Anthony D Ho

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Current status of hematopoietic cell transplantation in the treatment of systemic amyloid light-chain amyloidosis
    S O Schönland
    Department of Internal Medicine V Haematology, Oncology and Rheumatology, Amyloidosis Center, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Bone Marrow Transplant 47:895-905. 2012
  2. ncbi request reprint Indications for high-dose chemotherapy with autologous stem cell support in patients with systemic amyloid light chain amyloidosis
    Stefan O Schonland
    Department of Internal Medicine V Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Transplantation 80:S160-3. 2005
  3. ncbi request reprint Allogeneic and syngeneic hematopoietic cell transplantation in patients with amyloid light-chain amyloidosis: a report from the European Group for Blood and Marrow Transplantation
    Stefan O Schonland
    University of Heidelberg, Dept of Hematology Oncology and Rheumatology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Blood 107:2578-84. 2006
  4. doi request reprint Melan-A/MART1 analog peptide triggers anti-myeloma T-cells through crossreactivity with HM1.24
    Olaf Christensen
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    J Immunother 32:613-21. 2009
  5. ncbi request reprint Molecular and secretory profiles of human mesenchymal stromal cells and their abilities to maintain primitive hematopoietic progenitors
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Stem Cells 25:2638-47. 2007
  6. doi request reprint Autologous retransplantation for patients with recurrent multiple myeloma: a single-center experience with 200 patients
    Leopold Sellner
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cancer 119:2438-46. 2013
  7. pmc Co-culture with mesenchymal stromal cells increases proliferation and maintenance of haematopoietic progenitor cells
    Thomas Walenda
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    J Cell Mol Med 14:337-50. 2010
  8. ncbi request reprint High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II study
    Jolanta B Perz
    Department of Haematology Oncology, Clinic of Internal Medicine, University of Heidelberg, 69120 Heidelberg, Germany
    Br J Haematol 127:543-51. 2004
  9. ncbi request reprint One single dose of rituximab added to a standard regimen of CHOP in primary treatment of follicular lymphoma appears to result in a high clearance rate from circulating bcl-2/IgH positive cells: Is the end of molecular monitoring near?
    Christina Schmitt
    Department of Hematology Oncology, University of Heidelberg Medical Center, Heidelberg, Germany
    Leuk Res 30:1563-8. 2006
  10. ncbi request reprint Hematopoietic progenitor cells and cellular microenvironment: behavioral and molecular changes upon interaction
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Stem Cells 23:1180-91. 2005

Detail Information

Publications123 found, 100 shown here

  1. doi request reprint Current status of hematopoietic cell transplantation in the treatment of systemic amyloid light-chain amyloidosis
    S O Schönland
    Department of Internal Medicine V Haematology, Oncology and Rheumatology, Amyloidosis Center, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Bone Marrow Transplant 47:895-905. 2012
    ....
  2. ncbi request reprint Indications for high-dose chemotherapy with autologous stem cell support in patients with systemic amyloid light chain amyloidosis
    Stefan O Schonland
    Department of Internal Medicine V Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Transplantation 80:S160-3. 2005
    ..Here we review recent results of ASCT, eligibility criteria for HDM and report our own treatment results in 41 patients...
  3. ncbi request reprint Allogeneic and syngeneic hematopoietic cell transplantation in patients with amyloid light-chain amyloidosis: a report from the European Group for Blood and Marrow Transplantation
    Stefan O Schonland
    University of Heidelberg, Dept of Hematology Oncology and Rheumatology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Blood 107:2578-84. 2006
    ..These data suggest that allo-SCT might be a promising and potentially curative treatment modality for selected patients with AL amyloidosis...
  4. doi request reprint Melan-A/MART1 analog peptide triggers anti-myeloma T-cells through crossreactivity with HM1.24
    Olaf Christensen
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    J Immunother 32:613-21. 2009
    ..The current data demonstrate that Melan-A analog specific T-cells crossreact with HM1.24(aa22-30). They might be a tool for the future use in immunotherapy against MM...
  5. ncbi request reprint Molecular and secretory profiles of human mesenchymal stromal cells and their abilities to maintain primitive hematopoietic progenitors
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Stem Cells 25:2638-47. 2007
    ..The latter property is associated with specific molecular profiles indicating the significance of cell-cell junctions but not with secretory profiles. Disclosure of potential conflicts of interest is found at the end of this article...
  6. doi request reprint Autologous retransplantation for patients with recurrent multiple myeloma: a single-center experience with 200 patients
    Leopold Sellner
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cancer 119:2438-46. 2013
    ..Therapeutic options for patients with recurrent multiple myeloma after autologous stem cell transplantation (ASCT) include novel agents, conventional chemotherapy, or salvage ASCT with no standard of care...
  7. pmc Co-culture with mesenchymal stromal cells increases proliferation and maintenance of haematopoietic progenitor cells
    Thomas Walenda
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    J Cell Mol Med 14:337-50. 2010
    ..The use of early passages of MSC and genetic manipulation of proteins involved in HPC-MSC interaction might further enhance cord blood expansion on MSC...
  8. ncbi request reprint High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II study
    Jolanta B Perz
    Department of Haematology Oncology, Clinic of Internal Medicine, University of Heidelberg, 69120 Heidelberg, Germany
    Br J Haematol 127:543-51. 2004
    ..We could not show an additional benefit of VAD induction in terms of increasing haematological response rate; however the 13% mortality rate after HDM and ASCT in our series was lower than the previous report...
  9. ncbi request reprint One single dose of rituximab added to a standard regimen of CHOP in primary treatment of follicular lymphoma appears to result in a high clearance rate from circulating bcl-2/IgH positive cells: Is the end of molecular monitoring near?
    Christina Schmitt
    Department of Hematology Oncology, University of Heidelberg Medical Center, Heidelberg, Germany
    Leuk Res 30:1563-8. 2006
    ....
  10. ncbi request reprint Hematopoietic progenitor cells and cellular microenvironment: behavioral and molecular changes upon interaction
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Stem Cells 23:1180-91. 2005
    ....
  11. ncbi request reprint Cytokine-induced killer cells targeted by the novel bispecific antibody CD19xCD5 (HD37xT5.16) efficiently lyse B-lymphoma cells
    Freddy Tita-Nwa
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cancer Immunol Immunother 56:1911-20. 2007
    ..The in vitro studies outlined here support the experimental use of bsAb HD37xT5.16 in preclinical in vivo models for evaluation of its safety and efficacy profile...
  12. doi request reprint Chromosomal aberrations +1q21 and del(17p13) predict survival in patients with recurrent multiple myeloma treated with lenalidomide and dexamethasone
    Ulrike Klein
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cancer 117:2136-44. 2011
    ..In the era of novel agents such as lenalidomide and bortezomib, risk stratification by chromosomal abnormalities may enable a more rational selection of therapeutic approaches in patients with multiple myeloma (MM)...
  13. doi request reprint Clinical outcome of patients with follicular lymphoma and bulky disease after rituximab-CHOP immunochemotherapy with and without consolidating radiotherapy
    Fabienne McClanahan
    Department of Internal Medicine V, University Hospital of Heidelberg, Heidelberg, Germany
    Eur J Haematol 85:11-9. 2010
    ..The strategy to apply involved-field radiotherapy (IF-RT) after immunochemotherapy in patients with bulky follicular lymphoma (FL) remains controversial...
  14. doi request reprint Progression in smoldering myeloma is independently determined by the chromosomal abnormalities del(17p), t(4;14), gain 1q, hyperdiploidy, and tumor load
    Kai Neben
    Kai Neben, Anna Jauch, Jens Hillengass, Nicola Lehners, Martin Granzow, Marc S Raab, and Anthony D Ho, University of Heidelberg Thomas Hielscher, German Cancer Research Center and Anja Seckinger, Hartmut Goldschmidt, and Dirk Hose, University of Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany
    J Clin Oncol 31:4325-32. 2013
    ..The aim of this study was to analyze chromosomal aberrations in terms of frequency and impact on time to progression in patients with smoldering multiple myeloma (SMM) on the background of clinical prognostic factors...
  15. pmc A phase II study evaluating neo-/adjuvant EIA chemotherapy, surgical resection and radiotherapy in high-risk soft tissue sarcoma
    Thomas Schmitt
    Department of Hematology, Oncology, and Rheumatology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    BMC Cancer 11:510. 2011
    ..Here we report on the results of our non-randomized phase II study on neo-adjuvant treatment for high-risk STS...
  16. ncbi request reprint Retroviral integration sites correlate with expressed genes in hematopoietic stem cells
    Wolfgang Wagner
    Department of Internal Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Stem Cells 23:1050-8. 2005
    ..The association of gene expression and retrovirally targeted genes observed here will help to elucidate the molecular characteristics of primitive repopulating hematopoietic cells...
  17. ncbi request reprint Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 33:1402-16. 2005
    ..Whereas surface antigen markers have failed to precisely define this population, microarray analysis might provide a better tool for characterization of MSC...
  18. ncbi request reprint Adhesion of human hematopoietic progenitor cells to mesenchymal stromal cells involves CD44
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Cells Tissues Organs 188:160-9. 2008
    ..Maintenance of long-term culture-initiating cells was significantly lower on fibroblasts...
  19. doi request reprint Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcomes
    Dan Ran
    Department of Internal Medicine V, University of Heidelberg, Heidelberg 69120, Germany
    Exp Hematol 37:1423-34. 2009
    ..However, prospective isolation of human LSC from patients with acute myeloid leukemia (AML), as well as the assessment of their clinical significance, has remained a major challenge...
  20. doi request reprint Differences between healthy hematopoietic progenitors and leukemia cells with respect to CD44 mediated rolling versus adherence behavior on hyaluronic acid coated surfaces
    Maximilian Hanke
    Institute of Functional Interfaces, Karlsruhe Institute of Technology, Karlsruhe, Germany Applied Physical Chemistry, Heidelberg University, Heidelberg, Germany Analytical Chemistry Biointerfaces, Ruhr University Bochum, Bochum, Germany Department of Medicine V, Heidelberg University, Heidelberg, Germany
    Biomaterials 35:1411-9. 2014
    ..The latter property was associated with non-responsiveness to induction chemotherapy and subsequently poor clinical outcome. ..
  21. pmc Identification of HLA-A2 restricted T-cell epitopes within the conserved region of the immunoglobulin G heavy-chain in patients with multiple myeloma
    Sebastian Belle
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Eur J Haematol 81:26-35. 2008
    ..The aim of this study is the identification of HLA-A2 restricted T-cell epitopes in the conserved region of the immunoglobulin-G-heavy-chain (IgGH) that can be used for immunotherapy in multiple myeloma (MM) patients...
  22. doi request reprint Endothelial vulnerability and endothelial damage are associated with risk of graft-versus-host disease and response to steroid treatment
    Sascha Dietrich
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Biol Blood Marrow Transplant 19:22-7. 2013
    ..These findings provide evidence that endothelial function plays an important role in the pathogenesis of steroid refractoriness in ongoing GVHD; however, endothelial vulnerability does not predict incidence of GVHD...
  23. doi request reprint Staged heart transplantation and chemotherapy as a treatment option in patients with severe cardiac light-chain amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    Eur J Heart Fail 11:1014-20. 2009
    ..The prognosis of advanced cardiac light-chain amyloidosis is poor. Heart transplantation might enable causative therapy and ultimately improve prognosis...
  24. doi request reprint Regulation of NK cell function by human granulocyte arginase
    Johanna Oberlies
    Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
    J Immunol 182:5259-67. 2009
    ..Arginase inhibitors are therefore promising pharmacological agents to treat unwanted suppression of the innate (NK cell) as well as the adaptive (T cell) immune system...
  25. pmc Aging and replicative senescence have related effects on human stem and progenitor cells
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 4:e5846. 2009
    ..Changes upon aging of MSC and HPC are related to those of replicative senescence of MSC in vitro and this indicates that our stem and progenitor cells undergo a similar process also in vivo...
  26. doi request reprint Evaluation of the serum-free light chain test in untreated patients with AL amyloidosis
    Tilmann Bochtler
    Department of Internal Medicine Division of Hematology Oncology, Amyloidosis Clinic, University of Heidelberg, Germany
    Haematologica 93:459-62. 2008
    ..Higher FLC levels were associated with higher bone marrow plasmocytosis, poorer Karnofsky index and heart involvement, and therefore reflected disease severity...
  27. doi request reprint Adipogenic differentiation of human mesenchymal stromal cells is down-regulated by microRNA-369-5p and up-regulated by microRNA-371
    Simone Bork
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    J Cell Physiol 226:2226-34. 2011
    ..In summary, we identified miR-369-5p and miR-371 as antagonistic up-stream regulators of adipogenic differentiation and this might be indirectly mediated by epigenetic modifications...
  28. doi request reprint Effective prophylaxis of thromboembolic complications with low molecular weight heparin in relapsed multiple myeloma patients treated with lenalidomide and dexamethasone
    Ulrike Klein
    Department of Internal Medicine V, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Ann Hematol 88:67-71. 2009
    ..Therefore, we propose LMWH should be used in patients being treated with lenalidomide and dexamethasone at least for the first 3 months of treatment until randomized trials have proven the equality of other pharmacological prophylaxis...
  29. doi request reprint N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells
    Frederik Wein
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Stem Cell Res 4:129-39. 2010
    ..These results indicate that N-cadherin is involved in the bidirectional interaction of human HPC with their cellular determinants in the niche...
  30. doi request reprint Functional potentials of human hematopoietic progenitor cells are maintained by mesenchymal stromal cells and not impaired by plerixafor
    Annette Ludwig
    Department of Medicine V, Heidelberg University, Heidelberg, Germany
    Cytotherapy 16:111-21. 2014
    ....
  31. doi request reprint Identification and separation of normal hematopoietic stem cells and leukemia stem cells from patients with acute myeloid leukemia
    Van T Hoang
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Methods Mol Biol 1035:217-30. 2013
    ....
  32. doi request reprint Skeletal scintigraphy indicates disease severity of cardiac involvement in patients with senile systemic amyloidosis
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, Im Neuenheimer Feld 410, Heidelberg, Germany
    Int J Cardiol 164:179-84. 2013
    ..Senile systemic amyloidosis (SSA) is a common aging phenomenon in the elderly population. Nevertheless, pre-mortem diagnosis of SSA is rare. Thus, data on clinical characterization and disease severity are limited...
  33. doi request reprint The impact of high-dose chemotherapy, autologous stem cell transplant and conventional chemotherapy on quality of life of long-term survivors with follicular lymphoma
    Silke Andresen
    Department of Hematology and Oncology, University of Heidelberg, Heidelberg, Germany
    Leuk Lymphoma 53:386-93. 2012
    ..However, the negative impact of both HDCT and conventional therapy on the QoL of patients with follicular lymphoma should not be underestimated and should lead to the development of less toxic therapy strategies...
  34. doi request reprint Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p
    Kai Neben
    Department of Internal Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Blood 119:940-8. 2012
    ..In conclusion, the adverse impact of del(17p13) on PFS and OS could be significantly reduced by bortezomib-based treatment, suggesting that long-term administration of bortezomib should be recommended for patients carrying del(17p13)...
  35. ncbi request reprint Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals
    Thomas Luft
    The German Cancer Research Center, Dept of Molecular Oncology Hematology, Heidelberg, Germany
    Blood 107:4763-9. 2006
    ..The combined activities of these modules define the functional outcome of DC activation...
  36. doi request reprint IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production
    Michael Conzelmann
    German Cancer Research Center, Department of Molecular Oncology Hematology, Heidelberg, Germany
    Biochem Pharmacol 80:2074-86. 2010
    ..This suggests that a number of CD40 effects in chronic inflammatory diseases might be weakened by targeting JAK/STAT...
  37. pmc Combining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation
    Kai Neben
    Department of Internal Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Haematologica 95:1150-7. 2010
    ..Specific changes in interphase cells can be detected by fluorescent in situ hybridization, which overcomes the problem of the lack of dividing cells required for conventional cytogenetics...
  38. pmc The use of positron emission tomography in soft tissue sarcoma patients under therapy with trabectedin
    Bernd Kasper
    Department of Internal Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Mar Drugs 7:331-40. 2009
    ....
  39. doi request reprint Mesenchymal stem cells retain their defining stem cell characteristics after exposure to ionizing radiation
    Nils H Nicolay
    Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany Department of Molecular and Radiation Oncology, German Cancer Research Center, Heidelberg, Germany Electronic address
    Int J Radiat Oncol Biol Phys 87:1171-8. 2013
    ....
  40. doi request reprint Synergistic activity of nilotinib and established chemotherapeutic drugs in imatinib-sensitive and -resistant BCR-ABL-positive cells
    Aleksandar Radujkovic
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cancer Chemother Pharmacol 66:255-64. 2010
    ..This may be the foundation for further study on the potential of the applied combinations in a clinical setting...
  41. doi request reprint Identification of a human Th1-like IFNγ-secreting Treg subtype deriving from effector T cells
    Ram Kumar Chowdary Venigalla
    Division of Rheumatology, University of Heidelberg, 69120 Heidelberg, Germany
    J Autoimmun 39:377-87. 2012
    ..This report characterizes a new subpopulation of human adaptive regulatory T-cells that derive from effector Th-cells and concomitantly express Th1-specific T-bet and IFNγ with Foxp3...
  42. doi request reprint Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance
    Dan Ran
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 40:155-65.e1. 2012
    ..0095) affecting overall survival (hazard ratio = 9.107). LSCC are heterogeneous and best reflected by ALDH activity. The frequency of ALDH(bright) cells at diagnosis is a significant prognostic marker for acute myeloid leukemia...
  43. doi request reprint Blastic plasmacytoid dendritic cell neoplasia (BPDC) in elderly patients: results of a treatment algorithm employing allogeneic stem cell transplantation with moderately reduced conditioning intensity
    Sascha Dietrich
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Biol Blood Marrow Transplant 17:1250-4. 2011
    ....
  44. ncbi request reprint Primitive and committed human hematopoietic progenitor cells interact with primary murine neural cells and are induced to undergo self-renewing cell divisions
    Sandra Gottschling
    Department of Medicine V, Ruprecht Karls University, Heidelberg, Germany
    Exp Hematol 35:1858-71. 2007
    ..The interaction between HPC and the neural environment and the functional effect on hematopoiesis have not yet been defined...
  45. ncbi request reprint Serum cytokeratin-18 fragments as quantitative markers of epithelial apoptosis in liver and intestinal graft-versus-host disease
    Thomas Luft
    Department Medicine V, University of Heidelberg, Heidelberg, Germany
    Blood 110:4535-42. 2007
    ..Prospective studies are warranted to evaluate how CK18Fs may assist in the diagnosis, grading, and treatment guidance of GVHD...
  46. ncbi request reprint Rituximab-augmented myeloablation for first-line autologous stem cell transplantation for mantle cell lymphoma: effects on molecular response and clinical outcome
    Peter Dreger
    Department of Medicine V, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Haematologica 92:42-9. 2007
    ..Autologous stem cell transplantation (ASCT) is effective in mantle cell lymphoma (MCL). We investigated whether incorporation of rituximab into the high-dose regimen might further improve the results of ASCT in patients with MCL...
  47. doi request reprint Differential survival of AML subpopulations in NOD/SCID mice
    Mario Schubert
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 39:250-263.e4. 2011
    ..The latter still being discussed for acute myeloid leukemia (AML), nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice were used to evaluate long-time reconstitution and expansion of AML subpopulations...
  48. doi request reprint Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared with monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability
    Tilmann Bochtler
    Department of Internal Medicine, Division of Hematology Oncology, Amyloidosis Clinic, University of Heidelberg, Heidelberg, Germany
    Blood 111:4700-5. 2008
    ..001) in both groups. Similar branching patterns were observed in an oncogenetic tree model, indicating a common mechanism of underlying karyotypic instability in these plasma cell disorders...
  49. doi request reprint Early prediction of therapy outcome in patients with high-risk soft tissue sarcoma using positron emission tomography
    Bernd Kasper
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Onkologie 31:107-12. 2008
    ..We used 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) positron emission tomography (PET) to evaluate the FDG uptake in patients with soft tissue sarcoma (STS). Treatment effect was assessed with regard to prediction of therapy outcome...
  50. doi request reprint Gain of 1q21 and distinct adverse cytogenetic abnormalities correlate with increased microcirculation in multiple myeloma
    Jens Hillengass
    Department of Hematology, Oncology, and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 122:2871-5. 2008
    ..Our findings will have important implications for the design, analysis and stratification for clinical studies of patients with MM in particular if compounds with antiangiogenic activity are used...
  51. doi request reprint Poor mobilization of hematopoietic stem cells-definitions, incidence, risk factors, and impact on outcome of autologous transplantation
    Patrick Wuchter
    Department of Internal Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Biol Blood Marrow Transplant 16:490-9. 2010
    ..The majority of the patients today intended for autologous transplantations were able to mobilize readily. As long as > or =2.0 x 10(6) of CD34(+) cells/kg b.w. have been collected, PM was not associated with inferior engraftment...
  52. doi request reprint Lenalidomide in combination with dexamethasone: effective regimen in patients with relapsed or refractory multiple myeloma complicated by renal impairment
    Ulrike Klein
    Department of Internal Medicine V, Hematology and Oncology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    Ann Hematol 90:429-39. 2011
    ..In conclusion, lenalidomide plus dexamethasone is an effective regimen for relapsed or refractory patients with MM complicated by RI with manageable toxicity...
  53. ncbi request reprint GSK-3 mediates differentiation and activation of proinflammatory dendritic cells
    Elena Rodionova
    Department of Molecular Oncology Hematology, German Cancer Research Center, Heidelberg, Germany
    Blood 109:1584-92. 2007
    ..GSK-3 may therefore act as a key integrator of activating and inhibitory pathways involved in proinflammatory DC differentiation and activation...
  54. ncbi request reprint Effect of CD34 cell dose on hematopoietic reconstitution and outcome in 508 patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation
    Jens Klaus
    Department of Internal Medicine V, University Heidelberg, Heidelberg, Germany
    Eur J Haematol 78:21-8. 2007
    ..We analyzed the hematopoietic reconstitution and outcome of 508 patients with multiple myeloma (MM) with respect to the number of CD34+ cells reinfused at our center...
  55. ncbi request reprint The outcome of autologous stem cell transplantation in patients with plasma cell disorders and dialysis-dependent renal failure
    Marc S Raab
    Department of Internal Medicine V, University of Heidelberg, Germany
    Haematologica 91:1555-8. 2006
    ..They required significantly extended intravenous antibiotic treatment and longer hospitalization. Thus, melphalan 100 mg/m2 is less toxic, yet equally efficient and improves the prognosis of this group of patients...
  56. ncbi request reprint Human mesenchymal stromal cells regulate initial self-renewing divisions of hematopoietic progenitor cells by a beta1-integrin-dependent mechanism
    Sandra Gottschling
    Department of Medicine V, Ruprecht Karls University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Stem Cells 25:798-806. 2007
    ..These results have provided evidence that primary human MS cells are able to induce self-renewing divisions of HPC by a beta(1)-integrin-dependent mechanism...
  57. ncbi request reprint Long-term follow-up of patients with non-Hodgkin lymphoma following myeloablative therapy and autologous transplantation of CD34+-selected peripheral blood progenitor cells
    Mathias Witzens-Harig
    Department of Hematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany
    Stem Cells 25:228-35. 2007
    ....
  58. ncbi request reprint Adhesion of hematopoietic progenitor cells to human mesenchymal stem cells as a model for cell-cell interaction
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 35:314-25. 2007
    ..Human mesenchymal stem cell (MSC) feeder layers represent a surrogate model for this interaction. Specific adhesion molecules are responsible for this cell-cell contact...
  59. ncbi request reprint Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesis
    Norbert Blank
    Department of Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
    J Immunol 179:3613-21. 2007
    ..Statins induce both lower levels of low-density lipoprotein cholesterol and inhibition of T cell activation, which might contribute to an inhibition of atherosclerosis...
  60. doi request reprint Lenalidomide enhances antigen-specific activity and decreases CD45RA expression of T cells from patients with multiple myeloma
    Brigitte Neuber
    Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany
    J Immunol 187:1047-56. 2011
    ..We showed for the first time, to our knowledge, that lenalidomide enhances the Ag-specific activation of T cells and the subsequent downregulation of CD45RA expression of T cells in vitro and in vivo...
  61. doi request reprint Thalidomide maintenance therapy maturates the T cell compartment and compromises antigen-specific antitumor immunity in patients with multiple myeloma
    Isabelle Herth
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 41:231-40. 2013
    ..In conclusion, Thalidomide maintenance therapy has profound implications on T cell pattern and activation status, which compromise antigen specific antitumor immunity...
  62. doi request reprint Arginine deficiency leads to impaired cofilin dephosphorylation in activated human T lymphocytes
    Nadja Feldmeyer
    Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Int Immunol 24:303-13. 2012
    ..Our novel results identify cofilin as a potential regulator of human T-cell activation under conditions of inflammatory arginine deficiency...
  63. doi request reprint Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system
    Thomas Luft
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Blood 118:1685-92. 2011
    ..These results suggest that endothelial cell vulnerability and dysfunction, rather than refractory T-cell activity, drives treatment refractoriness of GVHD and opens new avenues for prediction and control of this devastating condition...
  64. doi request reprint Characterization of hematopoietic stem cell subsets from patients with multiple myeloma after mobilization with plerixafor
    Isabel Taubert
    Department of Medicine V, Heidelberg University, Heidelberg, Germany
    Cytotherapy 13:459-66. 2011
    ..In this study we analyzed the impact of adding plerixafor to G-CSF upon the mobilization of different HSC subsets...
  65. doi request reprint Large institutional experience with dose-intensive chemotherapy and stem cell support in the management of sarcoma patients
    Bernd Kasper
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Oncology 73:58-64. 2007
    ..The prognosis of patients with advanced sarcoma remains poor. Whether high-dose chemotherapy with stem cell support improves the long-term outcome for these patients or not is controversial...
  66. doi request reprint Hyperdiploidy is less frequent in AL amyloidosis compared with monoclonal gammopathy of undetermined significance and inversely associated with translocation t(11;14)
    Tilmann Bochtler
    Amyloidosis Center, Department of Internal Medicine, Division of Hematology Oncology Rheumatology, University of Heidelberg, Heidelberg, Germany
    Blood 117:3809-15. 2011
    ....
  67. doi request reprint Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging
    Michael T Bocker
    Division of Epigenetics, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    Blood 117:e182-9. 2011
    ..Our results thus provide detailed insight into the methylation dynamics during differentiation and suggest that epigenetic changes contribute to hematopoietic progenitor cell aging...
  68. ncbi request reprint High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B-cell chronic lymphocytic leukemia
    Manfred Hensel
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 121:978-83. 2007
    ..These findings suggest that, despite the common observation of most CLL cells remaining in G(0)/G(1) phase, their centrosome replication process is deregulated and correlates to the proliferative activity of CLL cells...
  69. doi request reprint Quality of life during maintenance therapy with the anti-CD20 antibody rituximab in patients with B cell non-Hodgkin's lymphoma: results of a prospective randomized controlled trial
    Mathias Witzens-Harig
    Department of Internal Medicine V, University Hospital of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Ann Hematol 88:51-7. 2009
    ..We conclude that rituximab maintenance therapy seems to be safe and does not impair quality of life in this patient population...
  70. pmc Shear stress regulates adhesion and rolling of CD44+ leukemic and hematopoietic progenitor cells on hyaluronan
    Christof Christophis
    Applied Physical Chemistry, University of Heidelberg, Heidelberg, Germany
    Biophys J 101:585-93. 2011
    ..Interestingly, the observations of flow-induced cell rolling are related to those found in the recruitment of leukocytes to inflammatory sites and the mechanisms of stem-cell homing into the bone marrow...
  71. pmc DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells
    Simone Bork
    Department of Medicine V, University of Heidelberg, 69120 Heidelberg, Germany
    Aging Cell 9:54-63. 2010
    ..This supports the notion that replicative senescence and aging represent developmental processes that are regulated by specific epigenetic modifications...
  72. ncbi request reprint Pentostatin/cyclophosphamide with or without rituximab: an effective regimen for patients with Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma
    Manfred Hensel
    Department of Internal Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Clin Lymphoma Myeloma 6:131-5. 2005
    ..Pentostatin has demonstrated significant activity as a single agent in patients with low-grade B-cell and T-cell lymphomas and is less myelosuppressive than other purine analogues...
  73. pmc Identification of a new HLA-A2-restricted T-cell epitope within HM1.24 as immunotherapy target for multiple myeloma
    Michael Hundemer
    Department of Internal Medicine V, University of Heidelberg, Germany
    Exp Hematol 34:486-96. 2006
    ..The aim of this study was identification of human leukocyte antigen (HLA)-A2-restricted T-cell epitopes within the HM1.24 antigen as target for multiple myeloma (MM)-directed specific peptide-based immunotherapy...
  74. doi request reprint Induction of CD4+ T-cell anergy and apoptosis by activated human B cells
    Theresa Tretter
    Department of Medicine V, Divisions of Rheumatology, Clinics of Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany
    Blood 112:4555-64. 2008
    ..We conclude that activated CD25(+) B cells are able to costimulate or down-regulate T-cell responses, depending on activation status and environmental conditions that might also influence their pathophysiological impact...
  75. pmc Replicative senescence of mesenchymal stem cells: a continuous and organized process
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 3:e2213. 2008
    ..This process includes far reaching alterations in phenotype, differentiation potential, global gene expression patterns, and miRNA profiles that need to be considered for therapeutic application of MSC preparations...
  76. ncbi request reprint Mesenchymal stem cell preparations--comparing apples and oranges
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Stem Cell Rev 3:239-48. 2007
    ..More precise molecular and cellular markers to define subsets of MSC and to standardize the protocols for expansion of MSC are urgently needed...
  77. ncbi request reprint Differences in functional activity and antigen expression of granulocytes primed in vivo with filgrastim, lenograstim, or pegfilgrastim
    Daniel Ribeiro
    Department of Internal Medicine V, University of Heidelberg, German Cancer Research Center, Heidelberg, Germany
    Transfusion 47:969-80. 2007
    ..Beside nonglycosylated filgrastim and glycosylated lenograstim, pegylated filgrastim (pegfilgrastim) has recently been introduced for single administration into clinical use...
  78. doi request reprint Cellular immune responses against the cancer-testis antigen SPAN-XB in healthy donors and patients with multiple myeloma
    Christian Frank
    Department of Haematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany
    Leuk Lymphoma 49:779-85. 2008
    ..We conclude that SPAN-XB-derived peptides can elicit a consistent CD8 T cell response in healthy donors and patients with MM...
  79. ncbi request reprint The symmetry of initial divisions of human hematopoietic progenitors is altered only by the cellular microenvironment
    Michael Punzel
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 31:339-47. 2003
    ..We examined if cellular elements or adhesive ligands were able to alter asymmetric divisions of CD34(+)/CD38(-) cells in contrast to soluble factors at a single cell level...
  80. pmc Trabectedin for metastatic soft tissue sarcoma: a retrospective single center analysis
    Thomas Schmitt
    Department of Internal Medicine V, Heidelberg University Clinics, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Mar Drugs 8:2647-58. 2010
    ..However, dose reductions due to side effects were necessary in five patients. We conclude that trabectedin is an effective and generally well tolerated treatment for STS even in a heavily pre-treated patient population...
  81. ncbi request reprint Level of CD 20-expression and efficacy of rituximab treatment in patients with resistant or relapsing B-cell prolymphocytic leukemia and B-cell chronic lymphocytic leukemia
    Jolanta Perz
    Department of Internal Medicine V, University of Heidelberg, Germany
    Leuk Lymphoma 43:149-51. 2002
    ..We could not identify any correlation between CD20-expression and efficacy of rituximab treatment...
  82. ncbi request reprint Dissociation of putative graft-versus-haematopoiesis and graft-versus-myeloma effects in patients with rapidly progressive multiple myeloma
    Thomas Luft
    Department of Hematology and Rheumatology, University of Heidelberg, Poliklinik and Medizinische Klinik V, Heidelberg, Germany
    Br J Haematol 123:646-53. 2003
    ..Secondly, the graft-versus-myeloma effect that induced CR did not correlate with FDC but was associated with grade III-IV GvHD in our group of heavily pretreated patients...
  83. ncbi request reprint Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Blood 104:675-86. 2004
    ..The majority of cells in the SDF are rhodamine-123dull. These results provide molecular evidence that the SDF is associated with primitive function and serves as basis for a detailed understanding of asymmetric division of stem cells...
  84. ncbi request reprint Stem cell dose and tumorbiologic parameters as prognostic markers for patients with metastatic breast cancer undergoing high-dose chemotherapy with autologous blood stem cell support
    Manfred Hensel
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Stem Cells 20:32-40. 2002
    ..Our observation might indicate a favorable effect of HDCT in MBC patients with overexpression of Her2/neu who might have a worse prognosis when treated with conventional chemotherapy...
  85. doi request reprint Modeling of asymmetric cell division in hematopoietic stem cells--regulation of self-renewal is essential for efficient repopulation
    Anna Marciniak-Czochra
    Interdisciplinary Center of Scientific Computing IWR, Institute of Applied Mathematics, University of Heidelberg, Heidelberg, Germany
    Stem Cells Dev 18:377-85. 2009
    ..The model is compatible with the increase of leukocyte numbers following HSC transplantation. This study demonstrates that extrinsic regulation of the self-renewal rate of HSC is most essential in the process of hematopoiesis...
  86. ncbi request reprint Functional analysis of initial cell divisions defines the subsequent fate of individual human CD34(+)CD38(-) cells
    Michael Punzel
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 30:464-72. 2002
    ..We assessed the relationship of individual cell divisional behavior with the functional fate of stem cell candidates at the single cell level...
  87. ncbi request reprint Dose-dependent effect of thalidomide on overall survival in relapsed multiple myeloma
    Kai Neben
    Department of Internal Medicine V, University of Heidelberg, 69115 Heidelberg, Germany
    Clin Cancer Res 8:3377-82. 2002
    ..The aim of this study was to analyze whether the effect of Thal in MM is dose dependent and whether the outcome might be improved when the Thal dosage is adjusted to parameters reflecting body size...
  88. ncbi request reprint Expression of centrosome-associated gene products is linked to tetraploidization in mantle cell lymphoma
    Kai Neben
    Molekulare Genetik B060, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Int J Cancer 120:1669-77. 2007
    ..The high expression level of centrosome-associated gene products in blastoid MCL matches the description of more frequent centrosome aberrations in this MCL variant...
  89. ncbi request reprint P53 is the strongest predictor of survival in high-risk primary breast cancer patients undergoing high-dose chemotherapy with autologous blood stem cell support
    Manfred Hensel
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 100:290-6. 2002
    ..The adverse impact of these biologic features was probably not altered by HDCT. For HRPBC patients with tumors not overexpressing Her2/neu or p53, HDCT may be an appropriate approach to achieve long-term survival and tumor control...
  90. ncbi request reprint Dose-intensive chemotherapy with stem cell support as a treatment strategy for bone and soft-tissue sarcomas
    Bernd Kasper
    University of Heidelberg, Department of Internal Medicine V, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Curr Stem Cell Res Ther 1:29-35. 2006
    ....
  91. ncbi request reprint Disease activity and pretreatment, rather than hypogammaglobulinaemia, are major risk factors for infectious complications in patients with chronic lymphocytic leukaemia
    Manfred Hensel
    Department of Internal Medicine V, University of Heidelberg, Hospitalstrasse 3, D 69115 Heidelberg, Germany
    Br J Haematol 122:600-6. 2003
    ..Preferably, prophylactic strategies should be evaluated in patients defined by these parameters...
  92. ncbi request reprint Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression
    Andreas Schneeweiss
    Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 107:346-52. 2003
    ..This might indicate a fundamental role of centrosomal dysfunction in disease evolution, possibly as a result of chromosome missegregation during mitosis...
  93. ncbi request reprint Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells
    Stephanie Laufs
    German Cancer Research Center, Research Program Diagnostics and Experimental Therapy, Heidelberg, Germany
    Blood 101:2191-8. 2003
    ..Preferred genomic target sites have previously only been reported for wild-type retroviruses. Our findings reveal for the first time that retroviral vector integration into human marrow-repopulating cells can be nonrandom (P =.000 37)...
  94. ncbi request reprint No regression of renal AL amyloid in monoclonal gammopathy after successful autologous blood stem cell transplantation and significant clinical improvement
    Martin Zeier
    Department of Medicine Nephrology, University of Heidelberg, Bergheimerstrasse 56a, D 69115 Heidelberg, Germany
    Nephrol Dial Transplant 18:2644-7. 2003
    ..High-dose chemotherapy followed by autologous blood stem cell transplantation induces remission of plasma cell dyscrasia in patients with AL amyloidosis. The impact of this treatment on the glomerular amyloid mass is still unknown...
  95. ncbi request reprint Cholera toxin binds to lipid rafts but has a limited specificity for ganglioside GM1
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
    Immunol Cell Biol 85:378-82. 2007
    ....
  96. ncbi request reprint Combination of imatinib and established antileukemic treatment modalities for otherwise refractory BCR-ABL positive lymphoblastic leukemia
    Stefan Fruehauf
    Department ofInternal Medicine V, University of Heidelberg, Germany
    Haematologica 87:ECR38. 2002
  97. ncbi request reprint [Stem cell transplantation in primary systemic vasculitis]
    Manfred Hensel
    Medizinische Klinik und Poliklinik V, Universitatsklinikum Heidelberg
    Med Klin (Munich) 98:13-8. 2003
    ..In some cases the complications might be fatal. Furthermore, prolonged immunosuppression with cyclophosphamide or corticosteroids often leads to long-term side effects, cumulative organ damage, and development of secondary malignancies...
  98. ncbi request reprint Autologous bone marrow transplantation in adult patients with acute lymphoblastic leukemia
    Gerlinde Egerer
    Department of Medicine V, University of Heidelberg, Hospitalstr 3, 69115 Heidelberg, Germany
    Leuk Lymphoma 44:9-14. 2003
    ..The tyrosine-kinase inhibitor STI 571 offers new perspectives for patients with the Phl/bcr/abl translocation. It may be especially useful for treating minimal residual disease (MRD) before and/or after ABMT...
  99. ncbi request reprint The beauty of asymmetry: asymmetric divisions and self-renewal in the haematopoietic system
    Anthony D Ho
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Curr Opin Hematol 14:330-6. 2007
    ..A central question in developmental biology is how can a single cell divide to produce two progeny cells that adopt different fates? We provided evidence of the significance of asymmetric division in human haematopoietic stem cells...
  100. doi request reprint Mycobacterium kansasii tenosynovitis in a rheumatoid arthritis patient with long-term therapeutic immunosuppression
    Hanns Martin Lorenz
    Department of Medicine, Division of Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
    Arthritis Rheum 59:900-3. 2008
  101. ncbi request reprint A new therapeutic approach in patients with advanced sarcoma
    Bernd Kasper
    University of Heidelberg, Department of Internal Medicine V, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Int J Clin Oncol 10:438-40. 2005
    ..This new triple combination of low-dose trofosfamide, pioglitazone, and rofecoxib may represent a feasible new alternative in the palliative treatment of sarcoma patients...