934-6. 2005
  16. ncbi request reprint New treatments for diabetic neuropathy: pathogenetically oriented treatment
    Angelika Bierhaus
    Department of Medicine I, University of Heidelberg, Germany
    Curr Diab Rep 3:452-8. 2003
    ....
  17. doi request reprint RAGE expression in the human peritoneal membrane
    Lars P Kihm
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 23:3302-6. 2008
    ..This study investigates the in vivo expression of RAGE in the peritoneal membrane of uraemic human patients...
  18. ncbi request reprint Decreased plasma lipoprotein lipase in hypoadiponectinemia: an association independent of systemic inflammation and insulin resistance
    Maximilian von Eynatten
    Department of Medicine I Endocrinology and Metabolism, University of Heidelberg, INF 410, D 69120 Heidelberg, Germany
    Diabetes Care 27:2925-9. 2004
    ..Recently, dramatically increased LPL activity was reported in mice overexpressing adiponectin. We therefore speculated that adiponectin may directly affect LPL in humans...
  19. ncbi request reprint Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes
    Gottfried Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Diabetes Care 29:89-94. 2006
    ..We studied the association between polymorphisms in the UCP genes and diabetes complications in patients with type 1 diabetes...
  20. doi request reprint Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans
    Michael Morcos
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Aging Cell 7:260-9. 2008
    ..elegans lifespan. In contrast, knock-down of CeGly increases MG modifications of mitochondrial proteins and mitochondrial ROS production, and decreases C. elegans lifespan...
  21. doi request reprint External electric muscle stimulation improves burning sensations and sleeping disturbances in patients with type 2 diabetes and symptomatic neuropathy
    Per M Humpert
    Medizinische Klinik 1 und Klinische Chemie, University Hospital, Heidelberg, Germany
    Pain Med 10:413-9. 2009
    ..However, differential effects on specific symptoms of neuropathy as well as determinants of treatment response have not been described...
  22. ncbi request reprint Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB
    A Bierhaus
    Department of Medicine I and Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Diabetes 50:2792-808. 2001
    ....
  23. ncbi request reprint A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetes
    G Rudofsky
    Department of Medicine I, Otto Meyerhof Zentrum and Department of Nephrology, University of Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 112:135-41. 2004
    ..The observed difference between type 1 and type 2 diabetes might point to diverse pathomechanisms of nephropathy in both types of diabetes...
  24. doi request reprint daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans
    Michael Mendler
    Department of Medicine 1 and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Diabetologia 58:393-401. 2015
    ....
  25. doi request reprint Urinary excretion of high molecular weight adiponectin is an independent predictor of decline of renal function in type 2 diabetes
    Stefan Kopf
    Department of Medicine 1 and Clinical Chemistry, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Acta Diabetol 51:479-89. 2014
    ..72 [95 % CI 0.63-0.81] vs. 0.80 [95 % CI 0.71-0.90], p < 0.05). In conclusion, urinary HMW-adiponectin excretion may identify diabetes patients at increased risk for progression of kidney disease. ..
  26. ncbi request reprint Tissue factor as a link between wounding and tissue repair
    Jiang Chen
    University of Heidelberg, Department of Medicine I, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Diabetes 54:2143-54. 2005
    ..These data establish TF expression as an important link between the early inflammatory response to cutaneous wounding and reparative processes...
  27. ncbi request reprint Evidence of left ventricular contractile asynchrony by echocardiographic phase imaging in patients with type 2 diabetes mellitus and without clinically evident heart disease
    Grigorios Korosoglou
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Am J Cardiol 98:1525-30. 2006
    ..05) and showed higher intraobserver variability (5.6% vs 3.2%, p <0.05). In conclusion, this is the first study showing increased left ventricular asynchrony in patients with DM and no clinical evidence of heart disease...
  28. ncbi request reprint [AGE-RAGE: a hypothesis or a mechanism?]
    Berend Isermann
    Abteilung Endokrinologie und Stoffwechsel, Universitätsklinik Heidelberg, Heidelberg
    Herz 29:504-9. 2004
    ..Thus, further studies are needed for the characterization of the ligand-RAGE-interaction. These studies will provide a rationale for the development of new therapeutic approaches for accelerated atherosclerosis in diabetes mellitus...
  29. doi request reprint Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers after renal transplantation
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:33-6. 2009
    ..In addition, we review their influence on morphologic and biochemical markers as well as on renal function, graft and patient survival after renal transplantation...
  30. doi request reprint Simultaneous pancreas-kidney transplantation in type 1 diabetes
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:115-20. 2009
    ..We give a short overview on SPK transplantation, with a focus on the effects of this procedure on diabetic complications as well as patient and kidney graft survival...
  31. doi request reprint [The unsolved problem of diabetes mellitus type 2 and associated complications]
    M Morcos
    Medizinische Klinik Krehl Klinik, Abteilung Innere Medizin 1 und Klinische Chemie, Universitatsklinikum Heidelberg, INF 410, 69120 Heidelberg, Deutschland
    Chirurg 80:398, 400-4, 406-9. 2009
    ..Finally, generating treatment guidelines is extremely difficult as clinical studies targeting vascular endpoints need more than 10 years to become informative, partly due to the so-called glycaemic memory...
  32. doi request reprint The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications
    G Rudofsky
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 41:308-13. 2009
    ..In conclusion these data suggest no major influence of the -174G>C variant in the promoter region of the IL-6 gene on the development of microvascular complications in patients with diabetes...
  33. ncbi request reprint Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patients
    P M Humpert
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Diabetologia 50:1517-22. 2007
    ....
  34. ncbi request reprint sRAGE and esRAGE are not associated with peripheral or autonomic neuropathy in type 2 diabetes
    P M Humpert
    Universitätsklinikum Heidelberg Medizinische Klinik 1 und Klinische Chemie, Heidelberg, Germany
    Horm Metab Res 39:899-902. 2007
    ..01) and presence of retinopathy (beta=-0.19, p<0.05). In contrast to classical risk factors, plasma soluble RAGE and endogenous secretory RAGE are not associated with measures of diabetic neuropathy in type 2 diabetes patients...
  35. ncbi request reprint A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 116:14-7. 2008
    ..We studied the association between a functionally relevant M55V polymorphism in the SUMO4 gene with microvascular diabetic complications in patients with type 1 diabetes...
  36. ncbi request reprint Improved vascular function upon pioglitazone treatment in type 2 diabetes is not associated with changes in mononuclear NF-kappaB binding activity
    G Rudofsky
    Department Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Horm Metab Res 39:665-71. 2007
    ....
  37. ncbi request reprint [Diabetic nephropathy]
    M Morcos
    Abteilung für Innere Medizin 1, Endokrinologie, Stoffwechsel und Klinische Chemie, Medizinische Universitätsklinik Heidelberg und Sektion Nephrologie, Medizinische Universitatsklinik Heidelberg
    Dtsch Med Wochenschr 132:1039-42. 2007
  38. ncbi request reprint Postprandial mononuclear NF-kappaB activation is independent of the AGE-content of a single meal
    S Schiekofer
    Department of Medicine I, University of Heidelberg, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 114:160-7. 2006
    ..The aim of this study was to analyze the postprandial effects of a casein meal with low or high AGE content on postprandial NF-kappaB activation in peripheral blood mononuclear cells (pBMC) of healthy volunteers...
  39. ncbi request reprint Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient
    P M Humpert
    Department of Medicine I, University Clinics Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 113:538-40. 2005
    ..Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders...
  40. ncbi request reprint [Oral diabetes treatment. Which substance is indicated at which time?]
    A Hamann
    Abteilung Innere Medizin I, Universitatsklinikum Heidelberg
    Internist (Berl) 45:1356-63. 2004
    ..This recommendation for monotherapy of overweight type 2 diabetics is supported by an endpoint study. In contrast, no equivalent evidence is available on any of the possible options for oral combination therapy...
  41. pmc Influence of insulin and glargine on outgrowth and number of circulating endothelial progenitor cells in type 2 diabetes patients: a partially double-blind, randomized, three-arm unicenter study
    Dimitrios Oikonomou
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany
    Cardiovasc Diabetol 13:137. 2014
    ..To study direct effects of insulin treatment on EPCs in type 2 diabetes patients, add-on basal insulin treatment was compared to an escalation of oral medication aiming at similar glucose control between the groups...
  42. doi request reprint Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
    Angelika Bierhaus
    Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
    Nat Med 18:926-33. 2012
    ..This previously undescribed concept of metabolically driven hyperalgesia provides a new basis for the design of therapeutic interventions for painful diabetic neuropathy...
  43. pmc A mechanism converting psychosocial stress into mononuclear cell activation
    Angelika Bierhaus
    Department of Medicine I, University of Heidelberg, Otto Meyerhof Zentrum, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:1920-5. 2003
    ..Activation of NF-kappaB represents a downstream effector for the neuroendocrine response to stressful psychosocial events and links changes in the activity of the neuroendocrine axis to the cellular response...
  44. pmc The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy
    Nadine Dietrich
    5th Medical Department, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    PLoS ONE 11:e0167853. 2016
    ..Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control in type 2 diabetes, however, their influence on the retinal neurovascular unit remains unclear...
  45. ncbi request reprint Variants in the human beta 1-, beta 2-, and beta 3-adrenergic receptor genes are not associated with morbid obesity in children and adolescents
    J Tafel
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, Universitatsklinikum Heidelberg, 69115 Heidelberg, Germany
    Diabetes Obes Metab 6:452-5. 2004
    ..We therefore investigated the possible association of polymorphisms in the beta-adrenergic receptor genes with early onset obesity...
  46. ncbi request reprint Human glomerular mesangial cells express CD16 and may be stimulated via this receptor
    M Morcos
    Institute of Immunology and Serology, Medical Faculty of Mannheim, University of Heidelberg, Germany
    Kidney Int 46:1627-34. 1994
    ..The occupancy of CD16 by immune complexes that may be deposited in various forms of glomerulonephritis might contribute to the perpetuation of inflammatory processes in the kidney...
  47. ncbi request reprint Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease
    T Forst
    Institute for Clinical Research and Development, Parcusstrasse 8, D 55116 Mainz, Germany
    Atherosclerosis 197:311-7. 2008
    ..No changes in these parameters could be observed during placebo treatment. Even before effects on glucose metabolism could be obtained, pioglitazone exerts immediate effects on plasma markers of plaque vulnerability and inflammation...
  48. ncbi request reprint [Adrenal cortex and steroids. Supplementary therapy in the perioperative phase]
    A S Milde
    Klinik fur Anaesthesiologie, Universitatsklinikum, Heidelberg
    Anaesthesist 54:639-54. 2005
    ..With regard to the broad spectrum of efficacy of glucocorticoids and their side effects, revision and modification of the historical regimen appear prudent...