Martin Merkel

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake
    Martin Merkel
    Department of Medicine, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 277:7405-11. 2002
  2. pmc Give me A5 for lipoprotein hydrolysis!
    Martin Merkel
    Department of Internal Medicine and IBM II Molecular Cell Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Clin Invest 115:2694-6. 2005
  3. ncbi request reprint [Lipoprotein lipase-mediated myopathy: implications for lipid metabolism and atherogenesis]
    Martin Merkel
    Medizinische Klinik I, Universitatsklinikum, Hamburg Eppendorf
    Med Klin (Munich) 98:679-84. 2003
  4. ncbi request reprint Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase
    Martin Merkel
    Department of Internal Medicine IUniversity Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    J Biol Chem 280:21553-60. 2005
  5. doi request reprint Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance
    Alexander Laatsch
    Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Atherosclerosis 204:105-11. 2009
  6. doi request reprint Brown adipose tissue activity controls triglyceride clearance
    Alexander Bartelt
    Institute of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Nat Med 17:200-5. 2011
  7. ncbi request reprint Endothelial-derived lipoprotein lipase is bound to postprandial triglyceride-rich lipoproteins and mediates their hepatic clearance in vivo
    Joerg Heeren
    Department of Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Mol Med (Berl) 80:576-84. 2002
  8. ncbi request reprint Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor
    Britta Loeffler
    Third Department of Internal Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Lipid Res 48:288-98. 2007
  9. ncbi request reprint Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice
    Sergei Ragozin
    Institute for Biochemistry and Molecular Biology II, Molecular Cell Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 25:1433-8. 2005
  10. doi request reprint Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function
    Andreas Niemeier
    Department of Orthopaedics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Bone 43:230-7. 2008

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake
    Martin Merkel
    Department of Medicine, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 277:7405-11. 2002
    ..In the absence of active LPL in the same tissue, inactive LPL only mediates selective cholesterol ester uptake...
  2. pmc Give me A5 for lipoprotein hydrolysis!
    Martin Merkel
    Department of Internal Medicine and IBM II Molecular Cell Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Clin Invest 115:2694-6. 2005
    ....
  3. ncbi request reprint [Lipoprotein lipase-mediated myopathy: implications for lipid metabolism and atherogenesis]
    Martin Merkel
    Medizinische Klinik I, Universitatsklinikum, Hamburg Eppendorf
    Med Klin (Munich) 98:679-84. 2003
    ..Some of these animals showed an LPL-mediated myopathy or cardiomyopathy. Comparing the histological changes with metabolic data provides new insights in the function of LPL in metabolism and for atherogenesis...
  4. ncbi request reprint Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase
    Martin Merkel
    Department of Internal Medicine IUniversity Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    J Biol Chem 280:21553-60. 2005
    ..A direct interaction between LPL and apoAV was found by ligand blotting. It is proposed, that apoAV reduces triglyceride levels by guiding VLDL and chylomicrons to proteoglycan-bound LPL for lipolysis...
  5. doi request reprint Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance
    Alexander Laatsch
    Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Atherosclerosis 204:105-11. 2009
    ..The dietary lipids are carried in chylomicron remnants (CR) which are taken up into the liver mainly via LDLR-related protein 1 (LRP1). In this study, the effect of insulin on LRP1-mediated hepatic CR uptake was investigated...
  6. doi request reprint Brown adipose tissue activity controls triglyceride clearance
    Alexander Bartelt
    Institute of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Nat Med 17:200-5. 2011
    ..Activation of BAT might be a therapeutic approach to reduce elevated triglyceride concentrations and combat obesity in humans...
  7. ncbi request reprint Endothelial-derived lipoprotein lipase is bound to postprandial triglyceride-rich lipoproteins and mediates their hepatic clearance in vivo
    Joerg Heeren
    Department of Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Mol Med (Berl) 80:576-84. 2002
    ..In conclusion, these data demonstrate for the first time that LPL is a structural component of postprandial TRL which facilitates hepatic TRL clearance from the circulation independent of its catalytic function...
  8. ncbi request reprint Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor
    Britta Loeffler
    Third Department of Internal Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Lipid Res 48:288-98. 2007
    ..Chylomicron uptake was not affected by the LDLR genotype. We conclude that LPL-mediated cellular uptake of LDL, but not of chylomicrons, is dependent on the presence of both LDLR and proteoglycans...
  9. ncbi request reprint Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice
    Sergei Ragozin
    Institute for Biochemistry and Molecular Biology II, Molecular Cell Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 25:1433-8. 2005
    ..To investigate the impact of hepatic ABCA1 on systemic lipoprotein metabolism in vivo by an adenovirus-mediated RNA interference approach...
  10. doi request reprint Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function
    Andreas Niemeier
    Department of Orthopaedics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Bone 43:230-7. 2008
    ..Osteoblasts participate in CR clearance from the circulation, which has a direct impact on the secretory function of osteoblasts...
  11. doi request reprint A new, powerful player in lipoprotein metabolism: brown adipose tissue
    Alexander Bartelt
    Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
    J Mol Med (Berl) 90:887-93. 2012
    ..Here, we will review recent insights on how BAT controls triglyceride clearance and the possible implications for the treatment of chronic diseases caused by lipid mishandling...
  12. doi request reprint Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals
    Oliver T Bruns
    IBM II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Nat Nanotechnol 4:193-201. 2009
    ..Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging...
  13. ncbi request reprint Lipoprotein lipase: genetics, lipid uptake, and regulation
    Martin Merkel
    Department of Medicine, University of Hamburg, Hamburg, Germany Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    J Lipid Res 43:1997-2006. 2002
    ..2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake. 3) LPL gene regulation: the LPL promoter and its regulatory elements are described...
  14. ncbi request reprint Scavenger receptor class B type I mediates the selective uptake of high-density lipoprotein-associated cholesteryl ester by the liver in mice
    May Brundert
    University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 25:143-8. 2005
    ..Class B type I scavenger receptor (SR-BI) mediates this uptake in vitro. The role of SR-BI in HDL metabolism was explored in mice...
  15. doi request reprint Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant
    Kirstin Albers
    Department of Biochemistry and Molecular Biology II, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Atherosclerosis 233:97-103. 2014
    ..The absence of apoA-V in plasma leads under conditions of fat-rich diets to severe chylomicronemia, suggestive for a modulatory role of apoA-V for lipoprotein lipase mediated intravascular triglyceride lipolysis. ..
  16. ncbi request reprint [L-carnitine and lipid lowering]
    Martin Merkel
    Zentrum fur Innere Medizin, Medizinische Klinik und Poliklinik, Universitatsklinikum, Hamburg Eppendorf, Hamburg
    Dtsch Med Wochenschr 128:1792. 2003
  17. doi request reprint [Obesity: ectopic fat distribution and the heart]
    Dirk Muller-Wieland
    Abteilung für Allgemeine Innere Medizin, Gastroenterologie, Endokrinologie, Diabetes und Stoffwechsel, Institut für diabetologische Versorgungsforschung, Asklepios Klinik St Georg, Hamburg, Germany
    Herz 35:198-205. 2010
    ..These new relations between obesity, fat distribution and cardiac function might help to identify and treat individuals at risk earlier and more appropriately...
  18. ncbi request reprint Mice expressing only covalent dimeric heparin binding-deficient lipoprotein lipase: muscles inefficiently secrete dimeric enzyme
    E Peer Lutz
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 279:238-44. 2004
    ..Thus, although muscle can synthesize tethered, dimeric LpL, efficient production of this enzyme leading to secretion, and physiological function appears to favor secretion of a noncovalent dimer composed of monomeric subunits...
  19. pmc Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
    Hiroaki Yagyu
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 111:419-26. 2003
    ..Hearts of transgenic mice were dilated, and left ventricular systolic function was impaired. Thus, lipoprotein lipase expressed on the surface of cardiomyocytes can increase lipid uptake and produce cardiomyopathy...
  20. ncbi request reprint Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice
    Roshni R Singaraja
    University of British Columbia, Vancouver, Canada
    Arterioscler Thromb Vasc Biol 26:1821-7. 2006
    ..However, the role of ABCA1 in the liver for HDL apolipoprotein and cholesteryl ester (CE) catabolism in vivo is unknown...
  21. pmc Pregnancies in glycogen storage disease type Ia
    Daniëlle H J Martens
    Department of Pediatrics, Beatrix Children s Hospital, University Medical Center Groningen, The Netherlands
    Am J Obstet Gynecol 198:646.e1-7. 2008
    ..Because of improved life expectancy, pregnancy is becoming an important issue. We describe 15 pregnancies by focusing on dietary treatment, biochemical parameters, and GSD-Ia complications...
  22. pmc Dietary methionine effects on plasma homocysteine and HDL metabolism in mice
    Wanda Velez-Carrasco
    Department of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021, USA
    J Nutr Biochem 19:362-70. 2008
    ..Mice on methionine diets had >20% decreased body weights and decreased HDL-C levels. An HDL turnover study demonstrated that the HDL-C production rate was significantly reduced in mice fed the methionine diet...