Thorsten Hoppe

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Less is more: how protein degradation regulates muscle development
    T Hoppe
    Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases at the Institute for Genetics, University of Cologne, Zülpicher Str 47, 50674 Cologne, Germany
    Ernst Schering Found Symp Proc . 2008
  2. ncbi request reprint Multiubiquitylation by E4 enzymes: 'one size' doesn't fit all
    Thorsten Hoppe
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Trends Biochem Sci 30:183-7. 2005
  3. doi request reprint The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis
    Kirsten Kuhlbrodt
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Nat Cell Biol 13:273-81. 2011
  4. pmc CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication
    Andre Franz
    Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
    Mol Cell 44:85-96. 2011
  5. pmc A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans
    Alexandra Segref
    Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, 50674 Cologne, Germany
    Genetics 187:1235-40. 2011
  6. pmc Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication
    Julien Mouysset
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Proc Natl Acad Sci U S A 105:12879-84. 2008
  7. ncbi request reprint The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy
    Philipp Christoph Janiesch
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Nat Cell Biol 9:379-90. 2007
  8. doi request reprint Protein quality control gets muscle into shape
    Johnny Kim
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Trends Cell Biol 18:264-72. 2008
  9. ncbi request reprint The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication
    Alexandra Deichsel
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Hamburg, Germany
    Cell Cycle 8:185-90. 2009
  10. pmc DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance
    Maria A Ermolaeva
    Cologne Excellence Cluster for Cellular Stress Responses in Aging Associated Diseases, Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
    Nature 501:416-20. 2013

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Less is more: how protein degradation regulates muscle development
    T Hoppe
    Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases at the Institute for Genetics, University of Cologne, Zülpicher Str 47, 50674 Cologne, Germany
    Ernst Schering Found Symp Proc . 2008
    ....
  2. ncbi request reprint Multiubiquitylation by E4 enzymes: 'one size' doesn't fit all
    Thorsten Hoppe
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Trends Biochem Sci 30:183-7. 2005
    ..Recent studies have provided accumulating evidence that has led some researchers in the field to conclude that E4, indeed, represents a distinct and novel class of enzymes...
  3. doi request reprint The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis
    Kirsten Kuhlbrodt
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Nat Cell Biol 13:273-81. 2011
    ....
  4. pmc CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication
    Andre Franz
    Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
    Mol Cell 44:85-96. 2011
    ..Moreover, our data confirmed a similar regulation in Xenopus egg extracts, emphasizing a conserved coordination of licensing and elongation events during eukaryotic DNA replication by CDC-48/p97...
  5. pmc A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans
    Alexandra Segref
    Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, 50674 Cologne, Germany
    Genetics 187:1235-40. 2011
    ....
  6. pmc Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication
    Julien Mouysset
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Proc Natl Acad Sci U S A 105:12879-84. 2008
    ..Our findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability...
  7. ncbi request reprint The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy
    Philipp Christoph Janiesch
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Nat Cell Biol 9:379-90. 2007
    ....
  8. doi request reprint Protein quality control gets muscle into shape
    Johnny Kim
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Trends Cell Biol 18:264-72. 2008
    ..Here, we highlight the interplay between chaperone activity and protein degradation in respect to the formation and maintenance of muscle during physiological and pathological conditions...
  9. ncbi request reprint The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication
    Alexandra Deichsel
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Hamburg, Germany
    Cell Cycle 8:185-90. 2009
    ..Here, we speculate on the function of CDC-48 (also known as Cdc48p in yeast and p97 in vertebrates) during DNA replication initiation, addressing its ubiquitin-selective chaperone activity...
  10. pmc DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance
    Maria A Ermolaeva
    Cologne Excellence Cluster for Cellular Stress Responses in Aging Associated Diseases, Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
    Nature 501:416-20. 2013
    ..We propose that elevated systemic stress resistance promotes endurance of somatic tissues to allow delay of progeny production when germ cells are genomically compromised. ..
  11. doi request reprint E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis
    Leena Ackermann
    Institute for Genetics, CECAD Research Center, University of Cologne, Cologne, Germany
    Nat Struct Mol Biol 23:995-1002. 2016
    ..Formation of UFD-2 foci also requires proapoptotic CEP-1 (p53) signaling. Our findings establish a central role of UFD-2 in the coordination between the DNA-repair process and the apoptotic response...
  12. pmc Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
    Andre Franz
    Institute for Genetics and CECAD Research Center, University of Cologne, Joseph Stelzmann Str 26, 50931 Cologne, Germany
    Nat Commun 7:10612. 2016
    ..Our work identifies a critical substrate selection module of CDC-48/p97 required for chromatin-associated protein degradation in both Caenorhabditis elegans and humans, which is relevant to oncogenesis and aging. ..
  13. doi request reprint Analysis of ubiquitin-dependent proteolysis in Caenorhabditis elegans
    Alexandra Segref
    Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Cologne, Germany
    Methods Mol Biol 832:531-44. 2012
    ....
  14. doi request reprint Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP
    Andre Franz
    Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Zülpicher Straße 47A, 50674 Cologne, Germany
    Biochim Biophys Acta 1843:205-15. 2014
    ..This article is part of a Special Issue entitled: Ubiquitin-Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf. ..
  15. ncbi request reprint A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation
    Julien Mouysset
    Centre for Molecular Neurobiology, ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    J Struct Biol 156:41-9. 2006
    ..Together, these data suggest an evolutionarily conserved retro-translocation machinery at the endoplasmic reticulum...
  16. ncbi request reprint Orchestra for assembly and fate of polyubiquitin chains
    Kirsten Kuhlbrodt
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Essays Biochem 41:1-14. 2005
    ..Here we propose a model in which E4-dependent polyubiquitination pathways are modulated by different ubiquitin-binding proteins, using ataxin-3 as an example...
  17. doi request reprint Double-edged alliance: mitochondrial surveillance by the UPS and autophagy
    Andre Franz
    Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Joseph Stelzmann Str 26, 50931 Cologne, Germany
    Curr Opin Cell Biol 37:18-27. 2015
    ..In this review, we discuss the role of ubiquitin-dependent protein degradation in mitochondrial functionality. ..
  18. doi request reprint Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system
    Alexandra Segref
    Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
    Cell Metab 19:642-52. 2014
    ..Reduced UPS activity during pathological conditions might potentiate disease progression and thus provides a valuable target for therapeutic intervention...
  19. pmc Think locally: control of ubiquitin-dependent protein degradation in neurons
    Alexandra Segref
    Centre for Molecular Neurobiology, ZMNH, University of Hamburg, Hamburg, Germany
    EMBO Rep 10:44-50. 2009
    ....
  20. ncbi request reprint Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans
    Thorsten Hoppe
    Department of Molecular Neurogenetics, Adolph Butenandt Institute, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    Cell 118:337-49. 2004
    ..These results identify CHN-1 and UFD-2 as a functional E3/E4 complex and UNC-45 as its physiologically relevant substrate...
  21. ncbi request reprint A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress
    Wolfdieter Springer
    ABI Molecular Neurogenetics, University of Munich, Germany
    Hum Mol Genet 14:3407-23. 2005
    ..Due to high-throughput capacity of C. elegans, this model is particularly well suited to identify genetic and chemical modifiers of toxicity...
  22. pmc The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans
    Megan L Landsverk
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Cell Biol 177:205-10. 2007
    ..These findings suggest a mechanism in which UNC-45-related proteins may contribute to the degradation of myosin in conditions such as heart failure and muscle wasting...