Affiliation: University Hospital
- Role of cellular mechanics in the function and life span of vascular endotheliumKatrin Kliche
Institute of Physiology II, University of Munster, Robert Koch Strasse 27b, Munster, Germany
Pflugers Arch 462:209-17. 2011..This may explain the recently observed beneficial effects of spironolactone on the cardiovascular system. Taken together, the review highlights the importance of elasticity for normal endothelial function...
- Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndromeVerena Drüppel
Institute of Physiology II, University of Munster, Munster, Germany
FASEB J 27:3652-9. 2013..This emphasizes the key role of vascular endothelium as a therapeutical target in cardiovascular disorders and might explain blood pressure independent actions of MR antagonism...
- Membrane potential depolarization decreases the stiffness of vascular endothelial cellsChiara Callies
Institute of Physiology II, University of Munster, Robert Koch Str 27b, 48149 Munster, Germany
J Cell Sci 124:1936-42. 2011..This depolarization-induced decrease in the stiffness of endothelial cells could play a role in flow-mediated nitric-oxide-dependent vasodilation...
- Endothelial sodium channels trigger endothelial salt sensitivity with agingMoritz Paar
From the Institute of Physiology II M P, K K V, V D, H O and Department of Internal Medicine D H P, K K, University Hospital of Munster, Munster, Germany
Hypertension 64:391-6. 2014..This mechanism might contribute to the development of age-related cardiovascular disease and suggests the usage of spironolactone and amiloride specifically in the elderly. ..
- Salt overload damages the glycocalyx sodium barrier of vascular endotheliumHans Oberleithner
Institute of Physiology II, University of Munster, Robert Koch Str 27b, 48149, Munster, Germany
Pflugers Arch 462:519-28. 2011..Damaged eGC facilitates sodium entry into the endothelial cells. This could explain endothelial dysfunction and arterial hypertension observed in sodium abuse...
- Recharging red blood cell surface by hemodialysisKatrin Kliche
Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital, Westfalische Wilhelms Universitat, Munster, Germany
Cell Physiol Biochem 35:1107-15. 2015..e. loss of negative charges) leads to increased erythrocyte sodium sensitivity (ESS) quantified by a recently developed salt-blood-test (SBT). The hypothesis was tested whether a regular 4-hour hemodialysis (4h-HD) alters ESS...
- C-reactive protein makes human endothelium stiff and tightKristina Kusche-Vihrog
Institute of Physiology II, Muenster, Germany
Hypertension 57:231-7. 2011..The data indicate that CRP enhances the effects of aldosterone on the mechanical properties of the endothelium. Thus, CRP could counteract any decrease in arterial blood pressure that accompanies severe acute inflammatory processes...