Hartwig Huland

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint The case against extended lymph-node dissection for prostate cancer
    Hartwig Huland
    Center of Operative Medicine, University Hospital Hamburg Eppendorf in Hamburg, Germany
    Nat Clin Pract Urol 3:456-7. 2006
  2. ncbi request reprint Prediction of tumor heterogeneity in localized prostate cancer
    Hartwig Huland
    Department of Urology, University Clinics Hamburg Eppendorf, Martinistrasse 52, D 20246, Hamburg, Germany
    Urol Clin North Am 29:213-22. 2002
  3. doi request reprint Radical prostatectomy improves progression-free and cancer-specific survival in men with lymph node positive prostate cancer in the prostate-specific antigen era: a confirmatory study
    Thomas Steuber
    Martini Clinic, Prostate Cancer Center, Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 107:1755-61. 2011
  4. doi request reprint The novel nomogram of Gleason sum upgrade: possible application for the eligible criteria of low dose rate brachytherapy
    Lars Budaus
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Urol 17:862-8. 2010
  5. doi request reprint Differences in histopathological and biochemical outcomes in patients with low Gleason score prostate cancer
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 105:818-23. 2010
  6. doi request reprint Initial prostate biopsy: development and internal validation of a biopsy-specific nomogram based on the prostate cancer antigen 3 assay
    Jens Hansen
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 63:201-9. 2013
  7. ncbi request reprint High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series
    Jochen Walz
    Department of Urology, University Medical Centre Eppendorf, Hamburg, Germany
    Eur Urol 50:498-505. 2006
  8. doi request reprint Prognostic significance of a positive surgical margin in pathologically organ-confined prostate cancer
    Sascha A Ahyai
    Department of Urology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 106:478-83. 2010
  9. doi request reprint External validation of a preoperative nomogram for prediction of the risk of recurrence after radical prostatectomy
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 77:788-92. 2010
  10. ncbi request reprint Association of free-prostate specific antigen subfractions and human glandular kallikrein 2 with volume of benign and malignant prostatic tissue
    Thomas Steuber
    Department of Urology, University of Hamburg Eppendorf, Hamburg, Germany
    Prostate 63:13-8. 2005

Detail Information

Publications124 found, 100 shown here

  1. ncbi request reprint The case against extended lymph-node dissection for prostate cancer
    Hartwig Huland
    Center of Operative Medicine, University Hospital Hamburg Eppendorf in Hamburg, Germany
    Nat Clin Pract Urol 3:456-7. 2006
  2. ncbi request reprint Prediction of tumor heterogeneity in localized prostate cancer
    Hartwig Huland
    Department of Urology, University Clinics Hamburg Eppendorf, Martinistrasse 52, D 20246, Hamburg, Germany
    Urol Clin North Am 29:213-22. 2002
    ..Clinical T1 or T2 prostatic carcinoma is a heterogeneous but fairly predictable tumor...
  3. doi request reprint Radical prostatectomy improves progression-free and cancer-specific survival in men with lymph node positive prostate cancer in the prostate-specific antigen era: a confirmatory study
    Thomas Steuber
    Martini Clinic, Prostate Cancer Center, Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 107:1755-61. 2011
    ..Therapy (outcomes research)...
  4. doi request reprint The novel nomogram of Gleason sum upgrade: possible application for the eligible criteria of low dose rate brachytherapy
    Lars Budaus
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Urol 17:862-8. 2010
    ....
  5. doi request reprint Differences in histopathological and biochemical outcomes in patients with low Gleason score prostate cancer
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 105:818-23. 2010
    ..Diagnosis (case series)...
  6. doi request reprint Initial prostate biopsy: development and internal validation of a biopsy-specific nomogram based on the prostate cancer antigen 3 assay
    Jens Hansen
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 63:201-9. 2013
    ..Urinary prostate cancer antigen 3 (PCA3) assay in combination with established clinical risk factors improves the identification of men at risk of harboring prostate cancer (PCa) at initial biopsy (IBX)...
  7. ncbi request reprint High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series
    Jochen Walz
    Department of Urology, University Medical Centre Eppendorf, Hamburg, Germany
    Eur Urol 50:498-505. 2006
    ..We explored the yield of saturation biopsy and developed a nomogram predicting the probability of prostate cancer (PCa) on the basis of saturation biopsy...
  8. doi request reprint Prognostic significance of a positive surgical margin in pathologically organ-confined prostate cancer
    Sascha A Ahyai
    Department of Urology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 106:478-83. 2010
    ....
  9. doi request reprint External validation of a preoperative nomogram for prediction of the risk of recurrence after radical prostatectomy
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 77:788-92. 2010
    ..To test the validity of an updated version of the preoperative Kattan nomogram for prediction of recurrence after radical prostatectomy (RP), published by Stephenson et al...
  10. ncbi request reprint Association of free-prostate specific antigen subfractions and human glandular kallikrein 2 with volume of benign and malignant prostatic tissue
    Thomas Steuber
    Department of Urology, University of Hamburg Eppendorf, Hamburg, Germany
    Prostate 63:13-8. 2005
    ....
  11. ncbi request reprint Zonal location of prostate cancer: significance for disease-free survival after radical prostatectomy?
    Herbert Augustin
    Department of Urology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Urology 62:79-85. 2003
    ..To analyze the zonal location of prostate cancer as a possible predictive feature of progression-free survival after radical prostatectomy...
  12. doi request reprint Assessment of rates of lymph nodes and lymph node metastases in periprostatic fat pads in a consecutive cohort treated with retropubic radical prostatectomy
    Jens Hansen
    Martini Clinic, Prostate Cancer Center at University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Urology 80:877-82. 2012
    ....
  13. doi request reprint Unilateral prostate cancer cannot be accurately predicted in low-risk patients
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 77:784-7. 2010
    ..We tested the accuracy of unilaterally unremarkable biopsy findings in cases of low-risk PCa patients who are potential candidates for HAT...
  14. ncbi request reprint Development and internal validation of preoperative transition zone prostate cancer nomogram
    Thomas Steuber
    Department of Urology, University of Hamburg, Hamburg, Germany
    Urology 68:1295-300. 2006
    ..TZ PCa may be associated with more favorable RP pathologic findings than peripheral zone (PZ) PCa. To identify these men, we developed a model capable of predicting the probability of TZ PCa at RP...
  15. ncbi request reprint Contemporary prostate cancer prevalence among T1c biopsy-referred men with a prostate-specific antigen level < or = 4.0 ng per milliliter
    Sascha A Ahyai
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 53:750-7. 2008
    ..To investigate the prostate cancer (PCa) prevalence and risk factors of men with prostate-specific antigen (PSA) level< or =4.0 ng/ml and an unsuspicious digital rectal examination (DRE) in a large biopsy referral cohort...
  16. doi request reprint Risk assessment of metastatic recurrence in patients with prostate cancer by using the Cancer of the Prostate Risk Assessment score: results from 2937 European patients
    Lars Budaus
    Department of Urology, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 110:1714-20. 2012
    ..2 and 78.5, respectively, in European patients. Therefore, the CAPRA score also allows reliable prediction of the examined endpoints in European patients...
  17. ncbi request reprint Prostate-specific antigen improves the ability of clinical stage and biopsy Gleason sum to predict the pathologic stage at radical prostatectomy in the new millennium
    Felix K H Chun
    Department of Urology, University Medical Centre, Eppendorf, Hamburg, Germany
    Eur Urol 52:1067-74. 2007
    ..The contemporary ability of prostate-specific antigen (PSA) to predict pathologic stage in men with localized prostate cancer was recently questioned...
  18. ncbi request reprint The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer
    Alexander Haese
    Department of Urology, University Hospital Hamburg, Germany
    Prostate 54:181-6. 2003
    ..In this study we investigated whether hK2 adds independent information when considered together with traditionally used parameters to predict organ confined (pT2a/b) PCa...
  19. doi request reprint Biochemical recurrence after radical prostatectomy: multiplicative interaction between surgical margin status and pathological stage
    Lars Budaus
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 184:1341-6. 2010
    ..We addressed the first degree of interaction between positive surgical margins and other established adverse predictors of biochemical recurrence after radical prostatectomy...
  20. doi request reprint Critical assessment of tools to predict clinically insignificant prostate cancer at radical prostatectomy in contemporary men
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    Cancer 113:701-9. 2008
    ..Overtreatment of prostate cancer (PCa) is a concern, especially in patients who might qualify for the diagnosis of insignificant prostate cancer (IPCa). The ability to identify IPCa prior to definitive therapy was tested...
  21. ncbi request reprint Prognostic significance of visible lesions on transrectal ultrasound in impalpable prostate cancers: implications for staging
    Herbert Augustin
    Department of Urology, University of Hamburg, Hamburg, Germany
    J Clin Oncol 21:2860-8. 2003
    ..The aim of this article is to provide a differentiated view of the significance of TRUS findings for staging purposes in impalpable prostate cancers...
  22. ncbi request reprint Total and Gleason grade 4/5 cancer volumes are major contributors of human kallikrein 2, whereas free prostate specific antigen is largely contributed by benign gland volume in serum from patients with prostate cancer or benign prostatic biopsies
    Alexander Haese
    Department of Urology, University Clinic Eppendorf, Hamburg, Germany
    J Urol 170:2269-73. 2003
    ....
  23. doi request reprint High tissue density of FOXP3+ T cells is associated with clinical outcome in prostate cancer
    Anna Flammiger
    Department of Oncology and Hematology, University Medical Center Hamburg Eppendorf, Hubertus Wald Tumorzentrum University Cancer Center Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Eur J Cancer 49:1273-9. 2013
    ..Our study suggests that the intratumoural presence of regulatory T cells may have substantial functional impact and may confer an adverse clinical course in prostate cancer...
  24. doi request reprint Long-term data on the survival of patients with prostate cancer treated with radical prostatectomy in the prostate-specific antigen era
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 106:37-43. 2010
    ..Therapy (case series) Level of Evidence 4...
  25. doi request reprint The presence of prostate cancer on saturation biopsy can be accurately predicted
    Sascha A Ahyai
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 105:636-41. 2010
    ..To improve the ability of our previously reported saturation biopsy nomogram quantifying the risk of prostate cancer, as the use of office-based saturation biopsy has increased...
  26. doi request reprint Effect of body mass index on histopathologic parameters: results of large European contemporary consecutive open radical prostatectomy series
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Urology 73:615-9. 2009
    ..Studies, predominantly derived from the United States, have suggested that an increased BMI is a significant predictor of adverse pathologic findings in patients treated with open RP...
  27. ncbi request reprint Frozen section for the management of intraoperatively detected palpable tumor lesions during nerve-sparing scheduled radical prostatectomy
    Christian Eichelberg
    Department of Urology, University Hospital Hamburg Eppendorf, Germany
    Eur Urol 49:1011-6; discussion 1016-8. 2006
    ..We investigated the use of frozen section (FS) analysis to monitor the safety and efficiency of NS during RP in patients with intraoperatively identified subcapsular tumor lesions...
  28. ncbi request reprint Assessment of clinical and pathologic characteristics predisposing to disease recurrence following radical prostatectomy in men with pathologically organ-confined prostate cancer
    R Jüri Palisaar
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 41:155-61. 2002
    ..To identify risk factors for biochemical failure after radical prostatectomy (RP) in men with pathologically organ-confined (OC) prostate cancer (PCa)...
  29. ncbi request reprint Comparative assessment of the 1992 and 2002 pathologic T3 substages for the prediction of biochemical recurrence after radical prostatectomy
    Thomas Steuber
    Department of Urology, University Hospital Hamburg Eppendorf, Germany
    Cancer 106:775-82. 2006
    ....
  30. ncbi request reprint Anatomic radical retropubic prostatectomy-long-term recurrence-free survival rates for localized prostate cancer
    Felix K H Chun
    Department of Urology, University Medical Center Eppendorf, Hamburg, Germany
    World J Urol 24:273-80. 2006
    ..Our findings confirm excellent long-term biochemical cancer-control outcomes after RRP. High grade prostate cancer at final pathology and seminal vesicle invasion proved to be the strongest risk factors of BCR after surgery...
  31. doi request reprint Distinct subcellular expression patterns of neutral endopeptidase (CD10) in prostate cancer predict diverging clinical courses in surgically treated patients
    Achim Fleischmann
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 14:7838-42. 2008
    ..Neutral endopeptidase (CD10), an ectopeptidase bound to the cell surface, is thought to be a potential prognostic marker for prostate cancer...
  32. doi request reprint Importance of baseline potency rate assessment of men diagnosed with clinically localized prostate cancer prior to radical prostatectomy
    Georg Salomon
    Martini Clinic, Prostate Cancer Center, University of Hamburg, Hamburg, Germany
    J Sex Med 6:498-504. 2009
    ..Knowledge about baseline potency is highly important in men undergoing treatment for prostate cancer (PCa) as it might influence judgments about impact of treatment and thereby treatment decisions...
  33. ncbi request reprint Biochemical recurrence following radical prostatectomy: a comparison between prostate cancers located in different anatomical zones
    Herbert Augustin
    Department of Urology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Prostate 55:48-54. 2003
    ..To assess whether differences of biochemical recurrence after radical prostatectomy exist between prostate cancers located in the transition zone (TZ) and peripheral zone (PZ)...
  34. doi request reprint Prostate cancer gene 3 (PCA3): development and internal validation of a novel biopsy nomogram
    Felix K Chun
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 56:659-67. 2009
    ..Urinary prostate cancer gene 3 (PCA3) represents a promising novel marker of prostate cancer detection...
  35. doi request reprint Recurrent deletion of 3p13 targets multiple tumour suppressor genes and defines a distinct subgroup of aggressive ERG fusion-positive prostate cancers
    Antje Krohn
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Pathol 231:130-41. 2013
    ..In summary, our data show that deletion of 3p13 defines a distinct and aggressive molecular subset of ERG(+) prostate cancers, which is possibly driven by inactivation of multiple tumour suppressors...
  36. ncbi request reprint Development and internal validation of a nomogram predicting the probability of prostate cancer Gleason sum upgrading between biopsy and radical prostatectomy pathology
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 49:820-6. 2006
    ..We explored the rate of upgrading from biopsy to RP specimen in our contemporary cohort, and developed a model capable of predicting the probability of biopsy Gleason sum upgrading...
  37. doi request reprint Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer
    Anna Flammiger
    Departments of Oncology and Hematology, University Medical Center Hamburg Eppendorf, Hubertus Wald Tumorzentrum University Cancer Center Hamburg, Hamburg, Germany
    APMIS 120:901-8. 2012
    ..This study indicates that the density of T but not B cells plays a functional role in the biology of prostate cancer and may have an impact on clinical outcome in this frequent neoplasia...
  38. ncbi request reprint Circulating tumour-associated plasma DNA represents an independent and informative predictor of prostate cancer
    Felix K H Chun
    Department of Urology, University Hospital Hamburg Epppendorf, Hamburg, Germany
    BJU Int 98:544-8. 2006
    ..To investigate whether preoperative plasma levels of free DNA can discriminate between men with localized prostate cancer and benign prostatic hyperplasia (BPH)...
  39. ncbi request reprint Zonal origin of localized prostate cancer does not affect the rate of biochemical recurrence after radical prostatectomy
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 51:949-55; discussion 955. 2007
    ..To investigate whether transition zone (TZ) prostate cancers demonstrate different rates of biochemical recurrence after radical prostatectomy compared to peripheral zone (PZ) cancers...
  40. ncbi request reprint Are false-positive urine markers for the detection of bladder carcinoma really wrong or do they predict tumor recurrence?
    Martin G Friedrich
    University Hospital Eppendorf, Department of Urology, University of Hamburg, Martinistrasse 52, D 20246, Hamburg, Germany
    Eur Urol 43:146-50; discussion 150-1. 2003
    ..We studied whether patients with false-positive results of various urine test had a higher recurrence rate than patients with true-negative results...
  41. ncbi request reprint Comparison of accuracy between the Partin tables of 1997 and 2001 to predict final pathological stage in clinically localized prostate cancer
    Herbert Augustin
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 171:177-81. 2004
    ..We validated externally the predictive accuracy of the 2001 Partin tables and compared the 1997 and 2001 versions...
  42. doi request reprint NY-ESO-1 expression is tightly linked to TMPRSS2-ERG fusion in prostate cancer
    Katharina Grupp
    General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg Eppendorf, Hamburg, Germany Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prostate 74:1012-22. 2014
    ..This study was undertaken to explore the relationship of NY-ESO-1 with tumor phenotype, biochemical recurrence, and molecular subgroups in hormone-naive prostate cancers...
  43. doi request reprint Clinical utility of the PCA3 urine assay in European men scheduled for repeat biopsy
    Alexander Haese
    Department of Urology, University Clinic Hamburg, Hamburg, Germany
    Eur Urol 54:1081-8. 2008
    ..The Prostate CAncer gene 3 (PCA3) assay has shown promise as an aid in prostate cancer (pCA) diagnosis in identifying men with a high probability of a positive (repeat) biopsy...
  44. ncbi request reprint Significant upgrading affects a third of men diagnosed with prostate cancer: predictive nomogram and internal validation
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    BJU Int 98:329-34. 2006
    ....
  45. ncbi request reprint Long-term intravesical adjuvant chemotherapy further reduces recurrence rate compared with short-term intravesical chemotherapy and short-term therapy with Bacillus Calmette-Guérin (BCG) in patients with non-muscle-invasive bladder carcinoma
    Martin G Friedrich
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 52:1123-29. 2007
    ....
  46. doi request reprint Current technique of open intrafascial nerve-sparing retropubic prostatectomy
    Lars Budaus
    Martini Clinic, Prostate Cancer Centre Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 56:317-24. 2009
    ..Even though the principles of the technique and its oncological efficacy have often been published, ongoing refinements allow further improvements in functional outcome and morbidity...
  47. doi request reprint Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer
    Sarah Minner
    Institute of Pathology, Department of Urology, Prostate Cancer Center University Medical Center, Hamburg Eppendorf, Germany
    Clin Cancer Res 16:1553-60. 2010
    ..The purpose of this study was to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in prostate cancer...
  48. doi request reprint Full functional-length urethral sphincter preservation during radical prostatectomy
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Centre, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 60:320-9. 2011
    ..A key prerequisite for urinary continence after radical prostatectomy (RP) is the functional length of the urethral sphincter and the stabilisation of its anatomic position within the pelvic floor...
  49. doi request reprint Inverse stage migration in patients undergoing radical prostatectomy: results of 8916 European patients treated within the last decade
    Lars Budaus
    Martiniclinic, Prostate Cancer Centre, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 108:1256-61. 2011
    ..To investigate the stage migration patterns during the last decade in European men treated with radical prostatectomy (RP)...
  50. ncbi request reprint Validation of a nomogram for prediction of side specific extracapsular extension at radical prostatectomy
    Thomas Steuber
    Department of Urology, Hamburg, Germany
    J Urol 175:939-44; discussion 944. 2006
    ..We developed a nomogram and compared the performance and discriminant properties of the tree regression and the nomogram in a contemporary cohort of European patients treated with radical retropubic prostatectomy...
  51. doi request reprint TMPRSS2-ERG fusions are strongly linked to young patient age in low-grade prostate cancer
    Stefan Steurer
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 66:978-81. 2014
    ..The strong link of ERG activation to young patient age and low-grade cancers may help to explain a slight predominance of low-grade cancers in young patients...
  52. ncbi request reprint Discrimination of benign from malignant prostatic disease by selective measurements of single chain, intact free prostate specific antigen
    Thomas Steuber
    Department of Urology, University of Hamburg Eppendorf, Germany
    J Urol 168:1917-22. 2002
    ..We assessed the ability of serum intact PSA to discriminate between benign and malignant prostatic disease...
  53. doi request reprint Neurovascular structure-adjacent frozen-section examination (NeuroSAFE) increases nerve-sparing frequency and reduces positive surgical margins in open and robot-assisted laparoscopic radical prostatectomy: experience after 11,069 consecutive patients
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 62:333-40. 2012
    ..Intraoperative frozen-section analysis allows real-time histologic assessment of surgical margins (SMs) and identification of candidates for nerve-sparing (NS) procedures...
  54. ncbi request reprint Influence of nerve-sparing (NS) procedure during radical prostatectomy (RP) on margin status and biochemical failure
    Rein Jüri Palisaar
    Department of Urology, University Clinics of Bochum, Marienhospital Herne, 44627 Herne, Germany
    Eur Urol 47:176-84. 2005
    ..To evaluate whether nerve-sparing procedure itself is a risk factor for biochemical recurrence in carefully selected patients...
  55. ncbi request reprint Reasonable delay of surgical treatment in men with localized prostate cancer--impact on prognosis?
    Markus Graefen
    Department of Urology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Urol 47:756-60. 2005
    ..We investigated whether a reasonable delay from diagnosis to definitive treatment impact recurrence free survival rates in men undergoing radical prostatectomy (RP) for localized prostate cancer...
  56. doi request reprint Evaluation of prostate cancer detection with ultrasound real-time elastography: a comparison with step section pathological analysis after radical prostatectomy
    Georg Salomon
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 54:1354-62. 2008
    ..Conventional gray scale ultrasound has a low sensitivity and specificity for prostate cancer detection. Better imaging modalities are needed...
  57. doi request reprint Immunological microenvironment in prostate cancer: high mast cell densities are associated with favorable tumor characteristics and good prognosis
    Achim Fleischmann
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prostate 69:976-81. 2009
    ..Number of intratumoral mast cells predicts survival in various cancers. The prognostic significance of such mast cells in surgically treated prostate cancer is unknown...
  58. ncbi request reprint Can predictive models for prostate cancer patients derived in the United States of America be utilized in European patients? A validation study of the Partin tables
    Markus Graefen
    Department of Urology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Eur Urol 43:6-10; discussion 11. 2003
    ..Accuracy of predictive tools derived in the US might therefore suffer when applied to European patients. We tested the validity of the widely accepted Partin tables for their ability to predict pathologic stage in German patients...
  59. ncbi request reprint Intraoperative and perioperative morbidity of contemporary radical retropubic prostatectomy in a consecutive series of 1243 patients: results of a single center between 1999 and 2002
    Herbert Augustin
    Department of Urology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg D 20246, Germany
    Eur Urol 43:113-8. 2003
    ..To up date counselling of patients in an experienced center, we assessed intraoperative and perioperative complications in a consecutive series of contemporary radical retropubic prostatectomy for localized prostate cancer...
  60. ncbi request reprint Insignificant prostate cancer in radical prostatectomy specimen: time trends and preoperative prediction
    Herbert Augustin
    Department of Urology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Eur Urol 43:455-60. 2003
    ..5 cm(3) and Gleason pattern < or =6)...
  61. ncbi request reprint Clinical use of urinary markers for the detection and prognosis of bladder carcinoma: a comparison of immunocytology with monoclonal antibodies against Lewis X and 486p3/12 with the BTA STAT and NMP22 tests
    Martin G Friedrich
    Department of Urology, University Hospital, University of Hamburg, Hamburg, Germany
    J Urol 168:470-4. 2002
    ..We compared the NMP22 (Matritech, Cambridge, Massachusetts) and BTA Stat (Bard Diagnostics, Redmond, Washington) tests with immunocytology using mAbs 486p3/12 and BG7 against Lewis X antigen...
  62. ncbi request reprint Does low-risk prostate cancer detection change with repeat biopsies?
    Bobby B Najari
    Weill Cornell Medical College, New York, NY University Medical Center Hamburg Eppendorf, Hamburg, Germany Department of Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany Martini Clinic Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany Hubertus Wald Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Oncol 30:188. 2012
    ..Although higher rates of low grade PCa on repeat PBx have been reported, we hypothesize that a considerable risk of clinically significant PCa remains...
  63. ncbi request reprint 10-year experience of robot-assisted radical prostatectomy: the road from cherry picking to standard procedure
    Jonas Schiffmann
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Minerva Urol Nefrol . 2016
    ..Patients treated with robot-assisted radical prostatectomy (RARP) are frequently selected according to more favorable characteristics. Such patient selection might decrease according to increasing experience...
  64. doi request reprint Salvage radical prostatectomy for recurrent prostate cancer: verification of European Association of Urology guideline criteria
    Philipp Mandel
    Martini Clinic Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 117:55-61. 2016
    ....
  65. doi request reprint Tumor volume in insignificant prostate cancer: increasing threshold gains increasing risk
    Jonas Schiffmann
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prostate 75:45-9. 2015
    ..5 ml) is suggested to define insignificant prostate cancer (iPCa). We hypothesize that an increasing tumor volume within iPCa patients increases the risk of biochemical recurrence (BCR) after radical prostatectomy (RP)...
  66. ncbi request reprint Percent free prostate specific antigen is not an independent predictor of organ confinement or prostate specific antigen recurrence in unscreened patients with localized prostate cancer treated with radical prostatectomy
    Markus Graefen
    Department of Urology, University Hospital Hamburg Eppendorf, Germany
    J Urol 167:1306-9. 2002
    ..We studied the controversial relationship of percent free prostate specific antigen (PSA) with organ confined prostate cancer and PSA failure after radical prostatectomy...
  67. doi request reprint The feasibility of prostate cancer detection by triple spectroscopy
    Georg Salomon
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 55:376-83. 2009
    ..We tested whether the combination of these techniques can differentiate malignant and benign prostate tissue ex vivo...
  68. ncbi request reprint Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, Department of Pathology and Urology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Clin Cancer Res 13:6579-84. 2007
    ..To determine its role in prostate cancer, we analyzed 2,497 prostate cancers on the DNA and protein level...
  69. doi request reprint High level PSMA expression is associated with early PSA recurrence in surgically treated prostate cancer
    Sarah Minner
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prostate 71:281-8. 2011
    ..This study was undertaken, to gain more insight on the role of PSMA in early prostate cancer and its distribution in various normal tissues...
  70. doi request reprint Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer
    Alexander T El Gammal
    Departments of Gynecology, Institute of Pathology, Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg, Germany
    Clin Cancer Res 16:56-64. 2010
    ..Deletions of 8p and gains of 8q belong to the most frequent cytogenetic alterations in prostate cancer. The target genes of these alterations and their biological significance are unknown...
  71. doi request reprint Detection of circulating tumour cells in peripheral blood of patients with advanced non-metastatic bladder cancer
    Michael Rink
    Department of Urology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    BJU Int 107:1668-75. 2011
    ..To prospectively detect and evaluate the biological significance of circulating tumour cells (CTC) in patients with bladder cancer, especially in those patients with non-metastatic, advanced bladder cancer (NMABC)...
  72. ncbi request reprint Prostate-specific antigen and related isoforms in the diagnosis and management of prostate cancer
    Alexander Haese
    Department of Urology, University Clinic Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Curr Urol Rep 5:231-40. 2004
    ..Newly discovered isoforms of free PSA also may impact early detection of prostate cancer with encouraging preliminary results that warrant further clinical investigation...
  73. ncbi request reprint Prospective validation of an algorithm with systematic sextant biopsy to predict pelvic lymph node metastasis in patients with clinically localized prostatic carcinoma
    Stefan Conrad
    Department of Urology, Institute of Mathematics and Computer Science in Medicine, University of Hamburg, Eppendorf University Hospital, Hamburg, Germany
    J Urol 167:521-5. 2002
    ..We prospectively validate an algorithm to predict pelvic lymph node metastasis in patients with clinically localized prostatic carcinoma...
  74. ncbi request reprint Nerve distribution along the prostatic capsule
    Christian Eichelberg
    Department of Urology, University Hospital Eppendorf, Hamburg, Germany
    Eur Urol 51:105-10; discussion 110-1. 2007
    ..The objective of this study therefore was to determine the typical pattern of nerve distribution along the prostatic capsule...
  75. ncbi request reprint Role of nomograms for prostate cancer in 2007
    Felix K H Chun
    Department of Urology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    World J Urol 25:131-42. 2007
    ..In 2007 and the future, more specific and refined nomograms will be available which address relevant clinical end points. Moreover, novel markers in PCa outcomes will be quantified using the nomogram approach...
  76. ncbi request reprint Expression of Maspin in non-muscle invasive bladder carcinoma: correlation with tumor angiogenesis and prognosis
    Martin G Friedrich
    Department of Urology, University of Hamburg, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Eur Urol 45:737-43. 2004
    ..We studied expression patterns of Maspin in pTa/pT1 urothelial carcinoma of the bladder and compared them with microvessel density (MVD) for two vascular markers (CD34 and CD105) and correlated the findings with clinical outcome...
  77. ncbi request reprint Tumour grade, proliferation, apoptosis, microvessel density, p53, and bcl-2 in prostate cancers: differences between tumours located in the transition zone and in the peripheral zone
    Andreas Erbersdobler
    Institute of Pathology, University of Hamburg, Germany
    Eur Urol 41:40-6. 2002
    ..It is unclear, however, whether this can be put down to anatomical reasons alone, or if there are further differences between tumours of both zones...
  78. doi request reprint Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer
    Nicole Fischer
    Institute for Medical Microbiology and Virology, University Medical Center Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Clin Virol 43:277-83. 2008
    ....
  79. ncbi request reprint Free PSA isoforms and intact and cleaved forms of urokinase plasminogen activator receptor in serum improve selection of patients for prostate cancer biopsy
    Thomas Steuber
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 120:1499-504. 2007
    ..0.715, p=0.039). In this setting, hK2 did not add diagnostic information. Measurements of individual forms of suPAR and PSA isoforms contributed significantly to discrimination of men with PCa from those with no evidence of malignancy...
  80. doi request reprint Genomic profiling of cell-free DNA in blood and bone marrow of prostate cancer patients
    Heidi Schwarzenbach
    Institute of Tumour Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, 20246, Germany
    J Cancer Res Clin Oncol 137:811-9. 2011
    ..MS-MLPA detects genetic and epigenetic aberrations of 37 tumor suppressor genes (TSG) in a single reaction and might, therefore, avoid the cumbersome single gene analyses...
  81. ncbi request reprint Open retropubic nerve-sparing radical prostatectomy
    Markus Graefen
    Department of Urology, University Medical Center Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Urol 49:38-48. 2006
    ..Furthermore, indication, oncologic outcome, and functional results addressing postoperative urinary continence and potency are discussed...
  82. ncbi request reprint Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma
    Martin G Friedrich
    Department of Urology, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Eur J Cancer 41:2769-78. 2005
    ..We identified one gene (TIMP-3) where methylation was associated with a more favourable outcome. Our data strongly support the usefulness of gene methylation as a prognostic marker in patients with non-muscle invasive bladder cancer...
  83. pmc Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hK2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum
    Thomas Steuber
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 118:1234-40. 2006
    ..Measurements of fPSA and hK2 improve on our ability to counsel patients prior to treatment as to their risk of BCR...
  84. ncbi request reprint Extraction and processing of high quality RNA from impalpable and macroscopically invisible prostate cancer for microarray gene expression analysis
    Thorsten Schlomm
    Department of Urology, University Clinic Hamburg Eppendorf, D 20246 Hamburg, Germany
    Int J Oncol 27:713-20. 2005
    ..Among these were several known prostate cancer relevant genes, such as AMACR, TARP, LIM, GPR160 (all up-regulated), CAV1, NTN1, MT1X; CLU, TRIM29, SPARCL1 and HSPB8 (all down-regulated)...
  85. ncbi request reprint Patient-reported sexual function after nerve-sparing radical retropubic prostatectomy
    Joachim Noldus
    Department of Urology, University of Hamburg, Martinistrasse 52, 20246, Hamburg, Germany
    Eur Urol 42:118-24. 2002
    ..Patient questionnaire based outcome analysis on post-operative erectile function after uni- or bilateral nerve-sparing RRP is described...
  86. doi request reprint Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Centre, Hamburg Eppendorf, Germany
    Eur Urol 55:394-401. 2009
    ..The presence of a tertiary Gleason grade (TGG) pattern in radical prostatectomy (RP) specimens has been described as associated with adverse pathology and a higher biochemical recurrence (BCR) rate after RP...
  87. doi request reprint Sequential use of the tyrosine kinase inhibitors sorafenib and sunitinib in metastatic renal cell carcinoma: a retrospective outcome analysis
    Christian Eichelberg
    Department of Urology, University Medical Centre Hamburg Eppendorf, Germany
    Eur Urol 54:1373-8. 2008
    ..To date, few data are available about the sequential use of the tyrosine kinase inhibitors (TKI) sorafenib and sunitinib in metastatic renal cell carcinoma (mRCC)...
  88. ncbi request reprint Basic principles of anatomy for optimal surgical treatment of prostate cancer
    Jochen Walz
    Department of Urology, University Medical Centre Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    World J Urol 25:31-8. 2007
    ..Respecting and considering these anatomic principles during NSRP should result in good postoperative functional outcome, as well as in good outcome in cancer control...
  89. ncbi request reprint Marked gene transcript level alterations occur early during radical prostatectomy
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Eur Urol 53:333-44. 2008
    ..However, transcript level patterns and RNA quality could rapidly change in response to ischemic and mechanical stress. Studies have shown that this occurs both perioperatively and after surgical removal of organs...
  90. doi request reprint A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer
    Olaf J C Hellwinkel
    Martini Klinik, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 101:1454-60. 2008
    ....
  91. doi request reprint Molecular cancer phenotype in normal prostate tissue
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Germany
    Eur Urol 55:885-90. 2009
    ..Insufficient sensitivity and specificity of prostate biopsies for cancer detection...
  92. doi request reprint Clinical significance of p53 alterations in surgically treated prostate cancers
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Mod Pathol 21:1371-8. 2008
    ..The rate of p53 alterations increases with prostate cancer progression...
  93. ncbi request reprint Percentage of positive biopsy cores can improve the ability to predict lymph node invasion in patients undergoing radical prostatectomy and extended pelvic lymph node dissection
    Alberto Briganti
    Department of Urology, Vita Salute University, Milan, Italy
    Eur Urol 51:1573-81. 2007
    ..We hypothesized that the information stemming from biopsy cores can enhance the ability to predict the rate of lymph node invasion (LNI) at radical retropubic prostatectomy (RRP) in men subjected to extended pelvic lymphadenectomy (ePLND)...
  94. ncbi request reprint Health-insurance status is a determinant of the stage at presentation and of cancer control in European men treated with radical prostatectomy for clinically localized prostate cancer
    Andrea Gallina
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    BJU Int 99:1404-8. 2007
    ....
  95. ncbi request reprint Prostate volume and adverse prostate cancer features: fact not artifact
    Alberto Briganti
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Canada
    Eur J Cancer 43:2669-77. 2007
    ..We investigated the association between prostate size and prostate cancer grade and stage in a large (n=3412) single center radical prostatectomy cohort, which was unexposed to any form of hormonal manipulation...
  96. ncbi request reprint Prostate cancers in the transition zone: Part 2; clinical aspects
    Herbert Augustin
    Department of Urology, University of Graz, Austria
    BJU Int 94:1226-9. 2004
  97. ncbi request reprint Comparison of predictive accuracy for pathologically organ confined clinical stage T1c prostate cancer using human glandular kallikrein 2 and prostate specific antigen combined with clinical stage and Gleason grade
    Alexander Haese
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 173:752-6. 2005
    ..Now we evaluated the usefulness of hK2, as measured by 2 entirely different immunoassay designs, to enhance the discrimination of pathologically organ from nonorgan confined clinical stage T1c PCa...
  98. ncbi request reprint Assessment of the enhancement in predictive accuracy provided by systematic biopsy in predicting outcome for clinically localized prostate cancer
    Markus Graefen
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Urol 171:200-3. 2004
    ..We investigated whether the addition of prostate biopsy features may enhance the accuracy of a nomogram predicting recurrence after radical prostatectomy (RP)...
  99. ncbi request reprint A preoperative nomogram identifying decreased risk of positive pelvic lymph nodes in patients with prostate cancer
    Ilias Cagiannos
    Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Urol 170:1798-803. 2003
    ..We developed a preoperative nomogram for prediction of lymph node metastases in patients with clinically localized prostate cancer...
  100. ncbi request reprint Counseling men with prostate cancer: a nomogram for predicting the presence of small, moderately differentiated, confined tumors
    Michael W Kattan
    Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Urol 170:1792-7. 2003
    ....
  101. ncbi request reprint Characterisation of biomolecular profiles in primary high-grade prostate cancer treated by radical prostatectomy
    Herbert Augustin
    Department of Urology, Karl Franzens University Graz, Auenbruggerplatz 7, 8036 Graz, Austria
    J Cancer Res Clin Oncol 129:662-8. 2003
    ..The aim of this study was to compare the biomolecular profile of high-grade (HG) with low-grade (LG) prostate cancers matched by preoperative serum prostate-specific antigen (PSA) levels...