Swen Hesse

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. doi request reprint Central serotonin transporter availability in highly obese individuals compared with non-obese controls: A [(11)C] DASB positron emission tomography study
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 43:1096-104. 2016
  2. doi request reprint Central noradrenaline transporter availability in highly obese, non-depressed individuals
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging . 2017
  3. doi request reprint Association of central serotonin transporter availability and body mass index in healthy Europeans
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany Leipzig University Medical Center, Integrated Research and Treatment Centre IFB Adiposity Diseases, Leipzig, Germany Electronic address
    Eur Neuropsychopharmacol 24:1240-7. 2014
  4. doi request reprint Altered serotonin transporter availability in patients with multiple sclerosis
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 41:827-35. 2014
  5. doi request reprint Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 39:1001-11. 2012
  6. doi request reprint Monoamine transporter availability in Parkinson's disease patients with or without depression
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:428-35. 2009
  7. doi request reprint The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Int J Neuropsychopharmacol 14:606-17. 2011
  8. doi request reprint Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Psychiatry Res 171:120-8. 2009
  9. doi request reprint Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up
    Swen Hesse
    Dept of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    J Neurol 255:1059-66. 2008
  10. ncbi request reprint Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D 04103 Leipzig, Germany
    Psychiatry Res 140:63-72. 2005

Detail Information

Publications41

  1. doi request reprint Central serotonin transporter availability in highly obese individuals compared with non-obese controls: A [(11)C] DASB positron emission tomography study
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 43:1096-104. 2016
    ..The aim of this study was therefore to assess 5-HTT availability in the brains of highly obese otherwise healthy individuals compared with non-obese healthy controls...
  2. doi request reprint Central noradrenaline transporter availability in highly obese, non-depressed individuals
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging . 2017
    ..The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate...
  3. doi request reprint Association of central serotonin transporter availability and body mass index in healthy Europeans
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany Leipzig University Medical Center, Integrated Research and Treatment Centre IFB Adiposity Diseases, Leipzig, Germany Electronic address
    Eur Neuropsychopharmacol 24:1240-7. 2014
    ..The aim of this study was to further test the association between SERT and BMI in a large cohort of healthy subjects...
  4. doi request reprint Altered serotonin transporter availability in patients with multiple sclerosis
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 41:827-35. 2014
    ..Central serotonergic mechanisms have not been investigated in MS by in vivo imaging. The objective of the study was to assess the availability of SERT in antidepressant-naive patients with MS by means of PET...
  5. doi request reprint Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 39:1001-11. 2012
    ..The aim of our study was to firstly use the new highly SERT-selective (18)F-labelled fluoromethyl analogue of (+)-McN5652 ((+)-[(18)F]FMe-McN5652) in humans and to evaluate its potential for SERT quantification...
  6. doi request reprint Monoamine transporter availability in Parkinson's disease patients with or without depression
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:428-35. 2009
    ..Therefore, we studied PD patients with depression (PD+D) and without depression (PD-D) using high-resolution single-photon emission computed tomography (SPECT) and the monoamine transporter marker [(123)I]FP-CIT...
  7. doi request reprint The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Int J Neuropsychopharmacol 14:606-17. 2011
    ..These findings suggest that late but not early onset of OCD is associated with abnormally low SERT availability. In part, functional polymorphisms of the SERT gene might determine the differences...
  8. doi request reprint Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Psychiatry Res 171:120-8. 2009
    ..Further studies will have to deal with the question of whether these findings have the potential to influence treatment decisions in this complex disorder...
  9. doi request reprint Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up
    Swen Hesse
    Dept of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    J Neurol 255:1059-66. 2008
    ..These data show that clinical improvement and reduction of dopaminergic drugs in patients with advanced PD undergoing bilateral STN-DBS are paralleled by stable DAT and recovery of striatal D2R availability 12 months after surgery...
  10. ncbi request reprint Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D 04103 Leipzig, Germany
    Psychiatry Res 140:63-72. 2005
    ..Our data provide evidence for imbalanced monoaminergic neurotransmitter modulation in OCD. Further studies with more selective DAT and SERT radiotracers are needed...
  11. ncbi request reprint Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Germany
    AJNR Am J Neuroradiol 24:234-8. 2003
    ..The present study was initiated to intra-individually determine the integrity of these compartments in patients with WD...
  12. doi request reprint Preserved serotonin transporter binding in de novo Parkinson's disease: negative correlation with the dopamine transporter
    Karl Strecker
    Department of Neurology, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany
    J Neurol 258:19-26. 2011
    ..No alteration of SERT binding in our patients suggests that the serotonergic system is remarkably preserved in early PD. Correlation with DAT might point to a compensatory regulation of the serotonergic system in early stages of PD...
  13. ncbi request reprint Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorder
    Katarina Stengler-Wenzke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neuropsychobiology 53:40-5. 2006
    ..The neurobiological mechanisms of SSRI action and failure to respond to SSRI treatment remain to be elucidated...
  14. doi request reprint Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:1702-14. 2011
    ..The value of various quantitative parameters derived from the PET scans as potential surrogate markers of cognitive decline was also investigated...
  15. ncbi request reprint Is correction for age necessary in neuroimaging studies of the central serotonin transporter?
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Eur J Nucl Med Mol Imaging 30:427-30. 2003
    ..From these results we conclude that age-related changes in SERT density need to be considered in future clinical studies...
  16. doi request reprint Robust, fully automatic delineation of the head contour by stereotactical normalization for attenuation correction according to Chang in dopamine transporter scintigraphy
    Catharina Lange
    Department of Nuclear Medicine, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany
    Eur Radiol 25:2709-17. 2015
    ..The present study proposes a new method for fully automated delineation of the head based on stereotactical normalization. The method was validated for SPECT with I-123-ioflupane...
  17. doi request reprint Reduced alpha4beta2*-nicotinic acetylcholine receptor binding and its relationship to mild cognitive and depressive symptoms in Parkinson disease
    Philipp M Meyer
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Arch Gen Psychiatry 66:866-77. 2009
    ..Cognitive or depressive disorders are frequently noted in patients with Parkinson disease (PD) and may be related to altered signaling through alpha4beta2*-nicotinic acetylcholine receptors (alpha4beta2*-nAChRs)...
  18. doi request reprint Evaluation of software tools for automated identification of neuroanatomical structures in quantitative β-amyloid PET imaging to diagnose Alzheimer's disease
    Tobias Tuszynski
    Department of Nuclear Medicine, Leipzig University Medical Centre, Liebigstraße 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 43:1077-87. 2016
    ..We systematically analyzed florbetaben brain PET and MRI data of ten patients with probable Alzheimer's dementia (AD) and ten age-matched healthy controls (HCs) collected in a previous clinical study...
  19. doi request reprint Implementation of the European multicentre database of healthy controls for [(123)I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes
    Nathalie L Albert
    Department of Nuclear Medicine, University of Munich, Ziemssenstr 1, 80336, Munich, Germany
    Eur J Nucl Med Mol Imaging 43:1315-22. 2016
    ....
  20. ncbi request reprint Reduced serotonin transporter-availability in obsessive-compulsive disorder (OCD)
    Katarina Stengler-Wenzke
    Dept of Psychiatry, University of Leipzig, Johannisallee 20, 04317 Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 254:252-5. 2004
    ..76 (OCD patients) and 3.53 +/- 1.01 (controls). This in vivo finding of significant reduced serotonin transporter availability in midbrain/brainstem using [(123)I] beta-CIT SPECT further supports the serotonin deficit hypothesis of OCD...
  21. doi request reprint Influence of scan duration on the accuracy of β-amyloid PET with florbetaben in patients with Alzheimer's disease and healthy volunteers
    Solveig Tiepolt
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 40:238-44. 2013
    ..In dementia imaging, shortening of scan duration may simplify future clinical use. The aim of this retrospective study was to investigate the effect of scan duration on diagnostic accuracy...
  22. doi request reprint Effortful control as a dimension of temperament is negatively associated with prefrontal serotonin transporter availability in obese and non-obese individuals
    Franziska Zientek
    Integrated Treatment and Research Centre IFB Adiposity Diseases, Leipzig University Medical Centre, Leipzig, Germany
    Eur J Neurosci 44:2460-2466. 2016
    ..The results indicate that regulative temperament - particularly the capacity to mitigate negatively toned impulses and to resist inappropriate avoidance behavior - might be associated with the prefrontal serotonergic system...
  23. doi request reprint Early [(18)F]florbetaben and [(11)C]PiB PET images are a surrogate biomarker of neuronal injury in Alzheimer's disease
    Solveig Tiepolt
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 43:1700-9. 2016
    ..Uptake data for (18)F-labelled Aβ PET tracers are, however, scarce. We investigated the value of early PET images using the novel Aβ tracer [(18)F]FBB in the diagnosis of Alzhimers disease (AD)...
  24. doi request reprint First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (-)-[(18)F]Flubatine
    Osama Sabri
    Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany Integrated Research and Treatment Centre IFB Adiposity Diseases, University of Leipzig, Philipp Rosenthal Straße 27, 04103 Leipzig, Germany Electronic address
    Neuroimage 118:199-208. 2015
    ....
  25. doi request reprint Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer's disease assessed with positron emission tomography
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:515-25. 2011
    ....
  26. doi request reprint Impact of EEG-vigilance on brain glucose uptake measured with [(18)F]FDG and PET in patients with depressive episode or mild cognitive impairment
    Thomas Guenther
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Neuroimage 56:93-101. 2011
    ..For the first time, the present study exploratively investigated this association in a routine diagnostic work-up...
  27. doi request reprint Kinetic analyses of [123I]IBZM SPECT for quantification of striatal dopamine D2 receptor binding: a critical evaluation of the single-scan approach
    Philipp T Meyer
    Department of Nuclear Medicine, University Hospital Aachen, Aachen, Germany
    Neuroimage 42:548-58. 2008
    ..The present study addresses these shortcomings...
  28. ncbi request reprint Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders
    Swen Hesse
    Department of Nuclear Medicine, University Hospital, University of Leipzig, Leipzig, Germany
    Neurosci Biobehav Rev 28:547-63. 2004
    ..We furthermore elucidate the potential of SERT imaging techniques in estimating the effect of selective serotonin reuptake-inhibitors...
  29. doi request reprint The effect of serum BDNF levels on central serotonin transporter availability in obese versus non-obese adults: A [(11)C]DASB positron emission tomography study
    Philipp Hinderberger
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany Integrated Research and Treatment Center IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
    Neuropharmacology 110:530-6. 2016
    ..This study aims to investigate the effect of BDNF, biallelic 5-HTTLPR, and central in-vivo 5-HTT availability in highly obese versus non-obese subjects using positron emission tomography (PET) and 5-HTT selective [(11)C]DASB...
  30. doi request reprint Dissociation between brown adipose tissue 18F-FDG uptake and thermogenesis in uncoupling protein 1 deficient mice
    Mohammed K Hankir
    IFB Adiposity Diseases, Department of Medicine, University of Leipzig, Germany
    J Nucl Med . 2017
    ..It remains uncertain whether BAT 18F-FDG uptake reliably tracks UCP1-mediated heat production...
  31. doi request reprint Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats
    Mohammed K Hankir
    Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, Universitat Leipzig, Liebigstraße 21, 04103 Leipzig, Germany
    Cell Metab . 2017
    ....
  32. doi request reprint Distinctive in vivo kinetics of the new σ1 receptor ligands (R)-(+)- and (S)-(-)-18F-fluspidine in porcine brain
    Peter Brust
    Helmholtz Zentrum Dresden Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig, Germany
    J Nucl Med 55:1730-6. 2014
    ....
  33. pmc A novel thermoregulatory role for PDE10A in mouse and human adipocytes
    Mohammed K Hankir
    Integrated Research and Treatment Centre for Adiposity Diseases, University Hospital University of Leipzig, Leipzig, Germany
    EMBO Mol Med 8:796-812. 2016
    ..Collectively, our findings highlight a novel thermoregulatory role for PDE10A in mouse and human adipocytes and promote PDE10A inhibitors as promising candidates for the treatment of obesity and diabetes. ..
  34. pmc Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
    Juliane Weiner
    Department of Endocrinology and Nephrology, University Hospital, Leipzig, Germany
    Sci Rep 6:38124. 2016
    ..Taken together, these results suggest that both the hyperthyroid and hypothyroid state stimulate WAT thermogenesis most likely as a consequence of enhanced adrenergic signaling or compensation for impaired BAT function, respectively...
  35. doi request reprint Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls
    Walter Koch
    Department of Nuclear Medicine, University of Munich, Marchioninistr 15, 81377, Munich, Germany
    Eur J Nucl Med Mol Imaging 41:1938-46. 2014
    ..The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls...
  36. ncbi request reprint Feasibility and acceptance of simultaneous amyloid PET/MRI
    Lisa Schütz
    Department of Nuclear Medicine, Leipzig University Hospital, Liebigstr 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 43:2236-2243. 2016
    ..The aim of this pilot study was to investigate this matter for the first time...
  37. pmc CT-based attenuation correction in I-123-ioflupane SPECT
    Catharina Lange
    Department of Nuclear Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 9:e108328. 2014
    ..The present study evaluated CT-based AC for dopamine transporter SPECT with I-123-ioflupane...
  38. ncbi request reprint Correlation between automated writing movements and striatal dopaminergic innervation in patients with Wilson's disease
    Wieland Hermann
    Department of Neurology, University of Leipzig, Liebigstr 22a, 04107 Leipzig, Germany
    J Neurol 249:1082-7. 2002
    ..Furthermore analysis of automated handwriting movements could be useful for therapy monitoring and evaluation of striatal dopaminergic innervation...
  39. doi request reprint Distinctive striatal dopamine signaling after dieting and gastric bypass
    Mohammed K Hankir
    Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany
    Trends Endocrinol Metab 26:223-30. 2015
    ..Enhancement of intestinal fat metabolism after gastric bypass may also modify striatal dopamine signaling contributing to its unique long-term effects on feeding behavior and body weight in obese individuals. ..
  40. pmc Thoracic [18F]fluorodeoxyglucose uptake measured by positron emission tomography/computed tomography in pulmonary hypertension
    Armin Frille
    aDepartment of Respiratory Medicine, University of Leipzig, Leipzig, Germany bDepartment of Nuclear Medicine, University of Leipzig, Leipzig, Germany cIntegrated Research and Treatment Center IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
    Medicine (Baltimore) 95:e3976. 2016
    ..Increased glucose metabolism in the central PAs seems to play a certain role in terms of severity of PH. These results suggest that [F]FDG-PET imaging can help understand the pathophysiology of PH as a proliferative pulmonary disease. ..
  41. doi request reprint Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (-)-[(18)F]Flubatine in humans
    Marianne Patt
    Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, D 04103 Leipzig, Germany Electronic address
    Nucl Med Biol 41:489-94. 2014
    ..From a total participant number of 21 Alzheimer's disease (AD) patients and 20 healthy controls (HCs), the following parameters were determined: plasma protein binding, metabolism and activity distribution between plasma and whole blood...