Hans Herfarth

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. pmc Lactobacillus GG in inducing and maintaining remission of Crohn's disease
    Michael Schultz
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    BMC Gastroenterol 4:5. 2004
  2. ncbi request reprint [Laboratory values, endoscopy and new imaging. What is the status of diagnosis?]
    H Herfarth
    Klinik und Poliklinik für Innere Medizin I, Universitat Regensburg, 93042 Regensburg
    Internist (Berl) 43:1354-8, 1361-6. 2002
  3. ncbi request reprint Can OCT be used to distinguish accurately between patients with ulcerative colitis and those with Crohn's disease?
    Hans Herfarth
    University of Regensburg, Germany
    Nat Clin Pract Gastroenterol Hepatol 2:172-3. 2005
  4. ncbi request reprint Analysis of the therapeutic efficacy of different doses of budesonide in patients with active Crohn's ileocolitis depending on disease activity and localization
    H Herfarth
    Department of Internal Medicine, University of Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 19:147-52. 2004
  5. ncbi request reprint [Low grade dysplasia in ulcerative colitis]
    H Herfarth
    Klinik und Poliklinik für Innere Medizin I, Klinikum der Universitat Regensburg
    Z Gastroenterol 41:351-3. 2003
  6. ncbi request reprint Inflammatory bowel disease
    H Herfarth
    Dept of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Endoscopy 37:42-7. 2005
  7. pmc IL-10 therapy in Crohn's disease: at the crossroads. Treatment of Crohn's disease with the anti-inflammatory cytokine interleukin 10
    H Herfarth
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gut 50:146-7. 2002
  8. ncbi request reprint Polymorphism of monocyte chemoattractant protein 1 in Crohn's disease
    Hans Herfarth
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 18:401-5. 2003
  9. pmc The virtuosity of virtuality or how real is virtual colonography
    H Herfarth
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gut 52:1662-4. 2003
  10. ncbi request reprint IL-15 protects intestinal epithelial cells
    Florian Obermeier
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Eur J Immunol 36:2691-9. 2006

Detail Information

Publications105 found, 100 shown here

  1. pmc Lactobacillus GG in inducing and maintaining remission of Crohn's disease
    Michael Schultz
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    BMC Gastroenterol 4:5. 2004
    ..The aim of this randomized, placebo-controlled trial was to determine the effect of oral Lactobacillus GG (L. GG) to induce or maintain medically induced remission...
  2. ncbi request reprint [Laboratory values, endoscopy and new imaging. What is the status of diagnosis?]
    H Herfarth
    Klinik und Poliklinik für Innere Medizin I, Universitat Regensburg, 93042 Regensburg
    Internist (Berl) 43:1354-8, 1361-6. 2002
  3. ncbi request reprint Can OCT be used to distinguish accurately between patients with ulcerative colitis and those with Crohn's disease?
    Hans Herfarth
    University of Regensburg, Germany
    Nat Clin Pract Gastroenterol Hepatol 2:172-3. 2005
  4. ncbi request reprint Analysis of the therapeutic efficacy of different doses of budesonide in patients with active Crohn's ileocolitis depending on disease activity and localization
    H Herfarth
    Department of Internal Medicine, University of Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 19:147-52. 2004
    ..This study investigated the optimal budesonide dose using a pH-dependent release formulation. The goal of treatment was the remission of CD (CDAI <150) within 6 weeks of treatment...
  5. ncbi request reprint [Low grade dysplasia in ulcerative colitis]
    H Herfarth
    Klinik und Poliklinik für Innere Medizin I, Klinikum der Universitat Regensburg
    Z Gastroenterol 41:351-3. 2003
  6. ncbi request reprint Inflammatory bowel disease
    H Herfarth
    Dept of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Endoscopy 37:42-7. 2005
    ..The results of long-term follow-up studies indicate that several dilation procedures are often necessary and that a relatively high percentage of patients still have to undergo surgery...
  7. pmc IL-10 therapy in Crohn's disease: at the crossroads. Treatment of Crohn's disease with the anti-inflammatory cytokine interleukin 10
    H Herfarth
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gut 50:146-7. 2002
  8. ncbi request reprint Polymorphism of monocyte chemoattractant protein 1 in Crohn's disease
    Hans Herfarth
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 18:401-5. 2003
    ..Furthermore, we studied whether a functional single nucleotide polymorphism (G or A) located in the distal regulatory region of the MCP-1 gene is associated with Crohn's disease and/or its phenotype...
  9. pmc The virtuosity of virtuality or how real is virtual colonography
    H Herfarth
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gut 52:1662-4. 2003
  10. ncbi request reprint IL-15 protects intestinal epithelial cells
    Florian Obermeier
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Eur J Immunol 36:2691-9. 2006
    ..According to this, endogenously produced IL-15 in chronic colitis does not only act as a proinflammatory cytokine but has at the same time the potential to reduce mucosal damage by preventing IEC apoptosis...
  11. ncbi request reprint Rapamycin decreases leukocyte migration in vivo and effectively reduces experimentally induced chronic colitis
    Stefan Farkas
    Department of Surgery, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Int J Colorectal Dis 21:747-53. 2006
    ..The aim of the present study was to test the immunosuppressive mammalian target of rapamycin inhibitor rapamycin in an experimental model of chronic colitis and to compare its effectiveness with CsA...
  12. ncbi request reprint Optimising the diagnostic value of anti-Saccharomyces cerevisiae-antibodies (ASCA) in Crohn's disease
    Frank H Klebl
    Department of Internal Medicine I, University of Regensburg, 93042, Regensburg, Germany
    Int J Colorectal Dis 19:319-24. 2004
    ..ASCA tests are not standardised and different methods for ASCA detection exist. This study was undertaken to compare ASCA tests and to clarify their diagnostic value...
  13. ncbi request reprint 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells
    Reinhold Altmann
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Biochem Pharmacol 74:612-22. 2007
    ..Highest activity of 13-HODE dehydrogenase is found in colonic epithelial cells (CECs). We therefore investigated whether 13-Oxo-ODE is a new endogenous ligand of PPARgamma in CECs...
  14. pmc Role of soluble factors and three-dimensional culture in in vitro differentiation of intestinal macrophages
    Tanja Spoettl
    Department of Internal Medicine I, University of Regensburg, Regensburg 93042, Germany
    World J Gastroenterol 13:1032-41. 2007
    ..To examine the factor(s) involved in differentiation of intestinal macrophages (IMACs) using a recently established in vitro model...
  15. ncbi request reprint Secretion of RANTES (CCL5) and interleukin-10 from mesenteric adipose tissue and from creeping fat in Crohn's disease: regulation by steroid treatment
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Gastroenterol Hepatol 21:1412-8. 2006
    ..Pro- or anti-inflammatory adipose tissue-derived secretory products (adipocytokines) might play a role in the pathogenesis of CD...
  16. doi request reprint Admission visfatin levels predict pancreatic and peripancreatic necrosis in acute pancreatitis and correlate with clinical severity
    Andreas Schaffler
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany andreas schaeffl
    Am J Gastroenterol 106:957-67. 2011
    ..It was the aim of this study to investigate whether the adipocytokine visfatin is able to serve as an early marker predicting peripancreatic necrosis and clinical severity...
  17. ncbi request reprint Vascular endothelial growth factor secretion from mesenteric adipose tissue and from creeping fat in Crohn's disease
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Gastroenterol Hepatol 21:1419-23. 2006
    ..Because VEGF serum levels and mucosal VEGF expression is elevated in CD patients, the aim of the present paper was to investigate creeping fat-derived VEGF secretion in CD...
  18. ncbi request reprint Profiling adipocytokine secretion from creeping fat in Crohn's disease
    Gisela Paul
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Inflamm Bowel Dis 12:471-7. 2006
    ..Creeping fat represents a characteristic feature of Crohn's disease (CD). Proinflammatory or anti-inflammatory adipose-derived secretory products, now generally called adipocytokines, may play a role in the pathogenesis of CD...
  19. ncbi request reprint Dark lumen magnetic resonance enteroclysis in combination with MRI colonography for whole bowel assessment in patients with Crohn's disease: first clinical experience
    Andreas G Schreyer
    Department of Radiology, University Hospital Regensburg, Regensburg, Germany
    Inflamm Bowel Dis 11:388-94. 2005
    ..In this feasibility study, we evaluated the combination of small bowel MRI with unprepared MRC as an integrative diagnostic approach of the whole bowel in patients with Crohn's disease...
  20. ncbi request reprint Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells
    Sabine Hoves
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    J Immunol 177:2691-8. 2006
    ..These results demonstrate that Mphi drive the differentiation of regulatory T cells and mediate anergy in allogeneic T cells, supporting the concept that Mphi maintain peripheral tolerance in vivo...
  21. ncbi request reprint Serum soluble TNF receptor I and II levels correlate with disease activity in IBD patients
    Tanja Spoettl
    Department of Internal Medicine I, University of Regensburg, Germany
    Inflamm Bowel Dis 13:727-32. 2007
    ..Soluble TNF receptors I and II (sTNF-RI + II) are released by proteolytic cleavage of the extracellular domains of these receptors. Soluble TNF-Rs act as TNF antagonists and can inhibit TNFalpha-mediated proinflammatory effects...
  22. ncbi request reprint (E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa
    Tanja Spoettl
    Department of Internal Medicine I, University of Regensburg, 93042, Regensburg, Germany
    Int J Colorectal Dis 22:303-12. 2007
    ..TC-2403-12 is a (E)-metanicotine hemigalactarate. The aim of this study was to determine the effectiveness of TC-2403-12 in the inhibition of TNF- and lipopolysaccharide (LPS)-induced cell activation...
  23. doi request reprint Gene expression profiles of mucosal fibroblasts from strictured and nonstrictured areas of patients with Crohn's disease
    Markus Lang
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Inflamm Bowel Dis 15:212-23. 2009
    ..We aimed to investigate differences in gene expression profiles between CLPF isolated from normal, inflamed and strictured areas of CD patients...
  24. ncbi request reprint Genomic organization, chromosomal localization and adipocytic expression of the murine gene for CORS-26 (collagenous repeat-containing sequence of 26 kDa protein)
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee11, D 93042, Regensburg, Germany
    Biochim Biophys Acta 1628:64-70. 2003
    ..The present data provide the basis for further investigation of the CORS-26 gene regulation in the context of mesenchymal tissue development, chondrocyte/adipocyte function and bone or skeletal disease...
  25. pmc Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases
    Andreas Schaffler
    Department of Internal Medicine I, Regensburg University Medical Center, Germany
    Cardiovasc Diabetol 6:3. 2007
    ..Omentin represents a new adipokine expressed in and secreted by omental adipose tissue. Therefore, it was the aim to investigate the putative role of a newly described sequence missense variation in the human omentin gene...
  26. doi request reprint Admission resistin levels predict peripancreatic necrosis and clinical severity in acute pancreatitis
    Andreas Schaffler
    Department of Internal Medicine I, University Hospital of Regensburg, Regensburg, Germany andreas schaeffl
    Am J Gastroenterol 105:2474-84. 2010
    ....
  27. ncbi request reprint A new organotypic model to study cell interactions in the intestinal mucosa
    Tanja Spottl
    Department of Internal Medicine I, University of Regensburg, Germany
    Eur J Gastroenterol Hepatol 18:901-9. 2006
    ..Here we describe a more organotypic model to study cell interactions in the intestinal mucosa...
  28. doi request reprint Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohn's disease
    Frauke Bataille
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Inflamm Bowel Dis 14:1514-27. 2008
    ..EMT has been suggested to be crucial in fibrosis found in different tissues and diseases. We therefore investigated whether EMT could be involved in the pathogenesis of fistulae formation in CD...
  29. pmc Glycoprotein (gp) 96 expression: induced during differentiation of intestinal macrophages but impaired in Crohn's disease
    K Schreiter
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Gut 54:935-43. 2005
    ..It is a chaperone with a binding domain for peptides generated by proteasomal degradation. During cellular stress, peptide loaded gp96 can be released and presented to T cells by antigen presenting cells (APCs)...
  30. pmc Analysis of intestinal haem-oxygenase-1 (HO-1) in clinical and experimental colitis
    G Paul
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 140:547-55. 2005
    ..However, as shown by the lack of effects in established acute or in chronic colitis, the induction of HO-1 may not be a promising approach for the treatment of IBD...
  31. ncbi request reprint Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer
    Nicole Deutscher
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 21:573-81. 2006
    ..The aim of this study was to investigate the expression profiling of IL-11Ralpha and its downstream signaling cascade in colonic adenoma and carcinoma...
  32. ncbi request reprint Controlled, open, randomized multicenter trial comparing the effects of treatment on quality of life, safety and efficacy of budesonide foam and betamethasone enemas in patients with active distal ulcerative colitis
    Angela Hammond
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Hepatogastroenterology 51:1345-9. 2004
    ..The purpose of this study was to assess the effect of treatment with budesonide foam or betamethasone enema on the quality of life and the clinical outcome in patients with distal ulcerative colitis...
  33. ncbi request reprint A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease
    Marcus Muhlbauer
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gastroenterology 125:1085-93. 2003
    ..In this study, we investigated the correlation of the functional -2518 MCP-1 promoter polymorphism with hepatic MCP-1 expression and the disease outcome in patients with HCV...
  34. doi request reprint The role of domestic hygiene in inflammatory bowel diseases: hepatitis A and worm infestations
    Stefan Hafner
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Eur J Gastroenterol Hepatol 20:561-6. 2008
    ....
  35. pmc Inducible CD40 expression mediates NFkappaB activation and cytokine secretion in human colonic fibroblasts
    C M Gelbmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Gut 52:1448-56. 2003
    ..As intestinal fibroblasts and myofibroblasts may play a role during mucosal inflammation, we investigated the functional consequences of CD40 induction in primary cultures of human colonic fibroblasts...
  36. ncbi request reprint Abdominal MRI after enteroclysis or with oral contrast in patients with suspected or proven Crohn's disease
    Andreas G Schreyer
    Department of Radiology, University of Regensburg, Germany
    Clin Gastroenterol Hepatol 2:491-7. 2004
    ....
  37. ncbi request reprint Comparison of capsule endoscopy and magnetic resonance (MR) enteroclysis in suspected small bowel disease
    Stefan K Gölder
    Department of Internal Medicine I, University of Regensburg, 93042, Regensburg, Germany
    Int J Colorectal Dis 21:97-104. 2006
    ..The aim of this study was to compare the diagnostic yield of WCE with MR enteroclysis in the detection of small bowel pathologies...
  38. ncbi request reprint Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients
    Julia Brenmoehl
    University Hospital of Regensburg, Department of Internal Medicine I, 93042 Regensburg, Germany
    Intensive Care Med 33:1541-8. 2007
    ..To assess a possible contribution of variants in the NOD2/CARD15 gene to sepsis related mortality (SRM) we investigated 132 prospectively characterised, consecutive patients with sepsis...
  39. ncbi request reprint Potential of adipocytokines in predicting peripancreatic necrosis and severity in acute pancreatitis: pilot study
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Gastroenterol Hepatol 22:326-34. 2007
    ....
  40. ncbi request reprint Plasminogen activator inhibitor-1 promoter activity in adipocytes is not influenced by the 4 G/5 G promoter polymorphism and is regulated by a USF-1/2 binding site immediately preceding the polymorphic region
    B Zietz
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Mol Endocrinol 32:155-63. 2004
    ..These data possibly explain the observation that PAI-1 secretion from adipose tissue is not influenced by the PAI-1 promoter polymorphism...
  41. pmc Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo
    K Menzel
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Clin Exp Immunol 146:169-80. 2006
    ..Inhibition of CTSD as well as CTSB/CTSL is followed by an amelioration of experimental colitis. The prevention of mucosal damage by cathepsin inhibition could represent a new approach for the therapy of IBD...
  42. ncbi request reprint Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis
    Stefan Farkas
    Department of Surgery, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Int J Colorectal Dis 21:71-8. 2006
    ..Here, we investigate the pathophysiologic role of MAdCAM-1 in the intestinal microcirculation in vivo...
  43. ncbi request reprint Physiological role of macrophage inflammatory protein-3 alpha induction during maturation of intestinal macrophages
    Martin Hausmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Immunol 175:1389-98. 2005
    ..MIP-3alpha is induced during the differentiation of monocytes into IMAC. Our data suggest that MIP-3alpha expression could be involved in the recruitment of CD45R0+ cells into the lamina propria...
  44. pmc Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes
    T Spoettl
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 145:190-9. 2006
    ..It may be speculated that MCP-1 could play a role in the disturbed IMAC differentiation in IBD mucosa...
  45. pmc Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 125:48-55. 2001
    ..In IBD macrophage-oxidative burst activity is increased and NADPH oxidase mRNA induced. Inhibition of NADPH oxidase could be a new therapeutical target in IBD and reduce mucosal tissue damage in active IBD...
  46. ncbi request reprint Caucasian patients with type 2 diabetes mellitus have elevated levels of monocyte chemoattractant protein-1 that are not influenced by the -2518 A-->G promoter polymorphism
    B Zietz
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Diabetes Obes Metab 7:570-8. 2005
    ....
  47. doi request reprint Comparison of conventional abdominal CT with MR-enterography in patients with active Crohn's disease and acute abdominal pain
    Andreas G Schreyer
    Department of Radiology, University Medical Center Regensburg, 93042 Regensburg, Germany
    Acad Radiol 17:352-7. 2010
    ..In a retrospective study, we compared the diagnostic value of a conventional abdominal CT with a dedicated small bowel MRE to assess bowel wall changes as well as typical complications in patients with advanced CD...
  48. ncbi request reprint Magnetic resonance imaging based colonography for diagnosis and assessment of diverticulosis and diverticulitis
    Andreas G Schreyer
    Department of Radiology, University Hospital Regensburg, Regensburg, Germany
    Int J Colorectal Dis 19:474-80. 2004
    ..This study evaluated the feasibility of MRI-based colonography to assess diverticulosis or diverticulitis...
  49. ncbi request reprint Association of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies with Vienna classification subtypes of Crohn's disease
    Frank H Klebl
    Department of Internal Medicine I, dagger Institute of Pathology, University of Regensburg, Regensburg, Germany
    Inflamm Bowel Dis 9:302-7. 2003
    ..AIM The aim of this study was to test whether perinuclear antineutrophil cytoplasmic antibodies (pANCAs) or anti-Saccharomyces cerevisiae antibodies (ASCAs) correlate to subtypes of CD according to this classification...
  50. ncbi request reprint Magnetic resonance imaging gastrography: evaluation of the dark lumen technique compared with conventional gastroscopy in patients with malignant gastric disease
    Karl Scheibl
    Department of Radiology, University Hospital Regensburg, Germany
    Invest Radiol 40:164-72. 2005
    ..The findings were correlated with conventional gastroscopy. In addition, we evaluated the screening for lymph nodes and liver metastases during the same session to identify potential tumor spread...
  51. ncbi request reprint Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation
    Ernst Holler
    Division of Hematology Oncology, University Hospital of Regensburg, Germany
    Blood 104:889-94. 2004
    ..Our findings indicate a major role of monocyte/macrophage dysfunction in the pathophysiology of GvHD and strongly suggest a future risk assessment or even donor selection through NOD2/CARD15 typing...
  52. ncbi request reprint Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: role of interleukin-6 and tumour necrosis factor
    Rainer H Straub
    Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Eur J Endocrinol 146:365-74. 2002
    ..Furthermore, the behaviour of serum levels of these hormones during an acute inflammatory stressful disease state is not well known...
  53. ncbi request reprint 3D modeling and virtual endoscopy of the small bowel based on magnetic resonance imaging in patients with inflammatory bowel disease
    Andreas G Schreyer
    Department of Radiology, University Hospital Regensburg, Germany
    Invest Radiol 37:528-33. 2002
    ..The aim of this study was to evaluate the feasibility of virtual small bowel endoscopy based on MR imaging in patients with Crohn disease...
  54. pmc (GT)N dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 153:81-5. 2008
    ..Our data indicate that (GT)(n) dinucleotide repeats of the HO-1 promotor region have no significance for the pathophysiology and disease course of IBD...
  55. pmc Short-term treatment with anti-CD44v7 antibody, but not CD44v4, restores the gut mucosa in established chronic dextran sulphate sodium (DSS)-induced colitis in mice
    S Farkas
    Department of Surgery, University of Regensburg, Germany
    Clin Exp Immunol 142:260-7. 2005
    ..Short-term treatment with anti-CD44v7 antibody blocks T cell extravasation and recruitment to the intestinal mucosa and cures established experimental colitis...
  56. pmc In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 148:373-81. 2007
    ..02). Inhibition of oxidative burst activity with acteoside reduced mucosal tissue damage in DSS colitis and could be a therapeutic alternative for IBD treatment. Further studies of this agent are warranted...
  57. ncbi request reprint Crohn's disease of the esophagus: treatment of an esophagobronchial fistula with the novel liquid embolic polymer "onyx"
    F Rieder
    Department of Internal Medicine I, University of Regensburg
    Z Gastroenterol 44:599-602. 2006
    ..This approach offers a new option for the treatment of this rare complication of Crohn's disease and should be considered if surgery is not possible...
  58. ncbi request reprint Use of anticoagulation during wireless capsule endoscopy for the investigation of recurrent obscure gastrointestinal bleeding
    F Rieder
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Endoscopy 38:526-8. 2006
    ..In both cases a gastrointestinal stromal tumor was identified as the bleeding source and was resected. These two cases demonstrate that provocation of bleeding during capsule endoscopy may increase its sensitivity...
  59. doi request reprint [Indications for magnetic resonance imaging in Internal Medicine. When do we really need this technology?]
    A G Schreyer
    Institut für Röntgendiagnostik, Universitatsklinikum Regensburg, 93042 Regensburg
    Internist (Berl) 51:451-62. 2010
    ..This review describes relevant indications for MRI in the different subspecialties of Internal Medicine and compares the diagnostic yield of MRI to other established modalities such as computed tomography and ultrasound...
  60. ncbi request reprint Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Biochim Biophys Acta 1732:96-102. 2005
    ..Based on this, omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease...
  61. pmc Comparison of magnetic resonance imaging colonography with conventional colonoscopy for the assessment of intestinal inflammation in patients with inflammatory bowel disease: a feasibility study
    A G Schreyer
    Department of Radiology, University Hospital, Regensburg, 93042 Regensburg, Germany
    Gut 54:250-6. 2005
    ..To evaluate this approach for patients with inflammatory bowel disease (IBD), we compared MRI based colonography with conventional colonoscopy for assessing the presence and extent of colonic inflammation...
  62. ncbi request reprint Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease
    T S Weiss
    Department of Surgery, University of Regensburg, Germany
    Inflamm Bowel Dis 10:529-35. 2004
    ..Increased spermidine and N8-acetylspermidine levels reflect increased uptake and metabolism likely due to accelerated proliferation and regeneration of CECs...
  63. pmc Morphological characterisation of Crohn's disease fistulae
    F Bataille
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Gut 53:1314-21. 2004
    ..To date, no histological comparison of Crohn's disease fistulae with non-inflammatory bowel disease fistulae has been performed. In addition, Crohn's disease fistulae have not been well characterised morphologically...
  64. ncbi request reprint Identification of influencing variables on adiponectin serum levels in diabetes mellitus type 1 and type 2
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Exp Clin Endocrinol Diabetes 112:383-9. 2004
    ..Adiponectin represents an adipocyte-specific secretory protein that has been discussed recently as candidate gene and promising new drug target to restore insulin sensitivity in diabetes mellitus type 2...
  65. ncbi request reprint Role of specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Biochim Biophys Acta 1678:150-6. 2004
    ..Pit-1 and PPARgamma can bind specifically to the promoter and might play an additive functional role in gene regulation of murine CORS-26...
  66. ncbi request reprint Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes
    B Zietz
    Department of Internal Medicine I, University of Regensburg, D 93042, Regensburg, Germany
    FEBS Lett 545:103-4. 2003
    ..0001) and positively (regression analysis: r=0.86) associated with HDL-cholesterol levels in type 2 diabetes...
  67. pmc Cathepsin D is up-regulated in inflammatory bowel disease macrophages
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Clin Exp Immunol 136:157-67. 2004
    ..This study shows that expression of cathepsin D is induced in inflammation-associated IMACs. The presence of cathepsin D might contribute to the mucosal damage in IBD...
  68. ncbi request reprint Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein)
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Biochim Biophys Acta 1630:123-9. 2003
    ..The present data provide the basis for further investigation of CORS-26 gene regulation in the context of mesenchymal tissue development and in the pathogenesis of bone or skeletal disease...
  69. pmc Quantification of mucosal leucocyte endothelial cell interaction by in vivo fluorescence microscopy in experimental colitis in mice
    S Farkas
    Department of Surgery, Klinik und Poliklinik für Chirurgie, Klinikum der Universitat Regensburg, Regensburg, Germany
    Clin Exp Immunol 126:250-8. 2001
    ....
  70. ncbi request reprint Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Horm Metab Res 36:702-7. 2004
    ..The physiological range of serum resistin levels, reference values or adjusted percentiles have not yet been determined, making the interpretation of serum resistin concentrations quite difficult...
  71. pmc Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis
    F Obermeier
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Clin Exp Immunol 134:217-24. 2003
    ..Therefore, the prophylactic effect of CpG-ODN might be explained by its tolerizing effect and/or the increased ability for IL-10 production during the consecutive intestinal inflammation...
  72. ncbi request reprint Preferential migration of CD62L cells into the appendix in mice with experimental chronic colitis
    S A Farkas
    Department of Surgery, University of Regensburg, Regensburg, Germany
    Eur Surg Res 37:115-22. 2005
    ..Clinical and experimental studies suggest that appendectomy can protect against development of ulcerative colitis and Crohn's disease. However, how T cells in the appendix affect the development of colitis has not been clarified...
  73. pmc Creeping fat in Crohn's disease: travelling in a creeper lane of research?
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Gut 54:742-4. 2005
  74. pmc Nuclear factor-kappa B activity and intestinal inflammation in dextran sulphate sodium (DSS)-induced colitis in mice is suppressed by gliotoxin
    H Herfarth
    Department of Internal Medicine I, Regensburg, and Department of Clinical Chemistry and Pathobiochemistry, Klinikum re d Isar, Munich, Germany
    Clin Exp Immunol 120:59-65. 2000
    ..These results demonstrate the essential role of NF-kappaB in DSS-induced colitis and indicate a molecular approach to the treatment of intestinal inflammatory disorders...
  75. pmc In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4+CD62L+ T cells which prevent intestinal inflammation in the SCID transfer model of colitis
    F Obermeier
    Department of Internal Medicine I, University of Regensburg, Germany
    Gut 54:1428-36. 2005
    ..To investigate the possible involvement of CD4(+) T cells in the prophylactic CpG-ODN effects, we used the SCID transfer model of colitis...
  76. ncbi request reprint CpG motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium-treated mice
    Florian Obermeier
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Eur J Immunol 32:2084-92. 2002
    ....
  77. ncbi request reprint The potential of adiponectin in driving arthritis
    Angela Ehling
    Department of Internal Medicine I, University Hospital Regensburg, Germany
    J Immunol 176:4468-78. 2006
    ..In summary, articular adipose tissue and adipocytokines cannot be regarded as innocent bystanders any more in chronic inflammatory diseases such as arthritis...
  78. ncbi request reprint New diagnostic avenues in inflammatory bowel diseases. Capsule endoscopy, magnetic resonance imaging and virtual enteroscopy
    Andreas G Schreyer
    Department of Radiology, University of Regensburg, Regensburg, Germany
    Dig Dis 21:129-37. 2003
    ..This article describes these recently introduced methods in the diagnostic assessment of the small bowel and discusses the clinical significance based on the current literature...
  79. ncbi request reprint Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gastroenterology 122:1987-2000. 2002
    ..Toll-like receptors (TLRs) TLR2 and TLR4 have been identified as signaling receptors activated by bacterial wall components...
  80. ncbi request reprint Monocyte differentiation in intestine-like macrophage phenotype induced by epithelial cells
    T Spottl
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    J Leukoc Biol 70:241-51. 2001
    ..For the first time an intestine-like macrophage-phenotype could be induced in vitro. Interactions with IECs play an essential role during this differentiation, which is of functional relevance, e.g., for LPS-induced cytokine secretion...
  81. doi request reprint Soluble CD163 is increased in patients with acute pancreatitis independent of disease severity
    Thomas Karrasch
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
    Exp Mol Pathol 99:236-9. 2015
    ..Soluble CD163 was not related to complications of acute pancreatitis. These data show that serum sCD163 is increased in acute pancreatitis indicating activation of macrophages but is not associated with disease severity and outcome. ..
  82. ncbi request reprint Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease?
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042, Germany
    J Neuroimmunol 126:116-25. 2002
    ..It is discussed how the uncoupling of the two anti-inflammatory stress axes can appear...
  83. pmc Soluble galectin-3 is a strong, colonic epithelial-cell-derived, lamina propria fibroblast-stimulating factor
    E Lippert
    Department of Internal Medicine I, University of Regensburg, Regensburg 93042, Germany
    Gut 56:43-51. 2007
    ..Colonic lamina propria fibroblasts (CLPFs) play an important role in the pathogenesis of fibrosis and strictures in Crohn's disease...
  84. ncbi request reprint MR colonography in inflammatory bowel disease
    A G Schreyer
    Department of Radiology, University Hospital Regensburg, 93042 Regensburg, Germany
    Abdom Imaging 31:302-7. 2006
    ..In addition, recently published studies concerning the sensitivity and accuracy in detecting inflammatory bowel changes in inflammatory bowel disease using MRI are discussed...
  85. ncbi request reprint Nonocclusive mesenteric ischemia induced by digitalis
    Joachim Weil
    Klinik und Poliklinik fur Innere Medizin II, Klinikum, Universitat Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 19:277-80. 2004
    ..Nonocclusive mesenteric ischemia is a rare but serious disorder with a high mortality rate; causal factors include cardiac glycosides, digoxin, and digitoxin in addition to severe hypotension, decompensated heart failure, and septic shock...
  86. ncbi request reprint Elimination of activated but not resting primary human CD4+ and CD8+ T cells by Fas ligand (FasL/CD95L)-expressing Killer-dendritic cells
    Sabine Hoves
    The University of Regensburg, Department of Internal Medicine I, 93042 Regensburg, Germany
    Immunobiology 208:463-75. 2004
    ....
  87. ncbi request reprint Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination
    Ernst Holler
    Department of Haematology Oncology, Medical Centre, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Blood 107:4189-93. 2006
    ..Our data further support an interaction between gastrointestinal defense mechanisms, activation of the innate immune system, and specific transplant-related complications...
  88. ncbi request reprint Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells
    M Muhlbauer
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Am J Physiol Gastrointest Liver Physiol 286:G1000-8. 2004
    ..These differences may have implications for the understanding of the pathophysiology of inflammation and carcinogenesis in the gut...
  89. ncbi request reprint Allelic frequency of the PAI-1 4G/5G promoter polymorphism in patients with type 2 diabetes mellitus and lack of association with PAI-1 plasma levels
    B Zietz
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Endocr Res 30:443-53. 2004
    ..In patients with type 2 diabetes mellitus, the PAI-1 4G/5G promoter polymorphism does not predict PAI-1 plasma levels and is not associated with common metabolic parameters besides fibrinogen levels...
  90. ncbi request reprint Polymorphism of CC chemokine receptors CCR2 and CCR5 in Crohn's disease
    H Herfarth
    Department of Internal Medicine, University of Regensburg, Regensburg, Germany
    Immunol Lett 77:113-7. 2001
    ..However, the associations observed are limited and await replication in other datasets. CCR2 and CCR5 polymorphisms are unlikely to be important determinants of overall disease susceptibility...
  91. ncbi request reprint Irinotecan plus gemcitabine and 5-fluorouracil in advanced pancreatic cancer: a phase II study
    E Endlicher
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Oncology 72:279-84. 2007
    ..Secondary efficacy end points included response rate, time to progression (TTP), overall survival (OS) and toxicity...
  92. ncbi request reprint Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis
    Matthias Schwab
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376 Stuttgart, Germany
    Gastroenterology 124:26-33. 2003
    ..Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis...
  93. ncbi request reprint [When is drug therapy with azathioprine indicated in Crohn's disease?]
    Gerhard Rogler
    Dtsch Med Wochenschr 127:1213-4. 2002
  94. ncbi request reprint Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine
    Karin Dilger
    Dr Falk Pharma GmbH, Freiburg, Germany
    Ther Drug Monit 29:1-5. 2007
    ..4. In a well-standardized clinical setting of inflammatory bowel disease, neither mesalazine nor azathioprine significantly affected TPMT activity during a whole year of treatment...
  95. ncbi request reprint Long-term effectiveness of azathioprine in IBD beyond 4 years: a European multicenter study in 1176 patients
    Martin H Holtmann
    First Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Dig Dis Sci 51:1516-24. 2006
    ..In all other CD patients and for UC patients in general, continuation seems beneficial. These results support a novel differential algorithm for long-term azathioprine therapy in IBD...
  96. ncbi request reprint Modern imaging using computer tomography and magnetic resonance imaging for inflammatory bowel disease (IBD) AU1
    Andreas G Schreyer
    Department of Radiology, University of Regensburg
    Inflamm Bowel Dis 10:45-54. 2004
    ..Future developments of CT- or MR-based virtual colonography and endoscopy in patients with inflammatory bowel disease are currently being investigated, but should momentarily be considered as purely experimental approaches...
  97. ncbi request reprint A case of recurrent gastrointestinal bleeding and protein-losing gastroenteropathy
    Hans Herfarth
    Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Nat Clin Pract Gastroenterol Hepatol 4:288-93. 2007
    ..He had recently recovered from a heart operation, which was performed to reconstruct the right ventricular outflow tract...
  98. ncbi request reprint Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study
    Nicolas von Ahsen
    Department of Clinical Chemistry, University of Gottingen, Gottingen, Germany
    Clin Chem 51:2282-8. 2005
    ..Inosine triphosphatase (ITPA) mutations are other pharmacogenetic polymorphisms possibly involved in thiopurine metabolism and tolerance...
  99. ncbi request reprint Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease--a randomized, controlled, open-label, multicenter study
    Oliver Schroder
    First Department of Internal Medicine, Division of Gastroenterology, ZAFES, Johann Wolfgang Goethe University, Frankfurt, Germany
    Am J Gastroenterol 100:2503-9. 2005
    ..We therefore evaluated the efficacy and safety of intravenous iron sucrose as compared with oral iron sulfate for the treatment of iron deficiency anemia (IDA) in patients with IBD...
  100. ncbi request reprint 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial
    Max Reinshagen
    Department of Medicine I, Klinikum Braunschweig, Braunschweig, Germany
    Clin Chem 53:1306-14. 2007
    ..A prospective randomized trial in patients with Crohn disease studied whether 6-thioguanine nucleotide (6-TGN) concentration-adapted azathioprine (AZA) therapy is clinically superior to a standard dose of 2.5 mg/kg/day AZA...
  101. doi request reprint Early combined immunosuppression in Crohn's disease
    Hans Herfarth
    Lancet 371:1995-6; author reply 1996-7. 2008