Andreas Krieger

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Hippocampal seizure resistance and reduced neuronal excitotoxicity in mice lacking the Cav2.3 E/R-type voltage-gated calcium channel
    Marco Weiergräber
    Institute of Neurophysiology, University of Cologne D 50931 Cologne, Germany
    J Neurophysiol 97:3660-9. 2007
  2. ncbi request reprint Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel
    Marco Weiergräber
    Institute of Neurophysiology, University of Cologne, Koln, Germany
    Epilepsia 47:839-50. 2006
  3. ncbi request reprint The Ca(v)2.3 voltage-gated calcium channel in epileptogenesis--shedding new light on an enigmatic channel
    Marco Weiergräber
    Institute for Neurophysiology, University of Cologne, Robert Koch Str 39, D 50931 Cologne, Germany
    Neurosci Biobehav Rev 30:1122-44. 2006
  4. doi request reprint Voltage-gated calcium channels in the etiopathogenesis and treatment of absence epilepsy
    Marco Weiergräber
    Institute of Neurophysiology, University of Cologne, Germany
    Brain Res Rev 62:245-71. 2010
  5. doi request reprint [Human calcium channelopathies. Voltage-gated Ca(2+) channels in etiology, pathogenesis, and pharmacotherapy of neurologic disorders]
    M Weiergräber
    Institut fur Neurophysiologie, Medizinische Einrichtungen, Universitat zu Koln, Robert Koch Strasse 39, 50931, Koln, Deutschland
    Nervenarzt 79:426-36. 2008
  6. doi request reprint Altered thalamocortical rhythmicity in Ca(v)2.3-deficient mice
    Marco Weiergräber
    Institute of Neurophysiology, Faculty of Medicine, University of Cologne, Germany Center for Molecular Medicine Cologne CMMC, University of Cologne, Germany
    Mol Cell Neurosci 39:605-18. 2008
  7. ncbi request reprint The molecular chaperone hsp70 interacts with the cytosolic II-III loop of the Cav2.3 E-type voltage-gated Ca2+ channel
    Andreas Krieger
    Institute for Neurophysiology, University of Cologne, Germany
    Cell Physiol Biochem 17:97-110. 2006
  8. ncbi request reprint The cytosolic II-III loop of Cav2.3 provides an essential determinant for the phorbol ester-mediated stimulation of E-type Ca2+ channel activity
    Udo Klockner
    Institute of Vegetative Physiology, University of Cologne, Germany
    Eur J Neurosci 19:2659-68. 2004
  9. ncbi request reprint Arrhythmia in isolated prenatal hearts after ablation of the Cav2.3 (alpha1E) subunit of voltage-gated Ca2+ channels
    Zhong Ju Lu
    Institute of Neurophysiology, Medical Faculty, University of Koln, Germany
    Cell Physiol Biochem 14:11-22. 2004
  10. doi request reprint The C-terminus of human Ca(v)2.3 voltage-gated calcium channel interacts with alternatively spliced calmodulin-2 expressed in two human cell lines
    Marcel A Kamp
    Institute for Neurophysiology, University of Cologne, Germany
    Biochim Biophys Acta 1824:1045-57. 2012

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Hippocampal seizure resistance and reduced neuronal excitotoxicity in mice lacking the Cav2.3 E/R-type voltage-gated calcium channel
    Marco Weiergräber
    Institute of Neurophysiology, University of Cologne D 50931 Cologne, Germany
    J Neurophysiol 97:3660-9. 2007
    ..3 voltage-gated calcium channel plays a crucial role in both hippocampal ictogenesis and seizure generalization and is of central importance in neuronal degeneration after excitotoxic events...
  2. ncbi request reprint Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel
    Marco Weiergräber
    Institute of Neurophysiology, University of Cologne, Koln, Germany
    Epilepsia 47:839-50. 2006
    ..The aim of our study was to perform an electroencephalographic analysis, seizure-susceptibility testing, and histomorphologic characterization of Ca(v)2.3-/- mice to unravel the functional relevance of Ca(v)2.3 in ictogenesis...
  3. ncbi request reprint The Ca(v)2.3 voltage-gated calcium channel in epileptogenesis--shedding new light on an enigmatic channel
    Marco Weiergräber
    Institute for Neurophysiology, University of Cologne, Robert Koch Str 39, D 50931 Cologne, Germany
    Neurosci Biobehav Rev 30:1122-44. 2006
    ..3 in etiology and pathogenesis of human epileptic syndromes as well as development of new antiepileptic drugs specifically targeting Ca(v)2.3 turns out to become indispensable...
  4. doi request reprint Voltage-gated calcium channels in the etiopathogenesis and treatment of absence epilepsy
    Marco Weiergräber
    Institute of Neurophysiology, University of Cologne, Germany
    Brain Res Rev 62:245-71. 2010
    ..Finally, various antiepileptic drugs that have been proven to or are supposed to exert anti-absence effects are discussed with respect to their pharmacodynamics and pharmacokinetics...
  5. doi request reprint [Human calcium channelopathies. Voltage-gated Ca(2+) channels in etiology, pathogenesis, and pharmacotherapy of neurologic disorders]
    M Weiergräber
    Institut fur Neurophysiologie, Medizinische Einrichtungen, Universitat zu Koln, Robert Koch Strasse 39, 50931, Koln, Deutschland
    Nervenarzt 79:426-36. 2008
    ..In this review we characterise the different human Ca(2+) channelopathies known so far, further illuminating basic pathophysiologic mechanisms and clinical aspects...
  6. doi request reprint Altered thalamocortical rhythmicity in Ca(v)2.3-deficient mice
    Marco Weiergräber
    Institute of Neurophysiology, Faculty of Medicine, University of Cologne, Germany Center for Molecular Medicine Cologne CMMC, University of Cologne, Germany
    Mol Cell Neurosci 39:605-18. 2008
    ..This study provides evidence for the first time that Ca(v)2.3 E/R-type Ca2+ channels are important in modulating thalamocortical hyperoscillation exerting anti-epileptogenic effects in non-convulsive absence seizures...
  7. ncbi request reprint The molecular chaperone hsp70 interacts with the cytosolic II-III loop of the Cav2.3 E-type voltage-gated Ca2+ channel
    Andreas Krieger
    Institute for Neurophysiology, University of Cologne, Germany
    Cell Physiol Biochem 17:97-110. 2006
    ..3 splice variants stimulate autophosphorylation of PKCa, leading to the suggestion that hsp70--binding to the II-III loop--may act as an adaptor for Ca2+ dependent targeting of PKC to E-type Ca2+ channels...
  8. ncbi request reprint The cytosolic II-III loop of Cav2.3 provides an essential determinant for the phorbol ester-mediated stimulation of E-type Ca2+ channel activity
    Udo Klockner
    Institute of Vegetative Physiology, University of Cologne, Germany
    Eur J Neurosci 19:2659-68. 2004
    ..3 was eliminated. Receptor independent stimulation of PKC and its interaction with Ca(v)2.3 channels therefore represents an important positive feedback mechanism to decode electrical signals into a variety of cellular functions...
  9. ncbi request reprint Arrhythmia in isolated prenatal hearts after ablation of the Cav2.3 (alpha1E) subunit of voltage-gated Ca2+ channels
    Zhong Ju Lu
    Institute of Neurophysiology, Medical Faculty, University of Koln, Germany
    Cell Physiol Biochem 14:11-22. 2004
    ..3e as ion conducting pore stabilize a more regular heart beat in prenatal mice...
  10. doi request reprint The C-terminus of human Ca(v)2.3 voltage-gated calcium channel interacts with alternatively spliced calmodulin-2 expressed in two human cell lines
    Marcel A Kamp
    Institute for Neurophysiology, University of Cologne, Germany
    Biochim Biophys Acta 1824:1045-57. 2012
    ..The structure of the N-terminal extension is predicted to be more hydrophobic than the remaining CaM-2-ext protein, suggesting that it may help to dock it to the lipophilic membrane surrounding...
  11. doi request reprint APLP1 and Rab5A interact with the II-III loop of the voltage-gated Ca-channel Ca(v)2.3 and modulate its internalization differently
    Kayalvizhi Radhakrishnan
    Institute for Neurophysiology and Center for Molecular Medicine Cologne, University of Cologne, Robert Koch Strasse 39, Cologne, Germany
    Cell Physiol Biochem 28:603-12. 2011
    ..Among the different types of VGCCs, the Ca(v)2.3 calcium channel and its regulation mechanisms are least understood due to Ca(v)2.3's resistance to most pharmacological agents...
  12. ncbi request reprint Alternate splicing in the cytosolic II-III loop and the carboxy terminus of human E-type voltage-gated Ca(2+) channels: electrophysiological characterization of isoforms
    Alexey Pereverzev
    Institute of Neurophysiology, University of Cologne, Robert Koch Strasse 39, D 50931 Cologne, Germany
    Mol Cell Neurosci 21:352-65. 2002
    ..3 splice variants...
  13. doi request reprint Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds
    Sabine A Eming
    Department of Dermatology, Center for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, Institute for Oral and Musculoskeletal Biology, University of Cologne, Cologne, Germany
    J Proteome Res 9:4758-66. 2010
    ..This analysis therefore represents an important basis for the search for potential biomarkers, which give rise to a better understanding and monitoring of disease progression in chronic wounds...