Wolfgang A Linke

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium
    Wolfgang A Linke
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    J Muscle Res Cell Motil 23:483-97. 2002
  2. ncbi request reprint Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart
    Christiane A Opitz
    Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Circ Res 94:967-75. 2004
  3. ncbi request reprint Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness
    Ciprian Neagoe
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    J Muscle Res Cell Motil 24:175-89. 2003
  4. ncbi request reprint Plasticity of cardiac titin/connectin in heart development
    Christiane A Opitz
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120, Heidelberg, Germany
    J Muscle Res Cell Motil 26:333-42. 2005
  5. pmc Damped elastic recoil of the titin spring in myofibrils of human myocardium
    Christiane A Opitz
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:12688-93. 2003
  6. pmc Isoform diversity of giant proteins in relation to passive and active contractile properties of rabbit skeletal muscles
    Lucas G Prado
    Institute of Physiology and Pathophysiology, University of Heidelberg, D 69120 Heidelberg, Germany
    J Gen Physiol 126:461-80. 2005
  7. ncbi request reprint PEVK domain of titin: an entropic spring with actin-binding properties
    Wolfgang A Linke
    Institute of Physiology and Pathophysiology, University of Heidelberg, Germany
    J Struct Biol 137:194-205. 2002
  8. ncbi request reprint Titin isoform switch in ischemic human heart disease
    Ciprian Neagoe
    Institute of Physiology and Pathophysiology, University of Heidelberg, Germany
    Circulation 106:1333-41. 2002
  9. pmc Titin-based contribution to shortening velocity of rabbit skeletal myofibrils
    Ave Minajeva
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    J Physiol 540:177-88. 2002
  10. pmc The molecular elasticity of the insect flight muscle proteins projectin and kettin
    Belinda Bullard
    European Molecular Biology Laboratory, D 69012 Heidelberg, Germany
    Proc Natl Acad Sci U S A 103:4451-6. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium
    Wolfgang A Linke
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    J Muscle Res Cell Motil 23:483-97. 2002
    ..The combined results reveal the sources of velocity sensitive and insensitive force components of cardiomyofibrils stretched in diastole...
  2. ncbi request reprint Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart
    Christiane A Opitz
    Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Circ Res 94:967-75. 2004
    ....
  3. ncbi request reprint Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness
    Ciprian Neagoe
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    J Muscle Res Cell Motil 24:175-89. 2003
    ....
  4. ncbi request reprint Plasticity of cardiac titin/connectin in heart development
    Christiane A Opitz
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120, Heidelberg, Germany
    J Muscle Res Cell Motil 26:333-42. 2005
    ..Plasticity of titin/connectin at approximately the time of birth thus affects myocardial mechanics but could also be an important factor in developmentally regulated assembly and signalling processes...
  5. pmc Damped elastic recoil of the titin spring in myofibrils of human myocardium
    Christiane A Opitz
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:12688-93. 2003
    ..Damped myofibrillar elastic recoil could help accelerate active contraction speed of human myocardium during early systolic shortening...
  6. pmc Isoform diversity of giant proteins in relation to passive and active contractile properties of rabbit skeletal muscles
    Lucas G Prado
    Institute of Physiology and Pathophysiology, University of Heidelberg, D 69120 Heidelberg, Germany
    J Gen Physiol 126:461-80. 2005
    ..Titin contributes substantially to total passive stiffness, but this contribution varies greatly among muscles...
  7. ncbi request reprint PEVK domain of titin: an entropic spring with actin-binding properties
    Wolfgang A Linke
    Institute of Physiology and Pathophysiology, University of Heidelberg, Germany
    J Struct Biol 137:194-205. 2002
    ..Thus, the PEVK domain contributes not only to the extensibility of the sarcomere, but also affects contractile properties...
  8. ncbi request reprint Titin isoform switch in ischemic human heart disease
    Ciprian Neagoe
    Institute of Physiology and Pathophysiology, University of Heidelberg, Germany
    Circulation 106:1333-41. 2002
    ..Human heart sarcomeres coexpress 2 principal titin isoforms, a more compliant N2BA isoform and a stiffer N2B isoform. In comparison, normal rat hearts express almost no N2BA titin...
  9. pmc Titin-based contribution to shortening velocity of rabbit skeletal myofibrils
    Ave Minajeva
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    J Physiol 540:177-88. 2002
    ..However, elastic recoil may aid active shortening during phases of high elastic energy utilization, i.e. immediately after the onset of contraction under low or zero load or during prolonged shortening from greater physiological SLs...
  10. pmc The molecular elasticity of the insect flight muscle proteins projectin and kettin
    Belinda Bullard
    European Molecular Biology Laboratory, D 69012 Heidelberg, Germany
    Proc Natl Acad Sci U S A 103:4451-6. 2006
    ..Our results suggest that titin-like proteins in indirect flight muscles could function according to a folding-based-spring mechanism...
  11. ncbi request reprint Developmental changes in passive stiffness and myofilament Ca2+ sensitivity due to titin and troponin-I isoform switching are not critically triggered by birth
    Martina Kruger
    Physiology and Biophysics Unit, Univ of Muenster, Schlossplatz 5, D 48149 Muenster, Germany
    Am J Physiol Heart Circ Physiol 291:H496-506. 2006
    ..We conclude that TnI-isoform and titin-isoform switching and corresponding functional changes during heart development are not initiated by birth but are genetically programmed, species-specific regulated events...
  12. ncbi request reprint Mechanical properties of cardiac titin's N2B-region by single-molecule atomic force spectroscopy
    Mark C Leake
    Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU, UK
    J Struct Biol 155:263-72. 2006
    ..The softening effect of PKA on N2B-titin may require specific conditions/factors present inside the cardiomyocytes...
  13. ncbi request reprint Pulling single molecules of titin by AFM--recent advances and physiological implications
    Wolfgang A Linke
    Physiology and Biophysics Unit, University of Muenster, Schlossplatz 5, 48149 Muenster, Germany
    Pflugers Arch 456:101-15. 2008
    ..These studies help us understand how proteins respond to forces in cells and how mechanosensing and mechanosignaling events may proceed in vivo...
  14. ncbi request reprint Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction
    Wolfgang A Linke
    Physiology and Biophysics Unit, University of Muenster, Schlossplatz 5, Muenster, Germany
    Cardiovasc Res 77:637-48. 2008
    ..Titin and titin-based protein complexes are now recognized as integral parts of the mechanosensitive protein network and as critical components in cardiomyocyte stress/stretch signalling...
  15. ncbi request reprint Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension
    Martina Kruger
    Physiology and Biophysics Unit, University of Muenster, Schlossplatz 5, D 48149, Muenster, Germany
    J Muscle Res Cell Motil 27:435-44. 2006
    ..We conclude that PKA mediates phosphorylation of titin in normal human myocardium. Titin phosphorylation lowers titin-based passive stiffness in heart but not in skeletal muscle...
  16. ncbi request reprint Multiple sources of passive stress relaxation in muscle fibres
    Wolfgang A Linke
    Physiology and Biophysics Laboratory, University of Muenster, Schlossplatz 5, D 48149 Muenster, Germany
    Phys Med Biol 49:3613-27. 2004
    ..Evidence is provided that in intact myofibrils, an initial, rapid phase of stress relaxation results from viscous resistance due to the presence of actin filaments...
  17. ncbi request reprint Reverse engineering of the giant muscle protein titin
    Hongbin Li
    Department of Physiology and Biophysics, Mayo Foundation, Rochester, Minnesota 55905, USA
    Nature 418:998-1002. 2002
    ..We show that when these mechanical elements are combined, they explain the macroscopic behaviour of titin in intact muscle. Our studies show the functional reconstitution of a protein from the sum of its parts...
  18. ncbi request reprint Titin stiffness in heart disease
    Wolfgang A Linke
    Circulation 107:e73; author reply e73. 2003
  19. ncbi request reprint Varieties of elastic protein in invertebrate muscles
    Belinda Bullard
    European Molecular Biology Laboratory, D 69012 Heidelberg, Germany
    J Muscle Res Cell Motil 23:435-47. 2002
    ..We conclude that passive tension is due to kettin and projectin, either separate or linked in series...
  20. ncbi request reprint Association of the chaperone alphaB-crystallin with titin in heart muscle
    Belinda Bullard
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Biol Chem 279:7917-24. 2004
    ..Reversible association with alphaB-crystallin would protect I-band titin from stress liable to cause domain unfolding until conditions are favorable for refolding to the native state...
  21. ncbi request reprint Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/ AKT pathway
    Martina Kruger
    Physiology and Biophysics Unit, University of Muenster, Schlossplatz 5, D 48149 Muenster, Germany
    Circ Res 102:439-47. 2008
    ....
  22. pmc Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity
    M Charlotte Olsson
    Uppsala University, Department of Neuroscience, Clinical Neurophysiology, 75185 Uppsala, Sweden
    J Physiol 577:339-52. 2006
    ....
  23. ncbi request reprint Acute and chronic ventricular-arterial coupling in systole and diastole: insights from an elderly hypertensive model
    Brian P Shapiro
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hypertension 50:503-11. 2007
    ..These observations provide insight into the mechanisms whereby arterial remodeling and acute and chronic VA coupling in both systole and diastole may predispose to and interact with increases in load to cause HFnlEF...
  24. pmc A troponin switch that regulates muscle contraction by stretch instead of calcium
    Bogos Agianian
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
    EMBO J 23:772-9. 2004
    ....
  25. ncbi request reprint Mineralocorticoid signaling in transition to heart failure with normal ejection fraction
    Brian P Shapiro
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, USA
    Hypertension 51:289-95. 2008
    ....