Karin Hartmann

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Allergic contact dermatitis from cinnamon as an odour-neutralizing agent in shoe insoles
    Karin Hartmann
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Contact Dermatitis 50:253-4. 2004
  2. ncbi request reprint Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis
    Karin Hartmann
    Department of Dermatology, University of Cologne, Cologne, Germany
    Gastroenterology 129:1042-6. 2005
  3. ncbi request reprint Evidence for altered mast cell proliferation and apoptosis in cutaneous mastocytosis
    K Hartmann
    Departments of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
    Br J Dermatol 149:554-9. 2003
  4. ncbi request reprint Cutaneous mastocytosis -- clinical heterogeneity
    Karin Hartmann
    Department of Dermatology, University Hospital, Cologne, Germany
    Int Arch Allergy Immunol 127:143-6. 2002
  5. doi request reprint Effects of topical treatment with the raft modulator miltefosine and clobetasol in cutaneous mastocytosis: a randomized, double-blind, placebo-controlled trial
    K Hartmann
    Department of Dermatology, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Br J Dermatol 162:185-90. 2010
  6. ncbi request reprint [Urticaria. Classification and diagnosis]
    K Hartmann
    Klinik und Poliklinik für Dermatologie und Venerologie der Universität zu Köln, Koln
    Hautarzt 55:340-3. 2004
  7. pmc Expression of Bcl-2 and Bcl-xL in cutaneous and bone marrow lesions of mastocytosis
    Karin Hartmann
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Am J Pathol 163:819-26. 2003
  8. doi request reprint Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit
    Alexander Gerbaulet
    Department of Dermatology, University of Cologne, Cologne, Germany
    Blood 117:2012-21. 2011
  9. doi request reprint Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis
    Sebastian Willenborg
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Invest Dermatol 134:2005-15. 2014
  10. doi request reprint Mast cells play a protumorigenic role in primary cutaneous lymphoma
    Anja Rabenhorst
    Department of Dermatology, University Hospital Cologne, Cologne, Germany
    Blood 120:2042-54. 2012

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Allergic contact dermatitis from cinnamon as an odour-neutralizing agent in shoe insoles
    Karin Hartmann
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Contact Dermatitis 50:253-4. 2004
  2. ncbi request reprint Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis
    Karin Hartmann
    Department of Dermatology, University of Cologne, Cologne, Germany
    Gastroenterology 129:1042-6. 2005
    ..Our studies identify a new regulatory region in the KIT molecule and strongly suggest that patients with extracellular KIT mutations respond to tyrosine kinase inhibitors...
  3. ncbi request reprint Evidence for altered mast cell proliferation and apoptosis in cutaneous mastocytosis
    K Hartmann
    Departments of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
    Br J Dermatol 149:554-9. 2003
    ..Other factors such as prolonged survival of mast cells may therefore participate in causing and modulating the pathological increase of mast cells in mastocytosis...
  4. ncbi request reprint Cutaneous mastocytosis -- clinical heterogeneity
    Karin Hartmann
    Department of Dermatology, University Hospital, Cologne, Germany
    Int Arch Allergy Immunol 127:143-6. 2002
    ..A clear distinction of the type of CM in individual patients has important implications regarding patient management and prognosis...
  5. doi request reprint Effects of topical treatment with the raft modulator miltefosine and clobetasol in cutaneous mastocytosis: a randomized, double-blind, placebo-controlled trial
    K Hartmann
    Department of Dermatology, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Br J Dermatol 162:185-90. 2010
    ..Conclusions Raft modulators such as miltefosine are promising candidates for novel therapeutic strategies in patients with cutaneous mastocytosis. Future studies should be performed with improved formulations using nonirritant vehicles...
  6. ncbi request reprint [Urticaria. Classification and diagnosis]
    K Hartmann
    Klinik und Poliklinik für Dermatologie und Venerologie der Universität zu Köln, Koln
    Hautarzt 55:340-3. 2004
    ..For the diagnosis of physical urticaria, standardized provocation test are recommended...
  7. pmc Expression of Bcl-2 and Bcl-xL in cutaneous and bone marrow lesions of mastocytosis
    Karin Hartmann
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Am J Pathol 163:819-26. 2003
    ..Thus, overexpression of bcl-2 and bcl-xL leading to prolonged survival of mast cells may contribute to the pathogenesis of mastocytosis. Our findings may help to develop new strategies for the treatment of this disease...
  8. doi request reprint Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit
    Alexander Gerbaulet
    Department of Dermatology, University of Cologne, Cologne, Germany
    Blood 117:2012-21. 2011
    ..Our findings demonstrate that the effects of constitutive kit signaling critically depend on the developmental stage and the state of differentiation of the cell hit by the gain-of-function mutation...
  9. doi request reprint Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis
    Sebastian Willenborg
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Invest Dermatol 134:2005-15. 2014
    ....
  10. doi request reprint Mast cells play a protumorigenic role in primary cutaneous lymphoma
    Anja Rabenhorst
    Department of Dermatology, University Hospital Cologne, Cologne, Germany
    Blood 120:2042-54. 2012
    ..Taken together, these experiments show that mast cells play a protumorigenic role in CTCL and CBCL. Our data provide a rationale for exploiting tumor-associated mast cells as a prognostic marker and therapeutic target in PCL...
  11. doi request reprint Large maculopapular cutaneous lesions are associated with favorable outcome in childhood-onset mastocytosis
    Tim Wiechers
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Allergy Clin Immunol 136:1581-1590.e3. 2015
    ..However, there are some patients with persistent disease resembling adulthood-onset mastocytosis...
  12. doi request reprint Dimethylfumarate induces apoptosis in human mast cells
    Anja Förster
    Department of Dermatology, University of Cologne, Cologne, Germany
    Exp Dermatol 22:719-24. 2013
    ..Our study contributes to the understanding of the beneficial effects of FAEs in autoimmune diseases and provides a rationale for exploiting FAEs for other diseases associated with mast cells. ..
  13. ncbi request reprint Mast cell apoptosis
    Alexander Gerbaulet
    Department of Dermatology, University of Cologne, Cologne, Germany
    Methods Mol Biol 315:407-23. 2006
    ....
  14. pmc Mast cell-specific Cre/loxP-mediated recombination in vivo
    Julia Scholten
    Department of Dermatology, University of Cologne, Kerpener Str 62, 50937, Cologne, Germany
    Transgenic Res 17:307-15. 2008
    ..Our results show that the Mcpt5 promoter can drive Cre expression in a mast cell-specific fashion. We expect that our Mcpt5-Cre mice will be a useful tool for the investigation of mast cell biology...
  15. ncbi request reprint Ultraviolet irradiation induces apoptosis in human immature, but not in skin mast cells
    Sven Guhl
    Department of Dermatology, University of Cologne, Germany
    J Invest Dermatol 121:837-44. 2003
    ....
  16. ncbi request reprint Mastocytosis: review of clinical and experimental aspects
    K Hartmann
    Department of Dermatology, University of Cologne, Germany
    J Investig Dermatol Symp Proc 6:143-7. 2001
    ..Despite significant advances in research on mastocytosis, curative treatment is not yet available. Current management is based on avoidance of mediator-releasing triggers and symptomatic treatment...
  17. doi request reprint Interleukin-31: a novel diagnostic marker of allergic diseases
    Anja Rabenhorst
    Department of Dermatology, University of Cologne, Kerpener Str 62, 50937, Cologne, Germany
    Curr Allergy Asthma Rep 14:423. 2014
    ..We conclude that growing knowledge about IL-31, its receptors and signaling pathways serves to better understand the pathogenesis of allergic diseases and may lead to the development of novel treatment approaches. ..
  18. ncbi request reprint African tick bite fever--papulovesicular exanthem with fever after staying in South Africa
    Jan Schuster
    Department of Dermatology, University of Cologne, Germany
    J Dtsch Dermatol Ges 6:379-81. 2008
    ..Antibodies against rickettsia of the spotted fever group were detected serologically. Oral doxycycline led to clearance of the disease after few days of treatment...
  19. doi request reprint Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils
    Anja Förster
    Department of Dermatology, University of Cologne, Cologne, Germany
    Leuk Lymphoma 54:835-42. 2013
    ..Our data show that anti-Fas/CD95 and TRAIL differentially regulate apoptosis of normal and neoplastic human basophils, which may direct the development of novel therapeutic strategies...
  20. ncbi request reprint Expression of mast cell growth modulating and chemotactic factors and their receptors in human cutaneous scars
    B Hermes
    Department of Dermatology, , Koln, Germany
    J Invest Dermatol 116:387-93. 2001
    ....
  21. pmc Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
    Athanasios Stratis
    Department of Dermatology and Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    J Clin Invest 116:2094-104. 2006
    ....
  22. doi request reprint Mild recessive dystrophic epidermolysis bullosa associated with two compound heterozygous COL7A1 mutations
    Wibke von Bartenwerffer
    Department of Dermatology, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Eur J Dermatol 21:170-2. 2011
    ..3832-2A > G and the glycine substitution p.G1347W. Our data extend the current knowledge on genotype-phenotype correlations in dystrophic epidermolysis bullosa...
  23. pmc A case of linear porokeratosis superimposed on disseminated superficial actinic porokeratosis
    Rebecca Löhrer
    Department of Dermatology, University of Cologne, Cologne, Germany
    Case Rep Dermatol 2:130-4. 2010
    ..Molecular analysis of cases of type 2 segmental involvement may help elucidate the genetic defect causing DSAP...
  24. ncbi request reprint A teledermatological approach to enhance diagnostic accuracy in dermatohistopathology
    R Schiener
    Department of Dermatology, Armed Forces Hospital Ulm, Germany
    J Telemed Telecare 9:135-9. 2003
    ..Digital photographs of skin lesions are likely to refine diagnostic accuracy in histopathology...
  25. ncbi request reprint Role of stem cell factor and monocyte chemoattractant protein-1 in the interaction between fibroblasts and mast cells in fibrosis
    T Yamamoto
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Dermatol Sci 26:106-11. 2001
    ..Our data may indicate an important interaction of fibroblasts and mast cells, via SCF and MCP-1, in the induction of fibrosis...
  26. ncbi request reprint Expression of matrilin-2 in human skin
    Dorothea Piecha
    Department of Dermatology, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    J Invest Dermatol 119:38-43. 2002
    ..These findings demonstrate that matrilin-2 is expressed in normal skin by keratinocytes and fibroblasts and may thus contribute to cutaneous homeostasis...
  27. ncbi request reprint Mastocytosis: recent advances in defining the disease
    K Hartmann
    Department of Dermatology, University of Cologne, Joseph-Stelzmann-Str. 9, 50931 Cologne, Germany
    Br J Dermatol 144:682-95. 2001
    ....
  28. ncbi request reprint Expression and functional activity of the IL-8 receptor type CXCR1 and CXCR2 on human mast cells
    U Lippert
    Department of Dermatology, Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    J Immunol 161:2600-8. 1998
    ..These findings demonstrate for the first time the functional expression of both types of IL-8 receptors on human mast cells, suggesting a role for their ligands during mast cell activation and recruitment...
  29. doi request reprint Elevated levels of tryptase in children with nummular eczema
    L Lange
    Children s Hospital, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Allergy 63:947-9. 2008
  30. ncbi request reprint Altered apoptosis and cell cycling of mast cells in bone marrow lesions of patients with systemic mastocytosis
    Stephan E Baldus
    Haematologica 89:1525-7. 2004
    ..An altered rate of apoptosis and cell cycling may contribute to accumulation of mast cells in mastocytosis...
  31. ncbi request reprint Classification of cutaneous mastocytosis: a modified consensus proposal
    Karin Hartmann
    Leuk Res 26:483-4; author reply 485-6. 2002
  32. ncbi request reprint The European Competence Network on Mastocytosis (ECNM)
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria
    Wien Klin Wochenschr 116:647-51. 2004
    ..In addition, the ECNM is dedicated to provide the best available information about the disease to patients and physicians...