Christoph Hiemke

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011
    C Hiemke
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Germany
    Pharmacopsychiatry 44:195-235. 2011
  2. doi Interactions and monitoring of antipsychotic drugs
    Christoph Hiemke
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany
    Handb Exp Pharmacol . 2012
  3. ncbi Consensus Guideline Based Therapeutic Drug Monitoring (TDM) in Psychiatry and Neurology
    Christoph Hiemke
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Germany
    Curr Drug Deliv 13:353-61. 2016
  4. ncbi Phenotyping and genotyping of drug metabolism to guide pharmacotherapy in psychiatry
    Christoph Hiemke
    Department of Psychiatry and Psychotherapy University Medical Center, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Curr Drug Deliv 10:46-53. 2013
  5. doi Striatal and extrastriatal D2/D3-receptor-binding properties of ziprasidone: a positron emission tomography study with [18F]Fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone)
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    J Clin Psychopharmacol 28:608-17. 2008
  6. doi Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam
    Rafal Rygula
    Department of Psychiatry and Psychotherapy, University of Gottingen, Gottingen, Germany
    Behav Pharmacol 19:183-96. 2008
  7. doi Dopamine D2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, and JARA Translational Brain Medicine, Germany
    Int J Neuropsychopharmacol 13:951-60. 2010
  8. doi Low novelty seeking and high self directedness scores in alcohol-dependent patients without comorbid psychiatric disorders homozygous for the A10 allele of the dopamine transporter gene
    Ion Anghelescu
    Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    World J Biol Psychiatry 11:382-9. 2010
  9. doi Potential cost-effectiveness of therapeutic drug monitoring for depressed patients treated with citalopram
    Elnaz Ostad Haji
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Mainz, Germany
    Ther Drug Monit 35:396-401. 2013
  10. doi Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression
    Nadine Dreimüller
    Department of Psychiatry and Psychotherapy, University Medical Centre of the Johannes Gutenberg University Mainz, Untere Zahlbacher Str 8, Germany
    Neuropharmacology 62:264-9. 2012

Detail Information

Publications64

  1. ncbi AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011
    C Hiemke
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Germany
    Pharmacopsychiatry 44:195-235. 2011
    ..Thereby, one should never forget that TDM is an interdisciplinary task that sometimes requires the respectful discussion of apparently discrepant data so that, ultimately, the patient can profit from such a joint eff ort...
  2. doi Interactions and monitoring of antipsychotic drugs
    Christoph Hiemke
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany
    Handb Exp Pharmacol . 2012
    ....
  3. ncbi Consensus Guideline Based Therapeutic Drug Monitoring (TDM) in Psychiatry and Neurology
    Christoph Hiemke
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Germany
    Curr Drug Deliv 13:353-61. 2016
    ..There is potential to accelerate improvement. Reducing phases of suffering will not only have medical benefits for the patients but also an impact on costs for the health system which needs to be clarified by controlled studies. ..
  4. ncbi Phenotyping and genotyping of drug metabolism to guide pharmacotherapy in psychiatry
    Christoph Hiemke
    Department of Psychiatry and Psychotherapy University Medical Center, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Curr Drug Deliv 10:46-53. 2013
    ..When used appropriately, phenotyping and genotyping methods are most helpful for problem solving and improvement of the outcomes of psychopharmacotherapy for many patients...
  5. doi Striatal and extrastriatal D2/D3-receptor-binding properties of ziprasidone: a positron emission tomography study with [18F]Fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone)
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    J Clin Psychopharmacol 28:608-17. 2008
    ..The discrepancies between single-dose and steady-state results are important for the future design of dose-finding PET occupancy studies of novel antipsychotics. Single-dose studies may not be totally relied on for final dose selection...
  6. doi Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam
    Rafal Rygula
    Department of Psychiatry and Psychotherapy, University of Gottingen, Gottingen, Germany
    Behav Pharmacol 19:183-96. 2008
    ....
  7. doi Dopamine D2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, and JARA Translational Brain Medicine, Germany
    Int J Neuropsychopharmacol 13:951-60. 2010
    ..Taken together, quetiapine shows preferential extrastriatal binding at D2/3Rs; the extent of this difference is comparable to that previously described for clozapine. Both antipsychotics show very low affinity for D2/3Rs...
  8. doi Low novelty seeking and high self directedness scores in alcohol-dependent patients without comorbid psychiatric disorders homozygous for the A10 allele of the dopamine transporter gene
    Ion Anghelescu
    Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    World J Biol Psychiatry 11:382-9. 2010
    ..Summarizing, the 40-bp VNTR did not help to differentiate between ADP and CO, but might contribute to some personality dimensions in certain ADP subgroups...
  9. doi Potential cost-effectiveness of therapeutic drug monitoring for depressed patients treated with citalopram
    Elnaz Ostad Haji
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Mainz, Germany
    Ther Drug Monit 35:396-401. 2013
    ..The aim of this post hoc analysis was to calculate a potential cost-effectiveness of therapeutic drug monitoring (TDM) considering costs for hospitalization, medication, and drug analysis...
  10. doi Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression
    Nadine Dreimüller
    Department of Psychiatry and Psychotherapy, University Medical Centre of the Johannes Gutenberg University Mainz, Untere Zahlbacher Str 8, Germany
    Neuropharmacology 62:264-9. 2012
    ..This has to be confirmed in further investigations. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  11. ncbi High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia
    Ingo Vernaleken
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Int J Neuropsychopharmacol 7:421-30. 2004
    ..However, our data show high striatal D2-like receptor occupancies under rising plasma concentrations. Using the full range of recommended amisulpride dosage, striatal occupancies up to 90% can be measured...
  12. ncbi The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Neuropsychopharmacology 31:1027-35. 2006
    ..Extrastriatal binding of clozapine may be more relevant to its antipsychotic actions than striatal. However, further studies with an intraindividual comparison of untreated vs treated state are desirable to confirm this finding...
  13. doi Inflammation and psychotropic drugs: the relationship between C-reactive protein and antipsychotic drug levels
    Gudrun Hefner
    Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany
    Psychopharmacology (Berl) 233:1695-705. 2016
    ..In psychiatric clinical practice, there is a need to identify psychotropic drugs whose metabolisms are prone to be altered with increased inflammatory activity in an individual patient...
  14. doi Serum concentrations of paliperidone versus risperidone and clinical effects
    Yasmin Nazirizadeh
    Department of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, Untere Zahlbacher Str 8, 55131 Mainz, Germany
    Eur J Clin Pharmacol 66:797-803. 2010
    ..Intra-individual variability in trough serum concentrations was also analyzed in patients under treatment with either the paliperidone-extended release (ER) formulation or the risperidone immediate-release formulation...
  15. doi Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET study
    Gerhard Grunder
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Am J Psychiatry 165:988-95. 2008
    ....
  16. doi Cerebrospinal fluid tau protein levels and 18F-fluorodeoxyglucose positron emission tomography in the differential diagnosis of Alzheimer's disease
    Igor Yakushev
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany
    Dement Geriatr Cogn Disord 30:245-53. 2010
    ....
  17. doi Risperidone-induced extrapyramidal side effects: is the need for anticholinergics the consequence of high plasma concentrations?
    Georgios Schoretsanitis
    aDepartment of Psychiatry, Psychotherapy and Psychosomatics, and JARA Translational Brain Medicine, RWTH Aachen University, Aachen bClinical Pharmacology, Departments of Psychiatry and Psychotherapy, and Pharmacology and Toxicology, University of Regensburg, Regensburg cDepartment of Psychiatry and Psychotherapy and Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of Mainz, Mainz, Germany dSchool for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands eUniversity Hospital of Psychiatry, Bern, Switzerland
    Int Clin Psychopharmacol 31:259-64. 2016
    ..053). Data indicate enhanced AM plasma concentrations of RIS in patients comedicated with biperiden as an EPS treatment. This might underscore an association between higher plasma concentrations of the AM and treatment-requiring EPS. ..
  18. doi Quetiapine and norquetiapine serum concentrations and clinical effects in depressed patients under augmentation therapy with quetiapine
    Elnaz Ostad Haji
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, 55131 Mainz, Germany
    Ther Drug Monit 35:539-45. 2013
    ..The aim of this cross-sectional analysis was to relate quetiapine (Q) doses to serum concentrations of Q and its active metabolite and clinical effects...
  19. doi Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice
    Katrin M Kirschbaum
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, Mainz, Germany
    Behav Brain Res 188:298-303. 2008
    ..P-gp-dependent brain distribution kinetics and behavioral effects of risperidone give evidence that the expression of P-gp has an impact on psychotropic drug actions when treating patients with drugs that are substrates of P-gp...
  20. doi The use of ziprasidone in clinical practice: analysis of pharmacokinetic and pharmacodynamic aspects from data of a drug monitoring survey
    Friederike Vogel
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Eur Psychiatry 24:143-8. 2009
    ..05) with doses or serum levels. It is concluded that TDM of ziprasidone may be useful for treatment optimization because of highly variable serum concentrations resulting under therapeutically recommended doses of the drug...
  21. ncbi Clinical improvement in a case of frontotemporal dementia under aripiprazole treatment corresponds to partial recovery of disturbed frontal glucose metabolism
    Andreas Fellgiebel
    Department of Psychiatry, University Hospital of Mainz, Mainz, Germany
    World J Biol Psychiatry 8:123-6. 2007
    ....
  22. doi Association between citalopram serum levels and clinical improvement of patients with major depression
    Elnaz Ostad Haji
    Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
    J Clin Psychopharmacol 31:281-6. 2011
    ....
  23. pmc Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany
    BMC Psychiatry 11:16. 2011
    ..Peripheral blood markers and executive functions are particularly promising candidates as markers for the onset of action and thus the prediction of final treatment outcome in MDD...
  24. ncbi Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spectrophotometric detection
    Julia Sachse
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 830:342-8. 2006
    ..The method was thus suitable for routine therapeutic drug monitoring and may be extended to other drugs...
  25. doi Measuring citalopram in blood and central nervous system: revealing a distribution pattern that differs from other antidepressants
    Michael Paulzen
    aDepartment of Psychiatry, Psychotherapy and Psychosomatics, JARA Translational Brain Medicine bDepartment of Neurology, RWTH Aachen University, Aachen cDepartment of Psychiatry and Psychotherapy, University Medical Center of Mainz, Institute of Clinical Chemistry and Laboratory Medicine, Mainz, Germany
    Int Clin Psychopharmacol 31:119-26. 2016
    ..The results suggest a high ability of citalopram to enter the brain with sufficiently high drug concentrations at the target sites within the brain, contributing toward clinical efficacy...
  26. doi P-glycoprotein influence on the brain uptake of a 5-HT(2A) ligand: [(18)F]MH.MZ
    Ulrich Schmitt
    Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    Neuropsychobiology 63:183-90. 2011
    ..The aim of this study was to determine whether transport by P-gp influences the distribution ratio of [(18)F]MH.MZ in the frontal cortex...
  27. ncbi Therapeutic drug monitoring for optimizing amisulpride therapy in patients with schizophrenia
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    J Psychiatr Res 41:673-9. 2007
    ..Although our results were mainly explorative, TDM of amisulpride seems very useful for clinical decision making...
  28. doi Effects of escitalopram on the regulation of brain-derived neurotrophic factor and nerve growth factor protein levels in a rat model of chronic stress
    Olaf Schulte-Herbrüggen
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Neurosci Res 87:2551-60. 2009
    ..In conclusion, BDNF and NGF show substantial changes in this rodent model of chronic social stress, which is susceptible to antidepressant treatment with ES-CIT and therefore may constitute a neurobiological correlate for the disease...
  29. doi The early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: a pilot study
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 35:415-20. 2011
    ..If replicated, this combined marker could be considered useful for prospective confirmatory trials in patients with MDD...
  30. doi Severe tremor after cotrimoxazole-induced elevation of venlafaxine serum concentrations in a patient with major depressive disorder
    Christian Geber
    Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Ther Drug Monit 35:279-82. 2013
    ..The observed overall pharmacokinetic effect was most probably the result of decreased N-demethylation of venlafaxine by (1) reduced expression of CYP2C19 due to a genetic deficit and (2) inhibition of CYP2C9 by cotrimoxazole...
  31. ncbi Therapeutic monitoring of aripiprazole by HPLC with column-switching and spectrophotometric detection
    Katrin M Kirschbaum
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Clin Chem 51:1718-21. 2005
  32. doi In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes
    Ulrich Schmitt
    Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, D 55131 Mainz, Germany
    Pharmacol Biochem Behav 102:312-20. 2012
    ..Thus drug-dependent inhibition, induction or genetic variation of P-gp impacts drug therapy...
  33. ncbi Rotarod impairment: catalepsy-like screening test for antipsychotic side effects
    Katrin M Kirschbaum
    Department of Psychiatry and Psychotherapeutics, University of Mainz, Mainz, Germany
    Int J Neurosci 119:1509-22. 2009
    ..Catalepsy test provided more specificity whereas the rotarod test provided higher degree of sensitivity to motor impairment including catalepsy...
  34. pmc Rationale and design of the randomised clinical trial comparing early medication change (EMC) strategy with treatment as usual (TAU) in patients with major depressive disorder--the EMC trial
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Germany
    Trials 11:21. 2010
    ..Even more important, non-improvement (HAMD decrease <20%) after 14 days of treatment was found to be highly predictive for a poor final treatment outcome...
  35. doi Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice
    Katrin M Kirschbaum
    Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Neuropharmacology 59:474-9. 2010
    ..For the new antipsychotic aripiprazole and its active metabolite dehydroaripiprazole differences in disposition in blood and brain were investigated after acute and sub-chronic administration in a P-gp knockout mouse model...
  36. ncbi Therapeutic drug monitoring for antidepressant drug treatment
    Elnaz Ostad Haji
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Germany
    Curr Pharm Des 18:5818-27. 2012
    ....
  37. doi Acitretin, an enhancer of alpha-secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein
    David Holthoewer
    Department of Psychiatry and Psychotherapy, Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Neurodegener Dis 10:224-8. 2012
    ..Enhancement of ADAM10's gene expression may therefore present a valuable therapeutic approach for the treatment of Alzheimer's disease (AD), where Aβ peptides are severely involved in the pathogenesis...
  38. ncbi Pharmacokinetic Drug-Drug Interactions of Mood Stabilizers and Risperidone in Patients Under Combined Treatment
    Georgios Schoretsanitis
    From the Departmentof Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University and JARA Translational Brain Medicine, Aachen, Germany University Hospital of Psychiatry, Bern, Switzerland Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands Department of Psychiatry and Psychotherapy and Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of Mainz, Germany
    J Clin Psychopharmacol 36:554-561. 2016
    ..The objective of the study was to identify pharmacokinetic interactions of different mood stabilizers on the metabolism of risperidone (RIS) under natural conditions...
  39. ncbi Automated determination of ziprasidone by HPLC with column switching and spectrophotometric detection
    Julia Sachse
    Department of Psychiatry, University of Mainz, Untere Zahlbacherstrasse 8, D 55131 Mainz, Germany
    Ther Drug Monit 27:158-62. 2005
    ..Forty to 130 ng/mL may be considered the recommended target plasma concentration range. HPLC with column switching and UV detection as described here is suitable for therapeutic drug monitoring of ziprasidone...
  40. doi No effect of six weeks of treatment with escitalopram on mood in healthy volunteers--irrespective of genotype for the promoter of the serotonin transporter
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Psychiatry Res 161:339-43. 2008
    ..No significant effect on negative affect, positive affect, or state anxiety was detected, irrespective of serotonin transporter gene-linked polymorphism...
  41. doi HPMA based amphiphilic copolymers mediate central nervous effects of domperidone
    Mirjam Hemmelmann
    Institute of Organic Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10 14, Mainz, Germany
    Macromol Rapid Commun 32:712-7. 2011
    ..The hydrodynamic radii (R(h) ) of amphiphilic p(HPMA)-co-p(LMA) alone and loaded with domperidone were determined by fluorescence correlation spectroscopy...
  42. doi Consensus guideline for therapeutic drug monitoring in psychiatry (2004): Bibliometric analysis of citations for the period 2004-2011
    Andreas Schafer
    a Andreas Schäfer, Department of Psychiatry, University Medical Centre, Mainz, Germany
    Nord J Psychiatry 70:202-7. 2016
    ..To evaluate the awareness of guidelines for the therapeutic monitoring (TDM) of neuropsychiatric drugs by the scientific community, a bibliometric analysis was carried out...
  43. doi Hamilton depression rating subscales to predict antidepressant treatment outcome in the early course of treatment
    Isabella Helmreich
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Mainz, Germany Electronic address
    J Affect Disord 175:199-208. 2015
    ..The present study investigated in patients with major depression (MD) whether the subscales are a comparable option to predict treatment remission in the early course of treatment...
  44. doi Amphiphilic Copolymers Shuttle Drugs Across the Blood-Brain Barrier
    Mirjam Clemens-Hemmelmann
    Institute for Organic Chemistry, Johannes Gutenberg University Mainz, 55128, Mainz, Germany
    Macromol Biosci 16:655-65. 2016
    ..At that time point serum domperidone is increased 48-fold. Most importantly, domperidone is exclusively detectable in high amounts in the brain of PolyDOM injected mice and not in mice injected with bare domperidone. ..
  45. doi The value of drug and metabolite concentration in blood as a biomarker of psychopharmacological therapy
    Gudrun Hefner
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Germany
    Int Rev Psychiatry 25:494-508. 2013
    ..Monitoring of drug concentration is suitable to improve efficacy and safety of the pharmacotherapy, especially in elderly patients who require complex pharmacological therapies...
  46. ncbi Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats
    Rafal Rygula
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    Behav Pharmacol 17:19-29. 2006
    ..These observations provide evidence for the predictive validity of the chronic social stress paradigm as a model of depressive symptoms in rats...
  47. ncbi Appropriateness of therapeutic drug monitoring for antidepressants in routine psychiatric inpatient care
    Klaus Mann
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Ther Drug Monit 28:83-8. 2006
    ....
  48. ncbi Measurement of duloxetine in blood using high-performance liquid chromatography with spectrophotometric detection and column switching
    Christine Waldschmitt
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Ther Drug Monit 29:767-72. 2007
    ..HPLC with column switching and ultraviolet detection as described here is suitable for pharmacokinetic studies and therapeutic drug monitoring of duloxetine...
  49. doi Clinical utility of drug measurement and pharmacokinetics: therapeutic drug monitoring in psychiatry
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Eur J Clin Pharmacol 64:159-66. 2008
    ..This would merely increase the amount of work and costs, as high-throughput methods are now available in many laboratories. Any progress in TDM has direct benefits for the treatment of many individual patients...
  50. doi Therapeutic drug monitoring in neuropsychopharmacology: does it hold its promises?
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 258:21-7. 2008
    ..Moreover, many drug interactions have been detected by using TDM. In conclusion, TDM is a reliable tool to optimise psychopharmacotherapy. When used adequately it is helpful for many psychiatric patients and in many situations...
  51. doi Lamotrigine in pregnancy - therapeutic drug monitoring in maternal blood, amniotic fluid, and cord blood
    Michael Paulzen
    aDepartment of Psychiatry, Psychotherapy and Psychosomatics and JARA Translational Brain Medicine bDepartment of Gynaecology and Obstetrics, RWTH Aachen University, Aachen cDepartment of Psychiatry and Psychotherapy, Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of Mainz, Mainz, Germany
    Int Clin Psychopharmacol 30:249-54. 2015
    ..Furthermore, the penetration ratio into umbilical cord blood calculated here is in line with the largest study carried out so far to explore transplacental transfer. ..
  52. doi Determination of naltrexone and 6beta-naltrexol in human blood: comparison of high-performance liquid chromatography with spectrophotometric and tandem-mass-spectrometric detection
    Sonja Brünen
    Department of Psychiatry and Psychotherapy, University of Mainz, Untere Zahlbacherstrasse 8, 55131, Mainz, Germany
    Anal Bioanal Chem 396:1249-57. 2010
    ..967; p < 0.001). Both methods could be used for therapeutic drug monitoring. The HPLC/UV method was advantageous regarding automatization and costs, whereas LC-MS/MS was superior with regard to sensitivity...
  53. doi Therapeutic drug monitoring for drugs used in the treatment of substance-related disorders: literature review using a therapeutic drug monitoring appropriateness rating scale
    Sonja Brünen
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Mainz, Germany
    Ther Drug Monit 33:561-72. 2011
    ..Because TDM for most of those drugs is not established, the authors reviewed the literature and built a rating scale to detect the potential added value of TDM for these pharmacologic agents...
  54. ncbi The TPH intron 7 A218C polymorphism and TCI dimension scores in alcohol-dependent patients: hints to nonspecific psychopathology
    Ion Anghelescu
    Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Addict Behav 30:1135-43. 2005
    ....
  55. pmc Induction of Drug Transporters Alters Disposition of Risperidone - A Study in Mice
    David Holthoewer
    Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Untere Zahlbacher Strasse 8, 55101 Mainz, Germany
    Pharmaceutics 2:258-274. 2010
    ..Disposition of risperidone and 9-hydroxyrisperidone was dramatically decreased in mouse brain and serum after drug transporter induction. The metabolism of risperidone was also affected...
  56. doi Therapeutic drug monitoring for patients with Alzheimer dementia to improve treatment with donepezil
    Gudrun Hefner
    Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center and Department of Psychiatry and Psychotherapy, University Medical Center, Mainz, Germany
    Ther Drug Monit 37:353-61. 2015
    ....
  57. ncbi Therapeutic drug monitoring of the antidepressant mirtazapine and its N-demethylated metabolite in human serum
    Mohamed Shams
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Ther Drug Monit 26:78-84. 2004
    ..05) lower N-desmethylmirtazapine/mirtazapine ratios were found under concomitant medications of the antidepressant sertraline and the antipsychotic amisulpride...
  58. doi Melperone but not bisoprolol or metoprolol is a clinically relevant inhibitor of CYP2D6: evidence from a therapeutic drug monitoring survey
    Gudrun Hefner
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Mainz, Germany
    J Neural Transm (Vienna) 122:1609-17. 2015
    ..90, range 0.14-15.15), compared to the control group (2.39, range 0.06-15.31). The results of this study provided evidence that melperone but not bisoprolol or metoprolol has a clinically relevant inhibitory potential on CYP2D6. ..
  59. doi Elevated risperidone serum concentrations during acute inflammation, two cases
    Gudrun Hefner
    Department of Psychiatry and Psychotherapy, University Medical Center, Mainz, Germany Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center, Mainz, Germany
    Int J Psychiatry Med 50:335-44. 2015
    ..It is concluded that elevated C-reactive protein should be considered as an indication to control blood levels of risperidone and possibly dose adaption. ..
  60. doi Side effects related to potentially inappropriate medications in elderly psychiatric patients under everyday pharmacotherapy
    Gudrun Hefner
    Department of Psychiatry and Psychotherapy, University Medical Center, Mainz, Germany
    Eur J Clin Pharmacol 71:165-72. 2015
    ....
  61. ncbi Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Nucl Med 44:109-16. 2003
    ..18)F-Desmethoxyfallypride ((18)F-DMFP) is a benzamide tracer with the advantage of an (18)F label. We optimized the synthesis and evaluated (18)F-DMFP in PET studies on healthy human volunteers...
  62. doi Serum concentrations of hydroxybupropion for dose optimization of depressed patients treated with bupropion
    Anne K Laib
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Mainz, Germany Department of Pharmacy, Institut universitaire en santé mentale de Montréal, Faculty of Pharmacy, Universite de Montreal, Montreal, Canada and Institute of Clinical Chemistry and Laboratory Medicine, University Medical Centre Mainz, Mainz, Germany
    Ther Drug Monit 36:473-9. 2014
    ..This investigation sought to determine if the major, active, and chemically stable metabolite 4-hydroxybupropion is a suitable measure to guide antidepressant drug therapy with bupropion...
  63. doi The "DGPPN-Cohort": A national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients
    Heike Anderson-Schmidt
    Section of Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Centre Göttingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 263:695-701. 2013
    ..While the main focus lies on biological research, it will be open to all kinds of scientific investigations, including epidemiological, clinical or health-service research...
  64. ncbi New dopamine D2 receptor polymorphisms in rats and association with apomorphine-induced stereotypies
    Sabine Germeyer
    Department of Psychiatry of the University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Brain Res 926:1-9. 2002
    ..These findings indicate that in Wistar rats at least part of an individual apomorphine stimulated behavioural phenotype might be due to an individual dopamine receptor D2 genotype...