Genomes and Genes
Affiliation: University of Cologne
- Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathologyChristoph Kohler
Medical Faculty, Institute II for Anatomy, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
Acta Neuropathol 132:339-59. 2016..This review provides a detailed overview of the various aspects of GVD and focuses on the relationship between tau pathology and GVD. ..
- Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosisChristoph Kohler
Institute II for Anatomy, Medical Faculty, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany Electronic address
Neurobiol Dis 71:169-79. 2014..Our results suggest that NFT-formation activates the UPR in pR5 mice and that it is the early stages of neurofibrillary tangle formation that are accompanied by GVD, in line with observations from studies on human autopsy cases. ..
- The actin-binding protein caldesmon is in spleen and lymph nodes predominately expressed by smooth-muscle cells, reticular cells, and follicular dendritic cellsChristoph N Köhler
Institute II of Anatomy, Medical Faculty, University of Cologne, 50931 Cologne, Germany
J Histochem Cytochem 58:183-93. 2010..In spleen of SCID mice, caldesmon was expressed by reticular cells in the absence of lymphocytes...
- Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic miceChristoph Kohler
Institute II for Anatomy, Medical Faculty, University of Cologne, Cologne, Germany
Neurobiol Aging 34:1369-79. 2013..They also reveal for the mouse models studied, that tau- rather than an amyloid-β peptide-induced pathology is associated with increased neuronal tyrosine phosphorylation...
- Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levelsChristoph Kohler
Institute II of Anatomy, Department of Neuroanatomy, University of Cologne, Josef Stelzmann Strasse 9, D 50931 Cologne, Germany
Neurobiol Dis 20:528-40. 2005..However, plaque development started much later and developed slowly until the age of 18 months but then increased more rapidly...
- Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastasesChristoph Kohler
Institute II of Anatomy, Medical Faculty, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Virchows Arch 459:81-9. 2011..Our results show a differential behavior of h- and l-caldesmon isoforms in epithelium and stroma of colon adenocarcinoma and lymph node metastases...
- Histochemical localization of caldesmon in the CNS and ganglia of the mouseChristoph N Köhler
Institute II of Anatomy, Medical Faculty, University of Cologne, Cologne, Germany
J Histochem Cytochem 59:504-17. 2011....
- Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathyC Kohler
Dept of Anatomy Neuroanatomy, University Hospital Cologne, Cologne, Germany
Brain Res 1347:111-24. 2010..Our data show that although pR5 mice develop neurofibrillary lesions, they do not model the degeneration of basal forebrain cholinergic neurons observed in Alzheimer's disease...
- Allograft inflammatory factor-1/Ionized calcium-binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testisChristoph Kohler
Institute II of Anatomy, University of Cologne, Joseph Stelzmann Strasse 9, 50931, Cologne, Germany
Cell Tissue Res 330:291-302. 2007..AIF-1/Iba1 can be regarded a "pan-macrophage marker" because, except for alveolar macrophages, all subpopulations of macrophages examined express AIF-1/Iba1...
- IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelinationSusanna Freude
Department of Internal Medicine II, University of Cologne, Cologne, Germany
J Neurochem 107:907-17. 2008..Furthermore, in neuronal/brain-specific insulin receptor knockout mice myelination was unchanged. Thus, our experiments reveal that IGF-1R/IRS-2 mediated signals are critical for appropriate timing of myelination in vivo...
- Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic miceKerstin Morcinek
Department of Anatomy II Neuroanatomy, University of Cologne, Kerpener Straβe 62, 50924 Cologne, Germany
Brain Res 1497:73-84. 2013....
- Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's diseaseSusanna Freude
Department of Internal Medicine II, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
FASEB J 23:3315-24. 2009..However, neuronal IR deletion had no influence on lethality of Tg2576 mice. Thus, impaired IGF-1/IRS-2 signaling prevents premature death and delays amyloid accumulation in a model of AD...
- Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicingYlva Mende
Institute of Human Genetics, Center for Molecular Medicine Cologne, University of Cologne, Cologne 50931, Germany
Hum Mol Genet 19:2154-67. 2010..Surprisingly, deletion of Sfrs10 by recombinant Cre showed no impact on SMN2 splicing but increased SMN levels. Our findings highlight the complexity by which alternatively spliced exons are regulated in vivo...
- Analysis of ribosomal protein S6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampusMaria Klingebiel
Institute II for Anatomy, Medical Faculty, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Brain Res . 2017....