C Lange

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. pmc Hepatocytic differentiation of mesenchymal stem cells in cocultures with fetal liver cells
    Claudia Lange
    Center of Bone Marrow Transplantation, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    World J Gastroenterol 12:2394-7. 2006
  2. pmc Radiation rescue: mesenchymal stromal cells protect from lethal irradiation
    Claudia Lange
    Clinic for Stem Cell Transplantation, Department of Cell and Gene Therapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e14486. 2011
  3. ncbi request reprint Liver-specific gene expression in mesenchymal stem cells is induced by liver cells
    Claudia Lange
    Center of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    World J Gastroenterol 11:4497-504. 2005
  4. ncbi request reprint Hepatocytic gene expression in cultured rat mesenchymal stem cells
    C Lange
    Center of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transplant Proc 37:276-9. 2005
  5. ncbi request reprint High-potential human mesenchymal stem cells
    Claudia Lange
    University Hospital Hamburg Eppendorf, Center of Bone Marrow Transplantation, 20246 Hamburg, Germany
    Stem Cells Dev 14:70-80. 2005
  6. ncbi request reprint Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine
    Claudia Lange
    Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Cell Physiol 213:18-26. 2007
  7. ncbi request reprint [Magnetic resonance imaging of single SPIO labeled mesenchymal stem cells at 3 Tesla]
    K Peldschus
    Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitatsklinikum Hamburg Eppendorf
    Rofo 179:473-9. 2007
  8. ncbi request reprint [Labeling of mesenchymal stem cells with different superparamagnetic particles of iron oxide and detectability with MRI at 3T]
    H Ittrich
    Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Radiologisches Zentrum, Universitatsklinikum Hamburg Eppendorf
    Rofo 177:1151-63. 2005
  9. ncbi request reprint In vivo magnetic resonance imaging of iron oxide-labeled, arterially-injected mesenchymal stem cells in kidneys of rats with acute ischemic kidney injury: detection and monitoring at 3T
    Harald Ittrich
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, DE 20246 Hamburg, Germany
    J Magn Reson Imaging 25:1179-91. 2007
  10. pmc Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development: an immunohistochemical study
    Jozef Zustin
    Institute of Pathology, University of Hamburg Eppendorf, Hamburg, Germany
    Am J Pathol 177:1072-8. 2010

Collaborators

Detail Information

Publications30

  1. pmc Hepatocytic differentiation of mesenchymal stem cells in cocultures with fetal liver cells
    Claudia Lange
    Center of Bone Marrow Transplantation, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    World J Gastroenterol 12:2394-7. 2006
    ..To investigate the hepatocytic differentiation of mesenchymal stem cells (MSCs) in co-cultures with fetal liver cells (FLC) and the possibility to expand differentiated hepatocytic cells...
  2. pmc Radiation rescue: mesenchymal stromal cells protect from lethal irradiation
    Claudia Lange
    Clinic for Stem Cell Transplantation, Department of Cell and Gene Therapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e14486. 2011
    ..Because of time consuming donor search and uncertain outcome we propose MSC treatment as an alternative treatment for severely radiation-affected individuals...
  3. ncbi request reprint Liver-specific gene expression in mesenchymal stem cells is induced by liver cells
    Claudia Lange
    Center of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    World J Gastroenterol 11:4497-504. 2005
    ..Furthermore, we assessed the influence of cocultured liver cells on induction of liver-specific gene expression...
  4. ncbi request reprint Hepatocytic gene expression in cultured rat mesenchymal stem cells
    C Lange
    Center of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transplant Proc 37:276-9. 2005
    ..We conclude that MSC may possess an enhanced capacity to differentiate into functional liver cells. Additionally, environmental factors seem to be crucial for specific and directed differentiation...
  5. ncbi request reprint High-potential human mesenchymal stem cells
    Claudia Lange
    University Hospital Hamburg Eppendorf, Center of Bone Marrow Transplantation, 20246 Hamburg, Germany
    Stem Cells Dev 14:70-80. 2005
    ..Separation of these cells provide an effective and convenient method for rapid expansion of pluripotential human MSCs for clinical use where large amounts of stem cells are needed...
  6. ncbi request reprint Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine
    Claudia Lange
    Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Cell Physiol 213:18-26. 2007
    ..In summary, we have established a GMP-compatible protocol for safe and accelerated expansion of hMSC to be used in cell and tissue therapy...
  7. ncbi request reprint [Magnetic resonance imaging of single SPIO labeled mesenchymal stem cells at 3 Tesla]
    K Peldschus
    Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitatsklinikum Hamburg Eppendorf
    Rofo 179:473-9. 2007
    ..To assess the detectability of single magnetically labeled mesenchymal stem cells (MSC) in-vitro on a clinical 3T MR scanner using a small animal volume coil...
  8. ncbi request reprint [Labeling of mesenchymal stem cells with different superparamagnetic particles of iron oxide and detectability with MRI at 3T]
    H Ittrich
    Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Radiologisches Zentrum, Universitatsklinikum Hamburg Eppendorf
    Rofo 177:1151-63. 2005
    ..In vitro evaluation of labeling efficiency of human mesenchymal stem cells (hMSCs) with different types of superparamagnetic iron oxide nanoparticles as well as detection and quantification by MRI at 3T...
  9. ncbi request reprint In vivo magnetic resonance imaging of iron oxide-labeled, arterially-injected mesenchymal stem cells in kidneys of rats with acute ischemic kidney injury: detection and monitoring at 3T
    Harald Ittrich
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, DE 20246 Hamburg, Germany
    J Magn Reson Imaging 25:1179-91. 2007
    ..To evaluate MRI for a qualitative and quantitative in vivo tracking of intraaortal injected iron oxide-labeled mesenchymal stem cells (MSC) into rats with acute kidney injury (AKI)...
  10. pmc Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development: an immunohistochemical study
    Jozef Zustin
    Institute of Pathology, University of Hamburg Eppendorf, Hamburg, Germany
    Am J Pathol 177:1072-8. 2010
    ....
  11. ncbi request reprint Fetal and adult liver stem cells for liver regeneration and tissue engineering
    H C Fiegel
    Pediatric Surgery, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Cell Mol Med 10:577-87. 2006
    ..Future studies have to investigate, which stem cell and environmental conditions would be most suitable for the use of stem cells for liver regeneration or tissue engineering approaches...
  12. doi request reprint Neurogenic transdifferentiation of human adipose-derived stem cells? A critical protocol reevaluation with special emphasis on cell proliferation and cell cycle alterations
    Kai Michael Kompisch
    Department of Anatomy II Experimental Morphology, Center for Experimental Medicine, University Hospital Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Histochem Cell Biol 134:453-68. 2010
    ....
  13. ncbi request reprint Liver-specific gene expression in cultured human hematopoietic stem cells
    Henning C Fiegel
    Bone Marrow Transplantation Center, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Stem Cells 21:98-104. 2003
    ..The results indicate that CD34(+) adult human bone marrow stem cells can differentiate into hepatocytic cells in vitro...
  14. ncbi request reprint Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use
    Norbert Stute
    Bone Marrow Transplant Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 32:1212-25. 2004
    ..One major obstacle for their clinical use is the biosafety of fetal calf serum (FCS), which is a crucial part of all media currently used for the culture of MSC...
  15. ncbi request reprint CD34 modulates the trafficking behavior of hematopoietic cells in vivo
    Claudia Lange
    Bone Marrow Transplantation, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Stem Cells Dev 16:297-304. 2007
    ..Our data indicate that CD34 expression in mature blood cells has a suppressive effect on cellular trafficking to hematopoietic stroma organs, thereby supporting a modulating role of the CD34 molecule in cytoadhesion...
  16. ncbi request reprint Reduction of myocardial scar size after implantation of mesenchymal stem cells in rats: what is the mechanism?
    Kai Jaquet
    Department of Cardiology Cell Biology, St Georg Hospital, Hamburg, Germany
    Stem Cells Dev 14:299-309. 2005
    ..But, whether this strategy is directly transferable to the patient suffering from heart disease has to be determined. In addition, the mechanism by which MSC act in the ischemic heart remains to be determined...
  17. ncbi request reprint Sensitive balance of suppressing and activating effects of mesenchymal stem cells on T-cell proliferation
    Lubin Fang
    Bone Marrow Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Transplantation 82:1370-3. 2006
    ..Thus the "immune-privileged" state of MSC represents a sensitive balance of suppressing and activating effects, which should be considered in a clinical setting with limited cell amounts...
  18. doi request reprint Limited immune-modulating activity of porcine mesenchymal stromal cells abolishes their protective efficacy in acute kidney injury
    Bärbel Brunswig-Spickenheier
    Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Stem Cells Dev 19:719-29. 2010
    ..We expect, however, that the treatment of human IRI of the kidney with immune-modulating MSCs will be as effective as in rodent models...
  19. ncbi request reprint Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats
    Claudia Lange
    Department of Bone Marrow Transplantation, University of Hamburg, Hamburg, Germany
    Kidney Int 68:1613-7. 2005
    ..The aim of this study was, therefore, to evaluate the therapeutic effectiveness of bone marrow-derived mesenchymal stem cells in a rat model of ischemia/reperfusion (I/R) ARF...
  20. doi request reprint Endocardial electrogram analysis after intramyocardial injection of mesenchymal stem cells in the chronic ischemic myocardium
    Korff Krause
    Department of Cardiology and Heart Surgery, Asklepios Hospital St Georg, Hamburg, Germany
    Pacing Clin Electrophysiol 32:1319-28. 2009
    ..Cell injection therapies have been introduced for the treatment of patients with coronary heart disease. However, intramyocardial injection of bone marrow (BM)-derived cells may generate proarrhythmogenicity...
  21. ncbi request reprint Minor histocompatibility antigens on canine hemopoietic progenitor cells
    Martin Weber
    Clinical Cooperative Group Hemopoietic Cell Transplantation, University of Munich, Munich, Germany
    J Immunol 170:5861-8. 2003
    ..We conclude that CTL can be produced in vitro and in vivo against mHA on canine hemopoietic progenitor cells using bone marrow-derived DCs...
  22. ncbi request reprint Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector dose
    Zhixiong Li
    Experimental Cell Therapy, Department of Hematology and Oncology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Exp Hematol 31:1206-14. 2003
    ..We developed and evaluated a reliable transduction protocol that is more related to clinical methods...
  23. ncbi request reprint Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene
    Hrvoje Miletic
    Abteilung für Neuropathologie, Universitat zu Koln, Koln, Germany
    Mol Ther 15:1373-81. 2007
    ..In conclusion, BM-TICs expressing a suicide gene were highly effective in the treatment of malignant glioma in a rat model and therefore hold great potential for the therapy of malignant brain tumors in humans...
  24. ncbi request reprint Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms
    Florian Tögel
    Division of Nephrology, University of Utah, Salt Lake City, UT 84148, USA
    Am J Physiol Renal Physiol 289:F31-42. 2005
    ....
  25. ncbi request reprint Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells
    Sonja Schrepfer
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Stem Cells Dev 16:105-7. 2007
    ..We further show that cytokine supplementation enhances MSC proliferation without jeopardizing their pluripotency...
  26. ncbi request reprint Bovine herpesvirus 4 based vector interaction with liver cells in vitro and in vivo
    Gaetano Donofrio
    Dipartimento di Salute Animale, Facolta di Medicina Veterinaria, Sezione di Malattie Infettive degli Animali, Universita di Parma, Via del Taglio 8, 43100 Parma, Italy
    J Virol Methods 136:126-36. 2006
    ..The present study serves as a starting point for study of the use of BoHV-4 based vectors to target gene delivery to vascular endothelial cells...
  27. ncbi request reprint Improved functional mapping of the human amygdala using a standard functional magnetic resonance imaging sequence with simple modifications
    Carmen Morawetz
    MR Research in Neurology and Psychiatry, Medical Faculty, Georg August University Gottingen, 37099 Gottingen, Germany
    Magn Reson Imaging 26:45-53. 2008
    ..e., the reduction of section thickness) is sufficient to improve the detectability of amygdala activation...
  28. ncbi request reprint Size abnormalities of the superior parietal cortices are related to dissociation in borderline personality disorder
    Eva Irle
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, D 37075 Gottingen, Germany
    Psychiatry Res 156:139-49. 2007
    ..Possibly, larger precuneus size in BPD is related to symptoms of depersonalization. Increased postcentral gyrus size in BPD may be related to the development of DA or DID in the presence of severe childhood abuse...
  29. ncbi request reprint Abnormal size of the amygdala predicts impaired emotional memory in major depressive disorder
    Godehard Weniger
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, D 37075 Gottingen, FRG, Germany
    J Affect Disord 94:219-29. 2006
    ..Individuals with MDD have difficulties in emotional memory. A relationship between emotional memory deficits and structural abnormalities of amygdala and hippocampus in MDD has been proposed but not shown, yet...
  30. ncbi request reprint Interleukin-10 modulation of alloreactivity and graft-versus-host reactions
    Xiao Nong Wang
    Department of Haematology, School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Transplantation 74:772-8. 2002
    ..This study aims to demonstrate, for the first time, whether the addition of exogenous IL-10 can reduce the severity of graft-versus-host reactions (GvHR) in humans...