A Gratchev

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Molecular genetics of Xeroderma pigmentosum variant
    Alexei Gratchev
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Exp Dermatol 12:529-36. 2003
  2. ncbi Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein betaIG-H3
    A Gratchev
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    Scand J Immunol 53:386-92. 2001
  3. ncbi Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages
    A Gratchev
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Scand J Immunol 61:10-7. 2005
  4. ncbi Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals
    Alexei Gratchev
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Immunobiology 211:473-86. 2006
  5. ncbi The receptor for interleukin-17E is induced by Th2 cytokines in antigen-presenting cells
    A Gratchev
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Scand J Immunol 60:233-7. 2004
  6. ncbi Alternative versus classical activation of macrophages
    S Goerdt
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    Pathobiology 67:222-6. 1999
  7. ncbi [beta-catenin overexpression in metastasized colorectal carcinoma--an important mechanism in progression of the disease?]
    B Mann
    Chirurgische Klinik, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin
    Langenbecks Arch Chir Suppl Kongressbd 115:303-6. 1998
  8. pmc Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
    B Mann
    Department of Surgery, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin, Germany
    Proc Natl Acad Sci U S A 96:1603-8. 1999
  9. pmc Stabilin-1, a homeostatic scavenger receptor with multiple functions
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Cell Mol Med 10:635-49. 2006
  10. ncbi Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing
    A Gratchev
    Department of Dermatology, University Medical Center Mannheim, Ruprecht-Karl University Heidelberg, Mannheim, Germany
    Skin Pharmacol Appl Skin Physiol 14:272-9. 2001

Collaborators

Detail Information

Publications32

  1. ncbi Molecular genetics of Xeroderma pigmentosum variant
    Alexei Gratchev
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Exp Dermatol 12:529-36. 2003
    ..Identification of POLH as the XPV gene provides an important instrument for improving molecular diagnostics in XPV families...
  2. ncbi Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein betaIG-H3
    A Gratchev
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    Scand J Immunol 53:386-92. 2001
    ....
  3. ncbi Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages
    A Gratchev
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Scand J Immunol 61:10-7. 2005
    ..In conclusion, stimulation of Mphi with IL-4 and GC regulate antagonistically the expression of ECM remodelling-related molecules and phagocytosis of opsonized and non-opsonized particles...
  4. ncbi Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals
    Alexei Gratchev
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Immunobiology 211:473-86. 2006
    ..Selective refractoriness of Mphi1 and Mphi2 to IFNgamma- and LPS-induced cytokine secretion may contribute to prevent autoimmunity...
  5. ncbi The receptor for interleukin-17E is induced by Th2 cytokines in antigen-presenting cells
    A Gratchev
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Scand J Immunol 60:233-7. 2004
    ..These results indicate that IL-17BR-expressing APC2s may mediate the development of the IL-17E-mediated immunological reaction patterns observed in vivo...
  6. ncbi Alternative versus classical activation of macrophages
    S Goerdt
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    Pathobiology 67:222-6. 1999
    ..Thus, classically and alternatively activated APC secure the balance between proinflammatory and anti-inflammatory immune reactions...
  7. ncbi [beta-catenin overexpression in metastasized colorectal carcinoma--an important mechanism in progression of the disease?]
    B Mann
    Chirurgische Klinik, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin
    Langenbecks Arch Chir Suppl Kongressbd 115:303-6. 1998
    ..The resulting increased transcription of hitherto unknown target genes might be involved in the progression and the metastatic process of CRC...
  8. pmc Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
    B Mann
    Department of Surgery, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin, Germany
    Proc Natl Acad Sci U S A 96:1603-8. 1999
    ..Together with the other alterations, beta-catenin accumulation may contribute to the development and progression of colon carcinoma both by dedifferentiation and through proteolytic activity...
  9. pmc Stabilin-1, a homeostatic scavenger receptor with multiple functions
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Cell Mol Med 10:635-49. 2006
    ..In summary, stabilin-1 is a homeostatic receptor which links signals from the extracellular environment to intracellular vesicular processes, creating a potential impact on the macrophage secretion profile...
  10. ncbi Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing
    A Gratchev
    Department of Dermatology, University Medical Center Mannheim, Ruprecht-Karl University Heidelberg, Mannheim, Germany
    Skin Pharmacol Appl Skin Physiol 14:272-9. 2001
    ..Thus, APC2 represent a hitherto neglected, but indispensable major pathway of APC activation and function...
  11. ncbi Overexpression of c-myb in leukaemic and non-leukaemic variants of cutaneous T-cell lymphoma
    N Poenitz
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    Dermatology 211:84-92. 2005
    ....
  12. ncbi Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms
    Jochen Utikal
    Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    J Cutan Pathol 33:20-3. 2006
    ..Cutaneous leiomyomas and leiomyosarcomas are rare tumors that originate from the arrector muscle of hair follicles or the smooth muscle of blood vessels...
  13. ncbi Perspectives of mathematical modelling for understanding of intracellular signalling and vesicular trafficking in macrophages
    Julia Kzhyshkowska
    Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
    Immunobiology 212:813-25. 2007
    ..Identified critical elements of the system will facilitate the isolation of predictive/diagnostic markers as well as potential therapeutic targets...
  14. ncbi Functional characterization of the epidermal cholinergic system in vitro
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Invest Dermatol 126:2458-72. 2006
    ..In summary, we show that epidermal AChR are crucially involved in the regulation of epidermal homeostasis...
  15. ncbi Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis
    Julia Kzhyshkowska
    Department of Dermatology, Venerology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Germany
    J Immunol 180:3028-37. 2008
    ..5 microg/ml in fetal circulation. We propose that stabilin-1-positive macrophages determine the difference in PL levels between maternal and fetal circulation...
  16. ncbi Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Immunol 176:5825-32. 2006
    ..We propose that alternatively activated macrophages coordinate extracellular matrix remodeling, angiogenesis, and tumor progression via stabilin-1-mediated endocytosis of SPARC and thereby regulate its extracellular concentration...
  17. ncbi Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway
    Julia Kzhyshkowska
    Department of Dermatology, Venerology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Blood 107:3221-8. 2006
    ..The 1C11 mAb detected SI-CLP in human bronchoalveolar lavage and peripheral-blood leukocytes (PBLs), and can be used to analyze the role of SI-CLP in human disorders...
  18. ncbi Additional Her 2/neu gene copies in patients with Sézary syndrome
    Jochen Utikal
    Department of Dermatology, Venerology and Allergology, University Medical Center Mannheim, Ruprecht Karl University Heidelberg, Mannheim, Germany
    Leuk Res 30:755-60. 2006
    ..Her 2/neu gene amplification has been reported in several types of cancer. Monoclonal antibodies against the Her 2/neu receptor are used as a treatment in e.g. metastatic breast cancer...
  19. ncbi Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II
    Alexei Gratchev
    Department of Dermatology, Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    J Immunol 180:6553-65. 2008
    ....
  20. ncbi Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Leukoc Biol 76:1151-61. 2004
    ....
  21. ncbi Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDL
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Immunobiology 210:161-73. 2005
    ..Our data indicate that PI3K activity is required for the transfer of stabilin-1 and its ligand acLDL from early to late endosomal compartments...
  22. ncbi Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3
    N Booken
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    Leukemia 22:393-9. 2008
    ..Furthermore, CDO1 catalyzes taurine synthesis and taurine inhibits apoptosis and promotes chemoprotection. In summary, CDO1 and DNM3 may improve the diagnosis of SS and open novel clues to its pathogenesis...
  23. pmc Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues
    Oliver Politz
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Biochem J 362:155-64. 2002
    ....
  24. ncbi Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis
    J H Martens
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    J Pathol 208:574-89. 2006
    ....
  25. ncbi Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation
    A Gratchev
    Medizinische Klinik I, Gastroenterologie und Infektiologie, , D-12200, Berlin, Germany
    Cancer Lett 168:71-80. 2001
    ..They indicate that MUC2 expression in vivo is regulated by promoter methylation and support the hypothesis that cells with goblet-like differentiation give rise to mucinous colonic carcinomas...
  26. ncbi Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin
    Hjalmar Kurzen
    Department of Dermatology, University Medical Center Heidelberg, Germany
    J Invest Dermatol 123:937-49. 2004
    ..Taken together, our data result in a complete molecular map of the extraneuronal cholinergic system of the skin that may be translated into distinct functional reaction patterns...
  27. ncbi Functional significance of non-neuronal acetylcholine in skin epithelia
    Anisa Hana
    Department of Dermatology, Venereology and Allergology, Medical Faculty of Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Life Sci 80:2214-20. 2007
    ..Altogether we provide first hints for a causative role of the non-neuronal cholinergic system in the pathogenesis of HS by promoting infundibular epithelial hyperplasia and thus follicular plugging...
  28. ncbi De novo expression of the Muc2 gene in pancreas carcinoma cells is triggered by promoter demethylation
    A Siedow
    Medizinische Klinik I, Gastroenterologie und Infektiologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    Tumour Biol 23:54-60. 2002
    ..They warrant further investigations on the relationship between MUC2 promoter demethylation in pancreatic cancer and the prognosis of carcinoma patients...
  29. ncbi The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation
    Jochen Utikal
    Department of Dermatology, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    Int J Cancer 119:2287-93. 2006
    ..In conclusion, we clearly demonstrate here that the expression of metastasis suppressor MIM is regulated by DNA methylation of a CpG island within its promoter region...
  30. ncbi Macrophages of human first trimester decidua express markers associated to alternative activation
    Kristijan Cupurdija
    Institute of Histology and Embryology, Karl Franzens University, Graz, Austria
    Am J Reprod Immunol 51:117-22. 2004
    ..To date, not much is known about the activation phenotype of decidua macrophages, which - together with NK cells - constitute the majority of bone marrow derived cells at this location...
  31. doi Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
    Wim J Kleijer
    Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands
    DNA Repair (Amst) 7:744-50. 2008
    ..1 per million for TTD. Perhaps contrary to general conceptions, compared to XP the incidence of CS appears to be somewhat higher and the incidence of TTD to be quite similar in the native West-European population...
  32. pmc Xeroderma pigmentosum-variant patients from America, Europe, and Asia
    Hiroki Inui
    DNA Repair Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4258, USA
    J Invest Dermatol 128:2055-68. 2008
    ..We found a wide spectrum of mutations in the POLH gene among XP-V patients in different countries, suggesting that many of these mutations arose independently...