Ferdinand Hofstaedter

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. pmc Loss of aquaporin 3 protein expression constitutes an independent prognostic factor for progression-free survival: an immunohistochemical study on stage pT1 urothelial bladder cancer
    Wolfgang Otto
    St Josef Medical Centre, Department of Urology of Regensburg University, Regensburg, Germany
    BMC Cancer 12:459. 2012
  2. pmc Alterations of global histone H4K20 methylation during prostate carcinogenesis
    Turang E Behbahani
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    BMC Urol 12:5. 2012
  3. pmc Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores
    Kristian Ikenberg
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    BMC Cancer 10:341. 2010
  4. doi request reprint [Urothelial carcinoma. Does surgical pathology learn from molecular pathology?]
    F Hofstadter
    Institut fur Pathologie, Universitatsklinikum Regensburg
    Pathologe 29:145-8. 2008
  5. doi request reprint [Renal pelvic carcinoma: a different urothelial tumor?]
    F Hofstadter
    Institut fur Pathologie, Universitat Regensburg, 93053 Regensburg
    Pathologe 30:185-7. 2009
  6. pmc Granuloma formation in the different phenotypes of Crohn's disease
    F Hofstaedter
    Institute of Pathology, University of Regensburg, F J Strauss Allee 11, Regensburg D 93042, Germany
    Gut 54:180-1. 2005
  7. doi request reprint [Precursor lesions: epidemiology--is there enough evidence?]
    F Hofstadter
    Institut fur Pathologie, Universitat Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Deutschland
    Pathologe 32:185-7. 2011
  8. pmc Presence of HER4 associates with increased sensitivity to Herceptin in patients with metastatic breast cancer
    Andrea Sassen
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Breast Cancer Res 11:R50. 2009
  9. doi request reprint Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions
    Petra Ruemmele
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Am J Surg Pathol 33:691-704. 2009
  10. ncbi request reprint FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 20:895-903. 2007

Detail Information

Publications85

  1. pmc Loss of aquaporin 3 protein expression constitutes an independent prognostic factor for progression-free survival: an immunohistochemical study on stage pT1 urothelial bladder cancer
    Wolfgang Otto
    St Josef Medical Centre, Department of Urology of Regensburg University, Regensburg, Germany
    BMC Cancer 12:459. 2012
    ..Loss of aquaporin (AQP) 3 protein expression has previously been shown in muscle-invasive UBC. The aim of the present study was to investigate the prognostic value of AQP3 protein expression with regard to the prognosis of stage pT1 UBC...
  2. pmc Alterations of global histone H4K20 methylation during prostate carcinogenesis
    Turang E Behbahani
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    BMC Urol 12:5. 2012
    ..Our study was designed to assess global methylation levels of histone 4 lysine 20 (H4K20me1-3) at different stages of prostate cancer (PCA) carcinogenesis...
  3. pmc Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores
    Kristian Ikenberg
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    BMC Cancer 10:341. 2010
    ..To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far...
  4. doi request reprint [Urothelial carcinoma. Does surgical pathology learn from molecular pathology?]
    F Hofstadter
    Institut fur Pathologie, Universitatsklinikum Regensburg
    Pathologe 29:145-8. 2008
    ..The expression signatures of stromal invasive tumors compared with non-invasive ones points to the major importance of an exact histopathological diagnosis in this area...
  5. doi request reprint [Renal pelvic carcinoma: a different urothelial tumor?]
    F Hofstadter
    Institut fur Pathologie, Universitat Regensburg, 93053 Regensburg
    Pathologe 30:185-7. 2009
    ..g. hereditary non-polyposis colorectal cancer, HNPCC) and tumor propagation (seeding) are described for tumors of the upper urinary tract. Clinical epidemiological data indicate specific correlations between the two tumor locations...
  6. pmc Granuloma formation in the different phenotypes of Crohn's disease
    F Hofstaedter
    Institute of Pathology, University of Regensburg, F J Strauss Allee 11, Regensburg D 93042, Germany
    Gut 54:180-1. 2005
  7. doi request reprint [Precursor lesions: epidemiology--is there enough evidence?]
    F Hofstadter
    Institut fur Pathologie, Universitat Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Deutschland
    Pathologe 32:185-7. 2011
    ..Imprecise and redundant terminology represents a crucial reason for the lack of data availability...
  8. pmc Presence of HER4 associates with increased sensitivity to Herceptin in patients with metastatic breast cancer
    Andrea Sassen
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Breast Cancer Res 11:R50. 2009
    ....
  9. doi request reprint Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions
    Petra Ruemmele
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Am J Surg Pathol 33:691-704. 2009
    ..The MMR deficient molecular pathway of carcinogenesis is associated with a histopathologic phenotype in ampullary cancer, similar to the one that has been well described in colon cancer...
  10. ncbi request reprint FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 20:895-903. 2007
    ..Increased age appears to be a risk factor for these mutations. The preferential occurrence of FGFR3 mutations in seborrheic keratoses of the head and neck suggests a causative role for cumulative lifetime ultraviolet light exposure...
  11. ncbi request reprint Deletions at chromosome 2q and 12p are early and frequent molecular alterations in bronchial epithelium and NSCLC of long-term smokers
    Ulrike Grepmeier
    Department of Pathology, University of Regensburg, Germany
    Int J Oncol 27:481-8. 2005
    ..These chromosomal regions represent interesting loci for potential NSCLC associated tumor suppressor genes and could be useful as screening markers for molecular risk assessment of smokers...
  12. doi request reprint Methylthioadenosine phosphorylase represents a predictive marker for response to adjuvant interferon therapy in patients with malignant melanoma
    Stefanie Meyer
    Department of Dermatology, University Hospital of Regensburg, Regensburg, Germany
    Exp Dermatol 19:e251-7. 2010
    ..In conclusion, MTAP represents a highly promising immunohistochemical marker for prognosis and interferon response of patients with malignant melanoma...
  13. ncbi request reprint Primary and metastatic high-grade pleomorphic sarcoma/malignant fibrous histiocytoma of the gastrointestinal tract: an approach to the differential diagnosis in a series of five cases with emphasis on myofibroblastic differentiation
    Abbas Agaimy
    Institute of Pathology, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419 Nurnberg, Germany
    Virchows Arch 451:949-57. 2007
    ..They should be distinguished from a variety of primary and metastatic pleomorphic neoplasms, in particular high-grade sarcomatous GI stromal tumours (GIST), pleomorphic leiomyosarcoma, sarcomatoid carcinoma and other mimics...
  14. doi request reprint MethyQESD, a robust and fast method for quantitative methylation analyses in HNPCC diagnostics using formalin-fixed and paraffin-embedded tissue samples
    Marcus Bettstetter
    Institute of Pathology and Molecular Diagnostics, University of Regensburg, Regensburg, Germany
    Lab Invest 88:1367-75. 2008
    ..Furthermore, MethyQESD works reliably with formalin-fixed paraffin-embedded tissue and simplifies DNA MA both for research and diagnostic purposes...
  15. ncbi request reprint Multitarget FISH and LOH analyses at chromosome 3p in non-small cell lung cancer and adjacent bronchial epithelium
    Matthias Woenckhaus
    Department of Pathology, University of Regensburg, Germany
    Am J Clin Pathol 123:752-61. 2005
    ..Multicolor FISH analysis is able to detect a tumor-associated molecular field effect in bronchi adjacent to NSCLC...
  16. ncbi request reprint Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer
    Matthias Woenckhaus
    Department of Pathology, University of Regensburg, D 93053 Regensburg, Germany
    Hum Pathol 39:126-36. 2008
    ....
  17. ncbi request reprint Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR
    Marcus Bettstetter
    Institute of Pathology and Molecular Diagnostics, University of Regensburg, Regensburg, Germany
    Clin Cancer Res 13:3221-8. 2007
    ..The aim of this study is to establish a reliable and quantitative MLH1 methylation analysis technique and to define valid MLH1 methylation cutoff values for HNPCC diagnostics...
  18. doi request reprint Mismatch repair proteins hMLH1 and hMSH2 are differently expressed in the three main subtypes of sporadic renal cell carcinoma
    Christine Stoehr
    Institute of Pathology, University of Erlangen, Erlangen, Germany
    Pathobiology 79:162-8. 2012
    ..We studied the role of minor mismatch repair proteins (MMR) human MutL homologue 1 (hMLH1) and human MutS homologue 2 (hMSH2) in the main subtypes of renal cell carcinoma (RCC)...
  19. pmc Cell cycle phase distribution analysis in chronic lymphocytic leukaemia: a significant number of cells reside in early G1-phase
    Ellen C Obermann
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    J Clin Pathol 60:794-7. 2007
    ..Chronic lymphocytic leukaemia (CLL) is a frequent non-Hodgkin lymphoma characterised by a heterogeneous clinical course. Assessment of cell cycle phase kinetics might be important for prediction of clinical behaviour and prognosis...
  20. ncbi request reprint Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract
    Matthias Eiber
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Am J Surg Pathol 31:938-46. 2007
    ..Ancillary markers may help to resolve such cases and clarify the reported malignant potential of some IPs...
  21. ncbi request reprint Bone morphogenetic protein 7 (BMP7) expression is a potential novel prognostic marker for recurrence in patients with primary melanoma
    Tanja Rothhammer
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Cancer Biomark 3:111-7. 2007
    ..05). In summary, induction of BMP7 expression is frequent in melanomas and may serve as a novel prognostic marker of progression in melanoma patients...
  22. ncbi request reprint Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model
    Sven A Lang
    Department of Surgery, University of Regensburg, Medical Center, Regensburg, Germany
    Int J Cancer 120:1803-10. 2007
    ..In conclusion, mTOR is frequently activated in human gastric cancer and represents a promising new molecular target for therapy...
  23. pmc Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi
    Christian Hafner
    Department of Dermatology, University of Regensburg, Germany
    J Clin Invest 116:2201-2207. 2006
    ..The R248C mutation appears to be a hot spot for FGFR3 mutations in epidermal nevi...
  24. ncbi request reprint Epithelioid gastric stromal tumours of the antrum in young females with the Carney triad: a report of three new cases with mutational analysis and comparative genomic hybridization
    Abbas Agaimy
    Institute of Pathology, Klinikum Nürnberg, 90419 Nurnberg, Germany
    Oncol Rep 18:9-15. 2007
    ....
  25. ncbi request reprint Microsatellite instability at chromosome 8p in non-small cell lung cancer is associated with lymph node metastasis and squamous differentiation
    Matthias Woenckhaus
    Department of Pathology, University of Regensburg, Regensburg, Germany
    Int J Oncol 23:1357-63. 2003
    ..The tetranucleotide marker panel used in this study was able to indicate lymph node metastasis and high risk disease in patients with resectable squamous cell lung cancer...
  26. pmc Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients
    Andrea Sassen
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Breast Cancer Res 10:R2. 2008
    ..However, the clinical outcome with regard to total HER receptor state remains largely unknown...
  27. doi request reprint Multichromatic phenotyping of HER receptor coexpression in breast tumor tissue samples using flow cytometry--possibilities and limitations
    Arabel Vollmann-Zwerenz
    Institute of Pathology, University of Regensburg, Germany
    Cytometry A 77:387-98. 2010
    ..Combined with DNA, i.e. ploidy quantification, the approach resulted in a six-parameter assay that could complement the diagnosis of a variety of diseases in which HER receptor expression has a pivotal impact on the degree of malignancy...
  28. doi request reprint Prediction of progression of non-muscle-invasive bladder cancer by WHO 1973 and 2004 grading and by FGFR3 mutation status: a prospective study
    Maximilian Burger
    Department of Urology, University of Regensburg, Regensburg, Germany
    Eur Urol 54:835-43. 2008
    ..Aim of this study was to investigate the prognostic value of the WHO 1973 and 2004 grading systems and biomarkers FGFR3, CK20 and Ki-67...
  29. ncbi request reprint Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors
    Peter J Wild
    Institute of Pathology and Department of Dermatology, University of Regensburg, Germany
    Arch Dermatol 142:471-6. 2006
    ..This was not seen in the patients with MTAP-negative tumors. Conclusion Methylthioadenosine phosphorylase protein expression may be a predictive marker of interferon therapy resistance in patients with melanoma and disease progression...
  30. ncbi request reprint Epidermal growth factor receptor coexpression modulates susceptibility to Herceptin in HER2/neu overexpressing breast cancer cells via specific erbB-receptor interaction and activation
    Simone Diermeier
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Exp Cell Res 304:604-19. 2005
    ....
  31. doi request reprint P53 codon 72 (Arg72Pro) polymorphism and prostate cancer risk: association between disease onset and proline genotype
    Anja Rogler
    Institute of Pathology, University Hospital Erlangen, Erlangen, Germany
    Pathobiology 78:193-200. 2011
    ..However, disease onset might be modulated by the p53 Pro72 allele, suggesting an important role of apoptosis regulation in prostate carcinogenesis...
  32. ncbi request reprint Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations
    Abbas Agaimy
    Institute of Pathology, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419 Nuremberg, Germany
    Am J Surg Pathol 31:113-20. 2007
    ..GIST tumorlets likely represent preclinical (preneoplastic) lesions that need additional stimuli to evolve into clinical GISTs, raising the possibility of a hyperplasia-neoplasia sequence in the development of sporadic GISTs...
  33. ncbi request reprint No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract
    Robert Stoehr
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Oncol Rep 11:137-41. 2004
    ..The most frequent alterations in the B-RAF gene do not seem to be involved in urothelial carcinogenesis, and there is no correlation between MMR-deficiency and B-RAF mutations in urothelial tumors...
  34. doi request reprint Persistent histological changes in the exstrophic bladder after primary closure-a cause for concern?
    Peter C Rubenwolf
    Department of Pediatric Urology, University Medical Center Regensburg, Regensburg, Germany
    J Urol 189:671-7. 2013
    ..We investigated bladder biopsies from patients with classic bladder exstrophy for the histological features and discuss the potential clinical significance of the findings...
  35. ncbi request reprint Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 127:1883-5. 2007
    ..Each patient showed at least four different mutated loci. FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots...
  36. ncbi request reprint Gene expression profiling of colorectal cancer and metastases divides tumours according to their clinicopathological stage
    Astrid Koehler
    Department of Pathology, University of Regensburg, Germany
    J Pathol 204:65-74. 2004
    ..These genes may represent important targets in colorectal carcinogenesis and might provide useful clinicopathological tools in the management of colorectal cancer...
  37. ncbi request reprint Multiple molecular analyses from minimal cell quantities by sequential isolation and preamplification of DNA and RNA
    Astrid Koehler
    Department of Pathology and Molecular Diagnostics, University of Regensburg, Germany
    Diagn Mol Pathol 16:141-6. 2007
    ..RNA suitable for various reverse transcription-PCR approaches and sequencing analyses could simultaneously be isolated even from single cell preparations...
  38. pmc Microsatellite analysis of pleural supernatants could increase sensitivity of pleural fluid cytology
    Matthias Woenckhaus
    Department of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    J Mol Diagn 7:517-24. 2005
    ....
  39. ncbi request reprint High frequency of FGFR3 mutations in adenoid seborrheic keratoses
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 126:2404-7. 2006
    ..The mechanism for the high rate of somatic FGFR3 mutations in these benign skin tumors remains elusive, but UV light exposure may play a potential role, especially in the R248C mutations...
  40. ncbi request reprint Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer
    Robert Stoehr
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Lab Invest 84:465-78. 2004
    ..The sFRP1 gene on chromosome 8p12-11.1 could be a candidate gene for the predicted, progression-related tumor suppressor gene in bladder cancer and could contribute to urothelial carcinogenesis...
  41. ncbi request reprint Simultaneous detection of HER2/neu gene amplification and protein overexpression in paraffin-embedded breast cancer
    Christian Lottner
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    J Pathol 205:577-84. 2005
    ..3%) had HER2/neu gene amplification without protein overexpression. The main advantage of this novel approach is that polysomy, aneuploidy, gene amplification, and protein content can be analysed simultaneously in the same cell...
  42. pmc Ultrastructural evidence of dermal gadolinium deposits in a patient with nephrogenic systemic fibrosis and end-stage renal disease
    Josef A Schroeder
    Klinik und Poliklinik für Innere, Medizin II Nephrologie, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Clin J Am Soc Nephrol 3:968-75. 2008
    ..A role for circulating fibroblasts in the fibrosing tissue is hypothetical, and the mechanism of the assumed trigger function of gadolinium remains elusive...
  43. pmc Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Proc Natl Acad Sci U S A 104:13450-4. 2007
    ..The remarkable genotype-phenotype correlation as observed in this study points to a distinct etiopathogenesis of the mutations in keratinocytes occuring either during fetal development or in adult life...
  44. pmc Implementing a system of quality-of-life diagnosis and therapy for breast cancer patients: results of an exploratory trial as a prerequisite for a subsequent RCT
    M Klinkhammer-Schalke
    Tumor Center Regensburg eV, Regensburg 93053, Germany
    Br J Cancer 99:415-22. 2008
    ....
  45. doi request reprint Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma. A study of 18 cases
    A Gaumann
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042, Regensburg, Germany
    Virchows Arch 453:473-84. 2008
    ..Despite myofibroblastic phenotype, APC/beta-catenin pathway changes are rare. Cyclin D1, only expressed in the myxofibrosarcoma-type, is likely transcribed via factors other than beta-catenin...
  46. ncbi request reprint Murine models of anaemia of inflammation: extramedullary haematopoiesis represents a species specific difference to human anaemia of inflammation that can be eliminated by splenectomy
    T E O Schubert
    Department of Pathology, University of Regensburg, Regensburg, Germany
    Int J Immunopathol Pharmacol 21:577-84. 2008
    ..Our results demonstrate that murine AI differs from human AI with respect to increased splenic extramedullary haematopoiesis. Our data demonstrate that induction of AI in splenectomised mice represents a good way to model human AI...
  47. ncbi request reprint Microsatellite instability in tumor and nonneoplastic colorectal cells from hereditary non-polyposis colorectal cancer and sporadic high microsatellite-instable tumor patients
    W Dietmaier
    Molecular Pathology Diagnostic Unit, University of Regensburg, Germany
    Pathobiology 68:227-31. 2000
    ..These differences were not detectable in larger tumor regions containing about 10,000 cells. Thus, heterogeneity of the MSI pattern (e.g. intratumoral MSI) is an important feature of tumors with the MSI-H phenotype...
  48. ncbi request reprint Leukoencephalopathy and chronic pancreatitis as concomitant manifestations of systemic lupus erythematosus related to anticardiolipin antibodies
    J Swol-Ben
    Department of Surgery, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Rheumatol Int 24:177-81. 2004
    ..Subsequent complications of pancreatitis are responsible for the critical, life-threatening state of these patients and may be prevented by early identification of anticardiolipin antibodies and therapy for SLE...
  49. ncbi request reprint A multimodal treatment approach including high-dose chemotherapy in very advanced gastric cancer: evidence for control of metastatic disease
    A Reichle
    Department of Hematology and Oncology, University of Regensberg, Germany
    Bone Marrow Transplant 32:665-71. 2003
    ..The combined treatment approach is tolerable and feasible in advanced disease and opens a therapeutic window for a significant proportion of patients, even in cases with histologically proven peritoneal carcinomatosis...
  50. pmc Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancer
    F Bataille
    Department of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Mol Pathol 56:286-92. 2003
    ..To evaluate the usefulness of molecular markers in predicting histopathological and clinical response to preoperative high dose chemotherapy (HDCT) and survival of patients with advanced gastric cancer...
  51. pmc Morphological characterisation of Crohn's disease fistulae
    F Bataille
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Gut 53:1314-21. 2004
    ..To date, no histological comparison of Crohn's disease fistulae with non-inflammatory bowel disease fistulae has been performed. In addition, Crohn's disease fistulae have not been well characterised morphologically...
  52. pmc Multiple mutation analyses in single tumor cells with improved whole genome amplification
    W Dietmaier
    Institute of Pathology, The Department of Surgery, University of Regensburg, Germany
    Am J Pathol 154:83-95. 1999
    ....
  53. pmc Achilles tendinosis is associated with sprouting of substance P positive nerve fibres
    T E O Schubert
    Department of Pathology, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Ann Rheum Dis 64:1083-6. 2005
    ..To identify and characterise nerve fibres and inflammatory alterations in painful Achilles tendinosis and thus gain evidence about the origin of pain in Achilles tendinosis...
  54. ncbi request reprint [Histological and immunohistochemical investigations with capsular contracture after breast augmentation with smooth silicone gel implants]
    L Prantl
    Klinik für Plastische Chirurgie, Universitatsklinikum Regensburg
    Handchir Mikrochir Plast Chir 38:224-32. 2006
    ..The necessity of an exact histological classification for comparing objectively the different findings of capsular contracture is shown...
  55. ncbi request reprint Detection of microsatellite instability by real time PCR and hybridization probe melting point analysis
    W Dietmaier
    Molecular Pathology Diagnostic Unit, University of Regensburg, Regensburg, Germany
    Lab Invest 81:1453-6. 2001
    ..This new technique allows MSI detection within less than a hour and provides a basis for fast, high-throughput MSI analysis...
  56. ncbi request reprint Cyclin B1 expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma
    Ellen C Obermann
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Oncol Rep 14:1461-7. 2005
    ....
  57. ncbi request reprint [A new quantitative DNA-methylation analysis of MSI colorectal cancers helps to separate sporadic colorectal cancers from HNPCC-candidates]
    M Bettstetter
    Institut fur Pathologie, Universitat Regensburg
    Verh Dtsch Ges Pathol 90:236-43. 2006
    ..Our aim was to establish a quantitative and precise method to analyze promoter methylation of tumor samples in order to identify HNPCC candidates...
  58. doi request reprint Immunologic and metabolic characteristics of HPV-negative and HPV-positive head and neck squamous cell carcinomas are strikingly different
    Rosemarie Krupar
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Virchows Arch 465:299-312. 2014
    ..Therefore, targeting metabolic pathways could represent a promising adjunct in the therapy of HPV-positive HNSCC...
  59. doi request reprint Expression and potential clinical significance of urothelial cytodifferentiation markers in the exstrophic bladder
    Peter C Rubenwolf
    Department of Pediatric Urology, University Medical Center Regensburg, Regensburg, Germany
    J Urol 187:1806-11. 2012
    ....
  60. ncbi request reprint Tissue microarray construction from bone marrow biopsies
    Ellen C Obermann
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Biotechniques 39:822, 824, 826. 2005
  61. pmc The combined effects of high-energy shock waves and cytostatic drugs or cytokines on human bladder cancer cells
    K Worle
    Universitat Regensburg, Institut fur Pathologie, Germany
    Br J Cancer 69:58-65. 1994
    ....
  62. doi request reprint Comparison of HPV prevalence in HNSCC patients with regard to regional and socioeconomic factors
    Rosemarie Krupar
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Eur Arch Otorhinolaryngol 271:1737-45. 2014
    ....
  63. doi request reprint Secondary sclerosing cholangitis
    Petra Ruemmele
    Department of Internal Medicine I, University of Regensburg, Germany
    Nat Rev Gastroenterol Hepatol 6:287-95. 2009
    ..Sclerosing cholangitis in critically ill patients, in particular, is associated with rapid disease progression and poor outcome...
  64. ncbi request reprint Development of de novo cancer in p53 knock-out mice is dependent on the type of long-term immunosuppression used
    Gudrun E Koehl
    Department of Surgery, University of Regensburg, Regensburg, Germany
    Transplantation 82:741-8. 2006
    ..Recent publications suggest that rapamycin (RAPA), or possibly mycophenolate mofetil (MMF), may reduce established tumor growth; however, experimental data is lacking for de novo cancer prevention...
  65. ncbi request reprint Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro
    Leoni A Kunz-Schughart
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Am J Physiol Cell Physiol 290:C1385-98. 2006
    ....
  66. ncbi request reprint Spontaneous rupture of a benign giant adrenal adenoma
    Stefan Denzinger
    Department of Urology, University of Regensburg, Germany
    APMIS 115:381-4. 2007
    ..A detailed literature search showed this to be the largest benign tumor of the adrenal cortex described so far. We discuss the diagnosis and treatment of this unusual tumor...
  67. ncbi request reprint Frequent microsatellite instability in sporadic tumors of the upper urinary tract
    Arndt Hartmann
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Cancer Res 62:6796-802. 2002
    ....
  68. ncbi request reprint Fibroadenoma of the axilla
    Brigitte Coras
    Department of Dermatology, University of Regensburg, Germany
    Dermatol Surg 31:1152-4. 2005
    ..Ectopic, axillary breast tissue can develop any disease that affects the normal breast, including fibroadenoma...
  69. pmc Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection
    J Ruschoff
    Institute of Pathology, University of Regensburg, D 93042 Regensburg, Germany
    Proc Natl Acad Sci U S A 95:11301-6. 1998
    ....
  70. ncbi request reprint Isolation of high quality protein samples from punches of formalin fixed and paraffin embedded tissue blocks
    J Kroll
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Histol Histopathol 23:391-5. 2008
    ..Interestingly, with this technique it is feasible to extract high quality proteins from 14 year old samples. In summary, the new technique makes a great pool of material now usable for molecular analysis with high throughput tools...
  71. ncbi request reprint Long-term effects of chondrospheres on cartilage lesions in an autologous chondrocyte implantation model as investigated in the SCID mouse model
    T Schubert
    Department of Pathology, University Hospital of Regensburg, Regensburg, Germany
    Int J Mol Med 23:455-60. 2009
    ..Moreover, chondrospheres adhere to full-thickness cartilage defects and appear to produce a cartilaginous extracellular matrix which fuses with native cartilage thus generating an autologous cartilage-like repair tissue...
  72. doi request reprint Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles
    M Plander
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Leukemia 23:2118-28. 2009
    ..Thus, we can assume that not only a different resistance to apoptosis, but also proliferation contributes to the progression of CLL resulting in bone marrow failure with thrombocytopenia and anemia...
  73. ncbi request reprint Differences in efficacy between intention-to-treat and per-protocol analyses for patients with psoriasis vulgaris and atopic dermatitis: clinical and pharmacoeconomic implications
    R Schiffner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Br J Dermatol 144:1154-60. 2001
    ..In most studies, only results for a treatment-optimized subpopulation (patients treated according to the protocol) are presented in publications. The relevance of such data for daily routine therapy is doubtful...
  74. ncbi request reprint Willingness to pay and time trade-off: sensitive to changes of quality of life in psoriasis patients?
    R Schiffner
    Department of Dermatology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Br J Dermatol 148:1153-60. 2003
    ..However, until now there have been no studies available individually comparing these measures pre- and post-treatment...
  75. ncbi request reprint Differential impact of Cetuximab, Pertuzumab and Trastuzumab on BT474 and SK-BR-3 breast cancer cell proliferation
    G Brockhoff
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Cell Prolif 40:488-507. 2007
    ..It is anticipated that there would be differences between specific erbB receptor co-expression profiles that would affect tumour cell growth...
  76. ncbi request reprint Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and BT474 breast carcinoma cells
    G Brockhoff
    Institute of Pathology, University Regensburg, Regensberg, Germany
    Cytometry 44:338-48. 2001
    ..We investigated the recruitment of receptor complexes in two c-erbB2-overexpressing breast carcinoma cell lines, SK-BR-3 and BT474, after ligand binding and its effects on intracellular signal transduction and cell cycle regulation...
  77. ncbi request reprint In vitro and ex vivo expression of nucleolar proteins B23 and p120 in benign and malignant epithelial lesions of the prostate
    T Bocker
    Institute of Pathology, University of Regensburg, Germany
    Mod Pathol 8:226-31. 1995
    ....
  78. ncbi request reprint [Interdisciplinary networking for clinical and molecular questions in non-muscle invasive urothelial carcinoma of the bladder]
    S Denzinger
    Klinik für Urologie, Caritas Krankenhaus St Josef, Universitat, Landshuterstrasse 65, 93053 Regensburg
    Urologe A 46:1126-8. 2007
  79. pmc Prognostic relevance of P-cadherin expression in melanocytic skin tumours analysed by high-throughput tissue microarrays
    R Bauer
    Institute of Pathology, University of Regensburg, Germany
    J Clin Pathol 59:699-705. 2006
    ..To investigate whether protein expression or cellular localisation of P-cadherin is associated with clinicopathological characteristics in benign and malignant melanocytic skin tumours...
  80. ncbi request reprint [Organization of data and tissue banks for new prognostic factors in adenocarcinoma of the prostate. An interdisciplinary uropathologic approach]
    M Burger
    Klinik für Urologie der Universität Regensburg am Caritas Krankenhaus St Josef, Landshuterstrasse 65, 93053 Regensburg
    Urologe A 46:1094. 2007
  81. ncbi request reprint Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers
    M Woenckhaus
    Department of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    J Pathol 210:192-204. 2006
    ..These genes are involved in the metabolism of xenobiotics (eg GPX2 and FMO3) and may represent cigarette smoke-induced, cancer-related molecular targets that may be utilized to identify smokers with increased risk for lung cancer...
  82. ncbi request reprint Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH, and FISH analyses
    E C Obermann
    Institute of Pathology and Molecular Diagnostic Unit, University of Regensburg, Germany
    J Pathol 199:50-7. 2003
    ....
  83. ncbi request reprint CD137 expression in tumor vessel walls. High correlation with malignant tumors
    K Broll
    Department of Pathology, University of Regensburg, Regensburg, Germany
    Am J Clin Pathol 115:543-9. 2001
    ..Also, in benign tumors (2/14) and in inflammatory tissues (2/9) only a minority had CD137-expressing vessels. However, malignant tumors had a significantly enhanced frequency of CD137-expressing blood vessels (11/34)...
  84. ncbi request reprint Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review
    A Agaimy
    Institute of Pathology, Nuremberg Clinic Centre, Nuremberg, Germany
    J Clin Pathol 61:301-6. 2008
    ..Intra-abdominal LGMS are rare with only four unequivocal examples reported so far. Two further cases in females in their 60s and 70s are analysed here...
  85. pmc The genomic structure of the human AP-2 transcription factor
    R Bauer
    Department of Pathology, University of Regensburg Medical School, Germany
    Nucleic Acids Res 22:1413-20. 1994
    ..A partial AP-2 promoter fragment including the AP-2 consensus binding site is approximately 5-fold transactivated by cotransfection of an AP-2 expression plasmid...