Christian Hoffmann

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi request reprint Response to highly active antiretroviral therapy strongly predicts outcome in patients with AIDS-related lymphoma
    Christian Hoffmann
    University Hospital Kiel, Germany
    AIDS 17:1521-9. 2003
  2. pmc Progressive multifocal leucoencephalopathy with unusual inflammatory response during antiretroviral treatment
    C Hoffmann
    University of Kiel, Chemnitztrasse 33, 24116 Kiel, Germany
    J Neurol Neurosurg Psychiatry 74:1142-4. 2003
  3. ncbi request reprint HAART and cardiology--current controversies and consequences
    Christian Hoffmann
    II Medizinische Klinik und Poliklinik, University of Kiel, D 24116 Kiel, Germany
    Adv Cardiol 40:1-14. 2003
  4. ncbi request reprint Strong impact of highly active antiretroviral therapy on survival in patients with human immunodeficiency virus-associated Hodgkin's disease
    Christian Hoffmann
    II Department of Internal Medicine, University Hospital of Kiel, Kiel, Germany
    Br J Haematol 125:455-62. 2004
  5. ncbi request reprint [Premature arteriosclerosis in HIV-infected patients? Current status]
    Christian Hoffmann
    Universitatsklinikum Schleswig Holstein, Campus, Kiel
    Herz 30:467-71. 2005
  6. ncbi request reprint AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping
    Christian Hoffmann
    Infectious Diseases Outpatient Clinic, II Department of Medicine, Universitatsklinikum Schleswig Holstein, Campus Kiel, Chemnitzstrasse 33, 24116 Kiel, Germany
    Blood 106:1762-9. 2005
  7. ncbi request reprint AIDS-associated Burkitt or Burkitt-like lymphoma: short intensive polychemotherapy is feasible and effective
    Christian Hoffmann
    University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Leuk Lymphoma 47:1872-80. 2006
  8. pmc Intermittent viraemia and immune reconstitution in patients with more than 10-15 years of antiretroviral therapy: baseline values still matter
    Gesa Erdbeer
    University of Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Int AIDS Soc 17:19689. 2014
  9. ncbi request reprint Successful autologous stem cell transplantation in a severely immunocompromised patient with relapsed AIDS-related B-cell lymphoma
    Christian Hoffmann
    University Hospital of Schleswig Holstein, Campus Kiel, II Department of Medicine, Hamburg, Germany
    Eur J Med Res 11:73-6. 2006
  10. ncbi request reprint Malignant melanoma and HIV infection -- aggressive course despite immune reconstitution
    Christian Hoffmann
    II Medizinische Klinik und Poliklinik, Universitatsklinikum Schleswig Holstein, Campus Kiel, Germany
    Onkologie 28:35-7. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Response to highly active antiretroviral therapy strongly predicts outcome in patients with AIDS-related lymphoma
    Christian Hoffmann
    University Hospital Kiel, Germany
    AIDS 17:1521-9. 2003
    ..We analyzed the outcome of patients with ARL with respect to the use and efficacy of highly active antiretroviral therapy (HAART) and to potential prognostic factors...
  2. pmc Progressive multifocal leucoencephalopathy with unusual inflammatory response during antiretroviral treatment
    C Hoffmann
    University of Kiel, Chemnitztrasse 33, 24116 Kiel, Germany
    J Neurol Neurosurg Psychiatry 74:1142-4. 2003
    ....
  3. ncbi request reprint HAART and cardiology--current controversies and consequences
    Christian Hoffmann
    II Medizinische Klinik und Poliklinik, University of Kiel, D 24116 Kiel, Germany
    Adv Cardiol 40:1-14. 2003
  4. ncbi request reprint Strong impact of highly active antiretroviral therapy on survival in patients with human immunodeficiency virus-associated Hodgkin's disease
    Christian Hoffmann
    II Department of Internal Medicine, University Hospital of Kiel, Kiel, Germany
    Br J Haematol 125:455-62. 2004
    ..6 months, whereas the median survival time in patients with HAART response was not reached (89% OS at 24 months). In this cohort, a significant improvement in survival was found in patients with HIV-HD who responded to HAART...
  5. ncbi request reprint [Premature arteriosclerosis in HIV-infected patients? Current status]
    Christian Hoffmann
    Universitatsklinikum Schleswig Holstein, Campus, Kiel
    Herz 30:467-71. 2005
    ..In this review the key studies concerning the incidence of premature arteriosclerosis in HIV-infected patients are discussed...
  6. ncbi request reprint AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping
    Christian Hoffmann
    Infectious Diseases Outpatient Clinic, II Department of Medicine, Universitatsklinikum Schleswig Holstein, Campus Kiel, Chemnitzstrasse 33, 24116 Kiel, Germany
    Blood 106:1762-9. 2005
    ..04). In summary, lack of CD20 or CD10 expression and a post-germinal center signature are associated with a worse prognosis in ARL...
  7. ncbi request reprint AIDS-associated Burkitt or Burkitt-like lymphoma: short intensive polychemotherapy is feasible and effective
    Christian Hoffmann
    University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Leuk Lymphoma 47:1872-80. 2006
    ..Outcome may be improved compared to patients treated with CHOP-based regimens. In the era of HAART, more intensive chemotherapy regimens should be considered in patients with highly aggressive lymphomas...
  8. pmc Intermittent viraemia and immune reconstitution in patients with more than 10-15 years of antiretroviral therapy: baseline values still matter
    Gesa Erdbeer
    University of Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Int AIDS Soc 17:19689. 2014
    ..We were interested whether baseline parameters such as CD4 T-cell nadir or pre-treatment viraemia do have an impact on ART success after more than a decade of treatment...
  9. ncbi request reprint Successful autologous stem cell transplantation in a severely immunocompromised patient with relapsed AIDS-related B-cell lymphoma
    Christian Hoffmann
    University Hospital of Schleswig Holstein, Campus Kiel, II Department of Medicine, Hamburg, Germany
    Eur J Med Res 11:73-6. 2006
    ..Here we report an severely immunocompromised AIDS patient with recurrent ARL who was successfully treated with autologous stem cell transplantation (ASCT). We also review the current literature of ASCT in HIV-infected patients...
  10. ncbi request reprint Malignant melanoma and HIV infection -- aggressive course despite immune reconstitution
    Christian Hoffmann
    II Medizinische Klinik und Poliklinik, Universitatsklinikum Schleswig Holstein, Campus Kiel, Germany
    Onkologie 28:35-7. 2005
    ..Highly active antiretroviral therapy (HAART) has altered the course of most AIDS-related malignancies. There is some evidence that cellular immunity plays an important role in the progression of metastatic melanoma...
  11. pmc Everything fine so far? Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy
    Gesa Erdbeer
    University of Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Int AIDS Soc 17:19673. 2014
    ..The ACTG Augmented Symptoms Distress Module (ASDM) is a validated tool which measures the presence of a total of 22 symptoms seen with HIV and quantifies the extent to which they cause distress to the patient...
  12. ncbi request reprint Antiviral activity, pharmacokinetics and safety of vicriviroc, an oral CCR5 antagonist, during 14-day monotherapy in HIV-infected adults
    Dirk Schurmann
    Charite Universitatsmedizin, Berlin, Germany
    AIDS 21:1293-9. 2007
    ..To determine antiviral activity, pharmacokinetic properties, and safety of vicriviroc, an orally available CCR5 antagonist, as monotherapy in HIV-infected patients...
  13. ncbi request reprint Adoptive transfer of syngeneic T cells in HIV-1 discordant twins indicates rapid regulation of T-cell homeostasis
    Christian Hoffmann
    University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Br J Haematol 136:641-8. 2007
    ..The clearance kinetics of the transfused cells from peripheral blood indicates a very rapid regulation of T-cell homeostasis in HIV infection...
  14. doi request reprint Phase II study of vicriviroc versus efavirenz (both with zidovudine/lamivudine) in treatment-naive subjects with HIV-1 infection
    Raphael J Landovitz
    Schering Plough Research Institute, Kenilworth, New Jersey, USA
    J Infect Dis 198:1113-22. 2008
    ..We report the results of a phase II dose-finding study of VCV plus dual nucleoside reverse-transcriptase inhibitors (NRTIs) in the treatment-naive HIV-1-infected subjects...
  15. ncbi request reprint Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial)
    Hans Jurgen Stellbrink
    Department of Medicine, Eppendorf University, Hamburg, Germany
    AIDS 16:1479-87. 2002
    ..The effect of interleukin-2 (IL-2) in combination with antiretroviral therapy on HIV-1 replication and reservoirs was investigated...
  16. ncbi request reprint Combination of tenofovir and lamivudine versus tenofovir after lamivudine failure for therapy of hepatitis B in HIV-coinfection
    Guenther Schmutz
    Center for HIV and Hepatogastroenterology, Grafenberger Allee 128a, 40237 Duesseldorf, Germany
    AIDS 20:1951-4. 2006
    ..It is unknown to date whether combination therapy with lamivudine plus tenofovir could be superior to sequential therapy with tenofovir after the occurrence of lamivudine resistance...
  17. ncbi request reprint High serum urate in HIV-infected persons: the choice of the antiretroviral drug matters
    Ulrich A Walker
    Department of Clinical Immunology, Medizinische Universitatsklinik, Freiburg, Germany
    AIDS 20:1556-8. 2006
    ..In univariate and multivariate analysis, hyperuricaemia was associated with factors previously identified in HIV-uninfected individuals, but also with the use of some antiretroviral drugs, particularly with the use of stavudine...
  18. ncbi request reprint Progressive multifocal leukencephalopathy in patients on highly active antiretroviral therapy: survival and risk factors of death
    Christoph Wyen
    Klinik I fur Innere Medizin, University of Cologne, Cologne, Germany
    J Acquir Immune Defic Syndr 37:1263-8. 2004
    ..To describe the clinical course and risk factors of death in highly active antiretroviral therapy (HAART)-treated patients with progressive multifocal leukencephalopathy (PML); to evaluate the efficacy of cidofovir in addition to HAART...
  19. ncbi request reprint Low rate of treatment failure on antiretroviral therapy with tenofovir, lamivudine and zidovudine
    Stefan Mauss
    AIDS 19:101-2. 2005
  20. pmc Massively parallel pyrosequencing in HIV research
    Frederic D Bushman
    Department of Microbiology, University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    AIDS 22:1411-5. 2008
  21. pmc Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients
    Christoph Wyen
    Department of Internal Medicine, University of Cologne, Koln, Germany
    J Antimicrob Chemother 61:914-8. 2008
    ..The aim of this study was to investigate the frequency of CYP2B6 polymorphisms (according to ethnicity) and the influence of heterozygosity and homozygosity on plasma concentrations of efavirenz and nevirapine...
  22. ncbi request reprint The epidemiology of HIV coreceptor tropism
    Christian Hoffmann
    Infektionsmedizinisches Centrum Hamburg, Grindelallee 35, 20146 Hamburg, Germany
    Eur J Med Res 12:385-90. 2007
    ..This review will focus on current knowledge of the epidemiology of HIV coreceptor tropism...
  23. pmc DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutations
    Christian Hoffmann
    Department of Microbiology, University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    Nucleic Acids Res 35:e91. 2007
    ....
  24. ncbi request reprint Fatal cerebral lymphomatoid granulomatosis in an HIV-1-infected patient
    Christoph Wyen
    Department of Internal Medicine, University of Cologne, Cologne, Germany
    J Infect 54:e175-8. 2007
    ..We present a rare case of isolated cerebral LYG developing in an HIV-1-infected patient after initiation of highly active antiretroviral therapy (HAART)...