Ulrich Kunzendorf

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi request reprint CCR7 signaling inhibits T cell proliferation
    Ekkehard Ziegler
    Department of Nephrology and Hypertension, University of Kiel, Kiel, Germany
    J Immunol 179:6485-93. 2007
  2. ncbi request reprint Programmed necrosis in acute kidney injury
    Andreas Linkermann
    Correspondence and offprint requests to Ulrich Kunzendorf E mail
    Nephrol Dial Transplant 27:3412-9. 2012
  3. ncbi request reprint FTY720--the first compound of a new promising class of immunosuppressive drugs
    Ulrich Kunzendorf
    Division of Nephrology and Hypertension, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    Nephrol Dial Transplant 19:1677-81. 2004
  4. ncbi request reprint [Chronic renal failure and transplantation]
    U Kunzendorf
    Klinik für Nieren und Hochdruckkrankheiten, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 12, 24105 Kiel
    Internist (Berl) 48:804-12. 2007
  5. doi request reprint Novel aspects of pharmacological therapies for acute renal failure
    Ulrich Kunzendorf
    Division of Nephrology and Hypertension, University of Kiel, Kiel, Germany
    Drugs 70:1099-114. 2010
  6. doi request reprint A cell-based approach to the minimization of immunosuppression in renal transplantation
    James A Hutchinson
    Laboratory of Transplantation Research of the Clinic of General and Thoracic Surgery, University of Schleswig Holstein, Kiel, Germany
    Transpl Int 21:742-54. 2008
  7. doi request reprint Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation
    James A Hutchinson
    Laboratory for Transplantation Research, Department of General and Cardiothoracic Surgery, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transpl Int 21:728-41. 2008
  8. pmc Effective blockage of both the extrinsic and intrinsic pathways of apoptosis in mice by TAT-crmA
    Stefan Krautwald
    Division of Nephrology and Hypertension, University of Kiel, 24105 Kiel, Germany
    J Biol Chem 285:19997-20005. 2010
  9. doi request reprint Preoperative treatment of a presensitized kidney transplant recipient with donor-derived transplant acceptance-inducing cells
    James A Hutchinson
    Laboratory of Transplantation Research of the Clinic of General and Thoracic Surgery, University of Schleswig Holstein, Kiel, Germany
    Transpl Int 21:808-13. 2008
  10. ncbi request reprint CCL19-IgG prevents allograft rejection by impairment of immune cell trafficking
    Ekkehard Ziegler
    Address correspondence to Dr Ulrich Kunzendorf, University of Kiel, Department of Nephrology and Hypertension, Schittenhelmstrasse 12, 24105 Kiel, Germany
    J Am Soc Nephrol 17:2521-32. 2006

Detail Information

Publications37

  1. ncbi request reprint CCR7 signaling inhibits T cell proliferation
    Ekkehard Ziegler
    Department of Nephrology and Hypertension, University of Kiel, Kiel, Germany
    J Immunol 179:6485-93. 2007
    ..Thus, CCR7, a chemokine receptor that has been demonstrated to play an essential role during activation of the immune response, is also competent to directly inhibit T cell proliferation...
  2. ncbi request reprint Programmed necrosis in acute kidney injury
    Andreas Linkermann
    Correspondence and offprint requests to Ulrich Kunzendorf E mail
    Nephrol Dial Transplant 27:3412-9. 2012
    ..We conclude that pathologists were quite right to refer to ischaemic kidney injury as 'acute tubular necrosis'...
  3. ncbi request reprint FTY720--the first compound of a new promising class of immunosuppressive drugs
    Ulrich Kunzendorf
    Division of Nephrology and Hypertension, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    Nephrol Dial Transplant 19:1677-81. 2004
  4. ncbi request reprint [Chronic renal failure and transplantation]
    U Kunzendorf
    Klinik für Nieren und Hochdruckkrankheiten, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 12, 24105 Kiel
    Internist (Berl) 48:804-12. 2007
    ..To address these problems, specific recommendations for patient surveillance have been provided by different transplantation societies...
  5. doi request reprint Novel aspects of pharmacological therapies for acute renal failure
    Ulrich Kunzendorf
    Division of Nephrology and Hypertension, University of Kiel, Kiel, Germany
    Drugs 70:1099-114. 2010
    ..In the future, these new approaches will enable us to extend our therapeutic repertoire...
  6. doi request reprint A cell-based approach to the minimization of immunosuppression in renal transplantation
    James A Hutchinson
    Laboratory of Transplantation Research of the Clinic of General and Thoracic Surgery, University of Schleswig Holstein, Kiel, Germany
    Transpl Int 21:742-54. 2008
    ....
  7. doi request reprint Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation
    James A Hutchinson
    Laboratory for Transplantation Research, Department of General and Cardiothoracic Surgery, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transpl Int 21:728-41. 2008
    ..It is concluded that TAIC therapy is both safe and clinically practicable; however, the TAIC-I trial was unable to provide evidence that postoperative TAIC administration has a beneficial effect...
  8. pmc Effective blockage of both the extrinsic and intrinsic pathways of apoptosis in mice by TAT-crmA
    Stefan Krautwald
    Division of Nephrology and Hypertension, University of Kiel, 24105 Kiel, Germany
    J Biol Chem 285:19997-20005. 2010
    ..In summary, these results provide a proof of principle for the inhibition of apoptosis with TAT-crmA, which might provide a new treatment option for ischemia-reperfusion injuries...
  9. doi request reprint Preoperative treatment of a presensitized kidney transplant recipient with donor-derived transplant acceptance-inducing cells
    James A Hutchinson
    Laboratory of Transplantation Research of the Clinic of General and Thoracic Surgery, University of Schleswig Holstein, Kiel, Germany
    Transpl Int 21:808-13. 2008
    ..The case of patient FR provides further evidence of the safety of pre-transplantation treatment with TAICs...
  10. ncbi request reprint CCL19-IgG prevents allograft rejection by impairment of immune cell trafficking
    Ekkehard Ziegler
    Address correspondence to Dr Ulrich Kunzendorf, University of Kiel, Department of Nephrology and Hypertension, Schittenhelmstrasse 12, 24105 Kiel, Germany
    J Am Soc Nephrol 17:2521-32. 2006
    ..This shows that in contrast to only limited prolongation of graft survival in CCR7 knockout models, the therapeutic application of a CCR7 ligand in a wild-type environment provides a benefit in terms of immunosuppression...
  11. pmc Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock
    Andreas Linkermann
    Division of Nephrology and Hypertension, Christian Albrechts University, Kiel, Germany
    Mol Med 18:577-86. 2012
    ..These data highlight the importance of separating genetic RIP3 deficiency from RIP1 inhibition by Nec-1 application in vivo and challenge the current definition of necroptosis...
  12. pmc The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice
    Andreas Linkermann
    Division of Nephrology and Hypertension, Christian Albrechts University, Kiel, Germany
    J Am Soc Nephrol 24:1545-57. 2013
    ..In addition, Nec-1 prevented RCM-induced dilation of peritubular capillaries, suggesting a novel role unrelated to cell death for the RIP1 kinase domain in the regulation of microvascular hemodynamics and pathophysiology of CIAKI. ..
  13. ncbi request reprint Low-dose sirolimus in combination with mycophenolate mofetil improves kidney graft function late after renal transplantation and suggests pharmacokinetic interaction of both immunosuppressive drugs
    Lutz Renders
    Department of Nephrology, University of Kiel, Germany
    Kidney Blood Press Res 27:181-5. 2004
    ....
  14. pmc Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury
    Andreas Linkermann
    Division of Nephrology and Hypertension and Institute for Pathology, Christian Albrechts University, 24105 Kiel, Germany
    Proc Natl Acad Sci U S A 110:12024-9. 2013
    ..The data demonstrate the pathophysiological coexistence and corelevance of two separate pathways of RN in IRI and suggest that combination therapy targeting distinct RN pathways can be beneficial in the treatment of ischemic injury. ..
  15. doi request reprint Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury
    Andreas Linkermann
    Division of Nephrology and Hypertension, Christian Albrechts University, Kiel, Germany
    Kidney Int 81:751-61. 2012
    ..Necrostatin-1 may have therapeutic potential to prevent and treat renal ischemia/reperfusion injury...
  16. doi request reprint Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure
    Andreas Linkermann
    Division of Nephrology and Hypertension, Christian Albrechts University, Kiel, Germany
    Kidney Int 79:169-78. 2011
    ..Thus, our study shows that cisplatin-induced nephropathy is mediated through FasL, functionally expressed on tubular cells that are capable of inducing death of cells of adjacent tubules...
  17. doi request reprint Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible
    James A Hutchinson
    Department of General and Cardiothoracic Surgery, Laboratory for Transplantation Research, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Clin Transplant 23:140-5. 2009
    ..It is concluded that the production and administration of TAICs to recipients of kidney transplants from deceased donors is technically feasible...
  18. doi request reprint Increased mycophenolic acid exposure in stable kidney transplant recipients on tacrolimus as compared with those on sirolimus: implications for pharmacokinetics
    F Braun
    Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Universitaetsklinikum Schleswig Holstein UKSH, Campus Kiel, Kiel, Germany
    Clin Pharmacol Ther 86:411-5. 2009
    ..It is suggested that the influence of tacrolimus on the pharmacokinetics of MPA reflects an interaction of the two agents at the level of their intestinal absorption...
  19. ncbi request reprint CYP3A5 genotype markedly influences the pharmacokinetics of tacrolimus and sirolimus in kidney transplant recipients
    L Renders
    Department of Nephrology and Hypertension, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Clin Pharmacol Ther 81:228-34. 2007
    ..Dose adaptation according to trough levels, however, appears to be sufficient to maintain similar concentration-time profiles...
  20. ncbi request reprint Determination of the pharmacokinetics of cerivastatin when administered in combination with sirolimus and cyclosporin A in patients with kidney transplant, and review of the relevant literature
    L Renders
    Division of Nephrology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Int J Clin Pharmacol Ther 41:499-503. 2003
    ....
  21. pmc Inhibition of regulated cell death by cell-penetrating peptides
    Stefan Krautwald
    Department of Nephrology and Hypertension, University Hospital Schleswig Holstein, 24105, Kiel, Germany
    Cell Mol Life Sci 73:2269-84. 2016
    ....
  22. pmc Synchronized renal tubular cell death involves ferroptosis
    Andreas Linkermann
    Clinic for Nephrology and Hypertension, Christian Albrechts University Kiel, 24105 Kiel, Germany
    Proc Natl Acad Sci U S A 111:16836-41. 2014
    ..Finally, ferroptosis mediates postischemic and toxic renal necrosis, which may be therapeutically targeted by ferrostatins and by combination therapy. ..
  23. pmc Ectopic expression of CCL19 impairs alloimmune response in mice
    Stefan Krautwald
    Department of Nephrology and Hypertension, University of Schleswig Holstein, Campus Kiel, Germany
    Immunology 112:301-9. 2004
    ....
  24. ncbi request reprint Transduction of the TAT-FLIP fusion protein results in transient resistance to Fas-induced apoptosis in vivo
    Stefan Krautwald
    Department of Nephrology and Hypertension, University of Schleswig Holstein, Campus Kiel, 24105, Germany
    J Biol Chem 279:44005-11. 2004
    ..Therefore, application of cellular FLIPS in the form of a TAT fusion protein may open a promising, easily applicable new tool for providing protection against transient, pathologically increased apoptosis in various diseases...
  25. doi request reprint Antibody-dependent cellular cytotoxicity in patients on chronic hemodialysis
    Till Koch
    Department of Internal Medicine IV, Nephrology and Hypertension, Christian Albrechts University, Kiel, Germany
    Am J Nephrol 38:379-87. 2013
    ..However, knowledge about ADCC capacity of dialysis patients (DP) is limited. The aim of our study was to investigate if ADCC capacity of effector cells obtained from DP differed from those of healthy individuals (HI)...
  26. pmc Regulated cell death in AKI
    Andreas Linkermann
    Clinic for Nephrology and Hypertension, Christian Albrechts University, Kiel, Germany
    J Am Soc Nephrol 25:2689-701. 2014
    ..Additionally, other cell death pathways, like pyroptosis and ferroptosis, may also be of pathophysiologic relevance in AKI. Combination therapy targeting multiple cell-death pathways may, therefore, provide maximal therapeutic benefits...
  27. doi request reprint Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus
    Henrike Bruckmueller
    Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig Holstein, Campus Kiel Department of Nephrology, University Hospital Rechts der Isar, Technical University of Munich Department of Nephrology and Hypertension, University Hospital Schleswig Holstein, Campus Kiel, Germany Department of Nephrology, Odense University Hospital, Institute of Molecular Medicine, Institute of Clinical Research, University of Southern Denmark, Odense and Institute of Medical Informatics and Statistics, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Ther Drug Monit 37:288-95. 2015
    ..We aimed to investigate combined effects of these gene variants on tacrolimus maintenance dose and PK in patients with stable kidney transplantation of 2 study centers...
  28. ncbi request reprint Images in clinical medicine. Radiographic appearance of lanthanum
    Simon Cerny
    University of Kiel, D 24105 Kiel, Germany
    N Engl J Med 355:1160. 2006
  29. pmc Tacrolimus and cerivastatin pharmacokinetics and adverse effects after single and multiple dosing with cerivastatin in renal transplant recipients
    Lutz Renders
    University Hospital of Schleswig Holstein, Campus Kiel, Division of Nephrology, 24105 Kiel, Germany
    Br J Clin Pharmacol 56:214-9. 2003
    ..The aim of this study was to investigate the pharmacokinetics, and adverse effects of cerivastatin combined with tacrolimus in renal transplant patients...
  30. doi request reprint Efficacy and safety of tacrolimus compared with ciclosporin A in renal transplantation: three-year observational results
    Bernhard K Krämer
    Klinik und Poliklinik für Innere Medizin II Nephrologie, Klinikum der Universitat Regensburg, Germany
    Nephrol Dial Transplant 23:2386-92. 2008
    ....
  31. ncbi request reprint Open prospective multicenter study of conversion to tacrolimus therapy in renal transplant patients experiencing ciclosporin-related side-effects
    Raimund Margreiter
    Landeskrankenhaus Innsbruck, Transplantation, Anichstr, Innsbruck, Austria
    Transpl Int 18:816-23. 2005
    ..Mean systolic blood pressure (SBP) was reduced from 152.9 to 137.5 mmHg and mean diastolic blood pressure (DBP) from 90.7 to 85.8 mmHg. Ciclosporin-related side-effects resolved or improved after conversion to tacrolimus...
  32. ncbi request reprint Efficacy and safety of tacrolimus compared with cyclosporin A microemulsion in renal transplantation: 2 year follow-up results
    Bernhard K Krämer
    Klinik und Poliklinik für Innere Medizin II Nephrologie, Klinikum der Universitat Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Nephrol Dial Transplant 20:968-73. 2005
    ....
  33. ncbi request reprint Restoration of renal allograft function by endovascular stenting of an iliac artery dissection
    Christian Delles
    Department of Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 17:1116-8. 2002
  34. ncbi request reprint Bone disease after renal transplantation
    Ulrich Kunzendorf
    Nephrol Dial Transplant 23:450-8. 2008
  35. ncbi request reprint Failure of cyclosporin A to induce transforming growth factor beta (TGF-beta) synthesis in activated peripheral blood lymphocytes
    Margarete Goppelt-Struebe
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Loschgestrasse 8, Germany
    Clin Transplant 17:20-5. 2003
    ..Furthermore, up-regulation of Cox-2 mRNA was inhibited by CsA. Taken together, there was no evidence for TGF-beta as a clinically relevant mediator being induced by CsA in activated peripheral blood T-lymphocytes...
  36. ncbi request reprint Duration of donor brain death and its influence on kidney graft function
    Ulrich Kunzendorf
    Department of Nephrology, Friedrich Alexander University, Erlangen, Germany
    Am J Transplant 2:292-4. 2002
    ....
  37. ncbi request reprint Dialysis-associated acquired cystic kidney disease imitating autosomal dominant polycystic kidney disease in a patient receiving long-term peritoneal dialysis
    Daniel Neureiter
    Department of Pathology, University of Erlangen, Heidelberg, Germany
    Nephrol Dial Transplant 17:500-3. 2002