Jorg Heller

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Increased urotensin II plasma levels in patients with cirrhosis and portal hypertension
    Jorg Heller
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Hepatol 37:767-72. 2002
  2. ncbi request reprint Acute haemodynamic effects of losartan in anaesthetized cirrhotic rats
    J Heller
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Clin Invest 33:1006-12. 2003
  3. ncbi request reprint Vascular, hemodynamic and renal effects of low-dose losartan in rats with secondary biliary cirrhosis
    Jorg Heller
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 25:657-66. 2005
  4. ncbi request reprint Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Gastroenterology 130:838-54. 2006
  5. ncbi request reprint Prognostic impact of renal impairment and sodium imbalance in patients undergoing transjugular intrahepatic portosystemic shunting for the prevention of variceal rebleeding
    Michael Schepke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Digestion 67:146-53. 2003
  6. doi request reprint Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 50:1924-35. 2009
  7. doi request reprint Degree of hepatic dysfunction and improvement of renal function predict survival in patients with HRS type I: a retrospective analysis
    Beate Appenrodt
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Gastroenterol Hepatol 21:1428-32. 2009
  8. ncbi request reprint Prognostic role of the initial portal pressure gradient reduction after TIPS in patients with cirrhosis
    Erwin Biecker
    Department of Internal Medicine I, University Hospital of Bonn, University of Bonn, Sigmund Freud Str 25, Bonn, Germany
    Eur J Gastroenterol Hepatol 19:846-52. 2007
  9. doi request reprint Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 47:1264-76. 2008
  10. doi request reprint Lack of effect of norfloxacin on hyperdynamic circulation in bile duct-ligated rats despite reduction of endothelial nitric oxide synthase function: result of unchanged vascular Rho-kinase?
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 29:933-41. 2009

Detail Information

Publications35

  1. ncbi request reprint Increased urotensin II plasma levels in patients with cirrhosis and portal hypertension
    Jorg Heller
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Hepatol 37:767-72. 2002
    ..We therefore investigated the role of Urotensin II (U II), a newly described peptide reported to be a vasoconstrictor in the central arterial compartment and a vasodilator in the splanchnic vasculature...
  2. ncbi request reprint Acute haemodynamic effects of losartan in anaesthetized cirrhotic rats
    J Heller
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Clin Invest 33:1006-12. 2003
    ..The angiotensin II type 1 receptor antagonist losartan has been suggested as a portal pressure-lowering drug in patients with cirrhosis...
  3. ncbi request reprint Vascular, hemodynamic and renal effects of low-dose losartan in rats with secondary biliary cirrhosis
    Jorg Heller
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 25:657-66. 2005
    ..We hypothesized that losartan decreases portal pressure by counteracting the impaired vascular responsive to alpha1-adrenoceptor agonists...
  4. ncbi request reprint Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Gastroenterology 130:838-54. 2006
    ..We investigated the role of the RhoA/Rho-kinase pathway in vascular smooth muscle hypocontractility of rats with secondary biliary cirrhosis...
  5. ncbi request reprint Prognostic impact of renal impairment and sodium imbalance in patients undergoing transjugular intrahepatic portosystemic shunting for the prevention of variceal rebleeding
    Michael Schepke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Digestion 67:146-53. 2003
    ....
  6. doi request reprint Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 50:1924-35. 2009
    ..beta(3)-AR agonists decrease intrahepatic resistance and portal pressure in cirrhotic rats...
  7. doi request reprint Degree of hepatic dysfunction and improvement of renal function predict survival in patients with HRS type I: a retrospective analysis
    Beate Appenrodt
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Gastroenterol Hepatol 21:1428-32. 2009
    ..Therefore, it is important to define parameters that predict an improved outcome in respect to kidney function and survival...
  8. ncbi request reprint Prognostic role of the initial portal pressure gradient reduction after TIPS in patients with cirrhosis
    Erwin Biecker
    Department of Internal Medicine I, University Hospital of Bonn, University of Bonn, Sigmund Freud Str 25, Bonn, Germany
    Eur J Gastroenterol Hepatol 19:846-52. 2007
    ....
  9. doi request reprint Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 47:1264-76. 2008
    ..Moreover, palosuran increased renal blood flow, sodium, and water excretion in BDL rats...
  10. doi request reprint Lack of effect of norfloxacin on hyperdynamic circulation in bile duct-ligated rats despite reduction of endothelial nitric oxide synthase function: result of unchanged vascular Rho-kinase?
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 29:933-41. 2009
    ..We investigated the haemodynamic and vascular effects of norfloxacin in rats with secondary biliary cirrhosis...
  11. ncbi request reprint Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 46:242-53. 2007
    ..Furthermore, in BDL rats, atorvastatin significantly increased hepatic endothelial nitric oxide synthase (eNOS) mRNA and protein levels, phospho-eNOS, nitrite/nitrate, and the activity of the NO effector protein kinase G (PKG)...
  12. doi request reprint Treatment of bile duct-ligated rats with the nitric oxide synthase transcription enhancer AVE 9488 ameliorates portal hypertension
    Erwin Biecker
    Department of Internal Medicine I, University Hospital of Bonn, University of Bonn, Bonn, Germany
    Liver Int 28:331-8. 2008
    ..Nitric oxide levels are decreased in the cirrhotic liver and increased in the systemic vasculature. We investigated whether the nitric oxide synthase (NOS) transcription enhancer AVE 9488 ameliorates portal hypertension in cirrhotic rats...
  13. doi request reprint Irbesartan plus low-dose propranolol versus low-dose propranolol alone in cirrhosis: a placebo-controlled, double-blind study
    Michael Schepke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Am J Gastroenterol 103:1152-8. 2008
    ..This study aimed at comparing the effects of a combined treatment using irbesartan plus propranolol with propranolol monotherapy on portal pressure and kidney function in patients with cirrhosis...
  14. doi request reprint Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 31:860-70. 2011
    ..To investigate the differences between CB(1) and CB(2) in the hepatic response to chronic alcohol intake, we examined CB knockout mice (CB(1)(-/-), CB(2)(-/-))...
  15. doi request reprint Hepatic VASP upregulation in rats with secondary biliary cirrhosis by expression in the peribiliary vascular plexus
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Germany
    Microvasc Res 78:235-40. 2009
    ..Here, we investigated hepatic VASP expression in response to bile duct ligation (BDL) of rats...
  16. doi request reprint Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Germany
    J Hepatol 53:702-12. 2010
    ..In vitro, HMG-CoA reductase inhibitors (statins) inhibit proliferation and induce apoptosis of myofibroblastic HSC. To investigate the antifibrotic effects of atorvastatin in vivo we used bile duct ligated rats (BDL)...
  17. ncbi request reprint Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 45:495-506. 2007
    ..Angiotensin II-stimulated moesin phosphorylation was decreased in aortas from BDL rats. MLC phosphatase activity was elevated in aortas from BDL rats...
  18. doi request reprint Hepatic and HSC-specific sorafenib effects in rats with established secondary biliary cirrhosis
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lab Invest 91:241-51. 2011
    ..This leads to the decrease in intrahepatic vascular resistance, but also to liver damage in the dosage we used. Therefore, any translation to portal hypertensive patients who may profit from sorafenib should be done with particular care...
  19. pmc Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis
    Q Zhou
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Gut 55:1296-305. 2006
    ..Activation of the RhoA/Rho-kinase pathway is essential for contraction of vascular smooth muscle. The aim of this study was to investigate RhoA/Rho-kinase mediated regulation of the intrahepatic vascular tone in cirrhotic rats...
  20. ncbi request reprint Agmatine (decarboxylated arginine), a modulator of liver cell homeostasis and proliferation
    Bettina Kribben
    Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, 53113 Bonn, Germany
    Naunyn Schmiedebergs Arch Pharmacol 369:160-5. 2004
    ..5+/-0.9% and 22.3+/-1.5% respectively. The decrease in regeneration correlated with a pronounced accumulation of agmatine in the liver. Hence, the present data provide evidence of an involvement of agmatine in liver cell growth...
  21. ncbi request reprint Prognostic factors for patients with cirrhosis and kidney dysfunction in the era of MELD: results of a prospective study
    Michael Schepke
    Department of Internal Medicine I, General Internal Medicine, University of Bonn, Germany
    Liver Int 26:834-9. 2006
    ..The current study prospectively evaluated the incidence and the prognostic relevance of different etiologies of kidney failure in cirrhotic patients...
  22. doi request reprint Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis
    M Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Clin Invest 39:906-13. 2009
    ..In this study, we analysed the interaction of AT(1) receptors with beta-arrestin-2 in the context of vascular hypocontractility in rats with CCl(4)-induced cirrhosis...
  23. doi request reprint Short-term effects of transjugular intrahepatic shunt on cardiac function assessed by cardiac MRI: preliminary results
    A Kovacs
    Department of Radiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Cardiovasc Intervent Radiol 33:290-6. 2010
    ..Normalization of cardiac dimensions was observed after months together with mild left ventricular hypertrophy...
  24. pmc Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis
    M Hennenberg
    Department of Internal Medicine I, University of Bonn, Germany
    Br J Pharmacol 157:258-70. 2009
    ..As the multikinase inhibitor sorafenib inhibits ERK, we tested the effect of sorafenib on haemodynamics and dysregulated vascular Rho kinase in rats with secondary biliary cirrhosis...
  25. doi request reprint Mechanisms of extrahepatic vasodilation in portal hypertension
    M Hennenberg
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Gut 57:1300-14. 2008
    ..The latter phenomenon has been termed "vascular hypocontractility". It is caused by a combination of different mechanisms and factors described in this review...
  26. ncbi request reprint Portal hypertension is associated with increased mRNA levels of vasopressor G-protein-coupled receptors in human hepatic arteries
    M Neef
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Clin Invest 33:249-55. 2003
    ....
  27. ncbi request reprint Comparison of capsule endoscopy and magnetic resonance imaging for the detection of polyps of the small intestine in patients with familial adenomatous polyposis or with Peutz-Jeghers' syndrome
    R Caspari
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Endoscopy 36:1054-9. 2004
    ..We have conducted a study to compare the diagnostic yields of magnetic resonance imaging (MRI) and capsule endoscopy for the detection of small-bowel polyps in patients with inherited polyposis syndromes...
  28. ncbi request reprint Biliary metal stents and air embolism: a note of caution
    C Rabe
    Department of Medicine I, University of Bonn, Bonn, Germany
    Endoscopy 38:648-50. 2006
    ..It is likely that the large diameter of metal stents and the potential for these stents to lacerate venous structures facilitate the entry of air into the venous circulation, an event which may have life-threatening consequences...
  29. ncbi request reprint Hemodynamic effects of the angiotensin II receptor antagonist irbesartan in patients with cirrhosis and portal hypertension
    M Schepke
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
    Gastroenterology 121:389-95. 2001
    ..This randomized, placebo-controlled, double-blind study aimed to assess the effect of the angiotensin II receptor antagonist irbesartan on portal and systemic hemodynamics and renal function in patients with cirrhosis...
  30. doi request reprint Prevention of paracentesis-induced circulatory dysfunction: midodrine vs albumin. A randomized pilot study
    Beate Appenrodt
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 28:1019-25. 2008
    ..Vasoconstrictors, e.g. terlipressin, may also prevent PICD. The aim was to compare the less expensive vasoconstrictor midodrine, an alpha-adrenoceptor agonist, with albumin in preventing PICD...
  31. pmc Diagnosis and management of upper gastrointestinal bleeding
    Erwin Biecker
    Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Dtsch Arztebl Int 105:85-94. 2008
    ..Its clinical presentations are hematemesis, melena stool, or even fresh bleeding per rectum. This paper reviews the diagnosis and treatment of upper GI bleeding...
  32. ncbi request reprint Prevention of recurrent haemorrhage
    Jorg Heller
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Best Pract Res Clin Gastroenterol 21:43-53. 2007
    ..If these preventive strategies fail, transjugular intrahepatic portosystemic shunt (covered) or a small-diameter surgical shunt is indicated...
  33. ncbi request reprint Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis: evidence for a receptor-specific mechanism
    M Schepke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 34:884-8. 2001
    ..Hence, the cause of the hyporesponsiveness to some vasoconstrictors in cirrhosis appears to be a receptor-specific phenomenon localized upstream from the G-protein level...
  34. ncbi request reprint [Medical therapy of complications in liver cirrhosis]
    F Grunhage
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, Bonn, Germany
    Internist (Berl) 48:1349-57. 2007
    ..At the same time treatment of the underlying disease, the identification and treatment of triggering factors and the possibility of liver transplantation should be kept in mind...
  35. doi request reprint Combination of bilateral metal stenting and trans-stent photodynamic therapy for palliative treatment of hilar cholangiocarcinoma
    T Gerhardt
    Department of Internal Medicine I, University Hospital, Bonn, Germany
    Z Gastroenterol 48:28-32. 2010
    ..3 +/- 15.8 vs. 14.4 +/- 22.5 days; p = 0.54). Bilateral insertion of Jostent SelfX in patients with proximal cholangiocarcinoma is feasible and effective and can be safely combined with trans-stent photodynamic therapy...