Jakob Matschke

Summary

Affiliation: University Medical Center Hamburg-Eppendorf
Country: Germany

Publications

  1. ncbi Fatal ischemic stroke due to dissecting aneurysm of the intracranial arteries presenting as sudden unexpected death in childhood
    Jakob Matschke
    Forensic Neuropathology Unit, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Forensic Med Pathol 31:364-9. 2010
  2. doi Encephalopathy and death in infants with abusive head trauma is due to hypoxic-ischemic injury following local brain trauma to vital brainstem centers
    Jakob Matschke
    Forensic Neuropathology Unit, University Medical Centre Hamburg Eppendorf, 20246, Hamburg, Germany
    Int J Legal Med 129:105-14. 2015
  3. doi Nonaccidental head injury is the most common cause of subdural bleeding in infants <1 year of age
    Jakob Matschke
    Forensic Neuropathology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Pediatrics 124:1587-94. 2009
  4. pmc Shaken baby syndrome: a common variant of non-accidental head injury in infants
    Jakob Matschke
    Forensische Neuropathologie, Institut für Neuropathologie, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Dtsch Arztebl Int 106:211-7. 2009
  5. doi Ocular pathology in shaken baby syndrome and other forms of infantile non-accidental head injury
    Jakob Matschke
    Forensic Neuropathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Int J Legal Med 123:189-97. 2009
  6. doi Secretory Meningiomas: Increased Prevalence of Seizures Secondary to Edema Formation in a Rare Histologic Subtype
    Malte Mohme
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    World Neurosurg 92:418-25. 2016
  7. doi High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease
    Frank Dohler
    1 Institute of Neuropathology, University Medical Centre Hamburg Eppendorf, D 20246 Hamburg, Germany
    Brain 137:873-86. 2014
  8. pmc Amyloid-β Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease
    Alvaro Barrera-Ocampo
    From the Institute of Neuropathology AB O, JM, BP, MG, DS F, Department of Psychiatry and Psychotherapy SA, HJ, University Medical Center Hamburg Eppendorf, Hamburg, Germany, Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany UH, Institute of Neuropathology, Bellvitge University Hospital, CIBERNED, Hospitalet de Llobregat, University of Barcelona, Spain IF, Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany PZ, and Department of Pharmaceutical Sciences, Natura Research Group, Faculty of Natural Sciences, Icesi University, Cali, Colombia AB O
    J Neuropathol Exp Neurol 75:903-16. 2016
  9. doi PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression
    Ina Hohensee
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, 20246, Germany
    Oncotarget . 2016
  10. pmc Meninigiomas of the Craniocervical Junction--A Distinctive Subgroup of Meningiomas
    Lasse Dührsen
    Department of Neurosurgery, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 11:e0153405. 2016

Collaborators

Detail Information

Publications28

  1. ncbi Fatal ischemic stroke due to dissecting aneurysm of the intracranial arteries presenting as sudden unexpected death in childhood
    Jakob Matschke
    Forensic Neuropathology Unit, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Forensic Med Pathol 31:364-9. 2010
    ..Outcome is poor, with more than 20% of patients dying. We report 4 cases of sudden unexpected death due to arterial ischemic stroke after cerebral arterial dissection in childhood and present a review of the literature...
  2. doi Encephalopathy and death in infants with abusive head trauma is due to hypoxic-ischemic injury following local brain trauma to vital brainstem centers
    Jakob Matschke
    Forensic Neuropathology Unit, University Medical Centre Hamburg Eppendorf, 20246, Hamburg, Germany
    Int J Legal Med 129:105-14. 2015
    ..We hypothesize that brain damage in AHT is due to hypoxic-ischemic injury with hypoxic-ischemic encephalopathy (HIE) rather than primary traumatic brain injury (TBI) with traumatic diffuse axonal injury (tDAI)...
  3. doi Nonaccidental head injury is the most common cause of subdural bleeding in infants <1 year of age
    Jakob Matschke
    Forensic Neuropathology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Pediatrics 124:1587-94. 2009
    ..We analyzed a large series of infants' autopsies for the presence and causes of SDB, which should be a common event according to the unified hypothesis...
  4. pmc Shaken baby syndrome: a common variant of non-accidental head injury in infants
    Jakob Matschke
    Forensische Neuropathologie, Institut für Neuropathologie, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Dtsch Arztebl Int 106:211-7. 2009
    ..Abuse of infants often leaves few external signs of injury and therefore merits special diligence, especially in the case of non-accidental head injury, which has high morbidity and mortality...
  5. doi Ocular pathology in shaken baby syndrome and other forms of infantile non-accidental head injury
    Jakob Matschke
    Forensic Neuropathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Int J Legal Med 123:189-97. 2009
    ..This review summarizes the present knowledge of ocular pathology in inflicted infantile neurotrauma, focusing strongly on SBS. Furthermore, a review of the most recent literature on the subject is given...
  6. doi Secretory Meningiomas: Increased Prevalence of Seizures Secondary to Edema Formation in a Rare Histologic Subtype
    Malte Mohme
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    World Neurosurg 92:418-25. 2016
    ..The aim of this study was to characterize the potential pitfalls in treatment of SMs by illustrating their characteristic clinical features...
  7. doi High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease
    Frank Dohler
    1 Institute of Neuropathology, University Medical Centre Hamburg Eppendorf, D 20246 Hamburg, Germany
    Brain 137:873-86. 2014
    ....
  8. pmc Amyloid-β Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease
    Alvaro Barrera-Ocampo
    From the Institute of Neuropathology AB O, JM, BP, MG, DS F, Department of Psychiatry and Psychotherapy SA, HJ, University Medical Center Hamburg Eppendorf, Hamburg, Germany, Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany UH, Institute of Neuropathology, Bellvitge University Hospital, CIBERNED, Hospitalet de Llobregat, University of Barcelona, Spain IF, Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany PZ, and Department of Pharmaceutical Sciences, Natura Research Group, Faculty of Natural Sciences, Icesi University, Cali, Colombia AB O
    J Neuropathol Exp Neurol 75:903-16. 2016
    ....
  9. doi PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression
    Ina Hohensee
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, 20246, Germany
    Oncotarget . 2016
    ..The findings of our functional studies suggest that PTEN loss promotes a feedback loop between tumor cells and glial cells, which might contribute to disease progression...
  10. pmc Meninigiomas of the Craniocervical Junction--A Distinctive Subgroup of Meningiomas
    Lasse Dührsen
    Department of Neurosurgery, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 11:e0153405. 2016
    ..The aim of this study was to evaluate the clinical course of patients operated for craniocervical meningioma (CCM) and to investigate the histological features of these tumors and their impact on recurrence rate...
  11. pmc Inhibition of intracerebral glioblastoma growth by targeting the insulin-like growth factor 1 receptor involves different context-dependent mechanisms
    Martin Zamykal
    Department of Neurosurgery M Z, T M, H S G, A K, A s, R P, M W, K L and Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany J M
    Neuro Oncol 17:1076-85. 2015
    ..We investigated the effect of the IGF-1R blocking antibody IMC-A12 on glioblastoma growth in different in vivo models...
  12. doi Plasma levels of neuron specific enolase quantify the extent of neuronal injury in murine models of ischemic stroke and multiple sclerosis
    Mathias Gelderblom
    Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Neurobiol Dis 59:177-82. 2013
    ..We aimed at validating a plasma biomarker for neuronal damage that can be used in acute and chronic models of neurological diseases...
  13. doi Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease
    Diego Sepulveda-Falla
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Brain Pathol 21:452-63. 2011
    ..The presence of pTau in cerebellum in PS1-E280A underscores the relevance of cerebellar involvement in AD and might be correlated to clinical phenotype...
  14. doi Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases
    Ina Hohensee
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Pathol 183:83-95. 2013
    ..In contrast, none of these pathways was associated with an increased risk of bone metastasis. These findings highlight the importance of both pathways as possible targets in the treatment of brain metastases in breast cancer...
  15. ncbi Intracranial arteriovenous malformations presenting as sudden unexpected death: a report of 3 cases and review of the literature
    Jakob Matschke
    Institute of Neuropathology, University Medical Center Hamburg, Hamburg, Germany
    Am J Forensic Med Pathol 28:173-6. 2007
    ..We present 3 cases of sudden death due to hemorrhage of AVM and discuss the literature and the differential diagnosis in cases of sudden death due to intracranial hemorrhage...
  16. doi Long-term vestibulocochlear functional outcome following retro-sigmoid approach to resection of vestibular schwannoma
    Tammam Abboud
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Eur Arch Otorhinolaryngol 273:719-25. 2016
    ..Absence of central compensation leads to increased postoperative balance disturbances. Preservation of serviceable postoperative hearing is associated with good preoperative hearing status, younger age, and smaller tumours...
  17. doi Secretory Meningiomas: Characteristic Features and Clinical Management of a Unique Subgroup
    Malte Mohme
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistr 52, Hamburg 20246, Germany
    Neurosurg Clin N Am 27:181-7. 2016
    ..The frequent presence of extensive peritumoral edema has become a hallmark of SM and can be associated with life-threatening complications. The exact pathophysiology of edema formation in SM is still unknown. ..
  18. doi Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden
    Alexander Kellner
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Ann Neurol 65:24-31. 2009
    ..Here, we investigate whether naturally occurring autoantibodies to beta-amyloid contribute to beta-amyloid plaque removal in nonimmunized AD patients...
  19. pmc Loss of CADM1 expression is associated with poor prognosis and brain metastasis in breast cancer patients
    Harriet Wikman
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Oncotarget 5:3076-87. 2014
    ..Loss of CADM1 expression is an independent prognostic factor especially associated with the development of brain metastases in breast cancer patients. ..
  20. doi Blister-like aneurysms--a diagnostic and therapeutic challenge
    Jan Regelsberger
    Universitatsklinikum Hamburg Eppendorf, Neurochirurgische Klinik, Hamburg, Germany
    Neurosurg Rev 34:409-16. 2011
    ..If endovascular treatment is not promising, wrapping and revascularization techniques come true to still be an important part of the neurosurgeons toolbox for reconstructing a vessel lumen and preserving a sufficient cerebral blood flow...
  21. doi Does usage of a parachute in contrast to free fall prevent major trauma?: a prospective randomised-controlled trial in rag dolls
    Patrick Czorlich
    Department of Neurosurgery, University Medical Centre Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Eur Spine J 25:1349-54. 2016
    ..The aim of this prospective randomised controlled trial was to prove the effectiveness of a parachute when falling from great height...
  22. doi Sexual Activity as a Risk Factor for the Spontaneous Rupture of Cerebral Aneurysms
    Constantin Blanke-Roeser
    From the Institute of Legal Medicine, University Medical Center, University of Hamburg, Germany, Hamburg, Germany
    Am J Forensic Med Pathol 37:70-3. 2016
    ..It is discussed with respect to the possible pathophysiological effects of sexual activity on cerebral aneurysms. ..
  23. ncbi Expression of doublecortin in tumours of the central and peripheral nervous system and in human non-neuronal tissues
    Christian Bernreuther
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Acta Neuropathol 111:247-54. 2006
    ....
  24. doi Hematogenous dissemination of glioblastoma multiforme
    Carolin Müller
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, D 201246 Hamburg, Germany
    Sci Transl Med 6:247ra101. 2014
    ..Release of CTCs was associated with EGFR gene amplification, suggesting a growth potential of these cells. We demonstrate that hematogenous GBM spread is an intrinsic feature of GBM biology. ..
  25. ncbi Sudden death due to central alveolar hypoventilation syndrome (Ondine's curse) in a 39-year-old woman with heterotopia of the inferior olive
    Jakob Matschke
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Forensic Med Pathol 28:141-4. 2007
    ..Mechanisms in the present case are discussed and a review of similar cases published so far is given. The necessity of sound investigation, including neuropathologic studies in cases of sudden unexplained death, is underlined...
  26. ncbi Understanding the natural variability of prion diseases
    Markus Geissen
    Institute of Neuropathology, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    Vaccine 25:5631-6. 2007
    ..Current classification systems are based on the assessment of clinical presentation, genetic investigations, neuropathological findings and biochemical analysis of PrP(Sc)...
  27. ncbi Sudden unexpected death due to undiagnosed glioblastoma: report of three cases and review of the literature
    Jakob Matschke
    Institute of Neuropathology, University Medical Centre, Martinistrasse 52, 20246 Hamburg, Germany
    Int J Legal Med 119:280-4. 2005
    ....
  28. ncbi Sudden death in a 35-year-old man with occult malformation of the brain and aseptic meningitis
    Jakob Matschke
    Institute of Neuropathology, University Hospital of Hamburg Eppendorf, Hamburg, Germany
    Am J Forensic Med Pathol 24:83-6. 2003
    ..The morphologic findings of this case are presented, and the probable mechanisms of death are discussed...