U Haberkorn

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi PET and SPECT
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Handb Exp Pharmacol . 2008
  2. ncbi Apoptosis and changes in glucose transport early after treatment of Morris hepatoma with gemcitabine
    U Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Eur J Nucl Med 28:418-25. 2001
  3. ncbi Iodide uptake in human anaplastic thyroid carcinoma cells after transfer of the human thyroid peroxidase gene
    U Haberkorn
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg
    Eur J Nucl Med 28:633-8. 2001
  4. ncbi Gene therapy with sodium/iodide symporter in hepatocarcinoma
    U Haberkorn
    Department of Nuclear Medicine, University of Heidelberg and Clinical Cooperation Unit Radiation Therapy, German Cancer Research Center, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 109:60-2. 2001
  5. ncbi Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone
    U Haberkorn
    Dept of Nuclear Medicine, University of Heidelberg, D 69120, Heidelberg, Germany
    Nucl Med Biol 28:793-8. 2001
  6. ncbi Glucose transport and apoptosis after gene therapy with HSV thymidine kinase
    U Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Eur J Nucl Med 28:1690-6. 2001
  7. ncbi Functional genomics and proteomics--the role of nuclear medicine
    Uwe Haberkorn
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 29:115-32. 2002
  8. ncbi Imaging methods in gene therapy of cancer
    U Haberkorn
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Dept of Nuclear Medicine, University of Heidelberg, Germany
    Curr Gene Ther 1:163-82. 2001
  9. ncbi Radionuclide imaging in the post-genomic era
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Germany
    J Cell Biochem Suppl 39:1-10. 2002
  10. ncbi Noninvasive imaging of protein-protein interactions in living organisms
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Trends Biotechnol 21:241-3. 2003

Detail Information

Publications138 found, 100 shown here

  1. doi PET and SPECT
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Handb Exp Pharmacol . 2008
    ..Furthermore, the characterization of tumor cell-specific properties allows the design of new treatment modalities, such as gene therapy, which circumvent resistance mechanisms towards conventional chemotherapeutic drugs...
  2. ncbi Apoptosis and changes in glucose transport early after treatment of Morris hepatoma with gemcitabine
    U Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Eur J Nucl Med 28:418-25. 2001
    ....
  3. ncbi Iodide uptake in human anaplastic thyroid carcinoma cells after transfer of the human thyroid peroxidase gene
    U Haberkorn
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg
    Eur J Nucl Med 28:633-8. 2001
    ..Future studies will have to concentrate on the possible expression of enzymatically active proteins or the transfer of multiple genes involved in iodide trapping...
  4. ncbi Gene therapy with sodium/iodide symporter in hepatocarcinoma
    U Haberkorn
    Department of Nuclear Medicine, University of Heidelberg and Clinical Cooperation Unit Radiation Therapy, German Cancer Research Center, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 109:60-2. 2001
    ..For a therapeutic application of the hNIS gene, however, additional conditions need to be defined which inhibit the iodide efflux...
  5. ncbi Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone
    U Haberkorn
    Dept of Nuclear Medicine, University of Heidelberg, D 69120, Heidelberg, Germany
    Nucl Med Biol 28:793-8. 2001
    ..Instead of using an inhibitor, synthetic caspase substrates are currently investigated which may accumulate in the apoptotic cell by metabolic trapping thereby enhancing the imaging signal...
  6. ncbi Glucose transport and apoptosis after gene therapy with HSV thymidine kinase
    U Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Eur J Nucl Med 28:1690-6. 2001
    ..Therefore, enhanced glucose transport seems to represent a stress reaction of tumour cells dedicated for the prevention of cell death...
  7. ncbi Functional genomics and proteomics--the role of nuclear medicine
    Uwe Haberkorn
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 29:115-32. 2002
    ..Finally, new biomolecules will be developed by bioengineering methods which may be used for isotope-based diagnosis and treatment of disease...
  8. ncbi Imaging methods in gene therapy of cancer
    U Haberkorn
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Dept of Nuclear Medicine, University of Heidelberg, Germany
    Curr Gene Ther 1:163-82. 2001
    ..Finally, enhancement of radioactive isotope accumulation in tumors by transfer of the appropriate genes may be used for the treatment of malignant tumors...
  9. ncbi Radionuclide imaging in the post-genomic era
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Germany
    J Cell Biochem Suppl 39:1-10. 2002
    ..Finally, new biomolecules will be developed by bioengineering methods, which may be used for isotope-based diagnosis and treatment of disease...
  10. ncbi Noninvasive imaging of protein-protein interactions in living organisms
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Trends Biotechnol 21:241-3. 2003
    ..Recently, a study by Paulmurugan et al. demonstrated a tool for in vivo noninvasive imaging of protein-protein interactions and intracellular networks...
  11. ncbi Functional genomics and radioisotope-based imaging procedures
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg and Clinical Cooperation Unit, Nuclear Medicine, German Cancer Research Center, Heidelberg, FRG
    Ann Med 35:370-9. 2003
    ..Finally, new biomolecules will be developed by bioengineering methods which may be used for isotope-based diagnosis and treatment of disease...
  12. ncbi Impact of functional genomics and proteomics on radionuclide imaging
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Germany
    Semin Nucl Med 34:4-22. 2004
    ..Finally, new biomolecules will be developed by bioengineering methods, which may be used for the isotope-based diagnosis and treatment of disease...
  13. ncbi Positron emission tomography in the diagnosis of mesothelioma
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, German Cancer Research Center, Im Neuenheimer Feld 400, D 69120
    Lung Cancer 45:S73-6. 2004
    ..Further evaluations of this technique included a combined experimental/clinical study to investigate the difference in rates of FDG uptake between malignant and inflammatory cells and processes...
  14. ncbi Scintigraphic imaging of gene expression and gene transfer
    Uwe Haberkorn
    Clinical Cooperation Unit Nuclear Medicine, DKFZ, Germany
    Curr Med Chem 12:779-94. 2005
    ..Pharmacogenomics will identify new surrogate markers for therapy monitoring which may represent potential new tracers for imaging...
  15. ncbi Changes in glucose metabolism and gene expression after transfer of anti-angiogenic genes in rat hepatoma
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 34:2011-23. 2007
    ..The aim of this study was to assess these reactions using FDG-PET and high-throughput methods such as gene profiling...
  16. ncbi Endoradiotherapy with peptides - status and future development
    Uwe Haberkorn
    Departmen of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120 Heidelberg, Germany
    Curr Med Chem 15:219-34. 2008
    ..After the characterization of the structure-function relationships for the lead compounds found in this process further improvement by rational design of analogs can be performed...
  17. ncbi Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase
    U Haberkorn
    Department of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Federal Republic of Germany
    Nucl Med Biol 25:367-73. 1998
    ..This may be the limiting factor for therapy success, necessitating the search for better substrates of HSV-tk...
  18. ncbi Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: uptake of specific substrates
    U Haberkorn
    Department of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, FRG
    J Nucl Med 38:287-94. 1997
    ..This study investigates the application of PET with specific substrates for the assessment of enzyme activity after transfer of the herpes simplex virus thymidine kinase (HSV-tk) gene...
  19. ncbi Tissue-specific gene expression in medullary thyroid carcinoma cells employing calcitonin regulatory elements and AAV vectors
    S Jiang
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    Cancer Gene Ther 8:469-72. 2001
    ....
  20. ncbi Enhanced iodide transport after transfer of the human sodium iodide symporter gene is associated with lack of retention and low absorbed dose
    U Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    Gene Ther 10:774-80. 2003
    ..With regard to a therapeutic application additional conditions need to be defined leading to iodide trapping...
  21. ncbi Impact of peptide receptor radionuclide therapy on the 68Ga-DOTATOC-PET/CT uptake in normal tissue
    F L Giesel
    Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Q J Nucl Med Mol Imaging 57:171-6. 2013
    ..We investigated the potential changes of normal tissue uptake in patients with neuroendocrine tumor undergoing peptide receptor radionuclide therapy (PRRT)...
  22. doi PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions
    A Afshar-Oromieh
    Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 40:486-95. 2013
    ..The aim of this study was to investigate its biodistribution in normal tissues and tumour lesions...
  23. ncbi Contrast-enhanced ultrasound monitoring of perfusion changes in hepatic neuroendocrine metastases after systemic versus selective arterial 177Lu/90Y-DOTATOC and 213Bi-DOTATOC radiopeptide therapy
    F L Giesel
    Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120 Heidelberg, Germany
    Exp Oncol 35:122-6. 2013
    ..Therefore we evaluated the ability of contrast-enhanced ultrasound (CEUS) to evaluate tumor perfusion as a response criteria...
  24. ncbi Radioiodinated N-(2-diethylaminoethyl)benzamide derivatives with high melanoma uptake: structure-affinity relationships, metabolic fate, and intracellular localization
    M Eisenhut
    Department of Nuclear Medicine, Center of Biochemistry, and Institute for Anatomy and Cell Biology, University of Heidelberg, D 69120 Heidelberg, Germany
    J Med Chem 43:3913-22. 2000
    ..The high uptake and slow clearance of 6 offer considerable potential for melanoma imaging in patients, and this compound may also prove to be useful for radionuclide therapy...
  25. pmc Intra-individual comparison of (68)Ga-PSMA-11-PET/CT and multi-parametric MR for imaging of primary prostate cancer
    F L Giesel
    Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 43:1400-6. 2016
    ..The actual investigation analyses the potential of (68)Ga-PSMA11-PET/CT to assess the extent of primary prostate cancer by intra-individual comparison to MP-MRI...
  26. ncbi PET imaging of somatostatin receptors using [68GA]DOTA-D-Phe1-Tyr3-octreotide: first results in patients with meningiomas
    M Henze
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    J Nucl Med 42:1053-6. 2001
    ..CONCLUSION: According to our initial experiences, [68Ga]DOTATOC seems to be a very promising new PET tracer for imaging SSTRs even in small meningiomas, offering excellent imaging properties and a very high tumor-to-background ratio...
  27. ncbi Comparison of pharmacokinetic MRI and [18F] fluorodeoxyglucose PET in the diagnosis of breast cancer: initial experience
    G Brix
    Research Program Radiological Diagnostics and Therapy, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Eur Radiol 11:2058-70. 2001
    ..An advantage of PET, however, is its ability to localize lymph node involvement and distant metastases as an integral part of the examination...
  28. ncbi Pharmacological properties of hydrophilic and lipophilic derivatives of octreotate
    Qin Wang
    Department of Nuclear Medicine, University Clinics, Heidelberg, Germany
    Nucl Med Biol 31:21-30. 2004
    ..In conclusion, the systematic modifications at the N-terminal result in a low effect on the receptor affinity but allow the modulation of the pharmacokinetic properties of octreotide derivatives...
  29. doi Comparison of neuroendocrine tumor detection and characterization using DOTATOC-PET in correlation with contrast enhanced CT and delayed contrast enhanced MRI
    F L Giesel
    Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120 Heidelberg, Germany
    Eur J Radiol 81:2820-5. 2012
    ..We evaluated the rate of successful characterization of gastroenteropancreatic neuroendocrine tumors (NETs) present with an increased somatostatin receptor, comparing CE-CT with CE-MRI, each in correlation with DOTATOC-PET...
  30. ncbi Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: a comparative animal study
    G Brix
    Research Program Radiological Diagnostics and Therapy, German Cancer Research Center DKFZ, Heidelberg, Germany
    Nucl Med Biol 23:897-906. 1996
    ..The MR images, however, yielded the additional information that 5-FU is converted to FBAL only in the liver and not in the hepatomas...
  31. ncbi Preparation and evaluation of tumor-targeting peptide-oligonucleotide conjugates
    W Mier
    Department of Nuclear Medicine, Universitatsklinikum Heidelberg, INF 400, 69120 Heidelberg, Germany
    Bioconjug Chem 11:855-60. 2000
    ..83 and 2.52 nM). Furthermore, melting studies with complementary DNA revealed that the terminal conjugation of the ODNs did not significantly affect their hybridization affinity...
  32. ncbi Positron emission tomography (PET) of non-small cell lung cancer
    U Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Clinical Cooperation Unit Nuclear Medicine German Cancer Research Center, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Lung Cancer 34:S115-21. 2001
    ..Furthermore, changes of tumor metabolism can be detected with PET at early stages after treatment, which can be used for therapy monitoring and for the detection of recurrent tumor tissue after completion of treatment...
  33. doi PAMAM structure-based multifunctional fluorescent conjugates for improved fluorescent labelling of biomacromolecules
    C Wangler
    Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Chemistry 14:8116-30. 2008
    ..We demonstrate the applicability of the dye oligomers to the efficient and applicable labelling of proteins and other large molecules that enables high dye concentrations and therefore high contrasts in fluorescence applications...
  34. ncbi Benzamides as melanotropic carriers for radioisotopes, metals, cytotoxic agents and as enzyme inhibitors
    D Oltmanns
    Department of Radiopharmaceutical Chemistry, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Curr Med Chem 16:2086-94. 2009
    ....
  35. ncbi GRP receptor-targeted PET of a rat pancreas carcinoma xenograft in nude mice with a 68Ga-labeled bombesin(6-14) analog
    Jochen Schuhmacher
    Department of Diagnostic and Therapeutic Radiology, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 46:691-9. 2005
    ..This study evaluated a novel BN analog labeled with the positron emitter 68Ga for receptor imaging with PET...
  36. doi SUV of [68Ga]DOTATOC-PET/CT Predicts Response Probability of PRRT in Neuroendocrine Tumors
    C Kratochwil
    Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany
    Mol Imaging Biol 17:313-8. 2015
    ....
  37. ncbi Increased MIBG uptake after transfer of the human norepinephrine transporter gene in rat hepatoma
    Annette Altmann
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 44:973-80. 2003
    ..Therefore, we investigated whether the accumulation of MIBG may be induced by retroviral transfection of the hNET gene in Morris hepatoma cells...
  38. ncbi A new prostate carcinoma binding peptide (DUP-1) for tumor imaging and therapy
    Sabine Zitzmann
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 11:139-46. 2005
    ..Radiolabeled peptides with high sensitivity and specificity for prostate cancer would be a desirable tool for tumor diagnosis and treatment...
  39. ncbi Effects of Pax8 and TTF-1 thyroid transcription factor gene transfer in hepatoma cells: imaging of functional protein-protein interaction and iodide uptake
    Annette Altmann
    Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Nucl Med 46:831-9. 2005
    ..The thyroid transcription factors TTF-1 and Pax8 cooperate in the transcriptional activation of thyroid-specific genes such as thyroglobulin (Tg), thyroperoxidase (TPO), and sodium/iodide symporter (NIS)...
  40. ncbi Bifunctional chelators in the design and application of radiopharmaceuticals for oncological diseases
    D Sarko
    University Hospital Heidelberg, Department of Nuclear Medicine, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Curr Med Chem 19:2667-88. 2012
    ....
  41. ncbi Immunoscintigraphy with positron emission tomography: gallium-68 chelate imaging of breast cancer pretargeted with bispecific anti-MUC1/anti-Ga chelate antibodies
    J Schuhmacher
    Departments of Diagnostic and Therapeutic Radiology, German Cancer Research Center, D-69120 Heidelberg, Germany
    Cancer Res 61:3712-7. 2001
    ..This could be demonstrated by the clear visualization of tumor sites 10 mm in size, which contrasted only by a factor of 2 from surrounding normal breast tissue...
  42. ncbi Quantification of [(18)F]FDG uptake in the normal liver using dynamic PET: impact and modeling of the dual hepatic blood supply
    G Brix
    Research Program Radiological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 42:1265-73. 2001
    ..However, the hepatic blood supply may be approximated by the arterial input function as well, especially for the evaluation of liver lesions mainly fed by the hepatic artery...
  43. ncbi 2,3,5,6-Tetrafluorophenyl N-(S-benzoylthioacetyl)glycylglycyl- p-aminobenzoate, a heterobifunctional (99m)Tc ligand for precomplexed antibody labeling
    O Calderon Sanchez
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    Bioconjug Chem 14:1209-13. 2003
    ..Compared to recently described methods, which need in situ activation of the (99m)Tc complex, the application of OC2 saved time and reduced the number of manipulations with radioactive material...
  44. doi Molecular imaging of tumor metabolism and apoptosis
    U Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    Oncogene 30:4141-51. 2011
    ....
  45. ncbi Detection of tumour progression in the follow-up of irradiated low-grade astrocytomas: comparison of 3-[123I]iodo-alpha-methyl- L-tyrosine and 99mTc-MIBI SPET
    Marcus Henze
    Department of Nuclear Medicine, University of Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 29:1455-61. 2002
    ..The sensitivity, specificity and predictive values of IMT SPET were obviously higher than those of MIBI SPET. IMT is considered to be a useful tracer for differentiating PT from nPT in the follow-up of irradiated low-grade astrocytomas...
  46. ncbi Tumor-specific gene expression using regulatory elements of the glucose transporter isoform 1 gene
    Stephanie Sieger
    Clinical Cooperation Unit Nuclear Medicine, Heidelberg, Germany
    Cancer Gene Ther 11:41-51. 2004
    ..In a therapy study of HSVtk-expressing tumors with GCV, we achieved total tumor remission...
  47. ncbi MIA (melanoma inhibitory activity) promoter mediated tissue-specific suicide gene therapy of malignant melanoma
    Frank Schoensiegel
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    Cancer Gene Ther 11:408-18. 2004
    ..In face of higher transduction efficiency, these rAAV particles might therefore be a useful tool for suicide gene therapy of malignant melanoma...
  48. ncbi 18F-FDG kinetics and gene expression in giant cell tumors
    Ludwig G Strauss
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 45:1528-35. 2004
    ..18F-FDG kinetics were evaluated by use of compartment and noncompartment models of giant cell tumors. The kinetic data were compared with the gene expression data for a subgroup of patients...
  49. ncbi Transfer of the sFLT-1 gene in Morris hepatoma results in decreased growth and perfusion and induction of genes associated with stress response
    Kerstin Schmidt
    Department of Anatomy and Cell Biology III, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Clin Cancer Res 11:2132-40. 2005
    ..Therefore, monitoring of antiangiogenic approaches with functional imaging and histomorphometrical analyses are desirable to evaluate the biological effects caused by this treatment modality...
  50. ncbi Characterization and development of a peptide (p160) with affinity for neuroblastoma cells
    Vasileios Askoxylakis
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center DKFZ and University of Heidelberg, Heidelberg, Germany
    J Nucl Med 47:981-8. 2006
    ..To identify and characterize new carrier molecules, we evaluated a peptide that had been identified by phage display technology...
  51. doi Novel Bispecific PSMA/GRPr Targeting Radioligands with Optimized Pharmacokinetics for Improved PET Imaging of Prostate Cancer
    C Liolios
    Division of Radiopharmaceutical Chemistry, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Bioconjug Chem 27:737-51. 2016
    ....
  52. doi (68)Ga-PSMA-11 dynamic PET/CT imaging in biochemical relapse of prostate cancer
    C Sachpekidis
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 43:1288-99. 2016
    ..The correlation between PSA levels and (68)Ga-PSMA-11 PET parameters is also investigated...
  53. pmc PSMA PET/CT with Glu-urea-Lys-(Ahx)-[⁶⁸Ga(HBED-CC)] versus 3D CT volumetric lymph node assessment in recurrent prostate cancer
    Frederik L Giesel
    Department of Nuclear Medicine, INF 400, University Hospital Heidelberg, University of Heidelberg, 69120, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 42:1794-800. 2015
    ..The purpose of this retrospective investigation was to evaluate the volume and dimensions of nodes identified by Glu-urea-Lys-(Ahx)-[(68)Ga(HBED-CC)] ((68)Ga-PSMA-11) in the setting of recurrent prostate cancer...
  54. ncbi Comparison of 68Ga-DOTATOC biodistribution in patients with and without spleenectomy
    C Kratochwil
    Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Q J Nucl Med Mol Imaging 59:116-20. 2015
    ..Therefore, we investigated the potential changes of normal tissue distribution and tumor concentration in patients with neuroendocrine tumors (NETs) with or without spleenectomy...
  55. ncbi Cancer with unknown primary: finding a needle in a hay stack
    F L Giesel
    Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Exp Oncol 34:64-5. 2012
    ..We here present a clinical case of patient with NET where these modalities help in both diagnostic and therapeutic surgery...
  56. ncbi Development of molecular techniques for imaging and treatment of tumors
    U Haberkorn
    Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany
    Q J Nucl Med Mol Imaging 55:655-70. 2011
    ..After the characterization of the structure-function relationships for the lead compounds found in this process further improvement by rational design of analogs can be performed...
  57. ncbi Imaging of lung cancer with CT, MRT and PET
    U Haberkorn
    Department of Nuclear Medicine, Universitats Strahlenklinik, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Lung Cancer 34:S13-23. 2001
    ..Noninvasive information about the stage of the disease is important for the planning and optimization of therapy. This may be done with imaging procedures such as, CT, MRT or PET...
  58. ncbi Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours
    I Buchmann
    Department of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 34:1617-26. 2007
    ..The aim of our study was to compare the value of (68)Ga-DOTATOC PET and (111)In-DTPAOC SPECT (Octreoscan) in the detection of NET manifestations...
  59. ncbi [Iodide enrichment in malignant tumours after gene transfer]
    U Haberkorn
    Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg
    Nuklearmedizin 49:S21-5. 2010
    ..Trials to enhance therapeutic efficiency by co-transfer of the gene encoding thyroperoxidase failed due to the low enzyme activity...
  60. ncbi Tumour-specific activation of the sodium/iodide symporter gene under control of the glucose transporter gene 1 promoter (GTI-1.3)
    Stephanie Sieger
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Centre, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 30:748-56. 2003
    ..However, for therapeutic application additional conditions need to be defined which inhibit the iodide efflux out of the tumour cells...
  61. ncbi Shortened PET data acquisition protocol for the quantification of 18F-FDG kinetics
    Ludwig G Strauss
    Medical PET Group, Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 44:1933-9. 2003
    ..A modified short dynamic protocol was defined and evaluated to predict kinetic parameters of (18)F-FDG metabolism from a dynamic data acquisition...
  62. ncbi Preclinical evaluation of the breast cancer cell-binding peptide, p160
    Vasileios Askoxylakis
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, University of Heidelberg, Germany
    Clin Cancer Res 11:6705-12. 2005
    ..To develop a peptide-based radiopharmaceutical, we investigated the properties of a peptide with affinity for human breast cancer, which has been selected through phage display...
  63. ncbi Evaluation of the pharmacokinetics of 68Ga-DOTATOC in patients with metastatic neuroendocrine tumours scheduled for 90Y-DOTATOC therapy
    Sophia Koukouraki
    Medical PET Group, Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 33:460-6. 2006
    ..i...
  64. ncbi Quantitative assessment of SSTR2 expression in patients with non-small cell lung cancer using(68)Ga-DOTATOC PET and comparison with (18)F-FDG PET
    Antonia Dimitrakopoulou-Strauss
    Medical PET Group Biological Imaging E0601, Clinical Cooperation Unit, Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 33:823-30. 2006
    ..Furthermore, dynamic(18)F-fluorodeoxyglucose (FDG) studies were performed in the same patients to compare the SSTR2 expression with the tumour viability...
  65. ncbi Comparison of the pharmacokinetics of 68Ga-DOTATOC and [18F]FDG in patients with metastatic neuroendocrine tumours scheduled for 90Y-DOTATOC therapy
    Sophia Koukouraki
    Medical PET Group Biological Imaging E0601, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 33:1115-22. 2006
    ....
  66. ncbi Angiopoietin-2 overexpression in morris hepatoma results in increased tumor perfusion and induction of critical angiogenesis-promoting genes
    Pierre Kunz
    Department of Anatomy and Cell Biology III, University of Heidelberg, Heidelberg, Germany
    J Nucl Med 47:1515-24. 2006
    ..In this study we wished to examine the complex effects of angiopoietin-2 (Ang-2) gene transfer in a rat hepatoma model...
  67. ncbi Identification and evaluation of a new tumor cell-binding peptide, FROP-1
    Sabine Zitzmann
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 48:965-72. 2007
    ....
  68. ncbi Influence of chelate conjugation on a newly identified tumor-targeting peptide
    Walter Mier
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    J Nucl Med 48:1545-52. 2007
    ..This study investigated whether coupling of a new peptide, FROP-1, to the chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) resulted in structural restriction and, consequently, improved binding and stability...
  69. ncbi Synthesis and evaluation of intercalating somatostatin receptor binding peptide conjugates for endoradiotherapy
    Keith Graham
    Universitatsklinikum Heidelberg, Department of Nuclear Medicine, 69120 Heidelberg, Germany
    J Pharm Pharm Sci 10:286s-297s. 2007
    ..In addition binding to the DNA might increase the retention in the receptor expressing tissues...
  70. doi Tetrafluorophenolate of HBED-CC: a versatile conjugation agent for 68Ga-labeled small recombinant antibodies
    Matthias Eder
    Radiopharmaceutical Chemistry, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 35:1878-86. 2008
    ....
  71. doi Early effects of FOLFOX treatment of colorectal tumour in an animal model: assessment of changes in gene expression and FDG kinetics
    Ludwig G Strauss
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 36:1226-34. 2009
    ..The aim of this study was to identify changes in gene expression patterns and to detect combinations of PET parameters that may be helpful in identifying treated tumours early after chemotherapy using dynamic PET studies...
  72. doi Sunflower trypsin inhibitor 1 derivatives as molecular scaffolds for the development of novel peptidic radiopharmaceuticals
    Regine Garcia Boy
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Mol Imaging Biol 12:377-85. 2010
    ..This study investigates the characteristics of derivatives of the sunflower trypsin inhibitor 1 (SFTI-1), a 14 amino acid peptide with high intrinsic stability...
  73. doi 68Ga-labelled recombinant antibody variants for immuno-PET imaging of solid tumours
    Matthias Eder
    Radiopharmaceutical Chemistry, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 37:1397-407. 2010
    ....
  74. ncbi Development of an oral cancer recurrence mouse model after surgical resection
    Andreas Behren
    Department of Otolaryngology, Head and Neck Surgery, University Hospital of Heidelberg, 69120 Heidelberg, Germany
    Int J Oncol 36:849-55. 2010
    ..In addition the model resembles all typical features of invasive head and neck cancers including the formation of lymph node metastasis and local infiltration...
  75. pmc ²¹³Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation: a first-in-human experience
    C Kratochwil
    Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 41:2106-19. 2014
    ..Alternative treatments for patients with refractory disease are rare. Here we report the first-in-human experience with (213)Bi-DOTATOC targeted alpha therapy (TAT) in patients pretreated with beta emitters...
  76. doi Comparison of PET/CT and PET/MRI hybrid systems using a 68Ga-labelled PSMA ligand for the diagnosis of recurrent prostate cancer: initial experience
    A Afshar-Oromieh
    Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 41:887-97. 2014
    ..68)Ga-labelled HBED-CC-PSMA is a highly promising tracer for imaging recurrent prostate cancer (PCa). The intention of this study was to evaluate the feasibility of PET/MRI with this tracer...
  77. doi [Importance of PET/CT in lymphoma diagnostics]
    A Afshar-Oromieh
    Abteilung für Nuklearmedizin, Radiologische Klinik, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland
    Radiologe 52:338-46. 2012
    ..Staging or re-staging of lymphomas using conventional imaging modalities is based on morphological changes, usually on the diameter of lesions. However, vitality of tumors cannot be evaluated...
  78. ncbi [Comparison of diagnostic accuracy of (18)F-FDG PET, (123)I-IMT- and (99m)Tc-MIBI SPECT: evaluation of tumour progression in irradiated low grade astrocytomas]
    M Henze
    Abt Nuklearmedizin, Universitätsklinik Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg
    Nuklearmedizin 45:49-56. 2006
    ....
  79. ncbi Improved syntheses and applicability of different DOTA building blocks for multiply derivatized scaffolds
    C Wangler
    German Cancer Research Center, Radiopharmaceutical Chemistry, INF 280, 69120 Heidelberg, Germany
    Bioorg Med Chem 16:2606-16. 2008
    ..Thiol-DOTA was found to be the best compound for efficient reactions with dendritic scaffolds generating highly homogeneous DOTA-multimers. This DOTA derivative could be quantitatively conjugated to a 128-mer dendrimer...
  80. ncbi Measurement of gastric emptying by 13C-octanoic acid breath test versus scintigraphy in diabetics
    A Zahn
    Innere Medizin IV, Medizinische Klinik IV, Klinikum der Universitat Heidelberg
    Z Gastroenterol 41:383-90. 2003
    ..It is not possible to predict diabetic gastroparesis on the basis of other autonomic function disorders or because of dyspeptic symptoms...
  81. doi [[18F]-FDG-PET in the diagnostics of gastrointestinal tumors]
    I Buchmann
    Abteilung für Nuklearmedizin, Universitätskliniken Heidelberg, Heidelberg
    Z Gastroenterol 46:367-75. 2008
    ..For gastrointestinal stroma tumours, FDG-PET is useful for the monitoring of therapy and the initial staging. For imaging of hepatocellular carcinoma and carcinoma of the gall bladder, FDG-PET is not sufficient...
  82. ncbi Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine
    Alexander Gutschalk
    Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany
    Neurosci Lett 332:115-8. 2002
    ..We hypothesize that this finding provides evidence for a primary neuronal dysfunction causing the prolonged neurological deficits in FHM...
  83. ncbi Peptide-PNA conjugates: targeted transport of antisense therapeutics into tumors
    Walter Mier
    Universitatsklinikum Heidelberg, Radiologische Klinik, Abteilung Nuklearmedizin, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Angew Chem Int Ed Engl 42:1968-71. 2003
  84. ncbi Evaluation of positron emission tomography imaging using [68Ga]-DOTA-D Phe(1)-Tyr(3)-Octreotide in comparison to [111In]-DTPAOC SPECT. First results in patients with neuroendocrine tumors
    Jörg Kowalski
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    Mol Imaging Biol 5:42-8. 2003
    ..This communication shows our initial experience using [68Ga]-DOTA-D-Phe(1)-Tyr(3)-Octreotide (DOTATOC) in comparison to [111In]-DTPAOC-SPECT in patients with neuroendocrine tumors...
  85. ncbi Exceptional increase in somatostatin receptor expression in pancreatic neuroendocrine tumour, visualised with (68)Ga-DOTATOC PET
    Marcus Henze
    Clinical Cooperation Unit, Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 31:466. 2004
  86. ncbi PET and SPECT for detection of tumor progression in irradiated low-grade astrocytoma: a receiver-operating-characteristic analysis
    Marcus Henze
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    J Nucl Med 45:579-86. 2004
    ....
  87. ncbi Iodide kinetics and dosimetry in vivo after transfer of the human sodium iodide symporter gene in rat thyroid carcinoma cells
    Uwe Haberkorn
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    J Nucl Med 45:827-33. 2004
    ..This study evaluates the iodide kinetics and dosimetry of iodide in hNIS-expressing thyroid carcinoma cells under optimized conditions...
  88. ncbi Comparison of real-time myocardial contrast echocardiography for the assessment of myocardial viability with fluorodeoxyglucose-18 positron emission tomography and dobutamine stress echocardiography
    Grigorios Korosoglou
    Department of Department, University of Heidelberg, Germany
    Am J Cardiol 94:570-6. 2004
    ..Normalization of contrast intensity to that of a reference control group is a valid approach for detection of myocardial viability and expands on information obtained from visual MCE and DSE...
  89. ncbi Conjugation of DOTA using isolated phenolic active esters: the labeling and biodistribution of albumin as blood pool marker
    Walter Mier
    Department of Nuclear Medicine, Universitatsklinikum Heidelberg, INF 400, 69120 Heidelberg, Germany
    Bioconjug Chem 16:237-40. 2005
    ..These results suggest that phenolic esters of DOTA represent versatile reagents to conjugate DOTA with proteins and other biomolecules in high yields...
  90. ncbi Gallium-68-DOTA-albumin as a PET blood-pool marker: experimental evaluation in vivo
    Johannes Hoffend
    Division of Nuclear Medicine, Department of Radiology, University of Heidelberg, 69120 Heidelberg, Germany
    Nucl Med Biol 32:287-92. 2005
    ..Our findings support clinical imaging using 68Ga-DOTA-labeled human serum albumin (HSA). The generator-produced label makes 68Ga-DOTA-labeled albumin continuously available even to centers lacking an in-house cyclotron...
  91. ncbi Characterization of 68Ga-DOTA-D-Phe1-Tyr3-octreotide kinetics in patients with meningiomas
    Marcus Henze
    Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Nucl Med 46:763-9. 2005
    ..In contrast to (18)F-FDG, this ligand shows high meningioma-to-background ratios. The aim was to evaluate kinetic parameters in meningiomas before radiotherapy...
  92. ncbi Identification of a new prostate-specific cyclic peptide with the bacterial FliTrx system
    Sabine Zitzmann
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Nucl Med 46:782-5. 2005
    ..Peptides are useful tools for directing radioisotopes into tumors. We evaluated the ability of a bacterial peptide display system to isolate new prostate tumor-specific peptides...
  93. ncbi Improved target volume definition for fractionated stereotactic radiotherapy in patients with intracranial meningiomas by correlation of CT, MRI, and [68Ga]-DOTATOC-PET
    Stefanie Milker-Zabel
    Department of Radiation Oncology, Radiation Therapy, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 65:222-7. 2006
    ..Because meningiomas show a high expression of somatostatin receptor subtype 2, somatostatin analogs such as DOTATOC offer the possibility of receptor-targeted imaging...
  94. ncbi Assessment of quantitative FDG PET data in primary colorectal tumours: which parameters are important with respect to tumour detection?
    Ludwig G Strauss
    Medical PET Group Biological Imaging E0601, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 34:868-77. 2007
    ..Dynamic PET data (DPET) were acquired, and compartment and non-compartment modelling applied. The discriminant power of single parameters and the combination of PET parameters was assessed. All lesions were confirmed by histology...
  95. ncbi 68Ga-labeled bombesin studies in patients with gastrointestinal stromal tumors: comparison with 18F-FDG
    Antonia Dimitrakopoulou-Strauss
    Medical PET Group Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 48:1245-50. 2007
    ..Furthermore, dynamic 18F-FDG studies were performed on the same patients...
  96. ncbi Transthyretin valine-94-alanine, a novel variant associated with late-onset systemic amyloidosis with cardiac involvement
    Arnt V Kristen
    Department of Cardiology, Medical University of Heidelberg, Heidelberg, Germany
    Amyloid 14:283-7. 2007
    ..Final clinical assessment of severity of cardiac involvement in the present patient is rendered complex by possible concomitant or preceding idiopathic dilated cardiomyopathy...
  97. ncbi Comparison of 99mtechnetium-pertechnetate and 123iodide SPECT with FDG-PET in patients suspicious for breast cancer
    Inga Buchmann
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    Cancer Biother Radiopharm 22:779-89. 2007
    ....
  98. doi Influence of cell proportions and proliferation rates on FDG uptake in squamous-cell esophageal carcinoma: a PET study
    Inga Buchmann
    Klinik und Poliklinik fur Nuklearmedizin, Universitätskliniken Mainz, Mainz, Germany
    Cancer Biother Radiopharm 23:172-80. 2008
    ..We investigated the influence of cell proportions and proliferation activities on tumor maximum standard uptake value (SUV(max)) in patients with squamous-cell esophageal cancer (SCEC)...
  99. doi Can the radiation dose to CT-enlarged but FDG-PET-negative inguinal lymph nodes in anal cancer be reduced?
    Sabine Kathrin Mai
    Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Germany
    Strahlenther Onkol 185:254-9. 2009
    ..To investigate whether a dose reduction to CT-enlarged but FDG-PET-negative (([(18)F]-fluoro-2-deoxy-D-glucose positron emission tomography) inguinal lymph nodes in radiochemotherapy of anal cancer is safe...
  100. doi Use of a new-generation reverse tetracycline transactivator system for quantitative control of conditional gene expression in the murine lung
    Julia Duerr
    Division of Pediatric Pulmonology, Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Germany
    Am J Respir Cell Mol Biol 44:244-54. 2011
    ....
  101. doi ScVEGF-PEG-HBED-CC and scVEGF-PEG-NOTA conjugates: comparison of easy-to-label recombinant proteins for [68Ga]PET imaging of VEGF receptors in angiogenic vasculature
    Matthias Eder
    Radiopharmaceutical Chemistry, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Nucl Med Biol 37:405-12. 2010
    ....