Claus Detlev Klemke

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi [Persistent hemorrhagic crusts on the lips of a 13-year-old patient. Cheilitis crustosa factitia]
    C D Klemke
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin
    Hautarzt 53:265-7. 2002
  2. ncbi Multiple juvenile xanthogranulomas successfully treated with CO laser
    Claus Detlev Klemke
    Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 5:30-3. 2007
  3. doi The diagnosis of Sézary syndrome on peripheral blood by flow cytometry requires the use of multiple markers
    C D Klemke
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, 68135 Mannheim, Germany
    Br J Dermatol 159:871-80. 2008
  4. ncbi Molecular biology and targeted therapy of cutaneous T-cell lymphomas
    C D Klemke
    Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    G Ital Dermatol Venereol 143:365-74. 2008
  5. ncbi Prognostic factors and prediction of prognosis by the CTCL Severity Index in mycosis fungoides and Sézary syndrome
    C D Klemke
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Br J Dermatol 153:118-24. 2005
  6. ncbi Atypical generalized eruptive histiocytosis associated with acute monocytic leukemia
    Claus Detlev Klemke
    Department of Dermatology, Free University of Berlin, University Medical Center Benjamin Franklin, Germany
    J Am Acad Dermatol 49:S233-6. 2003
  7. ncbi Clonal T cell receptor gamma-chain gene rearrangement by PCR-based GeneScan analysis in the skin and blood of patients with parapsoriasis and early-stage mycosis fungoides
    Claus Detlev Klemke
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Germany
    J Pathol 197:348-54. 2002
  8. ncbi New insights into the molecular biology and targeted therapy of cutaneous T-cell lymphomas
    Claus Detlev Klemke
    Department of Dermatology, Venereologie und Allergology, University Medical Center Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 4:395-406. 2006
  9. doi Clinical spectrum of primary cutaneous CD30-positive anaplastic large cell lymphoma: an analysis of the Mannheim Cutaneous Lymphoma Registry
    Nina Booken
    Department of Dermatology, Venereology, and Allergology, Mannheim University School of Medicine, Germany
    J Dtsch Dermatol Ges 10:331-9. 2012
  10. ncbi Common clonal T-cell origin in a patient with T-prolymphocytic leukaemia and associated cutaneous T-cell lymphomas
    Chalid Assaf
    Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Germany
    Br J Haematol 120:488-91. 2003

Detail Information

Publications24

  1. ncbi [Persistent hemorrhagic crusts on the lips of a 13-year-old patient. Cheilitis crustosa factitia]
    C D Klemke
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin
    Hautarzt 53:265-7. 2002
  2. ncbi Multiple juvenile xanthogranulomas successfully treated with CO laser
    Claus Detlev Klemke
    Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 5:30-3. 2007
    ..No diabetes insipidus, pituitary hyperplasia or paraproteinemia were observed. Skin lesions were treated with a CO(2) laser and did not reappear during a 5 years follow-up period...
  3. doi The diagnosis of Sézary syndrome on peripheral blood by flow cytometry requires the use of multiple markers
    C D Klemke
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, 68135 Mannheim, Germany
    Br J Dermatol 159:871-80. 2008
    ..Diagnosis of Sézary syndrome (SS)-defining blood involvement is hampered by the lack of Sézary cell-specific markers and nonspecific morphology of the tumour cells...
  4. ncbi Molecular biology and targeted therapy of cutaneous T-cell lymphomas
    C D Klemke
    Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    G Ital Dermatol Venereol 143:365-74. 2008
    ..Several clinical trials testing these targeted therapies have shown encouraging results. This article provides an overview of recent research developments and therapeutic strategies for cutaneous T-cell lymphoma...
  5. ncbi Prognostic factors and prediction of prognosis by the CTCL Severity Index in mycosis fungoides and Sézary syndrome
    C D Klemke
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Br J Dermatol 153:118-24. 2005
    ..Cutaneous T-cell lymphoma (CTCL) is a slowly progressive malignancy for which there is no cure. Therefore, accurate prediction of prognosis is important for the conduct of clinical trials and for counselling of individuals...
  6. ncbi Atypical generalized eruptive histiocytosis associated with acute monocytic leukemia
    Claus Detlev Klemke
    Department of Dermatology, Free University of Berlin, University Medical Center Benjamin Franklin, Germany
    J Am Acad Dermatol 49:S233-6. 2003
    ..We discuss the differential diagnoses of the clinical picture and stress that this benign cutaneous disorder may indicate an underlying hematologic malignancy...
  7. ncbi Clonal T cell receptor gamma-chain gene rearrangement by PCR-based GeneScan analysis in the skin and blood of patients with parapsoriasis and early-stage mycosis fungoides
    Claus Detlev Klemke
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Germany
    J Pathol 197:348-54. 2002
    ....
  8. ncbi New insights into the molecular biology and targeted therapy of cutaneous T-cell lymphomas
    Claus Detlev Klemke
    Department of Dermatology, Venereologie und Allergology, University Medical Center Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 4:395-406. 2006
    ..Several clinical trials testing these targeted therapies have shown encouraging results. This article provides an overview of recent research developments and therapeutic strategies for cutaneous T-cell lymphoma...
  9. doi Clinical spectrum of primary cutaneous CD30-positive anaplastic large cell lymphoma: an analysis of the Mannheim Cutaneous Lymphoma Registry
    Nina Booken
    Department of Dermatology, Venereology, and Allergology, Mannheim University School of Medicine, Germany
    J Dtsch Dermatol Ges 10:331-9. 2012
    ..The clinical features and disease courses of C-ALCL identified in the lymphoma registry of Mannheim University hospital are described in the following...
  10. ncbi Common clonal T-cell origin in a patient with T-prolymphocytic leukaemia and associated cutaneous T-cell lymphomas
    Chalid Assaf
    Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Germany
    Br J Haematol 120:488-91. 2003
    ..This unique observation suggests that in T-PLL, the leukaemic cells might undergo secondary transformation, subsequently resulting in different phenotypes of cutaneous T-cell lymphoma...
  11. doi Cutaneous tumor cell load correlates with survival in patients with Sézary syndrome
    Nina Booken
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 11:67-79. 2013
    ..Sézary syndrome (SS) is defined by the triad of erythroderma, generalized lymphadenopathy and more than 1 000 circulating Sézary cells/μl in the peripheral blood...
  12. doi Combination therapy with extracorporeal photopheresis, interferon-alpha, PUVA and topical corticosteroids in the management of Sézary syndrome
    Nina Booken
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 8:428-38. 2010
    ..Extracorporeal photopheresis (ECP) is recommended for the treatment of Sézary syndrome (SS), the leukemic variant of cutaneous T-cell lymphoma (CTCL). Several combination therapies are used to increase response rates to ECP...
  13. ncbi Predominant telangiectatic erythema in linear atrophoderma of Moulin: novel variant or separate entity?
    Jochen Utikal
    Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    Dermatology 207:310-5. 2003
    ..Due to considerable overlap, we do not favour the notion that our cases constitute an entity entirely separate from linear atrophoderma of Moulin...
  14. ncbi [Ulceration of the scalp: a unique manifestation of pyoderma gangrenosum]
    Nina Poenitz
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim
    J Dtsch Dermatol Ges 3:113-6. 2005
    ..In conclusion, we again draw attention to unilesional pyoderma gangrenosum of the scalp as a rare disease entity. Immunosuppressive drugs are an effective treatment modality...
  15. doi Lack of T-cell receptor-induced signaling is crucial for CD95 ligand up-regulation and protects cutaneous T-cell lymphoma cells from activation-induced cell death
    Claus Detlev Klemke
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Res 69:4175-83. 2009
    ..These results show a novel mechanism of AICD resistance in CTCL that could have future therapeutic implications to overcome apoptosis resistance in CTCL patients...
  16. doi The value of molecular diagnostics in primary cutaneous B-cell lymphomas in the context of clinical findings, histology, and immunohistochemistry
    Moritz Felcht
    Department of Dermatology, University Medicine Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    J Am Acad Dermatol 64:135-43, 143.e1-4. 2011
    ..Diagnosis of PCBCL is mainly based on clinical and (immuno)-histochemical grounds...
  17. pmc Warty skin changes, chronic scrotal lymphoedema, and facial dysmorphism
    Moritz Felcht
    University Medicine of Mannheim, Department of Dermatology, Venerology and Allergology, Mannheim, Germany
    BMJ Case Rep 2010:. 2010
    ..His ears were low set and retroverted with a thick helix. However, no diagnosis was made for 49 years. The interdisciplinary dialogue of various specialists to make the final diagnosis is presented and discussed...
  18. ncbi Additional Her 2/neu gene copies in patients with Sézary syndrome
    Jochen Utikal
    Department of Dermatology, Venerology and Allergology, University Medical Center Mannheim, Ruprecht Karl University Heidelberg, Mannheim, Germany
    Leuk Res 30:755-60. 2006
    ..Her 2/neu gene amplification has been reported in several types of cancer. Monoclonal antibodies against the Her 2/neu receptor are used as a treatment in e.g. metastatic breast cancer...
  19. ncbi Cutaneous lymphomas in Germany: an analysis of the Central Cutaneous Lymphoma Registry of the German Society of Dermatology (DDG)
    Chalid Assaf
    Department of Dermatology, Allergy and Venereology, Skin Tumor Center Charité HTCC, Charite University Medicine, Berlin, Germany
    J Dtsch Dermatol Ges 5:662-8. 2007
    ..The number of epidemiologic studies is small due to limited availability and limited comparability on population-based data...
  20. ncbi Functional characterization of the epidermal cholinergic system in vitro
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Invest Dermatol 126:2458-72. 2006
    ..In summary, we show that epidermal AChR are crucially involved in the regulation of epidermal homeostasis...
  21. doi [Annular erythema in a 78-year old woman]
    Nina Booken
    Universitätsklinik für Dermatologie, Venerologie und Allergologie Klinikum Mannheim gGmbH Medizinische Fakultät Mannheim der Ruprecht Karls Universität Heidelberg, Theodor Kutzer Ufer 1 3, D 68135 Mannheim
    J Dtsch Dermatol Ges 6:321-3. 2008
  22. ncbi [Cutaneous T-cell lymphoma]
    Edgar Dippel
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Mannheim, Ruprecht Karls Universitat Heidelberg
    J Dtsch Dermatol Ges 1:965-80; quiz 981-2. 2003
  23. ncbi [Ulcerated red, livid nodule on the scrotum of a 64-year old man]
    Tanja Hördt
    Klinik fur Dermatologie, Venerologie and Allergologie, Universitatsklinikum Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim
    J Dtsch Dermatol Ges 2:1027-9. 2004
  24. ncbi T-cell clonality of undetermined significance
    Claus Detlev Klemke
    Arch Dermatol 142:393-4. 2006