Michael G Hennerici

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Diffusion and perfusion MRI for the assessment of carotid atherosclerosis
    Kristina Szabo
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Neuroimaging Clin N Am 12:381-90. 2002
  2. doi request reprint Non-pharmacological strategies for the treatment of acute ischaemic stroke
    Michael G Hennerici
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Germany
    Lancet Neurol 12:572-84. 2013
  3. pmc Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project
    P Maeder
    Centre Hospitalier Universitaire Vaudois, Service de Radiologie, Lausanne, Switzerland
    J Neurol 258:795-803. 2011
  4. ncbi request reprint Cerebrovascular ultrasound
    M G Hennerici
    Department of Neurology, Klinikum Mannheim, University of Heidelberg, Germany
    Curr Opin Neurol 12:57-63. 1999
  5. doi request reprint Rationale and design of the Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin with Terutroban in Patients with a History of Ischemic Stroke or Transient Ischemic Attack (PERFORM) Study
    Michael G Hennerici
    University of Heidelberg, UMM, Theodor Kutzer Ufer 1 3, Mannheim DE 68135, Germany
    Cerebrovasc Dis 27:28-32. 2009
  6. ncbi request reprint The unstable plaque
    Michael G Hennerici
    Department of Neurology, University of Heidelberg, Klinikum Mannheim, Germany
    Cerebrovasc Dis 17:17-22. 2004
  7. pmc Rationale, design and population baseline characteristics of the PERFORM vascular project: an ancillary study of the Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke o
    Michael G Hennerici
    Department of Neurology, University of Heidelberg, Mannheim, Germany
    Cardiovasc Drugs Ther 24:175-80. 2010
  8. ncbi request reprint Ultrasound and arterial wall disease
    Michael Hennerici
    Department of Neurology, University of Heidelberg, Universitatsklinikum Mannheim, Mannheim, Germany
    Cerebrovasc Dis 17:19-33. 2004
  9. ncbi request reprint Refined analysis of transcranial Doppler HITS
    M G Hennerici
    Department of Neurology, Ruprecht Karls Universitat Heidelberg, Universitatsklinikum Mannheim, D 68135 Mannheim, Germany
    Lancet Neurol 1:406. 2002
  10. ncbi request reprint Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: a randomised controlled trial
    Michael G Hennerici
    Department of Neurology, University of Heidelberg, Universitatsklinikum Mannheim, D 68135 Mannheim, Germany
    Lancet 368:1871-8. 2006

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Diffusion and perfusion MRI for the assessment of carotid atherosclerosis
    Kristina Szabo
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Neuroimaging Clin N Am 12:381-90. 2002
    ..Obtaining background information using this array of MR data may eventually become a basis for optimal risk-benefit assessment in patients with carotid artery stenosis...
  2. doi request reprint Non-pharmacological strategies for the treatment of acute ischaemic stroke
    Michael G Hennerici
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Germany
    Lancet Neurol 12:572-84. 2013
    ..The future of acute stroke therapy relies on evidence for individually tailored, effective, safe, and rapidly accessible treatment probably consisting of combined pharmacological and improved non-pharmacological approaches...
  3. pmc Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project
    P Maeder
    Centre Hospitalier Universitaire Vaudois, Service de Radiologie, Lausanne, Switzerland
    J Neurol 258:795-803. 2011
    ....
  4. ncbi request reprint Cerebrovascular ultrasound
    M G Hennerici
    Department of Neurology, Klinikum Mannheim, University of Heidelberg, Germany
    Curr Opin Neurol 12:57-63. 1999
    ..Three recent consensus meetings have provided detailed recommendations on quantification of carotid artery stenosis, on characterization of carotid artery plaques and on microembolism detection by transcranial Doppler...
  5. doi request reprint Rationale and design of the Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin with Terutroban in Patients with a History of Ischemic Stroke or Transient Ischemic Attack (PERFORM) Study
    Michael G Hennerici
    University of Heidelberg, UMM, Theodor Kutzer Ufer 1 3, Mannheim DE 68135, Germany
    Cerebrovasc Dis 27:28-32. 2009
    ..Terutroban is a specific thromboxane A2 receptor antagonist with antithrombotic, antivasoconstrictive, and antiatherosclerotic properties, which make it a promising tool for secondary prevention of ischemic stroke...
  6. ncbi request reprint The unstable plaque
    Michael G Hennerici
    Department of Neurology, University of Heidelberg, Klinikum Mannheim, Germany
    Cerebrovasc Dis 17:17-22. 2004
    ..Unstable plaques place patients at risk of unpredictable ischaemic events and in patients with such lesions, specific preventive treatment beyond long-term antiplatelet therapy can be used to prevent new or recurrent events...
  7. pmc Rationale, design and population baseline characteristics of the PERFORM vascular project: an ancillary study of the Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke o
    Michael G Hennerici
    Department of Neurology, University of Heidelberg, Mannheim, Germany
    Cardiovasc Drugs Ther 24:175-80. 2010
    ..The PERFORM Vascular Project will evaluate the effect of terutroban on progression of atherosclerosis, as assessed by change in carotid intima-media thickness (CIMT) in a subgroup of patients...
  8. ncbi request reprint Ultrasound and arterial wall disease
    Michael Hennerici
    Department of Neurology, University of Heidelberg, Universitatsklinikum Mannheim, Mannheim, Germany
    Cerebrovasc Dis 17:19-33. 2004
    ....
  9. ncbi request reprint Refined analysis of transcranial Doppler HITS
    M G Hennerici
    Department of Neurology, Ruprecht Karls Universitat Heidelberg, Universitatsklinikum Mannheim, D 68135 Mannheim, Germany
    Lancet Neurol 1:406. 2002
  10. ncbi request reprint Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: a randomised controlled trial
    Michael G Hennerici
    Department of Neurology, University of Heidelberg, Universitatsklinikum Mannheim, D 68135 Mannheim, Germany
    Lancet 368:1871-8. 2006
    ..The European Stroke Treatment with Ancrod Trial was undertaken to assess the effects of ancrod when given within 6 h...
  11. ncbi request reprint Imaging arterial wall disease
    M Hennerici
    Department of Neurology, University of Heidelberg, Klinikum Mannheim, Mannheim, Germany
    Cerebrovasc Dis 10:9-20. 2000
    ..This article highlights pertinent issues of imaging of arterial wall disease and discusses important areas of current and future research in this field...
  12. doi request reprint Dynamic susceptibility contrast perfusion MRI identifies persistent vessel pathology in acute pontine stroke
    Alex Förster
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany a foerster neuro ma uni heidelberg de
    Cerebrovasc Dis 29:389-94. 2010
    ..The ability of MRA and conventional MRI sequences to demonstrate branches of the basilar artery (BA) is very limited. This study analyzes the value of the combined use of diffusion-weighted MRI (DWI), MRA and PWI in acute pontine stroke...
  13. doi request reprint Predictors and early outcome of hemorrhagic transformation after acute ischemic stroke
    Micha Kablau
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 32:334-41. 2011
    ..We analyzed potential predictors and early outcome of HT after stroke detected by MRI with T(2)*-weighted gradient echo sequences (T(2)*-MRI)...
  14. doi request reprint Loss of callosal fibre integrity in healthy elderly with age-related white matter changes
    Martin Griebe
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurol 258:1451-9. 2011
    ..Loss of tissue integrity and atrophy of the CC secondary to spatially remote lesions in the peri- and paraventricular white matter in ARWMC appear to be already detectable in healthy elderly individuals...
  15. doi request reprint Cerebral network disruption as a possible mechanism for impaired recovery after acute pontine stroke
    Alex Förster
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 31:499-505. 2011
    ..We tested the hypothesis that the extent of WML has an effect on functional recovery in acute pontine stroke by disrupting the integrity of the supratentorial cerebral network...
  16. doi request reprint TIMP-2 gene polymorphism is associated with intracerebral hemorrhage
    Bjoern Reuter
    Department of Neurology, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Cerebrovasc Dis 28:558-63. 2009
    ..TIMP-2 is an important endogenous inhibitor of MMP-2. Alterations in the TIMP-2 gene expression may contribute to the incidence of ischemic stroke and intracerebral hemorrhage...
  17. doi request reprint Clinical and MRI patterns of pericallosal artery infarctions: the significance of supplementary motor area lesions
    Angelika Alonso
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, 68167, Mannheim, Germany
    J Neurol 259:944-51. 2012
    ..Clinically, they are mainly characterized by hemiparesis predominately in the lower limb caused by involvement of supplementary motor cortex areas without affection of the corticospinal tract...
  18. doi request reprint Rapid response of parkinsonian tremor to STN-DBS changes: direct modulation of oscillatory basal ganglia activity?
    Christian Blahak
    Department of Neurology, Universitaetsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Mov Disord 24:1221-5. 2009
    ..These findings support the hypothesis that STN-DBS acts by direct interference with the neurotransmission of basal ganglia networks involved in tremor...
  19. doi request reprint Hippocampal lesion patterns in acute posterior cerebral artery stroke: clinical and MRI findings
    Kristina Szabo
    Department of Neurology, Universitatsklinikum Mannheim, Theodor Kutzer Ufer, 68137 Mannheim, Germany
    Stroke 40:2042-5. 2009
    ..Reports of ischemic stroke affecting the hippocampus are rare. In this study we used diffusion-weighted MRI (DWI) to characterize patients with posterior circulation stroke involving the hippocampus...
  20. doi request reprint Early spontaneous recanalization following acute carotid occlusion
    Kristina Szabo
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    J Neuroimaging 18:148-53. 2008
    ..Occlusion of the internal carotid artery (ICA) and stroke may be the consequence of either local thrombosis due to atherosclerosis or massive embolism. Up to date, there are only few reports of subsequent recanalization...
  21. doi request reprint Posterior versus Anterior Circulation Stroke in Young Adults: A Comparative Study of Stroke Aetiologies and Risk Factors in Stroke among Young Fabry Patients (sifap1)
    Bettina von Sarnowski
    Department of Neurology, University Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Cerebrovasc Dis 43:152-160. 2017
    ..Especially data on young patients is missing...
  22. doi request reprint Temporal profile of matrix metalloproteinases and their inhibitors in a human endothelial cell culture model of cerebral ischemia
    Björn Reuter
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 35:514-20. 2013
    ..Their effect is dampened by the endogenous tissue inhibitors of metalloproteinases (TIMPs). The respective cellular source of specific MMPs and TIMPs during BBB breakdown is still under investigation...
  23. doi request reprint Risk prediction of subsequent early stroke in patients with transient ischemic attacks
    Anastasios Chatzikonstantinou
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 36:106-9. 2013
    ..g. fluctuations) have been used to predict early stroke risk in patients admitted to hospital after transient ischemic attacks (TIAs). We compared the utility of these scores and signs for prognosis and outcome...
  24. doi request reprint Comparison of the European and Japanese guidelines for the management of ischemic stroke
    Rolf Kern
    Department of Neurology, UMM, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 35:402-18. 2013
    ..The first English version of the updated Japanese GLs was published only in 2011 and included differently approved drugs and drug dosages as compared with other American or European countries...
  25. doi request reprint Selective disruption of hippocampus-mediated recognition memory processes after episodes of transient global amnesia
    Theodor Jager
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Neuropsychologia 47:70-6. 2009
    ..In conclusion, consistent with recent neuroanatomical dual-process models of recognition memory, hippocampal dysfunction in patients with TGA is associated with a selective effect on specific recognition memory subprocesses...
  26. pmc Time to treatment with recombinant tissue plasminogen activator and outcome of stroke in clinical practice: retrospective analysis of hospital quality assurance data with comparison with results from randomised clinical trials
    Christoph Gumbinger
    Department of Neurology Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany
    BMJ 348:g3429. 2014
    ..To study the time dependent effectiveness of thrombolytic therapy for acute ischaemic stroke in daily clinical practice...
  27. doi request reprint MRI in acute cerebral ischemia of the young: the Stroke in Young Fabry Patients (sifap1) Study
    Franz Fazekas
    From the Departments of Neurology F F, C E, R S, S R and Radiology C E, Division of Neuroradiology, Medical University of Graz, Austria Institute for Stroke and Dementia Research M D, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munchen, Germany Department of Biostatistics and Clinical Epidemiology B G, M H, P M, Charite Universitatsmedizin, and Robert Koch Institut B G, Berlin Department of Neurology and Center for Stroke Research Berlin G J J, Charité Universitätsmedizin Berlin Department of Neurology M G H, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim Institute of Clinical Epidemiology and Biometry P H, Comprehensive Heart Failure Center, University of Wurzburg, and Centre for Clinical Studies, University Hospital Würzburg Justus Liebig University M K, C T, Giessen Department of Neurology C K, University of Greifswald, Germany Department of Neurology J P, T T, Helsinki University Central Hospital, Helsinki, Finland Department of Clinical Neuroscience B N, Lund University Hospital, Lund, Sweden and Albrecht Kossel Institute for Neuroregeneration A R, University of Rostock
    Neurology 81:1914-21. 2013
    ..We focused on cerebral imaging findings in a large cohort of young patients with a symptomatic ischemic cerebrovascular event (CVE) to extract relevant pathophysiologic and clinical information...
  28. doi request reprint Micrographia induced by pallidal DBS for segmental dystonia: a subtle sign of hypokinesia?
    Christian Blahak
    Department of Neurology, Universitaetsmedizin Mannheim, UMM, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    J Neural Transm (Vienna) 118:549-53. 2011
    ..We propose that this finding reflects GPi-DBS-induced disturbances of basal ganglia function in terms of a mild hypokinetic syndrome, as a result of outflow alterations in pallido-thalamo-cortical pathways...
  29. doi request reprint Improved detection of intracerebral hemorrhage with transcranial ultrasound perfusion imaging
    Rolf Kern
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 26:277-83. 2008
    ..In contrast to the increasing experience with this method in patients with ischemic stroke, data on the value of UPI for the diagnosis of intracerebral hemorrhage (ICH) are lacking...
  30. doi request reprint Heterogeneity of acute multiple sclerosis lesions on sodium (23Na) MRI
    Philipp Eisele
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Germany
    Mult Scler 22:1040-7. 2016
    ..Advanced magnetic resonance imaging (MRI) techniques provide a window into pathological processes in multiple sclerosis (MS). Nevertheless, to date only few studies have performed sodium MRI in MS...
  31. doi request reprint Thrombolysis in experimental cerebral amyloid angiopathy and the risk of secondary intracerebral hemorrhage
    Björn Reuter
    From the Department of Neurology, Universitätsmedizin Mannheim B R, S G, E C, S M, A E, M G H, M F and Computer Assisted Clinical Medicine, Medical Faculty Mannheim P H, L R S, University of Heidelberg, Mannheim, Germany and Nervous System Department, Novartis Institutes for BioMedical Research, Basel, Switzerland M S
    Stroke 45:2411-6. 2014
    ..Cerebral amyloid angiopathy increases the risk for spontaneous lobar ICH. Although thrombolysis may be performed in cerebral amyloid angiopathy-affected patients, there is still little knowledge available on the risk for secondary ICH...
  32. doi request reprint Real-time ultrasound perfusion imaging in acute stroke: assessment of cerebral perfusion deficits related to arterial recanalization
    Manuel Bolognese
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Ultrasound Med Biol 39:745-52. 2013
    ..This offers the chance for bedside monitoring of the hemodynamic compromise (e.g. during therapeutic interventions such as systemic thrombolysis)...
  33. doi request reprint Features of acute DWI abnormalities related to status epilepticus
    Anastasios Chatzikonstantinou
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Epilepsy Res 97:45-51. 2011
    ..This large series of patients with different features (SE type and cause, various epileptogenic lesions) demonstrates the heterogeneity of the phenomenon of peri-ictal DWI changes...
  34. doi request reprint The transience and nature of cognitive impairments in transient global amnesia: a meta-analysis
    Theodor Jager
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    J Clin Exp Neuropsychol 31:8-19. 2009
    ..32 and 0.44). All cognitive diminutions resolved within the long-term phase, by this calling into question previous reports of poorer performance of TGA patients relative to comparison subjects weeks or months after the attack...
  35. doi request reprint Lipoaspirate-derived adult mesenchymal stem cells improve functional outcome during intracerebral hemorrhage by proliferation of endogenous progenitor cells stem cells in intracerebral hemorrhages
    Marc Fatar
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Germany
    Neurosci Lett 443:174-8. 2008
    ..Treatment with PLA-MSC improved the functional outcome significantly in an experimental ICH model. This effect was achieved by stimulation of endogenous progenitor cells rather than integration and differentiation of the infused PLA-MSC...
  36. doi request reprint In vivo clot lysis of human thrombus with intravenous abciximab immunobubbles and ultrasound
    Angelika Alonso
    Department of Neurology, University Hospital of Mannheim, Germany
    Thromb Res 124:70-4. 2009
    ..2 MHz ultrasound in combination with abciximab immunobubbles induces thrombolysis without lytic agents that is superior to insonation of non-specific immunobubbles...
  37. doi request reprint Clearance of albumin following ultrasound-induced blood-brain barrier opening is mediated by glial but not neuronal cells
    Angelika Alonso
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Germany
    Brain Res 1411:9-16. 2011
    ..As albumin uptake into neurons has been shown to be neurotoxic, rapid albumin clearance by microglia might prevent neuronal cell death...
  38. ncbi request reprint Long-term follow-up of chronic spinal cord stimulation for medically intractable orthostatic tremor
    Christian Blahak
    Department of Neurology, Universitaetsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurol 263:2224-2228. 2016
    ..PSR score was 4 or 5 in three patients and 3 in the other. In conclusion, SCS is an effective long-term treatment option in patients with otherwise intractable OT...
  39. ncbi request reprint True Effects or Bias? MMP-2 and MMP-9 Serum Concentrations after Acute Stroke
    Stefan H Kreisel
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 42:352-360. 2016
    ..The aim of this study was to investigate the dynamics of these enzymes in repeated measurements in the acute post-stroke period, in respect to different stroke etiologies, and highlight potential sources for variability...
  40. doi request reprint Acute Stroke Syndromes with Isolated Hypoperfusion on MRI - A Clinical and MRI Study
    Angelika Alonso
    Department of Neurology, Universitx00E4 tsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Eur Neurol 75:27-32. 2016
    ....
  41. doi request reprint Brain magnetic resonance imaging findings fail to suspect Fabry disease in young patients with an acute cerebrovascular event
    Franz Fazekas
    From the Department of Neurology F F, C E, R S, S R and Division of Neuroradiology, Department of Radiology C E, Medical University of Graz, Graz, Austria Department of Biostatistics and Clinical Epidemiology, Charite Universitatsmedizin, Berlin, Germany U G Albrecht Kossel Institute for Neuroregeneration, University of Rostock, Rostock, Germany A K G, A R Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany M G H Department of Neurology, Klinikum Friedrichshafen, Friedrichshafen, Germany R H Department of Neurology, Jüdisches Krankenhaus, Berlin, Germany G J J Center for Stroke Research Berlin CSB, Charite Universitatsmedizin, Berlin, Germany G J J Justus Liebig University, Giessen, Germany M K, C T Department of Neurology, University Medicine Greifswald, Greifswald, Germany C K, B v S Institute for Biostatistics, University of Tubingen, Tubingen
    Stroke 46:1548-53. 2015
    ..In a large group of young patients with an acute cerebrovascular event, we wanted to test whether brain MRI findings can serve to suggest the presence of FD...
  42. doi request reprint Investigation of leptomeningeal enhancement in MS: a postcontrast FLAIR MRI study
    Philipp Eisele
    From the Department of Neurology P E, M G, K S, M E W, A A, M G H, A G, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany and Theodor Kocher Institute B E, University of Bern, Switzerland
    Neurology 84:770-5. 2015
    ..To investigate possible leptomeningeal contrast enhancement using postcontrast fluid-attenuated inversion recovery (FLAIR) MRI as an additional marker of inflammation in patients with multiple sclerosis (MS)...
  43. doi request reprint Effect of simvastatin on MMPs and TIMPs in human brain endothelial cells and experimental stroke
    Björn Reuter
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Transl Stroke Res 6:156-9. 2015
    ..Our results provide evidence for a positive effect of simvastatin on the MMP metabolism in human BMECs and experimental stroke mainly by means of the increased expression and secretion of TIMP-1 and TIMP-2. ..
  44. doi request reprint Cervical artery dissection in young adults in the stroke in young Fabry patients (sifap1) study
    Bettina von Sarnowski
    Department of Neurology, University Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Cerebrovasc Dis 39:110-21. 2015
    ....
  45. doi request reprint Thrombolysis in patients with lacunar stroke is safe: an observational study
    Martin Griebe
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    J Neurol 261:405-11. 2014
    ..Patients with acute lacunar stroke benefited from thrombolysis without additional complications. Thus, patients with suspected acute lacunar stroke or lacunar syndrome should not be treated differently than other stroke populations. ..
  46. doi request reprint Less is more: adaptation of voltage after battery replacement in deep brain stimulation for dystonia
    Christian Blahak
    Department of Neurology, Universitätsmedizin Mannheim UMM, University of Heidelberg, Mannheim, Germany
    Stereotact Funct Neurosurg 88:311-4. 2010
    ..So far however, no data are available regarding the adjustment of voltage after implantable pulse generator (IPG) replacement to achieve sustained optimal control of dystonia with the least side effects...
  47. ncbi request reprint Infrared spectroscopy: a new diagnostic tool in Alzheimer disease
    Martin Griebe
    Department of Neurology, Universitaetsklinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Neurosci Lett 420:29-33. 2007
    ..Larger sample numbers for ANN training and validation could increase diagnostic accuracy and thus prove to be a useful screening tool...
  48. pmc Real-time ultrasound brain perfusion imaging with analysis of microbubble replenishment in acute MCA stroke
    Rolf Kern
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    J Cereb Blood Flow Metab 31:1716-24. 2011
    ..76 and A × β<1.91. We conclude that rt-UPI with analysis of microbubble replenishment correctly identifies ischemic brain tissue in acute MCA stroke...
  49. ncbi request reprint Pathophysiology of stroke rehabilitation: the natural course of clinical recovery, use-dependent plasticity and rehabilitative outcome
    Stefan H Kreisel
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 23:243-55. 2007
    ..Though the interaction between rehabilitation and plasticity remains elusive, an attempt is made to clarify how and to what extent rehabilitative therapy shapes motor recovery...
  50. pmc Intracranial Hypertension as an Acute Complication of Aseptic Meningoencephalitis with Leptomeningeal Contrast Enhancement on FLAIR MRI
    Marc E Wolf
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Case Rep Neurol 8:10-5. 2016
    ..In such a prolonged course, a continuous lumbar drainage might be a temporary option to provide rapid symptom relief to the patient. ..
  51. doi request reprint Investigation of cerebral microbleeds in multiple sclerosis as a potential marker of blood-brain barrier dysfunction
    Philipp Eisele
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany Electronic address
    Mult Scler Relat Disord 7:61-4. 2016
    ..We were interested in the potential role of T(2)*-weighted MRI and CMBs as BBB integrity markers in MS...
  52. doi request reprint Body weight gain in patients with bilateral deep brain stimulation for dystonia
    Marc E Wolf
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    J Neural Transm (Vienna) 123:261-7. 2016
    ..This probably is a result of improvement of dystonic motor symptoms and recovery of eating dysfunction rather than a target-specific phenomenon. ..
  53. doi request reprint Prediction of Early Reperfusion From Repeated Arterial Spin Labeling Perfusion Magnetic Resonance Imaging During Intravenous Thrombolysis
    Shuhei Okazaki
    From the Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany S O, M G, J S S, M E W, A G, M G H, K S, R K mediri GmbH, Heidelberg, Germany J G, M G Institute for Medical Image Computing MEVIS, Fraunhofer MEVIS, Bremen, Germany M G MR Imaging and Spectroscopy, Faculty 01 Physics Electrical Engineering, University of Bremen, Bremen, Germany M G and Department of Neurology, Klinikum Kempten, Kempten Oberallgaeu, Germany R K
    Stroke 47:247-50. 2016
    ..We monitored the time course of cerebral perfusion changes in patients during thrombolysis with repeated arterial spin labeling perfusion magnetic resonance imaging...
  54. doi request reprint Cerebrospinal fluid pleocytosis in multiple sclerosis patients with lesions showing reduced diffusion
    Philipp Eisele
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Germany
    Mult Scler 20:1391-5. 2014
    ..Furthermore, the ADC reduction and CSF pleocytosis were observed only early after symptom onset, which suggests that both are typically early and transient phenomena...
  55. ncbi request reprint Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: results of a phase II clinical trial
    Michael Daffertshofer
    Department of Neurology, Universitatsklinikum Mannheim, Germany
    Stroke 36:1441-6. 2005
    ..We therefore conducted the first multicenter clinical trial to investigate safety of tPA plus low-frequency ultrasound (300 kHz)...
  56. doi request reprint MMP-2 concentrations in stroke according to etiology: adjusting for enzyme degradation in stored deep-frozen serum and other methodological pitfalls
    Stefan H Kreisel
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Heidelberg, Germany
    J Clin Neurosci 19:1564-7. 2012
    ..After adjustment for time to analysis and ELISA plate clustering, patients with cardioembolic stroke had significantly higher MMP-2 concentrations in comparison to all other stroke subtypes...
  57. doi request reprint Stroke and cancer: the importance of cancer-associated hypercoagulation as a possible stroke etiology
    Christopher J Schwarzbach
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Stroke 43:3029-34. 2012
    ..A recent study has suggested that cancer-associated hypercoagulation may be of special importance in the absence of conventional stroke mechanisms...
  58. pmc Stroke-Like Presentation of Toxic Leukoencephalopathy as the Initial Manifestation of HIV Infection
    Björn Reuter
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Case Rep Neurol 4:231-5. 2012
    ..We report a 23-year-old man with sudden onset of a right hemispheric sensorimotor syndrome and final diagnosis of HIV-induced toxic leukoencephalopathy...
  59. doi request reprint Microstructure of a three-way anatomical network predicts individual differences in response inhibition: a tractography study
    Andrea V King
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Square J5, 68159 Mannheim, Germany
    Neuroimage 59:1949-59. 2012
    ..These findings point to a specific contribution of white matter pathways connecting distinct basal ganglia structures with both medial frontal and ventrolateral prefrontal regions to response inhibition...
  60. doi request reprint Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain
    Julia Linke
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany
    Neuroimage 59:3288-96. 2012
    ..In sum, our findings show that ANK3 rs10994336 or a variant in linkage-disequilibrium is functional in the human brain and also influences behavioral phenotypes related to bipolar disorder...
  61. ncbi request reprint Vascular diagnosis and acute stroke: what, when and why not?
    Kristina Szabo
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 20:11-8. 2005
    ....
  62. doi request reprint Cerebral microbleeds are uncommon in ischemic stroke associated with nonvalvular atrial fibrillation
    Anastasios Chatzikonstantinou
    Department of Neurology, Universitatsklinikum Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim, Germany
    J Neuroimaging 21:103-7. 2011
    ..Patients with cardioembolic ischemic stroke from nonvalvular atrial fibrillation (NVAF) are candidates for long-term anticoagulation. This study examines the prevalence of cerebral microbleeds (MBs) in stroke patients with NVAF...
  63. pmc Reorganization of gap junctions after focused ultrasound blood-brain barrier opening in the rat brain
    Angelika Alonso
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    J Cereb Blood Flow Metab 30:1394-402. 2010
    ..The plaque-size increase may be a cellular response to imbalances in extracellular homeostasis after BBB leakage...
  64. ncbi request reprint Protein S-100B--a prognostic marker for cerebral damage
    Mark Stroick
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Germany
    Curr Med Chem 13:3053-60. 2006
    ..This review considers both conditions for S-100B measurement and illustrates advantages and limitations in comparison with clinical and neuroimaging data...
  65. ncbi request reprint Failure to improve the effect of thrombolysis by memantine in a rat embolic stroke model
    Tobias Back
    Department of Neurology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Neurol Res 29:264-9. 2007
    ..To translate this scenario into an experiment, memantine was combined with thrombolysis in an embolic stroke model and tissue outcome was assessed in terms of complete and incomplete damage...
  66. doi request reprint Outcome Predictors of Acute Stroke Patients in Need of Intensive Care Treatment
    Angelika Alonso
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 40:10-7. 2015
    ..The prognosis of stroke patients admitted to intensive care units (ICU) is commonly regarded to be poor. However, only limited data regarding outcome predictors are available...
  67. pmc DWI Lesion Patterns in Cancer-Related Stroke--Specifying the Phenotype
    Christopher Jan Schwarzbach
    Department of Neurology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany
    Cerebrovasc Dis Extra 5:139-45. 2015
    ....
  68. doi request reprint Transient global amnesia in legal proceedings
    Martin Griebe
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135, Mannheim, Germany
    Int J Legal Med 129:223-6. 2015
    ..In the context of forensic medicine, the knowledge of this disorder and recognition of its typical features are essential...
  69. pmc Reduced functional reserve in patients with age-related white matter changes: a preliminary FMRI study of working memory
    Martin Griebe
    Department of Neurology, MR Research Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    PLoS ONE 9:e103359. 2014
    ..This can be interpreted as a reduction of functional reserve and may pose a risk for cognitive decline in these patients. ..
  70. doi request reprint Presumptive progressive multifocal leukoencephalopathy in multiple sclerosis after natalizumab therapy
    Philipp Eisele
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Germany
    J Neuroimaging 24:425-8. 2014
    ..To describe a patient with relapsing remitting MS who was treated with natalizumab for 36 months. First symptoms of presumptive progressive multifocal leukoencephalopathy (PML) appeared 14 weeks after her last natalizumab infusion...
  71. doi request reprint Deterioration of gait and balance over time: the effects of age-related white matter change--the LADIS study
    Stefan H Kreisel
    Department of Neurology, University of Heidelberg, Universitatsmedizin Mannheim, Mannheim, Germany
    Cerebrovasc Dis 35:544-53. 2013
    ....
  72. pmc Pro-inflammatory mediators and apoptosis correlate to rt-PA response in a novel mouse model of thromboembolic stroke
    Saema Ansar
    Department of Neurology, University Medicine Mannheim, Heidelberg University, Heidelberg, Germany
    PLoS ONE 9:e85849. 2014
    ..We performed a study to elucidate possible mechanisms of this finding in a new model of thromboembolic stroke closely mimicking human pathophysiology...
  73. doi request reprint Prevalence of stenoses and occlusions of brain-supplying arteries in young stroke patients
    Bettina von Sarnowski
    Department of Neurology, University Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Neurology 80:1287-94. 2013
    ..However, data from large cohorts are limited. This study investigates the prevalence of extracranial and intracranial atherosclerosis in stroke and TIA patients aged 18-55 years in the multinational sifap1 study...
  74. pmc Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening
    Angelika Alonso
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Mol Ther Nucleic Acids 2:e73. 2013
    ..Molecular Therapy - Nucleic Acids (2013) 2, e73; doi:10.1038/mtna.2012.64; published online 19 February 2013...
  75. doi request reprint Ischemic stroke in young adults: classification and risk factors
    Anastasios Chatzikonstantinou
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurol 259:653-9. 2012
    ..The ASCO classification should be favored for a better classification of coexisting stroke subtypes and lower number of undetermined etiologies in this patient group...
  76. doi request reprint Pragmatic management of hyperglycaemia in acute ischaemic stroke: safety and feasibility of intensive intravenous insulin treatment
    Stefan H Kreisel
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer, Mannheim, Germany
    Cerebrovasc Dis 27:167-75. 2009
    ..Here we test the safety and feasibility of an intravenous insulin-only infusion protocol designed for pragmatic routine clinical use...
  77. doi request reprint Safety of Tirofiban in acute Ischemic Stroke: the SaTIS trial
    Mario Siebler
    Department of Neurology, University Hospital Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Stroke 42:2388-92. 2011
    ..Safety and efficacy in patients with ischemic stroke are uncertain. This was addressed in the Safety of Tirofiban in acute Ischemic Stroke (SaTIS) trial...
  78. doi request reprint Single-nucleotide polymorphisms of MMP-2 gene in stroke subtypes
    Marc Fatar
    Department of Neurology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 26:113-9. 2008
    ..We therefore evaluated single nucleotide polymorphisms (SNP) of MMP-2 in different subtypes of stroke patients in an association study using a case-control design...
  79. doi request reprint Recent advances in magnetic resonance imaging in posterior circulation stroke: implications for diagnosis and prognosis
    Alex Förster
    Department of Neurology, Universitätsmedizin Medizin Mannheim, Theodor Kutzer Ufer, 68137, Mannheim, Germany
    Curr Treat Options Cardiovasc Med 13:268-77. 2011
    ....
  80. doi request reprint Multimodal assessment of optokinetic visual stimulation response in migraine with aura
    Martin Griebe
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, 68167, Mannheim, Germany
    Headache 54:131-41. 2014
    ..This study aimed to assess activation patterns and the hemodynamic response to optokinetic stimulation in migraine with aura patients compared with controls...
  81. pmc Thromboembolic stroke in C57BL/6 mice monitored by 9.4 T MRI using a 1H cryo probe
    Friederike L Langhauser
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Exp Transl Stroke Med 4:18. 2012
    ..4 T MRI and a 1H surface cryo coil...
  82. ncbi request reprint Stenting for carotid artery stenosis
    Rolf Kern
    Universitatsklinikum Mannheim, University of Heidelberg, 68135 Mannheim, Germany
    Nat Clin Pract Neurol 3:212-20. 2007
    ..Two other randomized multicenter trials-ICSS and CREST-are ongoing. With an intended sample size of up to 7,000 patients, future meta-analyses will allow more-accurate treatment recommendations and subgroup analysis...
  83. doi request reprint Effects of prophylactic antibiotic therapy with mezlocillin plus sulbactam on the incidence and height of fever after severe acute ischemic stroke: the Mannheim infection in stroke study (MISS)
    Stefan Schwarz
    Departments of Neurology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Stroke 39:1220-7. 2008
    ..The aim of this pilot study was to evaluate the effects of prophylactic antibiotic therapy on the incidence and height of fever after acute ischemic stroke...
  84. doi request reprint Transient ischemic attack patients with fluctuations are at highest risk for early stroke
    Anastasios Chatzikonstantinou
    Department of Neurology, Universitatsklinikum Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 27:594-8. 2009
    ..The management and risk of early stroke are unclear in patients with fluctuating neurological symptoms. We aimed to evaluate the clinical course of these patients presenting within 24 h after onset of acute cerebral ischemia symptoms...
  85. doi request reprint Stroke Incidence and Survival in Ludwigshafen am Rhein, Germany: the Ludwigshafen Stroke Study (LuSSt)
    Frederick Palm
    Department of Neurology, Klinikum Ludwigshafen, Ludwigshafen, Germany
    Stroke 41:1865-70. 2010
    ..To test this hypothesis and to provide data on stroke incidence and case-fatality rates, a population-based stroke register was initiated...
  86. ncbi request reprint Pathophysiology of stroke rehabilitation: temporal aspects of neuro-functional recovery
    Stefan H Kreisel
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 21:6-17. 2006
    ..These pathophysiological processes potentially interact with rehabilitative interventions. They therefore form the foundation of positive, but possibly also negative recuperation under therapy...
  87. ncbi request reprint Recent advances in imaging in management of symptomatic internal carotid artery disease
    Kristina Szabo
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Stroke 2:97-103. 2007
    ..Furthermore, the results of recent clinical trails that need to be integrated in the optimal treatment plan of these patients are discussed...
  88. ncbi request reprint Tirofiban for the treatment of ischaemic stroke
    Simone C Bukow
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Germany
    Expert Opin Pharmacother 7:73-9. 2006
    ..In recent years, increasing effort in studying glycoprotein IIb/IIIa antagonists has been made, mostly for treatment with abciximab. However, there is one Phase II trial that investigated treatment with tirofiban...
  89. ncbi request reprint Deviations from the diffusion tensor model as revealed by contour plot visualization using high angular resolution diffusion-weighted imaging (HARDI)
    Jochen G Hirsch
    Department of Neurology, University Hospital Mannheim, University of Heidelberg, Germany
    MAGMA 16:93-102. 2003
    ..HARDI confirms and can visualize deviations from the tensor-like representation, thereby providing information on fiber structure complexity, which may be of considerable interest for clinical studies...
  90. ncbi request reprint Tremor reduction by subthalamic nucleus stimulation and medication in advanced Parkinson's disease
    Christian Blahak
    Department of Neurology, Universitäts klinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurol 254:169-78. 2007
    ....
  91. ncbi request reprint Clinical and molecular findings in a patient with a novel mutation in the deafness-dystonia peptide (DDP1) gene
    Johannes Binder
    Department of Neurology, University Hospital Mannheim, University of Heidelberg, Germany
    Brain 126:1814-20. 2003
    ....
  92. pmc Asymptomatic and symptomatic carotid stenosis: an obsolete classification?
    Anastasios Chatzikonstantinou
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Stroke Res Treat 2012:340798. 2012
    ..Patients in this short time window benefit from additional carotid intervention, under the condition of an individually favorable benefit-risk ratio ("individual vulnerability")...
  93. ncbi request reprint Brain temperature during 340-kHz pulsed ultrasound insonation: a safety study for sonothrombolysis
    Marc Fatar
    Department of Neurology, Klinikum Mannheim, University of Heidelberg, Germany
    Stroke 37:1883-7. 2006
    ....
  94. ncbi request reprint Stroke vignette. Nontraumatic combined intracranial hemorrhage in elderly patients
    Johannes Binder
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 17:351-2. 2004
  95. doi request reprint Motivational orientation modulates the neural response to reward
    Julia Linke
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany
    Neuroimage 49:2618-25. 2010
    ....
  96. pmc Thrombolytic stroke treatment of a 12-year-old girl with intracranial fibromuscular dysplasia
    Manuel Bolognese
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Case Rep Neurol 3:210-3. 2011
    ..We present a case of a 12-year-old girl with acute ischemic stroke, due to fibromuscular dysplasia of the distal internal carotid artery and the proximal middle cerebral artery, which was successfully treated with t-PA...
  97. ncbi request reprint Combined MR measurements of magnetization transfer, tissue diffusion and proton spectroscopy. A feasibility study with neurological cases
    Tobias Back
    Department of Neurology, Philipps University Marburg, R Bultmann Str 8, D 35039 Marburg, Germany
    Neurol Res 25:292-300. 2003
    ..Combined measurements of ADC, MTR and CSI are feasible and provide differential in-vivo information on various brain pathologies...
  98. doi request reprint Pathophysiological concepts of stroke in hemodynamic risk zones--do hypoperfusion and embolism interact?
    Alex Förster
    Stroke Unit, Department of Neurology, at the Universitätsklinikum Mannheim, Mannheim, Germany
    Nat Clin Pract Neurol 4:216-25. 2008
    ....
  99. ncbi request reprint Dystonia in the Mohr-Tranebjaerg syndrome responds to GABAergic substances
    Stefan H Kreisel
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Mov Disord 19:1241-3. 2004
    ..In the patient presented here, improvement of dystonic symptoms upon treatment with alcohol and GABAergic substances is demonstrated for the first time...
  100. doi request reprint Challenges to the management of high-risk stroke patients with multiple-site occlusive vascular disease
    Dirk Sander
    Department of Neurology, Benedictus Hospital, Tutzing, Germany
    Cerebrovasc Dis 31:315-21. 2011
    ..Optimised Stroke Care for Re-Admission Reduction in Europe (OSCARE) is an initiative that has been set up to address some of these shortcomings...
  101. ncbi request reprint Early motor evoked potentials in acute stroke: adjunctive measure to MRI for assessment of prognosis in acute stroke within 6 hours
    Johannes C Wohrle
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, DE 68167 Mannheim, Germany
    Cerebrovasc Dis 18:130-4. 2004
    ..Rather than relying on imaging, we evaluated motor evoked potentials (MEP) as a measure of cerebral function in the acute stroke setting...