K F Hilgers

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc Effects of diabetes and hypertension on macrophage infiltration and matrix expansion in the rat kidney
    Andrea Hartner
    Children and Youth Hospital, University of Erlangen Nuremberg, Loschgestrasse 15, D 91054 Erlangen, Germany
    BMC Nephrol 6:6. 2005
  2. ncbi request reprint Treatment strategies in patients with chronic renal disease: ACE inhibitors, angiotensin receptor antagonists, or both?
    Karl F Hilgers
    Department of Medicine IV, University of Erlangen Nurnberg, Germany
    Pediatr Nephrol 19:956-61. 2004
  3. ncbi request reprint Angiotensin II type 1 receptor blockade prevents lethal malignant hypertension: relation to kidney inflammation
    K F Hilgers
    Department of Medicine IV, University of Erlangen, Nurnberg, Germany
    Circulation 104:1436-40. 2001
  4. ncbi request reprint Renin uptake by the endothelium mediates vascular angiotensin formation
    K F Hilgers
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    Hypertension 38:243-8. 2001
  5. ncbi request reprint Monocyte chemoattractant protein-1 and macrophage infiltration in hypertensive kidney injury
    K F Hilgers
    Department of Medicine IV, University of Erlangen Nurnberg, Erlangen Max Delbrück Center, Berlin Buch, Germany
    Kidney Int 58:2408-19. 2000
  6. ncbi request reprint Glomerular osteopontin expression and macrophage infiltration in glomerulosclerosis of DOCA-salt rats
    A Hartner
    Department of Medicine IV, , Erlangen, Germany
    Am J Kidney Dis 38:153-64. 2001
  7. doi request reprint Sympathetic blockade prevents the decrease in cardiac VEGF expression and capillary supply in experimental renal failure
    K Amann
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 300:F105-12. 2011
  8. ncbi request reprint Angiotensinases restrict locally generated angiotensin II to the blood vessel wall
    K F Hilgers
    Department of Medicine IV, University of Erlangen, Germany
    Hypertension 31:368-72. 1998
  9. ncbi request reprint Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetes
    Andrea Hartner
    Children and Youth Hospital, University of Erlangen Nuremberg, Erlangen, Germany
    Am J Physiol Renal Physiol 292:F820-7. 2007
  10. ncbi request reprint Aldosterone synthase (CYP11B2) -344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension
    C Delles
    Department of Medicine/Nephrology, University of Erlangen, , Germany
    J Am Coll Cardiol 37:878-84. 2001

Collaborators

Detail Information

Publications70

  1. pmc Effects of diabetes and hypertension on macrophage infiltration and matrix expansion in the rat kidney
    Andrea Hartner
    Children and Youth Hospital, University of Erlangen Nuremberg, Loschgestrasse 15, D 91054 Erlangen, Germany
    BMC Nephrol 6:6. 2005
    ..Inflammatory mechanisms contribute to renal damage in both diseases. We investigated whether hypertension and diabetes mellitus act synergistically to induce macrophage infiltration and matrix expansion in the kidney...
  2. ncbi request reprint Treatment strategies in patients with chronic renal disease: ACE inhibitors, angiotensin receptor antagonists, or both?
    Karl F Hilgers
    Department of Medicine IV, University of Erlangen Nurnberg, Germany
    Pediatr Nephrol 19:956-61. 2004
    ..A trial of ARB plus ACEI is justified in selected patients if blood pressure and/or proteinuria cannot adequately be lowered by ACEI or ARB alone...
  3. ncbi request reprint Angiotensin II type 1 receptor blockade prevents lethal malignant hypertension: relation to kidney inflammation
    K F Hilgers
    Department of Medicine IV, University of Erlangen, Nurnberg, Germany
    Circulation 104:1436-40. 2001
    ..Angiotensin II is elevated in malignant hypertension. We tested the hypothesis that angiotensin II type 1 receptor blockade can prevent the development of malignant hypertension even in the absence of a blood pressure-lowering effect...
  4. ncbi request reprint Renin uptake by the endothelium mediates vascular angiotensin formation
    K F Hilgers
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    Hypertension 38:243-8. 2001
    ..The effects of endothelium destruction on Ang I formation support the notion that the endothelium mediates vascular angiotensin formation by taking up renin...
  5. ncbi request reprint Monocyte chemoattractant protein-1 and macrophage infiltration in hypertensive kidney injury
    K F Hilgers
    Department of Medicine IV, University of Erlangen Nurnberg, Erlangen Max Delbrück Center, Berlin Buch, Germany
    Kidney Int 58:2408-19. 2000
    ..We investigated whether monocyte chemoattractant protein-1 (MCP-1) is expressed in hypertensive nephrosclerosis, and tested the effect of angiotensin II type 1 receptor blockade on MCP-1 expression and macrophage (MPhi) infiltration...
  6. ncbi request reprint Glomerular osteopontin expression and macrophage infiltration in glomerulosclerosis of DOCA-salt rats
    A Hartner
    Department of Medicine IV, , Erlangen, Germany
    Am J Kidney Dis 38:153-64. 2001
    ..6 +/- 0.5; P < 0.05). Glomerular OPN expression occurs in chronic hypertensive glomerulosclerosis and is associated with macrophage infiltration. The data suggest a role for OPN as a chemoattractant in hypertensive glomerulosclerosis...
  7. doi request reprint Sympathetic blockade prevents the decrease in cardiac VEGF expression and capillary supply in experimental renal failure
    K Amann
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 300:F105-12. 2011
    ..The beneficial effect of sympathetic downregulation on cardiac structure and function in renal failure may be at least in part explained by increased cardiac VEGF gene expression...
  8. ncbi request reprint Angiotensinases restrict locally generated angiotensin II to the blood vessel wall
    K F Hilgers
    Department of Medicine IV, University of Erlangen, Germany
    Hypertension 31:368-72. 1998
    ..We conclude that the major part of locally generated angiotensins is not released into the circulation but degraded by angiotensinases within the tissue compartment...
  9. ncbi request reprint Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetes
    Andrea Hartner
    Children and Youth Hospital, University of Erlangen Nuremberg, Erlangen, Germany
    Am J Physiol Renal Physiol 292:F820-7. 2007
    ..However, the long-term course of this animal model resembles severe hypertensive nephrosclerosis, rather than progressive diabetic nephropathy...
  10. ncbi request reprint Aldosterone synthase (CYP11B2) -344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension
    C Delles
    Department of Medicine/Nephrology, University of Erlangen, , Germany
    J Am Coll Cardiol 37:878-84. 2001
    ..Differences in renal sodium handling across the genotypes might contribute to this finding...
  11. ncbi request reprint Statin treatment reduces glomerular inflammation and podocyte damage in rat deoxycorticosterone-acetate-salt hypertension
    Andrea Hartner
    Hospital for Children and Adolescents, Erlangen, Germany
    J Hypertens 27:376-85. 2009
    ..We examined the effects of fluvastatin treatment on the development of kidney injury in experimental deoxycorticosterone-acetate (DOCA)-salt hypertension...
  12. doi request reprint Lack of nidogen-2 increases blood pressure, glomerular and tubulointerstitial damage in DOCA-salt hypertension
    K Amann
    University of Erlangen Nuernberg, University of Luebeck, Erlangen, Germany
    Eur J Clin Invest 39:116-25. 2009
    ..We tested the hypothesis that nidogen-2 mediated cell-matrix interactions are important to maintain glomerular integrity and structure in renal hyperperfusion and hypertension...
  13. doi request reprint (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats
    Dominik N Muller
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic, and HELIOS Klinikum Berlin Buch, and Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 51:676-81. 2008
    ..Our results indicate that blockade of the (P)RR with HRP does not improve target organ damage in renovascular hypertensive rats...
  14. ncbi request reprint ACE inhibitors versus AT(1) receptor antagonists in patients with chronic renal disease
    Karl F Hilgers
    Department of Medicine IV, University of Erlangen Nurnberg, Nurnberg, Germany
    J Am Soc Nephrol 13:1100-8. 2002
  15. doi request reprint Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension
    Bernd Klanke
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 23:3456-63. 2008
    ..We examined the contribution of high blood pressure versus direct mineralocorticoid effects to the progression of kidney inflammation and fibrosis in established experimental deoxycorticosterone-acetate (DOCA)-salt hypertension...
  16. ncbi request reprint Subthreshold stimulation of a serotonin 5-HT3 reflex attenuates cardiovascular reflexes
    R Veelken
    Department of Internal Medicine, University of Erlangen Nurnberg, Germany
    Am J Physiol 271:R1500-6. 1996
    ..We conclude that 5-HT3-serotonergic cardiopulmonary chemoreceptors blunt the RSNA decrease to volume loading. This mechanism may facilitate volume retention when cardiac serotonin is increased...
  17. ncbi request reprint Intrauterine growth retardation aggravates the course of acute mesangioproliferative glomerulonephritis in the rat
    C Plank
    Department of Pediatrics and Adolescent Medicine, University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 70:1974-82. 2006
    ..We conclude that after IUGR inflammatory damage is aggravated and the reparation of the kidney is impaired during the course of acute mesangioproliferative GN, leading to more sclerotic lesions...
  18. ncbi request reprint Subtotal nephrectomy impairs ischemia-induced angiogenesis and hindlimb re-perfusion in rats
    J Jacobi
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Kidney Int 69:2013-21. 2006
    ..Impaired angioadaptation may contribute to the poor prognosis of patients with renal failure suffering from peripheral arterial disease...
  19. ncbi request reprint Nitric oxide synthase isoforms and glomerular hyperfiltration in early diabetic nephropathy
    R Veelken
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Germany
    J Am Soc Nephrol 11:71-9. 2000
    ..In contrast, we found no functional or molecular evidence for increased glomerular expression and activity of iNOS in diabetic rats...
  20. ncbi request reprint Angiotensin-dependent gene expression in the developing rat kidney
    K F Hilgers
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville, USA
    Kidney Int Suppl 67:S146-8. 1998
    ..We identified one novel rat partial cDNA, termed AD.5, that is related to a human orphan receptor. AD.5 was expressed in a developmentally regulated pattern and may be involved in kidney development and/or the trophic actions of Ang II...
  21. ncbi request reprint Characterization of the renal phenotype in a mouse model of Marfan syndrome
    Andrea Hartner
    Department of Pediatrics, University of Erlangen Nurnberg, Loschgestrasse 15, 91054 Erlangen, Germany
    Virchows Arch 445:382-8. 2004
    ..Alterations in renal histology were only subtle with a reduced glomerular volume and mesangial area likely due to a reduced mesangial cell volume...
  22. ncbi request reprint Effects of sympathetic nerves and angiotensin II on renal sodium and water handling in rats with common bile duct ligature
    Roland Veelken
    Dept of Medicine IV, Univ of Erlangen Nürnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 288:F1267-75. 2005
    ..We speculate that similar changes may contribute to long-term volume retention in liver cirrhosis...
  23. ncbi request reprint Internal sodium balance in DOCA-salt rats: a body composition study
    Jens Titze
    Forschungslabor der Medizinischen Klinik IV, Kreuzburger Strasse 2, 90471 Nürnberg, Germany
    Am J Physiol Renal Physiol 289:F793-802. 2005
    ..This "internal Na(+) escape" allows the maintenance of volume homeostasis despite increased total body Na(+)...
  24. ncbi request reprint Renin-angiotensin system and cardiovascular risk
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Lancet 369:1208-19. 2007
    ..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk...
  25. ncbi request reprint Adrenomedullin reduces mesangial cell number and glomerular inflammation in experimental mesangioproliferative glomerulonephritis
    Christian Plank
    Department of Pediatrics, University Erlangen Nuremberg, Germany
    Kidney Int 68:1086-95. 2005
    ..Whether or not treatment with ADM can reduce MC proliferation in vivo [i.e., in mesangioproliferative glomerulonephritis (GN)] is unknown. We tested the hypothesis that ADM substitution reduces MC proliferation in GN...
  26. ncbi request reprint Role of fibrillin-1 in hypertensive and diabetic glomerular disease
    Andrea Hartner
    Hospital for Children and Adolescents, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Physiol Renal Physiol 290:F1329-36. 2006
    ..We conclude that fibrillin-1 may contribute to glomerular damage in hypertensive and diabetic kidney disease...
  27. ncbi request reprint Angiotensin II formation in the kidney and nephrosclerosis in Ren-2 hypertensive rats
    Andrea Hartner
    University Hospital for Children and Adolescents, University of Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 21:1778-85. 2006
    ..We tested the hypothesis that local angiotensin II formation occurs at sites of renal vascular and interstitial injury in this model...
  28. ncbi request reprint Hypertension, sodium retention, calcium excretion and osteopenia in Dahl rats
    Jens Titze
    Department of Medicine IV, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Hypertens 22:803-10. 2004
    ..Salt-sensitive hypertension in the Dahl rat is associated with abnormalities in both calcium (Ca2+) and sodium (Na) homeostasis...
  29. ncbi request reprint Extrarenal Na+ balance, volume, and blood pressure homeostasis in intact and ovariectomized deoxycorticosterone-acetate salt rats
    Jens Titze
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Hypertension 47:1101-7. 2006
    ..Extrarenal Na+ and volume balance seem to play an important role in long-term volume and MAP control...
  30. doi request reprint Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Kidney Dis 53:281-9. 2009
    ..Basal nitric oxide (NO) activity has a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments, its alteration has been associated with morphological changes characteristic of diabetic nephropathy...
  31. ncbi request reprint Bimodality of cardiac vagal afferent C-fibres in the rat
    Roland Veelken
    Nephrologisches Labor, Department of Medicine IV, University of Erlangen Nurnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Pflugers Arch 446:516-22. 2003
    ..Our results emphasize the potential role of endogenous mediators in the afferent limb of cardiac reflexes...
  32. ncbi request reprint Fibrillin-1 regulates mesangial cell attachment, spreading, migration and proliferation
    M Porst
    Klinik fur Kinder und Jugendliche, Universitat Erlangen Nurnberg, Erlangen, Germany
    Kidney Int 69:450-6. 2006
    ..We conclude that fibrillin-1 promotes mesangial cell attachment, spreading, migration, and proliferation. We speculate that fibrillin-1 may thus contribute to mesangial hypercellularity during glomerular disease...
  33. ncbi request reprint Angiotensinogen gene core promoter variants and non-modulating hypertension
    K F Hilgers
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Nurnberg, Germany
    Hypertension 38:1250-4. 2001
    ..We conclude that the -20 C variant or the -20 C/-6 A haplotype of the angiotensinogen core promoter is associated with a blunted aldosterone response to Ang II and may thus contribute to the non-modulating phenotype...
  34. ncbi request reprint Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats
    Markus Schafflhuber
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Nurnberg, Germany
    Am J Physiol Renal Physiol 292:F1490-500. 2007
    ....
  35. ncbi request reprint Sensory neurons with afferents from hind limbs: enhanced sensitivity in secondary hypertension
    Peter Linz
    Department of Internal Medicine 4 Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Hypertension 47:527-31. 2006
    ..We speculate that this observation may indicate an increased activity of these neurons, their axons, and neurotransmitters in the control of resistance vessels in hypertension...
  36. ncbi request reprint Effect of the angiotensinogen genotype on experimental hypertension in mice
    Claudia Handtrack
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Mol Med (Berl) 85:343-50. 2007
    ..We conclude that the Agt genotype exerts a marked effect on blood pressure in a low-renin form of hypertension but no effect in the face of stimulated renin, at least in mice...
  37. ncbi request reprint Renal sympathetic nerves modulate erythropoietin plasma levels after transient hemorrhage in rats
    Tilmann Ditting
    Department of Nephrology, Friedrich Alexander Univ Erlangen Nürnberg, Erlangen, Germany
    Am J Physiol Renal Physiol 293:F1099-106. 2007
    ..Renal sympathoinhibition during hypotensive hemorrhage might help to preserve sufficient oxygenation of renal tissue by modulation of hemodynamic mechanisms that act to adapt renal oxygen availability to demand...
  38. doi request reprint Deletion of the alpha8 integrin gene does not protect mice from myocardial fibrosis in DOCA hypertension
    Andrea Hartner
    Department of Pediatric and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 22:92-9. 2009
    ..Integrins can contribute to tissue fibrosis in several organs. We tested the hypothesis that alpha8 integrin-mediated cell-matrix interactions add to cardiac fibrotic alterations during hypertension...
  39. ncbi request reprint Role of macula densa cyclooxygenase-2 in renovascular hypertension
    Andrea Hartner
    Department of Medicine IV, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 284:F498-502. 2003
    ..Thus either COX-2 is not necessary for the macula densa mechanism or the macula densa is not important for maintaining high renin in renovascular hypertension...
  40. pmc The alpha8 integrin chain affords mechanical stability to the glomerular capillary tuft in hypertensive glomerular disease
    Andrea Hartner
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 160:861-7. 2002
    ..Our findings indicate that mesangial alpha8 integrin contributes to maintain the integrity of the glomerular capillary tuft during mechanical stress, eg, in hypertension...
  41. ncbi request reprint Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis
    Andrea Hartner
    Medizinische Klinik IV, Universität Erlangen Nuremberg, Erlangen, Germany
    J Mol Med (Berl) 81:32-42. 2003
    ..1 nephritis. These results are in keeping with the notion that TGF-beta(2) and its receptors participate in the pathogenesis and/or resolution of this transient form of glomerulonephritis...
  42. ncbi request reprint Impaired endothelial function of the retinal vasculature in hypertensive patients
    Christian Delles
    Department of Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    Stroke 35:1289-93. 2004
    ..Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation...
  43. pmc Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine
    Johannes Jacobi
    Department of Nephrology and Hypertension, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Am J Pathol 176:2559-70. 2010
    ..Together, these results demonstrate that pharmacological interventions targeting the ADMA/DDAH pathway may represent a novel approach in the prevention and management of cardiovascular diseases...
  44. ncbi request reprint 825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension
    J Jacobi
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Germany
    J Hypertens 17:1457-62. 1999
    ..In this study, we investigated the impact of the 825T allele on left ventricular structure and function in mild to moderate essential hypertensive subjects...
  45. ncbi request reprint Glomerular regeneration is delayed in nephritic alpha 8-integrin-deficient mice: contribution of alpha 8-integrin to the regulation of mesangial cell apoptosis
    Andrea Hartner
    Hospital for Children and Adolescents, Erlangen, Germany
    Am J Nephrol 28:168-78. 2008
    ..We tested the hypothesis that alpha(8)-integrin is essential for the healing process after mesangioproliferative glomerulonephritis...
  46. ncbi request reprint Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice
    Johannes Jacobi
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Physiol Heart Circ Physiol 294:H1058-66. 2008
    ..However, an overexpression of DDAH1 alleviates ANG II-induced renal interstitial fibrosis and vascular oxidative stress, suggesting a blood pressure-independent effect of ADMA on ANG II-induced target organ damage...
  47. ncbi request reprint Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin
    Jens Titze
    Department of Medicine IV, Friedrich Alexander University Erlangen Nurnberg, Germany
    Am J Physiol Heart Circ Physiol 287:H203-8. 2004
    ..Inhibition or disinhibition of GAG chain polymerization may regulate osmotically inactive Na(+) storage...
  48. doi request reprint Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis
    Bettina Geissler
    Kinder und Jugendklinik, Erlangen, Germany
    Nephron Exp Nephrol 115:e80-8. 2010
    ..Adrenomedullin (ADM) has antiproliferative effects on glomerular mesangial cells. The study was performed to determine changes in glomerular gene expression of the ADM system by ADM treatment in anti-Thy1 glomerulonephritis (GN)...
  49. doi request reprint A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease
    Raoul Zeltner
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Nephron Clin Pract 108:c169-75. 2008
    ..We investigated whether the -414 T/C polymorphism in the promoter region of the alpha 8 integrin chain gene (ITGA8) is associated with the progression of renal disease in ADPKD...
  50. ncbi request reprint Left-ventricular structure and function are influenced by angiotensinogen gene polymorphism (-20 A/C) in young male patients
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 20:974-80. 2007
    ..Therefore, we questioned whether left-ventricular (LV) structure and function are influenced by the -20 A/C variant of the angiotensinogen (AGT) gene in young normotensive or mildly hypertensive patients...
  51. doi request reprint Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a
    Jens H Westhoff
    Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    Hypertension 52:123-9. 2008
    ..Thus, hypertension induces cellular senescence via p16(INK4a), possibly through p38, thereby contributing to hypertensive target organ damage. This detrimental effect can be overcome by different therapeutic drug strategies...
  52. ncbi request reprint Transient receptor potential vanilloid type 1 receptors in hypertensive renal damage: a promising therapeutic target?
    Tilmann Ditting
    Hypertension 52:213-4. 2008
  53. ncbi request reprint Strain differences in the development of hypertension and glomerular lesions induced by deoxycorticosterone acetate salt in mice
    Andrea Hartner
    Nephrology Research Laboratory, Loschgestrasse 8, D 91054 Erlangen, Germany
    Nephrol Dial Transplant 18:1999-2004. 2003
    ..We investigated its influence on the development of hypertension and renal injury following treatment with deoxycorticosterone acetate (DOCA) salt in several mouse strains...
  54. ncbi request reprint Putative role of epithelial sodium channels (ENaC) in the afferent limb of cardio renal reflexes in rats
    Tilmann Ditting
    Department of Nephrology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Basic Res Cardiol 98:388-400. 2003
    ..Other ion channels might be involved. Furthermore the observed findings in vivo could also be due to unspecific disturbance of afferent signal conduction...
  55. ncbi request reprint Osmotically inactive skin Na+ storage in rats
    Jens Titze
    Department of Nephrology, Friedrich Alexander University Erlangen Nuremberg, Loschgestrasse 8, D 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 285:F1108-17. 2003
    ..OVX leads to an acquired reduction of osmotically inactive Na+ storage in SD rats that predisposes the rats to volume excess despite a reduced Na+ content relative to body weight...
  56. ncbi request reprint Renoprotection with antihypertensive agents
    Karl F Hilgers
    Lancet 359:1693; author reply 1693-4. 2002
  57. ncbi request reprint Reduced osmotically inactive Na storage capacity and hypertension in the Dahl model
    Jens Titze
    Department of Nephrology, Friedrich Alexander University Erlangen Nurnberg, D 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 283:F134-41. 2002
    ..Additional factors, including impaired renal Na excretion, probably contribute to hypertension in SS rats. Our results draw attention to the role of osmotically inactive Na storage...
  58. pmc Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome
    Marko Bertog
    Institut fur Zellulare und Molekulare Physiologie, Waldstr 6, 91054 Erlangen, Germany
    J Physiol 586:459-75. 2008
    ..This may be pathophysiologically relevant in patients with Liddle's syndrome, in particular on a high salt diet, when suppression of P Aldo is likely to be insufficient to reduce Na+ absorption to an appropriate level...
  59. ncbi request reprint Association studies in cardiovascular medicine
    Karl F Hilgers
    J Hypertens 20:173-6. 2002
  60. ncbi request reprint Intrauterine growth after uterine artery ligation in rats: dependence on the fetal position in the uterine horn and need for prenatal marking of the animals
    Kai Dietrich Nüsken
    J Hypertens 25:247-8. 2007
  61. ncbi request reprint Detection of angiotensin II in supernatants of stimulated mononuclear leukocytes by matrix-assisted laser desorption ionization time-of-flight/time-of-flight mass analysis
    Vera Jankowski
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin Medizinische Klinik IV, Germany
    Hypertension 46:591-7. 2005
    ....
  62. ncbi request reprint Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b+/-) after unilateral nephrectomy
    Sabine Endele
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, University Hospital Erlangen, Schwabachanlage 10, 91054 Erlangen, Germany
    Transgenic Res 16:723-9. 2007
    ..Moreover, this is the first report of a phenotype in heterozygous Lmx1b (Lmx1b ( +/-)) knockout animals...
  63. ncbi request reprint Mechanosensitive cardiac C-fiber response to changes in left ventricular filling, coronary perfusion pressure, hemorrhage, and volume expansion in rats
    Tilmann Ditting
    Department of Nephrology, Johann Wolfgang University, Frankfurt, Germany
    Am J Physiol Heart Circ Physiol 288:H541-52. 2005
    ..Thus neither LVEDP nor CPP fully accounts directly for afferent C-fiber and reflex sympathetic responses. The intrinsic afferent stimuli and receptive fields accounting for reflex sympathoinhibition still remain cryptic...
  64. ncbi request reprint High sodium intake modulates left ventricular mass in patients with G expression of +1675 G/A angiotensin II receptor type 2 gene
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Nuremberg, Germany
    J Hypertens 25:1627-32. 2007
    ..Hypertension and LVH are often aggravated by salt intake. Our objective was to assess the relationship between AT2R gene variation and salt intake and their impact on left ventricular mass (LVM)...
  65. ncbi request reprint Type 2 diabetic nephropathy: never too early to treat?
    Karl F Hilgers
    J Am Soc Nephrol 16:574-5. 2005
  66. ncbi request reprint Gene variants of aldosterone synthase and hypertension
    Karl F Hilgers
    J Hypertens 23:1957-9. 2005
  67. ncbi request reprint The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia
    Markus P Schneider
    Universitat Erlangen Nurnberg, Medizinische Klinik IV 4, Klinikum Nürnberg Süd, Breslauer Strasse 201, D 90471 Nuremberg, Germany
    Clin Sci (Lond) 105:97-103. 2003
    ....
  68. ncbi request reprint Angiotensin II, the endothelium and superoxide anions
    Karl F Hilgers
    J Hypertens 20:1271-3. 2002
  69. ncbi request reprint How does minor renal dysfunction influence cardiovascular risk and the management of cardiovascular disease?
    Tobias Pinkau
    Department of Cardiology, German Heart Center, Munich, Germany
    J Am Soc Nephrol 15:517-23. 2004
    ..Further investigations should focus on the causes of and possible preventive interventions for the staggering cardiovascular risk in the ever-increasing number of people with minor renal dysfunction...
  70. ncbi request reprint Monocytes/macrophages in hypertension
    Karl F Hilgers
    J Hypertens 20:593-6. 2002