Chirstoph Herold

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Combined in vitro anti-tumoral action of tamoxifen and retinoic acid derivatives in hepatoma cells
    C Herold
    Department of Medicine I, D 91054 Erlangen, Germany
    Int J Oncol 20:89-96. 2002
  2. ncbi request reprint Prognosis of a large cohort of patients with hepatocellular carcinoma in a single European centre
    Christoph Herold
    Department of Medicine I, Department of Surgery, Institute for Medical Statistics, Biometry and Epidemiology, University of Erlangen Nuernberg, Germany
    Liver 22:23-8. 2002
  3. ncbi request reprint Changes in hepatic perfusion after administration of hydroxyethyl starch in intensive care patients assessed using color-coded Doppler sonography
    Christoph Herold
    Department of Medicine I, University of Erlangen Nuernberg, Krankenhausstr 12, 91054, Germany
    Clin Imaging 26:173-6. 2002
  4. ncbi request reprint Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells
    Christoph Herold
    Department of Internal Medicine I, University Erlangen Nuernberg, Ullmenweg 18, D 91054 Erlangen, Germany
    Int J Oncol 23:751-6. 2003
  5. ncbi request reprint Inducibility of microsomal liver function may differentiate cirrhotic patients with maintained compared with severely compromised liver reserve
    Chirstoph Herold
    Department of Medicine I, Unviersity of Erlangen Nuernberg, Erlangen Germany
    J Gastroenterol Hepatol 18:445-9. 2003
  6. ncbi request reprint Hepatocellular carcinomas do not compromise quantitative tests of liver function
    Marion Ganslmayer
    Department of Internal Medicine I, University of Erlangen Nuernberg, Germany
    Hepatogastroenterology 52:881-4. 2005
  7. ncbi request reprint Different capabilities of morphological pattern formation and its association with the expression of differentiation markers in a xenograft model of human pancreatic cancer cell lines
    Daniel Neureiter
    Department of Pathology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Pancreatology 5:387-97. 2005
  8. ncbi request reprint Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models
    Daniel Neureiter
    Institute of Pathology, Landeskliniken Salzburg, Salzburg, Austria
    Scand J Gastroenterol 42:103-16. 2007
  9. ncbi request reprint The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells
    Susanne Gahr
    Department of Medicine I, University Hospital Erlangen, Erlangen, Germany
    Int J Oncol 31:567-76. 2007
  10. ncbi request reprint Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo
    Steffen Zopf
    Department of Medicine 1, University Hospital Erlangen, D 91054, Erlangen, Germany
    Int J Oncol 31:1391-402. 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Combined in vitro anti-tumoral action of tamoxifen and retinoic acid derivatives in hepatoma cells
    C Herold
    Department of Medicine I, D 91054 Erlangen, Germany
    Int J Oncol 20:89-96. 2002
    ..Combination of TAM and CRA, but not ATRA, have an additive to synergistic anti-proliferative and pro-apoptotic effect on HCC cells. This justifies trials for HCC using combinations of these biological response modifiers...
  2. ncbi request reprint Prognosis of a large cohort of patients with hepatocellular carcinoma in a single European centre
    Christoph Herold
    Department of Medicine I, Department of Surgery, Institute for Medical Statistics, Biometry and Epidemiology, University of Erlangen Nuernberg, Germany
    Liver 22:23-8. 2002
    ..Only a few follow up data are available for patients with hepatocellular carcinoma (HCC) in Europe and the USA. Therefore, we analysed all HCC patients admitted to our hospital between 1988 and 1999...
  3. ncbi request reprint Changes in hepatic perfusion after administration of hydroxyethyl starch in intensive care patients assessed using color-coded Doppler sonography
    Christoph Herold
    Department of Medicine I, University of Erlangen Nuernberg, Krankenhausstr 12, 91054, Germany
    Clin Imaging 26:173-6. 2002
    ..CCDS is suitable to assess liver perfusion in intensive care patients. Since HES enhances splanchnic perfusion, its application improves hepatic perfusion in intensive care patients...
  4. ncbi request reprint Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells
    Christoph Herold
    Department of Internal Medicine I, University Erlangen Nuernberg, Ullmenweg 18, D 91054 Erlangen, Germany
    Int J Oncol 23:751-6. 2003
    ..Due to their known safety profile, this justifies clinical trials for colorectal cancer using combinations of these biological response modifiers...
  5. ncbi request reprint Inducibility of microsomal liver function may differentiate cirrhotic patients with maintained compared with severely compromised liver reserve
    Chirstoph Herold
    Department of Medicine I, Unviersity of Erlangen Nuernberg, Erlangen Germany
    J Gastroenterol Hepatol 18:445-9. 2003
    ..Quantitative tests of liver function (QTLF) can be modulated by enzyme-inducing agents. The objective of the study was to examine changes in QTLF after treatment with Phenobarbital, a potent cytochrome P450-inducing agent...
  6. ncbi request reprint Hepatocellular carcinomas do not compromise quantitative tests of liver function
    Marion Ganslmayer
    Department of Internal Medicine I, University of Erlangen Nuernberg, Germany
    Hepatogastroenterology 52:881-4. 2005
    ..If and how far hepatoma growth influences liver function is unclear. Therefore, we compared a broad panel of quantitative tests of liver function in cirrhotic patients with and without hepatocellular carcinoma...
  7. ncbi request reprint Different capabilities of morphological pattern formation and its association with the expression of differentiation markers in a xenograft model of human pancreatic cancer cell lines
    Daniel Neureiter
    Department of Pathology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Pancreatology 5:387-97. 2005
    ..The aim of our study was to investigate the possibility of differentiation pathways of human pancreatic cancer cell lines in vivo...
  8. ncbi request reprint Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models
    Daniel Neureiter
    Institute of Pathology, Landeskliniken Salzburg, Salzburg, Austria
    Scand J Gastroenterol 42:103-16. 2007
    ....
  9. ncbi request reprint The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells
    Susanne Gahr
    Department of Medicine I, University Hospital Erlangen, Erlangen, Germany
    Int J Oncol 31:567-76. 2007
    ..Bax, an apoptosis inducing protein, which destabilizes the mitochondrial membrane potential, was increasingly expressed. Combination of TSA and gemcitabine shows promise for treatment of pancreatic cancer in vivo...
  10. ncbi request reprint Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo
    Steffen Zopf
    Department of Medicine 1, University Hospital Erlangen, D 91054, Erlangen, Germany
    Int J Oncol 31:1391-402. 2007
    ..0 on the extrinsic cell death pathway through activation of TRAIL and its signalling pathway indicate that A-423378.0 may be a potent new therapeutic compound for the treatment of advanced colorectal cancer...
  11. ncbi request reprint The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells
    Matthias Ocker
    Department of Medicine I, University of Erlangen Nuernberg, Ulmenweg 18, 91054, Erlangen, Germany
    J Cancer Res Clin Oncol 131:385-94. 2005
    ..The use of the triple combination could optimize treatment results in vivo and needs further evaluation...
  12. ncbi request reprint The combination of tamoxifen and 9cis retinoic acid exerts overadditive anti-tumoral efficacy in rat hepatocellular carcinoma
    Marion Ganslmayer
    Department of Internal Medicine I, University Erlangen Nuernberg, Ulmenweg 18, D 91054 Erlangen, Germany
    J Hepatol 40:952-6. 2004
    ..While an acyclic retinoid improved tumor-free survival after hepatoma resection, tamoxifen finally proved ineffective. Combination therapy of both agents has not been investigated in vitro and in vivo...
  13. ncbi request reprint Potentiated anticancer effects on hepatoma cells by the retinoid adapalene
    Matthias Ocker
    Department of Internal Medicine I, University Erlangen Nuernberg, Ulmenweg 18, D 91054 Erlangen, Germany
    Cancer Lett 208:51-8. 2004
    ..3 in hepatoma cells. ADA inhibits hepatoma cell growth in vitro and is a powerful inducer of hepatoma cell apoptosis...
  14. ncbi request reprint A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells
    Marion Ganslmayer
    Medical Department I, University of Erlangen Nuernberg, D 91054 Erlangen, Germany
    Oncol Rep 11:943-50. 2004
    ..While the single substances were not effective on hepatoma cells in tolerable doses, their combination significantly increases anti-tumoral efficacy. Combination therapy with biomodulators is a promising treatment option for HCC...
  15. ncbi request reprint The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro
    Matthias Ocker
    Department of Internal Medicine I, University Erlangen Nuernberg, Erlangen, Germany
    Int J Cancer 107:453-9. 2003
    ..Our results clearly indicate the superiority of ADA compared to CRA. Therefore, we suggest that ADA may be far more suitable as an adjunctive therapeutic agent for treatment of colon cancer in vivo...
  16. ncbi request reprint Can quantitative tests of liver function discriminate between different etiologies of liver cirrhosis?
    Christoph Herold
    Department of Medicine I, University of Erlangen Nuernberg, Germany
    Dig Dis Sci 47:2669-73. 2002
    ..In conclusion, QTLF in ALC and VIC patients was more reduced than in patients with PBC. This may be due to saturation of enzymes in ALC and ongoing inflammation in VIC...
  17. ncbi request reprint The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells
    Christoph Herold
    Department of Medicine I, University of Erlangen Nuernberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Hepatol 36:233-40. 2002
    ..The histone-deacetylase inhibitor Trichostatin A (TSA) was shown to induce apoptosis in non-hepatic cells at submicromolar concentrations. However, the effect of TSA on hepatoma cells is unknown...
  18. ncbi request reprint The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice
    Kinya Okamoto
    Department of Medicine 1, University Hospital Erlangen, D 91054 Erlangen, Germany
    Int J Oncol 33:733-42. 2008
    ..Except for a reversible skin reaction and weight loss, no signs of toxicity were observed. AEE788 is a promising new option for the treatment of HCC...
  19. ncbi request reprint Improvement of quantitative testing of liver function in patients with chronic hepatitis C after installment of antiviral therapy
    Matthias Ocker
    Department of Medicine I, Ulmenweg 18, Erlangen D 91054, Germany
    World J Gastroenterol 11:5521-4. 2005
    ..To investigate if and to what extent antiviral therapy influenced a broad panel of quantitative testing of liver function (QTLF)...
  20. ncbi request reprint bcl-2-specific siRNAs restore gemcitabine sensitivity in human pancreatic cancer cells
    Kinya Okamoto
    Department of Medicine 1, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuernberg, Ulmenweg 18, D 91054 Erlangen, Germany
    J Cell Mol Med 11:349-61. 2007
    ..Our results demonstrate that siRNA-mediated silencing of anti-apoptotic bcl-2 enhances chemotherapy sensitivity in human pancreatic cancer cells in vitro and might lead to improved therapy responses in advanced stages of this disease...
  21. ncbi request reprint Quantitative testing of liver function compared to prognostic scores in patients with primary biliary cirrhosis
    Christoph Herold
    Department of Internal Medicine I, University of Erlangen Nuernberg, Germany
    Liver 22:159-65. 2002
    ..We investigated if quantitative tests of liver function (QTLF) and serum levels of a surrogate marker of hepatic fibrogenesis (PIIINP) provide information in addition to established prognostic scores...