Arnt V Kristen

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Skeletal scintigraphy indicates disease severity of cardiac involvement in patients with senile systemic amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, Im Neuenheimer Feld 410, Heidelberg, Germany
    Int J Cardiol 164:179-84. 2013
  2. pmc Green tea halts progression of cardiac transthyretin amyloidosis: an observational report
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Res Cardiol 101:805-13. 2012
  3. ncbi request reprint Risk stratification in cardiac amyloidosis: novel approaches
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Transplantation 80:S151-5. 2005
  4. doi request reprint Assessment of disease severity and outcome in patients with systemic light-chain amyloidosis by the high-sensitivity troponin T assay
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, Heidelberg University, Heidelberg, Germany
    Blood 116:2455-61. 2010
  5. doi request reprint Staged heart transplantation and chemotherapy as a treatment option in patients with severe cardiac light-chain amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    Eur J Heart Fail 11:1014-20. 2009
  6. doi request reprint [60-year old woman with round lesion of the right upper lobe of the lung after heart transplantation]
    A V Kristen
    Abteilung für Innere Medizin III, Medizinische Universitatsklinik Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg
    Internist (Berl) 51:207-12. 2010
  7. ncbi request reprint Transthyretin valine-94-alanine, a novel variant associated with late-onset systemic amyloidosis with cardiac involvement
    Arnt V Kristen
    Department of Cardiology, Medical University of Heidelberg, Heidelberg, Germany
    Amyloid 14:283-7. 2007
  8. doi request reprint Prophylactic implantation of cardioverter-defibrillator in patients with severe cardiac amyloidosis and high risk for sudden cardiac death
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Heart Rhythm 5:235-40. 2008
  9. doi request reprint High prevalence of amyloid in 150 surgically removed heart valves--a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditions
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    Cardiovasc Pathol 19:228-35. 2010
  10. doi request reprint [Risk stratification and treatment of cardiac amyloidoses]
    A V Kristen
    Abteilung für Innere Medizin III Kardiologie, Angiologie, Pneumologie, Medizinische Klinik der Universität Heidelberg Ludolf Krehl Klinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland
    Pathologe 30:212-8. 2009

Detail Information

Publications38

  1. doi request reprint Skeletal scintigraphy indicates disease severity of cardiac involvement in patients with senile systemic amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, Im Neuenheimer Feld 410, Heidelberg, Germany
    Int J Cardiol 164:179-84. 2013
    ..Senile systemic amyloidosis (SSA) is a common aging phenomenon in the elderly population. Nevertheless, pre-mortem diagnosis of SSA is rare. Thus, data on clinical characterization and disease severity are limited...
  2. pmc Green tea halts progression of cardiac transthyretin amyloidosis: an observational report
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Res Cardiol 101:805-13. 2012
    ..Thus, it might also halt progression of TTR amyloidosis. This is a single-center observational report on the effects of GT consumption in patients with ATTR cardiomopathy...
  3. ncbi request reprint Risk stratification in cardiac amyloidosis: novel approaches
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Transplantation 80:S151-5. 2005
    ..Heart transplantation based on novel risk markers including NT-proBNP might be a suitable therapeutic approach for patients with manifest cardiac amyloidosis, but will require alternative patient selection and listing criteria...
  4. doi request reprint Assessment of disease severity and outcome in patients with systemic light-chain amyloidosis by the high-sensitivity troponin T assay
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, Heidelberg University, Heidelberg, Germany
    Blood 116:2455-61. 2010
    ..Plasma levels of the hs-TnT assay are associated with the clinical, morphologic, and functional severity of cardiac AL amyloidosis and could provide useful information for clinicians on cardiac involvement and outcome...
  5. doi request reprint Staged heart transplantation and chemotherapy as a treatment option in patients with severe cardiac light-chain amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    Eur J Heart Fail 11:1014-20. 2009
    ..The prognosis of advanced cardiac light-chain amyloidosis is poor. Heart transplantation might enable causative therapy and ultimately improve prognosis...
  6. doi request reprint [60-year old woman with round lesion of the right upper lobe of the lung after heart transplantation]
    A V Kristen
    Abteilung für Innere Medizin III, Medizinische Universitatsklinik Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg
    Internist (Berl) 51:207-12. 2010
    ..Immunosuppressive treatment increases the risk for opportunistic infections early after transplantation as well as malignancies during the late course...
  7. ncbi request reprint Transthyretin valine-94-alanine, a novel variant associated with late-onset systemic amyloidosis with cardiac involvement
    Arnt V Kristen
    Department of Cardiology, Medical University of Heidelberg, Heidelberg, Germany
    Amyloid 14:283-7. 2007
    ..Final clinical assessment of severity of cardiac involvement in the present patient is rendered complex by possible concomitant or preceding idiopathic dilated cardiomyopathy...
  8. doi request reprint Prophylactic implantation of cardioverter-defibrillator in patients with severe cardiac amyloidosis and high risk for sudden cardiac death
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Heart Rhythm 5:235-40. 2008
    ..Cardiac light-chain amyloidosis carries a high risk for death predominantly from progressive cardiomyopathy or sudden death (SCD). Independent risk factors for SCD are syncope and complex nonsustained ventricular arrhythmias...
  9. doi request reprint High prevalence of amyloid in 150 surgically removed heart valves--a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditions
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    Cardiovasc Pathol 19:228-35. 2010
    ..The prevalence, pathophysiology, and clinical indicators of valvular amyloid deposition have not been clarified yet...
  10. doi request reprint [Risk stratification and treatment of cardiac amyloidoses]
    A V Kristen
    Abteilung für Innere Medizin III Kardiologie, Angiologie, Pneumologie, Medizinische Klinik der Universität Heidelberg Ludolf Krehl Klinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland
    Pathologe 30:212-8. 2009
    ..Referral to specialized centers is strongly recommended...
  11. ncbi request reprint Rapid progression of left ventricular wall thickness predicts mortality in cardiac light-chain amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 26:1313-9. 2007
    ..Due to its high mortality, identification of patients at high risk is crucial for treatment strategies such as heart transplantation prior to chemotherapy for amyloid disease...
  12. ncbi request reprint Non-invasive predictors of survival in cardiac amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Eur J Heart Fail 9:617-24. 2007
    ..Patients with cardiac amyloidosis (CA) have increased mortality...
  13. ncbi request reprint Indications for high-dose chemotherapy with autologous stem cell support in patients with systemic amyloid light chain amyloidosis
    Stefan O Schonland
    Department of Internal Medicine V Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Transplantation 80:S160-3. 2005
    ..Here we review recent results of ASCT, eligibility criteria for HDM and report our own treatment results in 41 patients...
  14. ncbi request reprint High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II study
    Jolanta B Perz
    Department of Haematology Oncology, Clinic of Internal Medicine, University of Heidelberg, 69120 Heidelberg, Germany
    Br J Haematol 127:543-51. 2004
    ..We could not show an additional benefit of VAD induction in terms of increasing haematological response rate; however the 13% mortality rate after HDM and ASCT in our series was lower than the previous report...
  15. doi request reprint Treatment with intravenous melphalan and dexamethasone is not able to overcome the poor prognosis of patients with newly diagnosed systemic light chain amyloidosis and severe cardiac involvement
    Sascha Dietrich
    Division of Hematology Oncology, Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Blood 116:522-8. 2010
    ..These parameters might help to identify patients who will not benefit from M-Dex chemotherapy...
  16. doi request reprint Serum levels of NT-proBNP as surrogate for cardiac amyloid burden: new evidence from gadolinium-enhanced cardiac magnetic resonance imaging in patients with amyloidosis
    Stephanie Lehrke
    Department of Medicine III, Division of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
    Amyloid 16:187-95. 2009
    ..We aimed to use contrast enhanced cardiac magnetic resonance imaging (CMR) to identify functional and structural alterations related to levels of NT-proBNP better to understand the mechanisms of its release in cardiac amyloidosis...
  17. doi request reprint Longitudinal left ventricular function for prediction of survival in systemic light-chain amyloidosis: incremental value compared with clinical and biochemical markers
    Sebastian J Buss
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Am Coll Cardiol 60:1067-76. 2012
    ..The aim of the study was to determine whether longitudinal left ventricular (LV) function provides prognostic information in a large cohort of patients with systemic light-chain (AL) amyloidosis...
  18. doi request reprint Late enhancement in cardiac amyloidosis: correlation of MRI enhancement pattern with histopathological findings
    Waldemar Hosch
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    Amyloid 15:196-204. 2008
    ..LE seems to be associated with fibrosis due to ischemia of cardiomyocytes by small vessel amyloid deposition rather than with amyloid deposition in CA, suggesting that amyloid deposition might be present prior to LE detection...
  19. doi request reprint Improvement of risk assessment in systemic light-chain amyloidosis using human placental growth factor
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, Heidelberg University, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 104:250-7. 2015
    ..g. endothelial dysfunction. This study evaluated the clinical role of PlGF in light-chain amyloidosis...
  20. ncbi request reprint MR-relaxometry of myocardial tissue: significant elevation of T1 and T2 relaxation times in cardiac amyloidosis
    Waldemar Hosch
    Department of Radiology, University Hospital Heidelberg, Heidelberg, Germany
    Invest Radiol 42:636-42. 2007
    ..Therefore, we measured T1 and T2 relaxation times (RT) of the left ventricular myocardium with magnetic resonance imaging at 1.5 T...
  21. ncbi request reprint Preserved norepinephrine reuptake but reduced sympathetic nerve endings in hypertrophic volume-overloaded rat hearts
    Arnt V Kristen
    Department of Cardiology, Medical University of Heidelberg, Heidelberg, Germany
    J Card Fail 12:577-83. 2006
    ..The underlying regulatory mechanisms are discussed controversially and were investigated in the present study in CHF resulting from volume overload...
  22. pmc Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study
    Fabian Aus dem Siepen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 9:6319-25. 2015
    ..We sought to investigate changes of cardiac function and morphology in patients with wtATTR-CM after consumption of green tea extract (GTE)...
  23. doi request reprint Extracellular remodeling in patients with wild-type amyloidosis consuming epigallocatechin-3-gallate: preliminary results of T1 mapping by cardiac magnetic resonance imaging in a small single center study
    Fabian Aus dem Siepen
    Department of Cardiology, Angiology, Pneumology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 104:640-7. 2015
    ..It remained unclear, whether reduction of LV myocardial mass reflects decrease of amyloid load or progressive atrophy of cardiomyocytes...
  24. doi request reprint Osteopontin: a novel predictor of survival in patients with systemic light-chain amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, Heidelberg University, Heidelberg, Germany
    Amyloid 21:202-10. 2014
    ..Recently, plasma level of osteopontin (OPN), a secreted phosphoglycoprotein expressed by a variety of cell types, has been reported as a risk predictor in various cardiovascular diseases...
  25. doi request reprint Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion
    Arnt V Kristen
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Cardiovasc Pathol 22:280-6. 2013
    ..This study using different transgenic mouse models provided first evidence that apoptosis in myocardial ischemia-reperfusion injury is rather linked to the mitochondrial pathway than to death receptor pathway...
  26. doi request reprint Return to work after heart transplantation: discrepancy with subjective work ability
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Transplantation 87:1001-5. 2009
    ....
  27. doi request reprint Right ventricular long axis strain-validation of a novel parameter in non-ischemic dilated cardiomyopathy using standard cardiac magnetic resonance imaging
    Nisha Arenja
    Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Eur J Radiol 85:1322-8. 2016
    ..The purpose of this study was the evaluation of its diagnostic performance in non-ischemic dilated cardiomyopathy (NIDCM) and the determination of reference values in controls...
  28. doi request reprint Cardiac Amyloid Load: A Prognostic and Predictive Biomarker in Patients With Light-Chain Amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University of Heidelberg, Heidelberg, Germany Electronic address
    J Am Coll Cardiol 68:13-24. 2016
    ..Cardiac amyloid load has not been analyzed for its effect on mortality in patients with amyloid light-chain (AL) cardiac amyloidosis...
  29. doi request reprint Anterior Aortic Plane Systolic Excursion: A Novel Indicator of Transplant-Free Survival in Systemic Light-Chain Amyloidosis
    Marco M Ochs
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany Electronic address
    J Am Soc Echocardiogr 29:1188-1196. 2016
    ..Anterior aortic plane systolic excursion (AAPSE) was evaluated in the present pilot study as a novel echocardiographic indicator of transplant-free survival in patients with systemic light-chain amyloidosis...
  30. doi request reprint The "Wagshurst study": p.Val40Ile transthyretin gene variant causes late-onset cardiomyopathy
    Ralf Bauer
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Amyloid 21:267-75. 2014
    ..This study aims to characterize a cohort of patients with the rare transthyretin (TTR) Val20Ile (p.TTRVal40Ile) variant...
  31. doi request reprint Noninvasive risk stratification of patients with transthyretin amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany Electronic address
    JACC Cardiovasc Imaging 7:502-10. 2014
    ....
  32. pmc In vivo detection of nerve injury in familial amyloid polyneuropathy by magnetic resonance neurography
    Jennifer Kollmer
    1 Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany 2 Amyloidosis Centre Heidelberg, University of Heidelberg, Heidelberg, Germany
    Brain 138:549-62. 2015
    ..Imaging of proximal nerve lesions, which are difficult to detect by nerve conduction studies, may have future implications also for other distally-symmetric polyneuropathies. ..
  33. pmc Fast assessment of long axis strain with standard cardiovascular magnetic resonance: a validation study of a novel parameter with reference values
    Johannes H Riffel
    Department of Cardiology, Angiology and Pneumology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    J Cardiovasc Magn Reson 17:69. 2015
    ..The aim of this study was to develop a fast assessable parameter for the measurement of long axis strain (LAS) with CMR...
  34. doi request reprint Acupuncture improves exercise tolerance of patients with heart failure: a placebo-controlled pilot study
    Arnt V Kristen
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Heart 96:1396-400. 2010
    ..Experimental data have shown that stimulation of certain acupoints decreases autonomic dysbalance...
  35. doi request reprint Coronary angiography-related myocardial injury as detected by high-sensitivity cardiac troponin T assay
    Haitham Abu Sharar
    Department of Cardiology, Heidelberg University Hospital, Heidelberg, Germany
    EuroIntervention 12:337-44. 2016
    ..We sought to evaluate rates and mechanisms of myocardial injury and type 4a myocardial infarction (MI) after an elective diagnostic coronary angiography (CAG) as detected by high-sensitivity cardiac troponin T (hsTnT) assay...
  36. ncbi request reprint Endothelin-1 inhibits the neuronal norepinephrine transporter in hearts of male rats
    Johannes Backs
    Department of Cardiology, University of Heidelberg, INF 410, D 69120 Heidelberg, Germany
    Cardiovasc Res 67:283-90. 2005
    ..An impairment of cardiac NE re-uptake by the neuronal NE transporter (NET) contributes to an increased NE net release in failing hearts. We hypothesized that both phenomena are caused by ET-1-mediated inhibition of NET...
  37. ncbi request reprint Genetic microheterogeneity of human transthyretin detected by IEF
    Klaus Altland
    Institut fur Humangenetik, Justus Liebig Universitat, Giessen, Germany
    Electrophoresis 28:2053-64. 2007
    ..All types of amyloidogenic mutations affected the stability of TTR tetramers...
  38. ncbi request reprint Suspected cardiac amyloidosis: endomyocardial biopsy remains the diagnostic gold-standard
    Arnt V Kristen
    Am J Hematol 82:328. 2007