Stefan Kippenberger

Summary

Affiliation: University of Frankfurt
Country: Germany

Publications

  1. ncbi request reprint Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor
    Stefan Kippenberger
    Department of Dermatology, University of Frankfurt Medical School, D 60596 FrankfurtMain, Germany
    J Biol Chem 280:3060-7. 2005
  2. doi request reprint Ligand activation of peroxisome proliferator-activated receptor delta suppresses cathepsin B expression in human endothelial cells in a posttranslational manner
    Gabi Reichenbach
    Department of Dermatology, Venereology and Allergology, Frankfurt am Main, Germany
    Exp Dermatol 21:751-7. 2012
  3. doi request reprint Ligation of beta4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament
    Stefan Kippenberger
    Department of Dermatology and Venerology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
    Biochim Biophys Acta 1803:940-50. 2010
  4. pmc The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways
    Igor Hrgovic
    Department of Dermatology, Venereology and Allergology, Goethe University, Theodor Stern Kai 7, Frankfurt Main, 60590, Germany
    BMC Cancer 16:763. 2016
  5. pmc Visible light is a better co-inducer of apoptosis for curcumin-treated human melanoma cells than UVA
    Stephan Buss
    Department of Dermatology, Venereology, and Allergology, University Hospital, J W Goethe University, Frankfurt Main, Germany
    PLoS ONE 8:e79748. 2013
  6. ncbi request reprint Dimethylfumarate inhibits melanoma cell proliferation via p21 and p53 induction and bcl-2 and cyclin B1 downregulation
    Irina Kaluzki
    Department of Dermatology, Venereology and Allergology, Goethe University, Theodor Stern Kai 7, D 60590, Frankfurt am Main, Germany
    Tumour Biol 37:13627-13635. 2016
  7. pmc STAT6-Dependent Collagen Synthesis in Human Fibroblasts Is Induced by Bovine Milk
    Stefan Kippenberger
    Department of Dermatology, Venereology and Allergy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    PLoS ONE 10:e0131783. 2015
  8. doi request reprint PPARα agonist Wy14643 suppresses cathepsin B in human endothelial cells via transcriptional, post-transcriptional and post-translational mechanisms
    Gabi Reichenbach
    Department of Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Angiogenesis 16:223-33. 2013
  9. ncbi request reprint Hypotonic stress induces E-cadherin expression in cultured human keratinocytes
    Stefan Kippenberger
    Department of Dermatology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
    FEBS Lett 579:207-14. 2005
  10. doi request reprint Development and Characterization of an Engraftable Tissue-Cultured Skin Autograft: Alternative Treatment for Severe Electrical Injuries
    Peter Golinski
    Department of Dermatology, Venereology and Allergology, University Hospital, Goethe University, Frankfurt am Main, Germany
    Cells Tissues Organs 200:227-39. 2014

Collaborators

  • Roland Kaufmann
  • Matthias Hofmann
  • Jan Havlicek
  • Jens Gille
  • Markus Meissner
  • August Bernd
  • Igor Hrgovic
  • Monika Doll
  • Jurgen Bereiter-Hahn
  • Eva Maria Valesky
  • Gabi Reichenbach
  • Johannes Kleemann
  • Nadja Zöller
  • Andreas Pinter
  • Eva Valesky
  • Manuel Butting
  • Vesselina Laubach
  • Nadja Nicole Zöller
  • Tsige Hailemariam-Jahn
  • Julia Naidenow
  • Irina Kaluzki
  • Nadja Zoeller
  • Frangis Nikfarjam
  • Xiao Fan Wang
  • Peter Golinski
  • Stephan Buss
  • Anna Starzinski-Powitz
  • Stephanie Hoffmann
  • Diamant Thaci
  • Annette Dorn
  • Jadranka Dujic
  • Yvonne Knies
  • Kim Beyer
  • Detlef Heidemann
  • Anke König
  • Victoria Lang
  • Nadja N Zoeller
  • Henrik Menke
  • Jadranka Dobra
  • Bonnie F Sloane
  • Kerstin Goerg
  • Maila Rossberg
  • Barbara Berlinski
  • Kerstin Görg
  • Karsten Mewes
  • Maike Schultz
  • Martina Spiegel
  • Andrea Sättler
  • Katja Hardt
  • Joquin Diaz-Alperi
  • Jaime Miquel
  • Ana Ramirez-Bosca
  • Andreas Bock
  • Ralf Joachim Ludwig

Detail Information

Publications28

  1. ncbi request reprint Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor
    Stefan Kippenberger
    Department of Dermatology, University of Frankfurt Medical School, D 60596 FrankfurtMain, Germany
    J Biol Chem 280:3060-7. 2005
    ..Evidence is provided that stretch-induced activation of PKB/Akt protects cells against induced apoptosis...
  2. doi request reprint Ligand activation of peroxisome proliferator-activated receptor delta suppresses cathepsin B expression in human endothelial cells in a posttranslational manner
    Gabi Reichenbach
    Department of Dermatology, Venereology and Allergology, Frankfurt am Main, Germany
    Exp Dermatol 21:751-7. 2012
    ..The results bolster other studies demonstrating PPARδ agonists as anti-inflammatory and anticarcinogenic agents and thus might have the potential to help to develop new pharmaceutical drugs...
  3. doi request reprint Ligation of beta4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament
    Stefan Kippenberger
    Department of Dermatology and Venerology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
    Biochim Biophys Acta 1803:940-50. 2010
    ..Taken together our data define a new model of beta4-dependent PKB/Akt and ERK1/2 activation demonstrating the keratin filament as a structure necessary in signal transmission...
  4. pmc The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways
    Igor Hrgovic
    Department of Dermatology, Venereology and Allergology, Goethe University, Theodor Stern Kai 7, Frankfurt Main, 60590, Germany
    BMC Cancer 16:763. 2016
    ..However, the underlying mechanisms of HDACi induced anti-lymphangiogenic properties are not fully investigated so far and in part remain unknown...
  5. pmc Visible light is a better co-inducer of apoptosis for curcumin-treated human melanoma cells than UVA
    Stephan Buss
    Department of Dermatology, Venereology, and Allergology, University Hospital, J W Goethe University, Frankfurt Main, Germany
    PLoS ONE 8:e79748. 2013
    ..These results indicate that a combination of curcumin and light irradiation may be a useful additional therapy in the treatment of malignant disease. ..
  6. ncbi request reprint Dimethylfumarate inhibits melanoma cell proliferation via p21 and p53 induction and bcl-2 and cyclin B1 downregulation
    Irina Kaluzki
    Department of Dermatology, Venereology and Allergology, Goethe University, Theodor Stern Kai 7, D 60590, Frankfurt am Main, Germany
    Tumour Biol 37:13627-13635. 2016
    ..Hence, DMF might be an interesting agent in the treatment of melanoma and is worth further investigation in vivo...
  7. pmc STAT6-Dependent Collagen Synthesis in Human Fibroblasts Is Induced by Bovine Milk
    Stefan Kippenberger
    Department of Dermatology, Venereology and Allergy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    PLoS ONE 10:e0131783. 2015
    ..Therefore, it is tempting to test the herein introduced concept in treatment of atrophic skin conditions induced e.g. by UV light or corticosteroids. ..
  8. doi request reprint PPARα agonist Wy14643 suppresses cathepsin B in human endothelial cells via transcriptional, post-transcriptional and post-translational mechanisms
    Gabi Reichenbach
    Department of Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Angiogenesis 16:223-33. 2013
    ..Overall, our results suggest that the PPARα-dependent anti-angiogenic action of Wy14643 seems to be mediated, in part, by Wy14643-dependent but PPARα-independent regulation of cathepsin B expression...
  9. ncbi request reprint Hypotonic stress induces E-cadherin expression in cultured human keratinocytes
    Stefan Kippenberger
    Department of Dermatology, University of Frankfurt Medical School, D 60590 Frankfurt Main, Germany
    FEBS Lett 579:207-14. 2005
    ..It is likely that induction of E-cadherin contributes to the stabilization between adjacent cells in order to withstand the physical forces induced by hypotonicity...
  10. doi request reprint Development and Characterization of an Engraftable Tissue-Cultured Skin Autograft: Alternative Treatment for Severe Electrical Injuries
    Peter Golinski
    Department of Dermatology, Venereology and Allergology, University Hospital, Goethe University, Frankfurt am Main, Germany
    Cells Tissues Organs 200:227-39. 2014
    ..Tissue-cultured skin autografts may be an alternative to mesh grafts and keratinocyte suspensions that are applied during surgical defect coverage...
  11. doi request reprint Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest
    Eva Maria Valesky
    Department of Dermatology, Venereology and Allergology, Goethe University, Frankfurt am Main, Germany
    Exp Dermatol 25:200-5. 2016
    ..Hence, DMF is a new antilymphangiogenic compound and might be used in various illnesses associated with increased lymphangiogenesis. ..
  12. pmc Peroxisome proliferator-activated receptor (PPAR) α and δ activators induce ICAM-1 expression in quiescent non stimulated endothelial cells
    Julia Naidenow
    Department of Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Inflamm (Lond) 13:27. 2016
    ..Therefore, we examined the effects of various PPARα and δ agonists on the expression of ICAM-1 in non-stimulated primary human endothelial cells...
  13. ncbi request reprint Restoration of E-cadherin sensitizes human melanoma cells for apoptosis
    Stefan Kippenberger
    Department of Dermatology, Division of Pneumology, University of Frankfurt Medical School, Frankfurt Main, Germany
    Melanoma Res 16:393-403. 2006
    ..In conclusion, our findings suggest therapeutic strategies that enable expression of E-cadherin in order to sensitize human melanoma cells towards apoptosis...
  14. doi request reprint Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin dependent mechanism
    Igor Hrgovic
    Department of Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Exp Dermatol . 2016
    ..This article is protected by copyright. All rights reserved...
  15. pmc Influence of Biodentine® - A Dentine Substitute - On Collagen Type I Synthesis in Pulp Fibroblasts In Vitro
    Frangis Nikfarjam
    Department of Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    PLoS ONE 11:e0167633. 2016
    ..However, dissolved particles of the moderate to high concentrated Biodentine® suspensions 24h after mixing induce a significant reduction of TGF-β1 release and reduce the secretion of collagen type I of primary pulp fibroblasts...
  16. doi request reprint Clinical application of a tissue-cultured skin autograft: an alternative for the treatment of non-healing or slowly healing wounds?
    Nadja Zöller
    Department of Dermatology, Venereology and Allergology, Goethe University Medical School, Frankfurt Main, Germany
    Dermatology 229:190-8. 2014
    ..The treatment regime of non-healing or slowly healing wounds is constantly improving. One aspect is surgical defect coverage whereby mesh grafts and keratinocyte suspension are applied...
  17. pmc Vascular endothelial growth factor C-induced lymphangiogenesis decreases tumor interstitial fluid pressure and tumor
    Matthias Hofmann
    Department of Dermatology, Venereology and Allergology, Goethe University, Frankfurt Main, Germany
    Transl Oncol 6:398-404. 2013
    ..This model represents a novel approach to modulate biomechanical properties of the tumor interstitium enabling a lowering of TIFP in vivo. ..
  18. doi request reprint 'Nosing Around' the human skin: what information is concealed in skin odour?
    Stefan Kippenberger
    Department of Dermatology, Venereology and Allergy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Exp Dermatol 21:655-9. 2012
    ..Finally, it is discussed if human skin odour has the quality to act as pheromone transmitting information between individuals in terms of major histocompatibility complex type or reproductive status...
  19. doi request reprint Integration of Langerhans-like cells into a human skin equivalent
    Vesselina Laubach
    Department of Dermatology, Venerology and Allergology, University Hospital, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt Main, Germany
    Arch Dermatol Res 303:135-9. 2011
    ..These skin models provide a tool to further investigate the interactions between Langerhans-like cells and other skin cells and particularly learn more about the cutaneous immune response...
  20. doi request reprint Dimethyl fumarate - only an anti-psoriatic medication?
    Markus Meissner
    Department of Dermatology, Venereology and Allergology, University of Frankfurt, Germany
    J Dtsch Dermatol Ges 10:793-801. 2012
    ..This valued and well-known drug mainly prescribed by dermatologists is now experiencing a renaissance far beyond dermatologic applications...
  21. doi request reprint AP1-dependent repression of TGFα-mediated MMP9 upregulation by PPARδ agonists in keratinocytes
    Markus Meissner
    Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Exp Dermatol 20:425-9. 2011
    ..In conclusion, our data provide the first evidence that MMP9 expression induced by TGFα is a valid target of PPARδ ligands in keratinocytes...
  22. ncbi request reprint Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light
    Jadranka Dujic
    Department of Dermatology and Venerology, Medical School, J W Goethe University, Frankfurt Main, Germany
    J Invest Dermatol 127:1992-2000. 2007
    ..In particular, the latter avoids the use of carcinogenic irradiation that is part of regular phototherapy...
  23. ncbi request reprint Mechanical pressure-induced phosphorylation of p38 mitogen-activated protein kinase in epithelial cells via Src and protein kinase C
    Matthias Hofmann
    Department of Dermatology and Venerology, University Hospital, Johann Wolfgang Goethe University, D 60590 Frankfurt Main, Germany
    Biochem Biophys Res Commun 316:673-9. 2004
    ..These findings suggest mechanical pressure as a new type of effector stimulus for the p38 pathway with implications to (patho-) physiological conditions...
  24. doi request reprint Evaluation of beneficial and adverse effects of glucocorticoids on a newly developed full-thickness skin model
    Nadja Nicole Zöller
    Department of Dermatology and Venerology, J W Goethe University, Medical School, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Toxicol In Vitro 22:747-59. 2008
    ..The present study demonstrates the versatility of this FTSM in the validation of effectiveness and safety of GCs...
  25. ncbi request reprint Long-term lowering of tumour interstitial fluid pressure reduces Ki-67 expression
    Matthias Hofmann
    Department of Dermatology and Venerology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    J Biomech 40:2324-9. 2007
    ..While a singular puncture had no effect catheterized tumours showed a significant decrease in Ki-67 expression. Our data suggest that long-term lowering of TIFP is required to reduce tumour proliferation...
  26. ncbi request reprint Oligonucleotides suppress IL-8 in skin keratinocytes in vitro and offer anti-inflammatory properties in vivo
    Annette Dorn
    Department of Dermatology and Venerology, J W Goethe University, Frankfurt Main, Germany
    J Invest Dermatol 127:846-54. 2007
    ..This effect seems to be independent from Toll-like receptor 9...
  27. ncbi request reprint Mechanical stretch induces clustering of beta1-integrins and facilitates adhesion
    Yvonne Knies
    Department of Dermatology and Venerology, University Hospital, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Exp Dermatol 15:347-55. 2006
    ..In summary, these results show a functional cooperation of beta1-integrins and EGFR in the adhesion complex supporting the transmission of stretch-induced signals...
  28. ncbi request reprint Ligation of the beta4 integrin triggers adhesion behavior of human keratinocytes by an "inside-out" mechanism
    Stefan Kippenberger
    Zentrum der Dermatologie und Venerologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    J Invest Dermatol 123:444-51. 2004
    ..Hence, these findings provide further insight into the conversion processes during carcinogenesis and show the beta(4) integrin to be a key regulator of cellular adhesion...