Rainer Hoffmann

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint Tissue Doppler and innovative myocardial-deformation imaging techniques for assessment of myocardial viability
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH Aachen, Germany
    Curr Opin Cardiol 21:438-42. 2006
  2. ncbi request reprint Evaluation of a high-dose dexamethasone-eluting stent
    Rainer Hoffmann
    Medical Clinic I, University Hospital Aachen, Germany
    Am J Cardiol 94:193-5. 2004
  3. ncbi request reprint Strain rate analysis allows detection of differences in diastolic function between viable and nonviable myocardial segments
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    J Am Soc Echocardiogr 18:330-5. 2005
  4. doi request reprint Comparison of two-dimensional and three-dimensional imaging techniques for measurement of aortic annulus diameters before transcatheter aortic valve implantation
    Ertunc Altiok
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Heart 97:1578-84. 2011
  5. doi request reprint Integrated analysis of cardiac tissue structure and function for improved identification of reversible myocardial dysfunction
    Rainer Hoffmann
    Department of Cardiology, University Hospital RWTH Aachen, Germany
    Coron Artery Dis 20:21-6. 2009
  6. ncbi request reprint Impact of flow level on coronary flow velocity pattern. A doppler flow study in patients with first acute myocardial infarction
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH Aachen, Germany
    Int J Cardiovasc Imaging 20:27-35. 2004
  7. doi request reprint Layer-specific analysis of myocardial deformation for assessment of infarct transmurality: comparison of strain-encoded cardiovascular magnetic resonance with 2D speckle tracking echocardiography
    Ertunc Altiok
    Department of Cardiology, Pneumology and Angiology, University Hospital RWTH Aachen, Aachen, Germany
    Eur Heart J Cardiovasc Imaging 14:570-8. 2013
  8. doi request reprint Dependency of cardiac resynchronization therapy on myocardial viability at the LV lead position
    Michael Becker
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    JACC Cardiovasc Imaging 4:366-74. 2011
  9. doi request reprint Incidence and predictors of left bundle branch block after transcatheter aortic valve implantation
    Omer Aktug
    Medical Clinic I, University RWTH Aachen, Germany
    Int J Cardiol 160:26-30. 2012
  10. doi request reprint Analysis of LV lead position in cardiac resynchronization therapy using different imaging modalities
    Michael Becker
    Department of Cardiology, University RWTH Aachen, Aachen, Germany
    JACC Cardiovasc Imaging 3:472-81. 2010

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Tissue Doppler and innovative myocardial-deformation imaging techniques for assessment of myocardial viability
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH Aachen, Germany
    Curr Opin Cardiol 21:438-42. 2006
    ....
  2. ncbi request reprint Evaluation of a high-dose dexamethasone-eluting stent
    Rainer Hoffmann
    Medical Clinic I, University Hospital Aachen, Germany
    Am J Cardiol 94:193-5. 2004
    ..96 +/- 0.63 mm due to an average intimal hyperplasia area obstruction of 32 +/- 21%, indicating that high-dose dexamethasone-loaded stents do not significantly reduce neointimal proliferation...
  3. ncbi request reprint Strain rate analysis allows detection of differences in diastolic function between viable and nonviable myocardial segments
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    J Am Soc Echocardiogr 18:330-5. 2005
    ..Dys-synergic viable myocardial segments demonstrate an increase in E and A waves SR with dobutamine stimulation whereas nonviable segments are less responsive to dobutamine...
  4. doi request reprint Comparison of two-dimensional and three-dimensional imaging techniques for measurement of aortic annulus diameters before transcatheter aortic valve implantation
    Ertunc Altiok
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Heart 97:1578-84. 2011
    ..This study sought to compare different 2D and 3D imaging techniques and determine the accuracy of 3D transoesophageal echocardiography (TEE) for accurate analysis of aortic annulus dimensions...
  5. doi request reprint Integrated analysis of cardiac tissue structure and function for improved identification of reversible myocardial dysfunction
    Rainer Hoffmann
    Department of Cardiology, University Hospital RWTH Aachen, Germany
    Coron Artery Dis 20:21-6. 2009
    ..This study evaluated the incremental predictive value of an integrated analysis of function and tissue structure for functional improvement after revascularization therapy...
  6. ncbi request reprint Impact of flow level on coronary flow velocity pattern. A doppler flow study in patients with first acute myocardial infarction
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH Aachen, Germany
    Int J Cardiovasc Imaging 20:27-35. 2004
    ..The coronary flow velocity pattern allows prediction of LV function at 4 weeks after AMI. However, it should be considered that some parameters of the flow velocity pattern are affected by the coronary flow level...
  7. doi request reprint Layer-specific analysis of myocardial deformation for assessment of infarct transmurality: comparison of strain-encoded cardiovascular magnetic resonance with 2D speckle tracking echocardiography
    Ertunc Altiok
    Department of Cardiology, Pneumology and Angiology, University Hospital RWTH Aachen, Aachen, Germany
    Eur Heart J Cardiovasc Imaging 14:570-8. 2013
    ..This study evaluated and compared both modalities for the assessment of infarct transmurality as defined by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR)...
  8. doi request reprint Dependency of cardiac resynchronization therapy on myocardial viability at the LV lead position
    Michael Becker
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    JACC Cardiovasc Imaging 4:366-74. 2011
    ..This study sought to analyze the effectiveness of cardiac resynchronization therapy (CRT) related to the viability in the segment of left ventricular (LV) lead position defined by myocardial deformation imaging...
  9. doi request reprint Incidence and predictors of left bundle branch block after transcatheter aortic valve implantation
    Omer Aktug
    Medical Clinic I, University RWTH Aachen, Germany
    Int J Cardiol 160:26-30. 2012
    ..The aim of this study was to evaluate the frequency and predictors of left bundle branch block (LBBB) after Transcatheter Aortic Valve Implantation (TAVI) using CoreValve and Edwards SAPIEN prosthesis...
  10. doi request reprint Analysis of LV lead position in cardiac resynchronization therapy using different imaging modalities
    Michael Becker
    Department of Cardiology, University RWTH Aachen, Aachen, Germany
    JACC Cardiovasc Imaging 3:472-81. 2010
    ....
  11. ncbi request reprint Intravascular ultrasonic comparative analysis of degree of intimal hyperplasia produced by four different stents in the coronary arteries
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Am J Cardiol 94:1548-50. 2004
    ..048 and p <0.001), respectively, whereas mean intimal hyperplasia thickness treated with dexamethasone-eluting stents was similar to those lesions treated with bare metal stents...
  12. ncbi request reprint Impact of left ventricular lead position in cardiac resynchronization therapy on left ventricular remodelling. A circumferential strain analysis based on 2D echocardiography
    Michael Becker
    Medical Clinic I, Department of Cardiology, University RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Eur Heart J 28:1211-20. 2007
    ..Aims: To assess if myocardial deformation imaging allows definition of an optimal left ventricular (LV) lead position with improved effectiveness of cardiac resynchronization therapy (CRT) on LV reverse remodelling...
  13. ncbi request reprint Effectiveness of everolimus-eluting stents in the treatment of drug-eluting stent versus bare-metal stent restenosis
    Mohammad Almalla
    Department of Cardiology, Medical Clinic I, University Hospital RWTH Aachen, Aachen, Germany
    Coron Artery Dis 23:492-6. 2012
    ..This study compared the clinical outcome after the use of everolimus-eluting stents (EES) for the treatment of bare-metal stent (BMS) versus DES restenosis...
  14. ncbi request reprint Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age
    Jan R Ortlepp
    Medical Clinic I, University Hospital of Aachen University of Technology, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Mol Med (Berl) 81:363-7. 2003
    ..If the CCR2 genotype is associated with higher mortality in the general population must be investigated in further studies...
  15. ncbi request reprint Analysis of regional left ventricular function by cineventriculography, cardiac magnetic resonance imaging, and unenhanced and contrast-enhanced echocardiography: a multicenter comparison of methods
    Rainer Hoffmann
    University Rheinisch Westfälischen Technischen Hochschule Aachen, Aachen, Germany
    J Am Coll Cardiol 47:121-8. 2006
    ..To define the use of cineventriculography, cardiac magnetic resonance imaging (cMRI), and unenhanced and contrast-enhanced echocardiography for detection of left ventricular (LV) regional wall motion abnormalities (RWMA)...
  16. doi request reprint Myocardial deformation imaging based on ultrasonic pixel tracking to identify reversible myocardial dysfunction
    Michael Becker
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    J Am Coll Cardiol 51:1473-81. 2008
    ..This study evaluated the predictive value of myocardial deformation imaging for improvement in cardiac function after revascularization therapy in comparison with contrast-enhanced cardiac magnetic resonance imaging (ceMRI)...
  17. ncbi request reprint Electrocardiographic and imaging predictors for permanent pacemaker requirement after transcatheter aortic valve implantation
    Ralf Koos
    Department of Cardiology, University Hospital RWTH Aachen, RWTH University Aachen, Aachen, Germany
    J Heart Valve Dis 20:83-90. 2011
    ..Pacemaker (PM) implantation is a possible requirement after transcatheter aortic valve implantation (TAVI). The study aim was to evaluate the electrocardiographic and imaging predictors of the need for PM implantation after TAVI...
  18. ncbi request reprint Preliminary experience in the assessment of aortic valve calcification by ECG-gated multislice spiral computed tomography
    Ralf Koos
    Department of Cardiology, University Hospital Aachen, Pauwelsstr 30, 52072 Aachen, Germany
    Int J Cardiol 102:195-200. 2005
    ....
  19. doi request reprint Association of aortic valve calcification severity with the degree of aortic regurgitation after transcatheter aortic valve implantation
    Ralf Koos
    Department of Cardiology, University Hospital RWTH Aachen, RWTH University Aachen, Aachen, Germany
    Int J Cardiol 150:142-5. 2011
    ....
  20. ncbi request reprint Long-term assessment of a novel biodegradable paclitaxel-eluting coronary polylactide stent
    Felix Vogt
    Medical Clinic I, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Eur Heart J 25:1330-40. 2004
    ..Paclitaxel was shown to inhibit vascular smooth muscle cell proliferation and migration...
  21. ncbi request reprint Two-year mortality after transcatheter aortic valve implantation versus medical therapy for high-surgical risk or inoperable aortic stenosis patients
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    J Heart Valve Dis 22:71-8. 2013
    ..The study aim was to compare the two-year mortality of high-risk or inoperable patients treated by TAVI compared to medical therapy, in a single-center setting...
  22. doi request reprint Three-year follow-up after treatment of bare-metal stent restenosis with first-generation or second-generation drug-eluting stents
    Mohammad Almalla
    Department of Cardiology, Medical Clinic I, University Hospital RWTH Aachen, Aachen, Germany
    Coron Artery Dis 24:165-70. 2013
    ..This study compared 3-year clinical outcomes after treatment of BMS ISR using second-generation everolimus-eluting stents (EES) to first-generation paclitaxel-eluting stents (PES) or sirolimus-eluting stents (SES)...
  23. doi request reprint Evaluation of aortic root for definition of prosthesis size by magnetic resonance imaging and cardiac computed tomography: implications for transcatheter aortic valve implantation
    Ralf Koos
    Department of Cardiology, University Hospital RWTH Aachen, RWTH University Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Int J Cardiol 158:353-8. 2012
    ..In addition, the potential impact of CMR and DSCT measurements on TAVI strategy defined by 2D-transesophageal echocardiography (TEE) was evaluated...
  24. doi request reprint Analysis of procedural effects of percutaneous edge-to-edge mitral valve repair by 2D and 3D echocardiography
    Ertunc Altiok
    Department of Cardiology, Pneumology, Angiology, Intensive Care Medicine, University Hospital RWTH Aachen, Aachen, Germany
    Circ Cardiovasc Imaging 5:748-55. 2012
    ..This study used 3D transesophageal echocardiography (TEE) to determine the functional and morphological effects of PMVR...
  25. doi request reprint Thirty-day outcome after transcatheter aortic valve implantation compared with surgical valve replacement in patients with high-risk aortic stenosis: a matched comparison
    Robert Stöhr
    Medical Clinic I, University RWTH Aachen, Germany
    Coron Artery Dis 22:595-600. 2011
    ..The aim of this study was to compare 30-day mortality of high-risk patients treated by TAVI versus surgical aortic valve replacement...
  26. ncbi request reprint Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years
    Jan R Ortlepp
    Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Int J Cardiol 105:90-5. 2005
    ..Cardiovascular risk factors (CRF) have been associated with myocardial infarction (MI), while the role of genetic risk factors (GRF) remains undetermined...
  27. doi request reprint Layer-specific analysis of myocardial function for accurate prediction of reversible ischaemic dysfunction in intermediate viability defined by contrast-enhanced MRI
    Michael Becker
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Heart 97:748-56. 2011
    ..Contrast-enhanced MRI (ceMRI) has impaired accuracy in the prediction of functional recovery after revascularisation in cases of intermediate myocardial viability...
  28. ncbi request reprint Relation of optimal lead positioning as defined by three-dimensional echocardiography to long-term benefit of cardiac resynchronization
    Michael Becker
    Department of Cardiology, University RWTH Aachen, Aachen, Germany
    Am J Cardiol 100:1671-6. 2007
    ..Thus, there is an optimal LV lead position that should be obtained...
  29. doi request reprint Follow-up results after interventional treatment of infarct-related saphenous vein graft occlusion
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, 52057 Aachen, Germany
    Coron Artery Dis 21:61-4. 2010
    ..Few data are available on intermediate and long-term results after revascularization of acute saphenous vein graft occlusion...
  30. ncbi request reprint Relation of stent design and stent surface material to subsequent in-stent intimal hyperplasia in coronary arteries determined by intravascular ultrasound
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Am J Cardiol 89:1360-4. 2002
    ..However, the differences in IH thickness between the analyzed stents were relatively small compared with the absolute lumen dimensions...
  31. ncbi request reprint Analysis of myocardial perfusion or myocardial function for detection of regional myocardial abnormalities. An echocardiographic multicenter comparison study using myocardial contrast echocardiography and 2D echocardiography
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Eur J Echocardiogr 8:438-48. 2007
    ..Echocardiography based myocardial perfusion imaging and regional wall motion analysis are used for evaluation of coronary artery disease and regional myocardial abnormalities...
  32. ncbi request reprint Association of C-reactive protein and myocardial perfusion in patients with ST-elevation acute myocardial infarction
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Atherosclerosis 186:177-83. 2006
    ..The combination of clinical data, myocardial reperfusion levels after primary angioplasty for AMI and admission CRP increases the predictive value for subsequent survival...
  33. doi request reprint Comparison of two- and three-dimensional transthoracic echocardiography to cardiac magnetic resonance imaging for assessment of paravalvular regurgitation after transcatheter aortic valve implantation
    Ertunc Altiok
    Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany
    Am J Cardiol 113:1859-66. 2014
    ..Three-dimensional TTE allows quantification of AR with greater accuracy than 2D TTE. Observer variability on RVol after TAVI is considerable using 2D TTE, significantly less using 3D TTE, and very low using CMR imaging...
  34. doi request reprint Impact of transcutaneous aortic valve implantation on myocardial deformation
    Eva Grabskaya
    Medical Clinic I, University Hospital RWTH Aachen, Aachen, Germany
    Echocardiography 28:397-401. 2011
    ..To define the impact of transcutaneous aortic valve implantation (TAVI) using the CoreValve prosthesis on myocardial deformation in a serial echocardiographic study with analysis of strain and strain rate...
  35. doi request reprint Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis
    Felix Vogt
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    J Am Coll Cardiol 52:302-11. 2008
    ..The aim of this study was to elucidate the role of angio-associated migratory cell protein (AAMP) for the migration of vascular smooth muscle cells (SMCs) and for the development of neointimal hyperplasia after vascular injury...
  36. ncbi request reprint Usefulness of myocardial blush grade early and late after primary coronary angioplasty for acute myocardial infarction in predicting left ventricular function
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH Aachen, Aachen, Germany
    Am J Cardiol 92:1015-9. 2003
    ..044, p = 0.033). In conclusion, tissue reperfusion after angioplasty for AMI is characterized by frequent improvement over time, as indicated by repeated MBG analysis. Patients with recovery of perfusion have better, final LV function...
  37. doi request reprint The risk of definitive stent thrombosis is increased after "off-label" stent implantation irrespective of drug-eluting stent or bare-metal stent use
    Rainer Hoffmann
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Clin Res Cardiol 98:549-54. 2009
    ..This study evaluated predictors of stent thrombosis in clinical practice after the use of drug-eluting as well as bare-metal stents (BMS), including adherence to the FDA indications for DES...
  38. doi request reprint Predictors and incidence of stent edge dissections in patients with type 2 diabetes as determined by optical coherence tomography
    Sebastian Reith
    Department of Internal Medicine I, University Hospital of the RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Int J Cardiovasc Imaging 29:1237-47. 2013
    ....
  39. ncbi request reprint Intravenous myocardial contrast echocardiography predicts left ventricular remodeling in patients with acute myocardial infarction
    Wolfgang Lepper
    Medical Clinic I, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Am Soc Echocardiogr 15:849-56. 2002
    ..This study evaluated the ability of intravenous myocardial contrast echocardiography (MCE) performed in the setting of acute myocardial infarction for prediction of left ventricular (LV) remodeling...
  40. ncbi request reprint Sirolimus- and paclitaxel-eluting stents in comparison with balloon angioplasty for treatment of in-stent restenosis
    Ekaterina Iofina
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Catheter Cardiovasc Interv 64:28-34. 2005
    ..The combination of improved acute gain and reduced late loss results in a significantly improved angiographic follow-up result in comparison with PTCA...
  41. doi request reprint Long-term outcome after angiographically proven coronary stent thrombosis
    Mohammad Almalla
    Department of Cardiology, Pneumology, Angiology, Intensive Care Medicine, University Hospital RWTH, Aachen, Germany
    Am J Cardiol 111:1289-94. 2013
    ..12, 95% CI 1.01 to 1.27, p = 0.0321). In conclusion, ST was associated with detrimental outcomes in the acute phase as well as the long-term phase. Recurrent ST was not infrequent...
  42. doi request reprint Comparison of accuracy of mitral valve regurgitation volume determined by three-dimensional transesophageal echocardiography versus cardiac magnetic resonance imaging
    Sandra Hamada
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Am J Cardiol 110:1015-20. 2012
    ..Changes in AROA during systole contribute much less to dynamic variation in mitral regurgitation severity than changes in regurgitant flow velocity...
  43. doi request reprint Advanced speckle tracking echocardiography allowing a three-myocardial layer-specific analysis of deformation parameters
    Umar Adamu
    Medical Clinic I, University RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Eur J Echocardiogr 10:303-8. 2009
    ..This study evaluated with a Novell analysis modality allowing layer-specific analysis of deformation if there are differences in myocardial deformation between different layers of myocardium...
  44. ncbi request reprint Polymer-based paclitaxel-eluting stents are superior to nonpolymer-based paclitaxel-eluting stents in the treatment of de novo coronary lesions
    Ekaterina Iofina
    The Medical Clinic I, University Aachen, Aachen, Germany
    Am J Cardiol 98:1022-7. 2006
    ..032). In conclusion, polymer-based PESs result in superior angiographic and IVUS follow-up findings compared with nonpolymer-based PESs...
  45. doi request reprint Effect of statin therapy before Q-wave myocardial infarction on myocardial perfusion
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH, Aachen, Germany
    Am J Cardiol 101:139-43. 2008
    ..In conclusion, statin pretreatment in patients with AMI was associated with decreased systemic inflammation and better perfusion after primary angioplasty of the infarct-related artery...
  46. ncbi request reprint A double-blind, randomized, placebo-controlled multicenter clinical trial to evaluate the effects of the angiotensin II receptor blocker candesartan cilexetil on intimal hyperplasia after coronary stent implantation
    Peter W Radke
    Medical Clinic I, RWTH University Hospital Aachen, Aachen, Germany
    Am Heart J 152:761.e1-6. 2006
    ..The AACHEN trial was a double-blind, randomized, placebo-controlled clinical multicenter trial to evaluate the effects of candesartan cilexetil on intimal hyperplasia after coronary stent implantation...
  47. ncbi request reprint Strain rate measurement by doppler echocardiography allows improved assessment of myocardial viability inpatients with depressed left ventricular function
    Rainer Hoffmann
    Medical Clinic I, University Rheinisch Westfälische Technische Hochschule, Aachen, Germany
    J Am Coll Cardiol 39:443-9. 2002
    ..This study sought to evaluate whether objective assessment of the myocardial functional reserve, using strain rate imaging (SRI), allows accurate detection of viable myocardium...
  48. ncbi request reprint Clinical significance of fractional flow reserve for evaluation of functional lesion severity in stent restenosis and native coronary arteries
    Stefan Kruger
    Medical Clinic I, University Hospital, University of Technology, Aachen, Germany
    Chest 128:1645-9. 2005
    ..Fractional flow reserve (FFR) is a valid surrogate for hemodynamic significance in stenotic native coronary arteries, but its validity in patients with coronary stent restenosis is unknown...
  49. ncbi request reprint Impact of the metabolic syndrome on angiographic and clinical events after coronary intervention using bare-metal or sirolimus-eluting stents
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Am J Cardiol 100:1347-52. 2007
    ..In contrast, DM is associated with significantly increased event rates...
  50. ncbi request reprint A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells
    Rüdiger Blindt
    Department of Cardiology, University Hospital Aachen, Aachen, Germany
    J Am Coll Cardiol 47:1786-95. 2006
    ..Novel stents loaded with an integrin-binding cyclic Arg-Gly-Asp peptide (cRGD) were analyzed for their potential to limit coronary neointima formation and to accelerate endothelialization by attracting endothelial progenitor cells (EPCs)...
  51. doi request reprint Impact of a new conduction defect after transcatheter aortic valve implantation on left ventricular function
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    JACC Cardiovasc Interv 5:1257-63. 2012
    ..This study sought to evaluate the impact of new conduction defects after transcatheter aortic valve implantation (TAVI) on the evolution of left ventricular (LV) function during 1-year follow-up...
  52. ncbi request reprint Treatment of in-stent restenosis using a paclitaxel-eluting stent: acute results and long-term follow-up of a matched-pair comparison with intracoronary beta-radiation therapy
    Peter W Radke
    Medical Clinic I, RWTH University Hospital, Pauwelsstrasse 30, 52057 Aachen, Germany
    Eur Heart J 25:920-5. 2004
    ..This matched-pair analysis compared the procedural and long-term clinical and angiographic outcome after treatment of diffuse ISR using a paclitaxel-eluting stent (PES) with intracoronary beta-radiation therapy...
  53. ncbi request reprint Three-year follow-up after intracoronary beta-radiation therapy for in-stent restenosis
    Ekaterina Iofina
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Catheter Cardiovasc Interv 67:600-6. 2006
    ..Whether the beneficial effect from radiation is sustained during long-term follow-up remains a concern. This study sought to evaluate the effectiveness of IRT using a beta-emitter during a 3-year follow-up period...
  54. doi request reprint Impact of infarct transmurality on layer-specific impairment of myocardial function: a myocardial deformation imaging study
    Michael Becker
    Medical Clinic I, University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen, Germany
    Eur Heart J 30:1467-76. 2009
    ....
  55. ncbi request reprint Treatment of In-Stent restenosis using a stent with non-polymer-based paclitaxel elution
    Rainer Hoffmann
    Medical Clinic I, University Aachen, Aachen, Germany
    Am J Cardiol 93:760-2. 2004
    ..At 6-month follow-up, in-stent late loss was 0.44 +/- 0.54 mm and the restenosis rate was 20%, indicating effective treatment for reduction of recurrent restenosis...
  56. ncbi request reprint Myocardial contrast echocardiography, single-photon emission computed tomography, and regional function analysis for coronary stenosis description during vasodilator stress
    Wolfgang Lepper
    Medical Clinic I, Aachen, Germany
    Am J Cardiol 91:445-8. 2003
  57. ncbi request reprint Correction of CoreValve position using snare traction from a right brachial artery access
    Rainer Hoffmann
    University Aachen, Medical Clinic I, Pauwelsstrasse, Aachen 52074, Germany
    J Invasive Cardiol 22:E59-60. 2010
    ..Snare traction resulted in upward motion of the valve with subsequent reduction of aortic regurgitation from grades III/IV to grade I...
  58. ncbi request reprint Long-term clinical outcome of sirolimus-eluting stent implantation in metabolic syndrome and diabetes
    Mohammad Almalla
    Medical Clinic I, University RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Invasive Cardiol 22:317-21. 2010
    ..Patients with metabolic syndrome (MetS) are at increased risk of cardiovascular events. The long-term effectiveness of sirolimus-eluting stents (SES) in patients with MetS and in diabetic patients is not well defined...
  59. doi request reprint Results of interventional treatment of stress positive coronary artery disease
    Umar Adamu
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Am J Cardiol 105:1535-9. 2010
    ..The PCI group complained less frequently of angina pectoris at long-term follow-up...
  60. doi request reprint Mechanical stretch induces nerve sprouting in rat sympathetic neurocytes
    Obaida R Rana
    Department of Cardiology, RWTH Aachen University, Aachen, 52074, Germany
    Auton Neurosci 155:25-32. 2010
    ..However, further in-vivo studies are required to address this important issue...
  61. ncbi request reprint Randomized comparison of direct stenting with predilatation followed by stenting on vessel trauma and restenosis
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH, Aachen, Germany
    Am Heart J 147:E13. 2004
    ..This study evaluated acute vessel trauma and acute and follow-up angiographic and intravascular ultrasound (IVUS) results after direct stenting in comparison to conventional stenting...
  62. ncbi request reprint Vascular response to sirolimus-eluting stents delivered with a nonaggressive implantation technique: comparison of intravascular ultrasound results from the multicenter, randomized E-SIRIUS, and SIRIUS trials
    Rainer Hoffmann
    Medical Clinic I, University Hospital Aachen, Aachen, Germany
    Catheter Cardiovasc Interv 66:499-506. 2005
    ....
  63. ncbi request reprint Insufficient tissue ablation by rotational atherectomy leads to worse long-term results in comparison with balloon angioplasty alone for the treatment of diffuse in-stent restenosis: insights from the intravascular ultrasound substudy of the ARTIST random
    Philipp K Haager
    Medizinische Klinik I, Universitätsklinik Aachen, Aachen, Germany
    Catheter Cardiovasc Interv 60:25-31. 2003
    ..Neointimal ablation by RA has only minor effects. Low-pressure PTCA does not prevent recurrent tissue growth and failed for treatment of ISR due to insufficient stent expansion...
  64. doi request reprint Real-time transesophageal three-dimensional echocardiography for guidance of percutaneous cardiac interventions: first experience
    Jan Balzer
    Department for Cardiology, Pulmonology, and Vascular Medicine, University Hospital RWTH Aachen, Aachen, Germany
    Clin Res Cardiol 97:565-74. 2008
    ..These benefits may accelerate the learning curve and improve confidence of the interventional cardiologist in order to increase safety, accuracy, and efficacy of interventional cardiac procedures...
  65. ncbi request reprint Impact of metabolic syndrome on clinical and angiographic outcome after sirolimus-eluting stent implantation
    Ekaterina Stellbrink
    Medical Clinic I, University Clinic Aachen, Aachen, Germany
    Coron Artery Dis 18:601-6. 2007
    ..Patients with metabolic syndrome (MetS) are at increased risk of cardiovascular events. The impact of MetS on clinical events and restenosis after drug-eluting stent placement is not well defined...
  66. doi request reprint Electrical stimulation of sympathetic neurons induces autocrine/paracrine effects of NGF mediated by TrkA
    Erol Saygili
    Department of Cardiology, University RWTH Aachen, Aachen, Germany
    J Mol Cell Cardiol 49:79-87. 2010
    ..In summary, this study provides evidence that high-rate electrical stimulation of sympathetic neurons mediates nerve sprouting by an increase in NGF expression that targets the TrkA receptor in an autocrine/paracrine manner...
  67. ncbi request reprint Aortic valve calcification as a marker for aortic stenosis severity: assessment on 16-MDCT
    Ralf Koos
    Department of Cardiology, University Hospital Aachen, Pauwelsstrasse 30, Aachen 52072, Germany
    AJR Am J Roentgenol 183:1813-8. 2004
    ..The degree of valvular calcification in patients with aortic stenosis was determined with retrospectively ECG-gated 16-MDCT and correlated with the severity of stenosis assessed at cardiac catheterization...
  68. doi request reprint Comparison of direct planimetry of mitral valve regurgitation orifice area by three-dimensional transesophageal echocardiography to effective regurgitant orifice area obtained by proximal flow convergence method and vena contracta area determined by color
    Ertunc Altiok
    Department of Cardiology, University Hospital RWTH Aachen, Germany
    Am J Cardiol 107:452-8. 2011
    ..Agreement between methods is better for patients with a circular regurgitation orifice area than in patients with a noncircular regurgitation orifice area...
  69. ncbi request reprint Parathyroid hormone gene variant and calcific aortic stenosis
    Fabian Schmitz
    Division of Cardiology, Pulmonary Diseases, and Vascular Medicine, Department of Medicine, University Hospital RWTH Aachen, Germany
    J Heart Valve Dis 18:262-7. 2009
    ..The vitamin D receptor (VDR) gene and parathyroid hormone (PTH) gene variants were selected as candidate genes...
  70. ncbi request reprint Prediction of clinical outcome after mechanical revascularization in acute myocardial infarction by markers of myocardial reperfusion
    Philipp K Haager
    Medical Clinic I, University Hospital RWTH, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Am Coll Cardiol 41:532-8. 2003
    ..We sought to evaluate and compare recently suggested parameters of reperfusion after angioplasty in acute myocardial infarction (AMI) for risk stratification during long-term follow-up...
  71. ncbi request reprint The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis
    Rüdiger Blindt
    Department of Cardiology, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Thromb Haemost 98:1329-34. 2007
    ..Patients with a VASP-PRI >48% seem to have a significantly increased risk...
  72. pmc Impact of left ventricular lead position on the efficacy of cardiac resynchronisation therapy: a two-dimensional strain echocardiography study
    Michael Becker
    University RWTH Aachen, Department of Cardiology, Aachen, Germany
    Heart 93:1197-203. 2007
    ..Definition of the optimal left ventricular (LV) lead position in cardiac resynchronisation therapy (CRT) is desirable...
  73. doi request reprint Augmentation of left ventricular contractility by cardiac sympathetic neural stimulation
    Christian Meyer
    Division of Cardiology, RWTH Aachen University, Aachen, Germany
    Circulation 121:1286-94. 2010
    ..The aim of this study was to identify sympathetic neural structures inside the heart that selectively control left ventricular inotropy and can be accessed by transvenous catheter stimulation...
  74. doi request reprint Optimized guidance of percutaneous edge-to edge repair of the mitral valve using real-time 3-D transesophageal echocardiography
    Ertunc Altiok
    Medical Clinic I, University RWTH Aachen, Pauwelsstrase 30, 52057, Aachen, Germany
    Clin Res Cardiol 100:675-81. 2011
    ..The impact of real-time three-dimensional transesophageal echocardiography (RT 3-D TEE) for guidance of this complex interventional procedure has not been evaluated...
  75. doi request reprint Functional cardiac MR imaging with true fast imaging with steady-state free precession before and after intravenous injection of contrast medium: comparison of image quality and accuracy
    Gabriele A Krombach
    Department of Diagnostic Radiology, University Hospital, RWTH Aachen, Aachen, Germany
    Eur Radiol 21:702-11. 2011
    ..To compare image quality and accuracy of left ventricular function of cine SSFP (steady-state free precession) images before and after injection of Gd-DTPA...
  76. doi request reprint Everolimus-eluting versus paclitaxel-eluting stents for treatment of bare metal stent restenosis
    Mohammad Almalla
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Am J Cardiol 108:518-22. 2011
    ..However, at long-term follow-up, the event rates between EES and PES were comparable after treatment of BMS ISR...
  77. ncbi request reprint Repeated assessment of coronary flow velocity pattern in patients with first acute myocardial infarction
    Wolfgang Lepper
    Medical Clinic I, University Hospital RWTH, Aachen, Germany
    J Am Coll Cardiol 39:1283-9. 2002
    ....
  78. ncbi request reprint Effects of gold coating of coronary stents on neointimal proliferation following stent implantation
    Jürgen vom Dahl
    Medizinische Klinik I, Universitätsklinikum der RWTH Aachen, Aachen, Germany
    Am J Cardiol 89:801-5. 2002
    ..47 +/- 0.57 vs 1.69 +/- 0.70 mm, p = 0.04), with a higher late luminal loss of 1.17 +/- 0.51 versus 0.82 +/- 0.56 mm (p = 0.001). Thus, gold coating of the tested stent type resulted in more neointimal tissue proliferation...
  79. ncbi request reprint Multislice spiral computed tomography for the detection of coronary stent restenosis and patency
    Stefan Kruger
    Medical Clinic I, University Hospital, University of Technology, Aachen, Germany
    Int J Cardiol 89:167-72. 2003
    ..We determined the value of MSCT to non-invasively detect significant in-stent restenosis after coronary artery stenting...
  80. ncbi request reprint Randomized comparison of success and adverse event rates and cost effectiveness of one long versus two short stents for treatment of long coronary narrowings
    Rainer Hoffmann
    Medical Clinic I, University Aachen, Aachen, Germany
    Am J Cardiol 90:460-4. 2002
    ..The restenosis rate is not reduced by the use of 1 long stent compared with 2 stents. However, long stent placement is highly cost effective...
  81. ncbi request reprint Dexamethasone and restenosis after coronary stent implantation: new indication for an old drug?
    Peter W Radke
    Medical Clinic I and Department of Molecular Cardiovascular Research, RWTH University Hospital, Aachen, Germany
    Curr Pharm Des 10:349-55. 2004
    ....
  82. ncbi request reprint The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis
    Jan R Ortlepp
    Medical Clinic I, University Hospital of Aachen, Aachen University of Technology, Pauwelsstrasse 30, 52152 Aachen, Germany
    Eur Heart J 25:514-22. 2004
    ..The study evaluated the relationship between cardiovascular risk factors (CRF), gene polymorphism, calcification and fibrosis of stenotic aortic valves...
  83. ncbi request reprint Regression of left ventricular mass one year after aortic valve replacement for pure severe aortic stenosis
    Harald P Kuhl
    Medizinische Klinik I, Aachen, Germany
    Am J Cardiol 89:408-13. 2002
    ..Preoperative LV function, but not patient gender, valve type, or size, was related to normalization of LVMI at follow-up in this selected study population...
  84. ncbi request reprint ECG-gated multislice spiral computed tomography to clarify lesion severity in a case of left main stenosis. Multislice spiral computed tomography to clarify lesion severity
    Ralf Koos
    Medical Clinic I, University Hospital RWTH Aachen, Germany
    Int J Cardiovasc Imaging 19:349-53. 2003
    ..MSCT was useful in this case to defer cardiac surgery and might be used as a noninvasive alternative to IVUS imaging in case of doubtful lesion severity...
  85. ncbi request reprint Relation of fasting insulin plasma levels to restenosis after elective coronary stent implantation in patients without diabetes mellitus
    Peter W Radke
    Medical Clinic I, RWTH University Hospital, Aachen, Germany
    Am J Cardiol 93:639-41. 2004
    ..49, p <0.0001). Furthermore, the waist-to-hip ratio and C-peptide and hemoglobin A1c serum levels were associated with the occurrence of binary angiographic restenosis...
  86. doi request reprint The right ventricular response to high afterload: comparison between healthy persons and patients with transposition of the great arteries: a 2D strain study
    Michael Becker
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Echocardiography 27:1256-62. 2010
    ..To evaluate the contraction pattern of the systemic right ventricle (RV) in comparison to healthy controls...
  87. ncbi request reprint Obesity is associated with a slower response to initial phenprocoumon therapy whereas CYP2C9 genotypes are not
    Cordula Meyer zu Schwabedissen
    Interdisciplinary Intermediate Care, University Hospital of Aachen, RWTH Aachen, 52057 Aachen, Germany
    Eur J Clin Pharmacol 62:713-20. 2006
    ..Initiation of phenprocoumon therapy is associated with a variable individual response. The CYP2C9 genotype has been shown to influence the response to warfarin therapy, but such an effect on phenprocoumon therapy remains uncertain...
  88. ncbi request reprint Impact of left ventricular loading conditions on myocardial deformation parameters: analysis of early and late changes of myocardial deformation parameters after aortic valve replacement
    Michael Becker
    Medical Clinic I, University Hospital RWTH, Aachen, Germany
    J Am Soc Echocardiogr 20:681-9. 2007
    ..In conclusion, myocardial deformation parameters change significantly immediately after aortic valve replacement for AS or AI indicating a dependency of determined myocardial deformation parameters on LV preload and afterload...
  89. ncbi request reprint Implantation of sirolimus-eluting stents in saphenous vein grafts is associated with high clinical follow-up event rates compared with treatment of native vessels
    Rainer Hoffmann
    aMedical Clinic I, University RWTH Aachen, Aachen, Germany
    Coron Artery Dis 18:559-64. 2007
    ..Patients treated with SES for saphenous vein graft disease were compared with patients receiving SES in native vessel disease...
  90. pmc Implantation of paclitaxel-eluting stents in saphenous vein grafts: clinical and angiographic follow-up results from a multicentre study
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Heart 93:331-4. 2007
    ..To define the clinical and angiographic follow-up results after implantation of paclitaxel-eluting stents (PESs) in stenotic saphenous vein grafts (SVGs)...
  91. ncbi request reprint Assessment of systolic left ventricular function: a multi-centre comparison of cineventriculography, cardiac magnetic resonance imaging, unenhanced and contrast-enhanced echocardiography
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Eur Heart J 26:607-16. 2005
    ....
  92. doi request reprint [Echocardiography in interventional mitral valve reconstruction]
    Rainer Hoffmann
    Medizinische Klinik I, Universität Aachen, Aachen, Germany
    Herz 34:426-34. 2009
    ..Immediately post intervention, echocardiography should be performed to define the obtained status, allowing detection of subsequent changes in left ventricular function and mitral insufficiency severity...
  93. doi request reprint Acetylcholine as an age-dependent non-neuronal source in the heart
    Obaida R Rana
    Department of Cardiology, RWTH Aachen University, Aachen, 52074, Germany
    Auton Neurosci 156:82-9. 2010
    ..This finding may provide new physiological/pathological aspects in the communication between cardiomyocytes and other cell types in the myocardium, e.g. fibrocytes, neurocytes or endothelial cells...
  94. ncbi request reprint Lower serum calcium levels are associated with greater calcium hydroxyapatite deposition in native aortic valves of male patients with severe calcific aortic stenosis
    Jan R Ortlepp
    Clinic for Interdisciplinary Intermediate Care and Medical Clinic I, University Hospital of Aachen, Germany
    J Heart Valve Dis 15:502-8. 2006
    ..The study aim was to evaluate the relationship between serum calcium levels and the degree of calcification found in stenotic aortic valves...
  95. ncbi request reprint Variants of the CYP11B2 gene predict response to therapy with candesartan
    Jan R Ortlepp
    Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Eur J Pharmacol 445:151-2. 2002
    ..Genotyping for two candidate genes was performed in 116 patients. Genotypes of the CYP11B2 promotor polymorphism significantly predicted a positive response to treatment (CC: 67%; TC: 34%; TT: 21%; p=0.005)...
  96. ncbi request reprint Comparison of magnetic resonance perfusion imaging versus invasive fractional flow reserve for assessment of the hemodynamic significance of epicardial coronary artery stenosis
    Harald P Kuhl
    Medical Clinic I, University Hospital RWTH, Aachen, Germany
    Am J Cardiol 99:1090-5. 2007
    ..0001), suggesting the presence of microvascular dysfunction. In conclusion, FP-CMR may be useful for assessment of the hemodynamic relevance of angiographically undetermined CAD...
  97. doi request reprint Impact of occluder device type on success of percutaneous closure of atrial septal defects--a medium-term follow-up study
    Michael Becker
    University Hospital RWTH Aachen, Department of Cardiology, Aachen, Germany
    J Interv Cardiol 22:503-10. 2009
    ..To identify differences between various occluder types regarding thromboembolic event rates and existence of residual shunts during medium-term follow-up...
  98. ncbi request reprint High-dose 7-hexanoyltaxol-eluting stent with polymer sleeves for coronary revascularization: one-year results from the SCORE randomized trial
    Eberhard Grube
    J Am Coll Cardiol 44:1368-72. 2004
    ..Santa Clara, California/Boston Scientific Corp., Natick, Massachusetts) versus uncoated control stents (n = 140) in focal, de novo coronary lesions...
  99. ncbi request reprint Rotational atherectomy does not reduce recurrent in-stent restenosis: results of the angioplasty versus rotational atherectomy for treatment of diffuse in-stent restenosis trial (ARTIST)
    Juergen vom Dahl
    Medizinische Klinik I, Universitatsklinikum, Rheinisch Westfaelische Technische Hochschule Aachen, Germany
    Circulation 105:583-8. 2002
    ....
  100. ncbi request reprint Intravascular ultrasound evaluating coronary stents for patients with coronary artery disease: compared old with new multilink stents
    Weixin Zhou
    Fuwai Cardiovascular Hospital, CAMS and PUMC, Beijing 100037
    Chin Med Sci J 17:95-100. 2002
    ..The purpose of this study is to compare the 6-month follow-up results between old and new Multilink stents with the method of intravascular ultrasound (IVUS) imaging...
  101. ncbi request reprint The demystification of magnetic resonance imaging?
    Rainer Hoffmann
    Eur Heart J 27:1394-5. 2006