Matthias Hammerschmidt

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. pmc Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis
    Fang Liu
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Development 140:1111-22. 2013
  2. pmc Adult zebrafish as a model system for cutaneous wound-healing research
    Rebecca Richardson
    Institute of Developmental Biology, University of Cologne, Cologne, Germany
    J Invest Dermatol 133:1655-65. 2013
  3. pmc Binding between Crossveinless-2 and Chordin von Willebrand factor type C domains promotes BMP signaling by blocking Chordin activity
    Jin Li Zhang
    Institute for Developmental Biology, Cologne Biocenter, University of Cologne, Cologne, Germany
    PLoS ONE 5:e12846. 2010
  4. doi request reprint Regulated adhesion as a driving force of gastrulation movements
    Matthias Hammerschmidt
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Development 135:3625-41. 2008
  5. ncbi request reprint The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion
    Sophia von der Hardt
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Curr Biol 17:475-87. 2007
  6. ncbi request reprint The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis
    Hans Martin Pogoda
    Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Development 133:1079-89. 2006
  7. ncbi request reprint Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation
    Fabian Rentzsch
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Development 133:801-11. 2006
  8. ncbi request reprint Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition
    Fabian Rentzsch
    Max Planck Institute for Immunobiology, Freiburg, Germany
    Dev Dyn 231:750-7. 2004
  9. pmc The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity
    Kathrin Laue
    Georges Koehler Laboratory, Max Planck Institute of Immunobiology, Freiburg, Germany
    Development 135:1935-46. 2008
  10. ncbi request reprint Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis
    Gabriela Nica
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Dev Biol 292:189-204. 2006

Collaborators

Detail Information

Publications45

  1. pmc Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis
    Fang Liu
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Development 140:1111-22. 2013
    ..Together, our studies suggest a model for the integrated neurohemal wiring of the hypothalamo-neurohypophyseal axis...
  2. pmc Adult zebrafish as a model system for cutaneous wound-healing research
    Rebecca Richardson
    Institute of Developmental Biology, University of Cologne, Cologne, Germany
    J Invest Dermatol 133:1655-65. 2013
    ..Together, these results demonstrate that major steps and principles of cutaneous wound healing are conserved among adult mammals and adult zebrafish, making zebrafish a valuable model for studying vertebrate skin repair...
  3. pmc Binding between Crossveinless-2 and Chordin von Willebrand factor type C domains promotes BMP signaling by blocking Chordin activity
    Jin Li Zhang
    Institute for Developmental Biology, Cologne Biocenter, University of Cologne, Cologne, Germany
    PLoS ONE 5:e12846. 2010
    ..More recently, it was shown that CV2 can also bind to the BMP inhibitor Chordin. However, it remained unclear which domains mediate this binding, and whether it accounts for an anti- or pro-BMP effect...
  4. doi request reprint Regulated adhesion as a driving force of gastrulation movements
    Matthias Hammerschmidt
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Development 135:3625-41. 2008
    ....
  5. ncbi request reprint The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion
    Sophia von der Hardt
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Curr Biol 17:475-87. 2007
    ....
  6. ncbi request reprint The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis
    Hans Martin Pogoda
    Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Development 133:1079-89. 2006
    ..Together, this suggests that Ascl1a might act downstream of diencephalic Fgf3 signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis...
  7. ncbi request reprint Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation
    Fabian Rentzsch
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Development 133:801-11. 2006
    ..Differential proteolytic processing as a mode of regulation might account for anti-Bmp effects in other contexts...
  8. ncbi request reprint Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition
    Fabian Rentzsch
    Max Planck Institute for Immunobiology, Freiburg, Germany
    Dev Dyn 231:750-7. 2004
    ....
  9. pmc The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity
    Kathrin Laue
    Georges Koehler Laboratory, Max Planck Institute of Immunobiology, Freiburg, Germany
    Development 135:1935-46. 2008
    ..We conclude that Brpf1, coordinated by its particular set of domains, acts by multiple mechanisms to mediate Moz-dependent histone acetylation and to mark Hox genes for maintained expression throughout vertebrate development...
  10. ncbi request reprint Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis
    Gabriela Nica
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Dev Biol 292:189-204. 2006
    ..Eya1 is required for lineage-specific differentiation of adenohypophyseal cells, but not for their survival, thereby uncoupling the differentiation-promoting and anti-apoptotic effects of Eya proteins seen in other tissues...
  11. ncbi request reprint Loss of maternal Smad5 in zebrafish embryos affects patterning and morphogenesis of optic primordia
    Matthias Hammerschmidt
    Max Planck Institute for Immunobiology, Freiburg, Germany
    Dev Dyn 227:128-33. 2003
    ..They can be best explained with a model according to which zebrafish eye morphogenesis occurs as a telescopic extension of disc-like, concentric primordia, similar to the development of appendages from imaginal discs in Drosophila...
  12. ncbi request reprint Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo
    Jeroen Bakkers
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Cell Cycle 4:790-800. 2005
    ..In sum, our data indicate that DeltaNp63alpha is ubiquitinated in a Nedd4- and sumoylated in a Ubc9-dependent fashion, and that these modifications can regulate DeltaNp63alpha stability in the zebrafish ectoderm...
  13. pmc Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid
    Kathrin Laue
    Institute of Developmental Biology, University of Cologne, D 50674 Cologne, Germany
    Am J Hum Genet 89:595-606. 2011
    ..This work reveals a physiological role for RA in partitioning skeletal elements and in the maintenance of cranial suture patency...
  14. pmc p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish
    Boris Fischer
    Institute of Developmental Biology, University of Cologne, Cologne, Germany
    PLoS Genet 10:e1004048. 2014
    ....
  15. pmc Hemicentin 2 and Fibulin 1 are required for epidermal-dermal junction formation and fin mesenchymal cell migration during zebrafish development
    Natália Martins Feitosa
    Institute of Developmental Biology, University of Cologne, Germany
    Dev Biol 369:235-48. 2012
    ....
  16. ncbi request reprint Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling
    Carina Kramer
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Dev Biol 250:263-79. 2002
    ..This indicates that maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2/7 signaling to establish the initial dorsoventral asymmetry...
  17. pmc Ubc9 regulates mitosis and cell survival during zebrafish development
    Matthias Nowak
    Georges Köhler Laboratory, Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Mol Biol Cell 17:5324-36. 2006
    ..Failed mitosis in the absence of Ubc9 is not necessarily coupled with cell death. Rather, cells can continue to replicate their DNA, grow to a larger size, and finish their normal developmental program...
  18. ncbi request reprint REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development
    Nikki Plaster
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 236:1891-904. 2007
    ..We present a model for RERE-dependent patterning in which tissue-specific transcriptional repression, by means of an REREa-HDAC complex, modulates growth factor signaling during embryogenesis...
  19. ncbi request reprint Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis
    Thomas J Carney
    Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 134:3461-71. 2007
    ..Our work provides direct genetic evidence for antagonistic in vivo roles of Hai1 and Matriptase1a to regulate skin homeostasis and remodeling...
  20. ncbi request reprint Specific and conserved roles of TAp73 during zebrafish development
    Fabian Rentzsch
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
    Gene 323:19-30. 2003
    ..Together, our data point to both conserved and class-specific roles of p73 during vertebrate development...
  21. ncbi request reprint Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation
    Jeroen Bakkers
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 131:525-37. 2004
    ..In addition, they suggest that the same HA pathways are active to auto-stimulate cell migration during tumor invasion and vertebrate embryogenesis...
  22. doi request reprint The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish
    Yobhana Quiroz
    Laboratory for Molecular Biology and Genetic Engineering, University of Cologne, D 50674 Cologne, Germany
    Mol Endocrinol 26:1014-27. 2012
    ....
  23. ncbi request reprint Foxi3 transcription factors and Notch signaling control the formation of skin ionocytes from epidermal precursors of the zebrafish embryo
    Martina Janicke
    Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Dev Biol 307:258-71. 2007
    ..A model for ionocyte versus keratinocyte development will be presented, postulating additional thus far unidentified pro-ionocyte factors...
  24. pmc A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear
    Katherine L Hammond
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 4:e4368. 2009
    ..Previous studies using conditional approaches in mouse and chicken have shown that Bmp4 has a role in semicircular canal and crista development, but there is currently no direct evidence for the role of Bmp2 in the developing inner ear...
  25. pmc PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis
    Andre Kleinridders
    Institute for Genetics, Department of Mouse Genetics and Metabolism, University of Cologne, Cologne, Germany
    Mol Cell Biol 29:3173-85. 2009
    ..Taken together, the results of this study identify PLRG1 as a critical nuclear regulator of p53-dependent cell cycle progression and apoptosis during both embryonic development and adult tissue homeostasis...
  26. pmc Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene
    Fan Suo Geng
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK
    Development 140:4362-74. 2013
    ..We propose that Gpr126 acts through a cAMP-mediated pathway to control the outgrowth and adhesion of canal projections in the zebrafish ear via the regulation of extracellular matrix gene expression. ..
  27. pmc AMACO is a component of the basement membrane-associated Fraser complex
    Rebecca J Richardson
    1 Institute of Developmental Biology, University of Cologne, Cologne, Germany 2 Center for Molecular Medicine Cologne, Medical Faculty, University of Cologne, Cologne, Germany
    J Invest Dermatol 134:1313-22. 2014
    ..Knockdown of vwa2, which alone causes no phenotype, enhances the phenotype of hypomorphic Fras1 mutant zebrafish. Together, our data suggest that AMACO represents a member of the Fraser complex. ..
  28. ncbi request reprint Molecular genetics of pituitary development in zebrafish
    Hans Martin Pogoda
    Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Semin Cell Dev Biol 18:543-58. 2007
    ..Finally, we discuss future directions, with particular focus on evolutionary aspects, and some novel functional aspects with growing medical and social relevance...
  29. ncbi request reprint Adenohypophysis formation in the zebrafish and its dependence on sonic hedgehog
    Wiebke Herzog
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108, Freiburg, Germany
    Dev Biol 254:36-49. 2003
    ....
  30. ncbi request reprint Differential expression of four protocadherin alpha and gamma clusters in the developing and adult zebrafish: DrPcdh2gamma but not DrPcdh1gamma is expressed in neuronal precursor cells, ependymal cells and non-neural epithelia
    Thilo Bass
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    Dev Genes Evol 217:337-51. 2007
    ..Thus, our findings in zebrafish open new perspectives to examine these functions in other vertebrate model organisms...
  31. pmc Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes
    Thomas J Carney
    Max Planck Institute of Immunobiology, Georges Koehler Laboratory, Freiburg, Germany
    PLoS Genet 6:e1000907. 2010
    ..In addition, the novel genes might prove helpful to unravel the molecular nature of thus far unresolved cases of the human disease...
  32. ncbi request reprint parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube
    Zsolt Lele
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 129:3281-94. 2002
    ..Our results thus highlight novel and crucial in vivo roles for Ncad in the control of cell convergence, maintenance of neuronal positioning and dorsal cell proliferation during vertebrate neural tube development...
  33. doi request reprint How to make a teleost adenohypophysis: molecular pathways of pituitary development in zebrafish
    Hans Martin Pogoda
    Institute for Developmental Biology, University of Cologne, Gyrhofstr 17, D 50931 Cologne, Germany
    Mol Cell Endocrinol 312:2-13. 2009
    ..In addition, zebrafish data will be discussed in comparison with current understanding of adenohypophysis development in mouse...
  34. doi request reprint CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
    Sebastian Willenborg
    Department of Dermatology, University of Cologne, Kerpenerstrasse 62, Cologne, Germany
    Blood 120:613-25. 2012
    ..Our findings may be relevant for novel monocyte-based therapies to promote tissue vascularization...
  35. doi request reprint Basement membrane diseases in zebrafish
    Natália Martins Feitosa
    Institute of Developmental Biology, University of Cologne, Cologne, Germany
    Methods Cell Biol 105:191-222. 2011
    ..In the second part, we will describe details of methods used to visualize and assess the structure of the BM in zebrafish, and to functionally analyze its different components...
  36. doi request reprint Zebrafish in endocrine systems: recent advances and implications for human disease
    Heiko Löhr
    Institute for Developmental Biology, University of Cologne, Germany
    Annu Rev Physiol 73:183-211. 2011
    ..Finally, we summarize the strengths and weaknesses of zebrafish as a model for studying endocrine systems...
  37. pmc Zebrafish grainyhead-like1 is a common marker of different non-keratinocyte epidermal cell lineages, which segregate from each other in a Foxi3-dependent manner
    Martina Janicke
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Int J Dev Biol 54:837-50. 2010
    ..We propose that grhl1 is a novel common marker of all or most "non-keratinocyte" epidermal progenitors, and that the sub-functionalisation of these cells is regulated by differential positive and negative effects of Foxi3 factors...
  38. pmc Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42
    Guntram Borck
    Institute of Human Genetics, University of Cologne, Cologne, Germany
    Am J Hum Genet 88:127-37. 2011
    ..These data identify loss-of-function mutations of ILDR1, a gene with a conserved expression pattern pointing to a conserved function in hearing in vertebrates, as underlying nonsyndromic prelingual sensorineural hearing impairment...
  39. ncbi request reprint A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment
    Michael Schorpp
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Mech Dev 118:179-85. 2002
    ..Our results provide the first specific marker for the epithelial compartment of the zebrafish thymus...
  40. pmc Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling
    Yun Li
    Center for Molecular Medicine Cologne, University of Cologne, Germany
    Am J Hum Genet 87:757-67. 2010
    ..In addition, we obtained strikingly similar zebrafish phenotypes after chsy1 overexpression, which might explain why, in humans, brachydactyly can be caused by mutations leading either to loss or to gain of BMP signaling...
  41. pmc Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development
    Kathrin Laue
    Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 135:3775-87. 2008
    ..cyp26b1 mutants may serve as a model to study the etiology of human vertebral disorders such as Klippel-Feil anomaly...
  42. pmc The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling
    Lori Borgal
    Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, 50937 Cologne, Germany
    J Biol Chem 287:25370-80. 2012
    ..Loss of this repressor function in nephronophthisis might be an important factor promoting Wnt activation and contributing to cyst formation...
  43. ncbi request reprint Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm
    Jeroen Bakkers
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Dev Cell 2:617-27. 2002
    ..Together, DeltaNp63 fulfills the criteria to be the neural repressor postulated by the "neural default model."..
  44. pmc The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development
    Krasimir Slanchev
    Georges Koehler Laboratory, Max Planck Institute of Immunobiology, Freiburg, Germany
    PLoS Genet 5:e1000563. 2009
    ..In addition, EpCAM is required for the interaction of the epithelia with underlying cell layers...
  45. doi request reprint Interrelation of immunity and tissue repair or regeneration
    Sabine A Eming
    Department of Dermatology, University of Cologne, Germany
    Semin Cell Dev Biol 20:517-27. 2009
    ..Finally, we report on new mechanistic insights on how these inflammatory pathways impair healing under pathological conditions and discuss therapeutic implications...