M Graefen

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Zonal location of prostate cancer: significance for disease-free survival after radical prostatectomy?
    Herbert Augustin
    Department of Urology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Urology 62:79-85. 2003
  2. ncbi request reprint Reasonable delay of surgical treatment in men with localized prostate cancer--impact on prognosis?
    Markus Graefen
    Department of Urology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Urol 47:756-60. 2005
  3. ncbi request reprint Open retropubic nerve-sparing radical prostatectomy
    Markus Graefen
    Department of Urology, University Medical Center Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Urol 49:38-48. 2006
  4. ncbi request reprint [Technique of nerve-sparing radical retropubic prostatectomy]
    M Graefen
    Urologische Klinik, Universitätskrankenhaus Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Urologe A 43:156-9. 2004
  5. doi request reprint [Active surveillance for prostate cancer]
    M Graefen
    Martini Klinik, Prostatazentrum an der Universitätsklinik Hamburg Eppendorf, Hamburg, Germany
    Urologe A 47:261-9. 2008
  6. ncbi request reprint [Indications for and results of radical prostatectomy]
    M Graefen
    Urologische Klinik, Universitätskrankenhaus, Hamburg Eppendorf, Hamburg
    Urologe A 42:1203-11. 2003
  7. ncbi request reprint [Can nomograms derived in the U.S. applied to German patients? A study about the validation of preoperative nomograms predicting the risk of recurrence after radical prostatectomy]
    M Graefen
    Klinik und Poliklinik fur Urologie, Universitätsklinik Hamburg Eppendorf
    Urologe A 42:685-92. 2003
  8. ncbi request reprint Can predictive models for prostate cancer patients derived in the United States of America be utilized in European patients? A validation study of the Partin tables
    Markus Graefen
    Department of Urology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Eur Urol 43:6-10; discussion 11. 2003
  9. ncbi request reprint [Selection criteria for the expected management of localised prostate cancer]
    M Graefen
    Martini Klinik, Prostatazentrum an der Universitätsklinik Hamburg Eppendorf
    Urologe A 44:1277-8, 1280-6. 2005
  10. doi request reprint Predicting the risk of lymph node invasion during radical prostatectomy using the European Association of Urology guideline nomogram: a validation study
    J Schmitges
    Martini Clinic, Prostate Cancer Center, Hamburg, Germany
    Eur J Surg Oncol 38:624-9. 2012

Detail Information

Publications137 found, 100 shown here

  1. ncbi request reprint Zonal location of prostate cancer: significance for disease-free survival after radical prostatectomy?
    Herbert Augustin
    Department of Urology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Urology 62:79-85. 2003
    ..To analyze the zonal location of prostate cancer as a possible predictive feature of progression-free survival after radical prostatectomy...
  2. ncbi request reprint Reasonable delay of surgical treatment in men with localized prostate cancer--impact on prognosis?
    Markus Graefen
    Department of Urology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Urol 47:756-60. 2005
    ..We investigated whether a reasonable delay from diagnosis to definitive treatment impact recurrence free survival rates in men undergoing radical prostatectomy (RP) for localized prostate cancer...
  3. ncbi request reprint Open retropubic nerve-sparing radical prostatectomy
    Markus Graefen
    Department of Urology, University Medical Center Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Urol 49:38-48. 2006
    ..Furthermore, indication, oncologic outcome, and functional results addressing postoperative urinary continence and potency are discussed...
  4. ncbi request reprint [Technique of nerve-sparing radical retropubic prostatectomy]
    M Graefen
    Urologische Klinik, Universitätskrankenhaus Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Urologe A 43:156-9. 2004
    ..This article gives a detailed description of our operative technique. Furthermore, a strategy for patient selection and tumor selection for the indication of a nerve-sparing radical prostatectomy is suggested...
  5. doi request reprint [Active surveillance for prostate cancer]
    M Graefen
    Martini Klinik, Prostatazentrum an der Universitätsklinik Hamburg Eppendorf, Hamburg, Germany
    Urologe A 47:261-9. 2008
    ..Active surveillance has the potential to lead to undertreatment as there is some evidence that prolonged treatment delay might adversely affect outcome of definitive therapy...
  6. ncbi request reprint [Indications for and results of radical prostatectomy]
    M Graefen
    Urologische Klinik, Universitätskrankenhaus, Hamburg Eppendorf, Hamburg
    Urologe A 42:1203-11. 2003
    ..A nerve-sparing modification of the operative technique does not compromise radicality of the procedure if patients are carefully selected. For this purpose simple and reliable algorithms are available...
  7. ncbi request reprint [Can nomograms derived in the U.S. applied to German patients? A study about the validation of preoperative nomograms predicting the risk of recurrence after radical prostatectomy]
    M Graefen
    Klinik und Poliklinik fur Urologie, Universitätsklinik Hamburg Eppendorf
    Urologe A 42:685-92. 2003
    ..0274). For that reason preoperative nomograms derived in the U.S. can be applied to german patients. However, we would recommend the utilization of the Kattan nomogram due to its higher predictive accuracy...
  8. ncbi request reprint Can predictive models for prostate cancer patients derived in the United States of America be utilized in European patients? A validation study of the Partin tables
    Markus Graefen
    Department of Urology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Eur Urol 43:6-10; discussion 11. 2003
    ..Accuracy of predictive tools derived in the US might therefore suffer when applied to European patients. We tested the validity of the widely accepted Partin tables for their ability to predict pathologic stage in German patients...
  9. ncbi request reprint [Selection criteria for the expected management of localised prostate cancer]
    M Graefen
    Martini Klinik, Prostatazentrum an der Universitätsklinik Hamburg Eppendorf
    Urologe A 44:1277-8, 1280-6. 2005
    ..In general, expected management is a suitable option for elderly patients with low grade cancers. Young patients and those with intermediate or high-grade cancers are most likely to benefit from active local treatment...
  10. doi request reprint Predicting the risk of lymph node invasion during radical prostatectomy using the European Association of Urology guideline nomogram: a validation study
    J Schmitges
    Martini Clinic, Prostate Cancer Center, Hamburg, Germany
    Eur J Surg Oncol 38:624-9. 2012
    ....
  11. ncbi request reprint [Technical aspects of nerve sparing during retropubic prostatectomy]
    J Walz
    Department of Urology, University Medical Center Eppendorf, Martinistr 52, 20246 Hamburg, Allemagne
    Ann Urol (Paris) 41:23-30. 2007
    ..This article gives a detailed description of the operative technique. Furthermore, a strategy for patient selection and tumour selection for the indication of nerve-sparing radical prostatectomy (NSRP) is suggested...
  12. doi request reprint Influence of low-molecular-weight heparin dosage on red blood cell transfusion, lymphocele rate and drainage duration after open radical prostatectomy
    J Schmitges
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Surg Oncol 38:1082-8. 2012
    ..To assess the rates of red blood cell (RBC) transfusions, pelvic lymphoceles, and prolonged drainage duration in patients after radical prostatectomy (RP) receiving perioperative bridging with low-molecular-weight heparin (LMWH)...
  13. ncbi request reprint A validated strategy for side specific prediction of organ confined prostate cancer: a tool to select for nerve sparing radical prostatectomy
    M Graefen
    Department of Urology and Institutes of Mathematics and Computer Science in Medicine, and Pathology University Hospital Eppendorf, Hamburg, Germany
    J Urol 165:857-63. 2001
    ..Side specific analysis of these parameters is a flexible and reliable tool for selecting patients for nerve sparing radical prostatectomy...
  14. ncbi request reprint [Nerve-sparing radical retropubic prostatectomy. Results of a patient survey]
    J Noldus
    Klinik und Poliklinik fur Urologie, Universtitätsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg
    Urologe A 40:102-6. 2001
    ..The results of the unilateral procedure were disappointing. However, the bilateral nerve-sparing method achieved much better results inasmuch as about 50% of the patients reported recovery of erections sufficient for sexual intercourse...
  15. ncbi request reprint [Influence of transrectal endosonography on the clinical staging of impalpable prostate cancer. A controversy over the TNM system]
    P G Hammerer
    Klinik und Poliklinik fur Urologie, Universitätsklinik Hamburg Eppendorf
    Urologe A 43:307-12. 2004
  16. ncbi request reprint Human glandular kallikrein 2 levels in serum for discrimination of pathologically organ-confined from locally-advanced prostate cancer in total PSA-levels below 10 ng/ml
    A Haese
    Department of Urology, University Clinic Eppendorf, Hamburg, Germany
    Prostate 49:101-9. 2001
    ..Further, we evaluated hK2, free- and tPSA-concentrations in all pathologic stages of PCa...
  17. ncbi request reprint Transition zone cancers undermine the predictive accuracy of Partin table stage predictions
    T Steuber
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 173:737-41. 2005
    ..We tested the predictive accuracy and performance of the Partin tables according to TZ vs PZ tumor predominance...
  18. doi request reprint No impact of blood transfusion on oncological outcome after radical prostatectomy in patients with prostate cancer
    K Boehm
    Martini Clinic, Prostate Cancer Center, Martinistr 52, 20246, Hamburg, Germany
    World J Urol 33:801-6. 2015
    ..Current studies addressing the relationship between BT, blood loss and BCR-free survival in prostate cancer patients are controversial and include only series with fairly small patient cohorts...
  19. ncbi request reprint [Transrectal ultrasound-guided punch biopsies of the prostate. Indication, technique, results, and complications]
    J Palisaar
    Klinik und Poliklinik fur Urologie, Universitatsklinikum, Hamburg Eppendorf, Hamburg
    Urologe A 42:1188-95. 2003
    ..This meant the systematic removal of three punch cylinders from both lateral lobes of the prostate in the parasagittal midline at various levels (apex, middle, and base)...
  20. ncbi request reprint Differences in biopsy features between prostate cancers located in the transition and peripheral zone
    H Augustin
    Department of Urology, University Hospital Hamburg Eppendorf, Germany
    BJU Int 91:477-81. 2003
    ....
  21. ncbi request reprint [Serum markers for early detection and staging of prostate cancer. Status report on current and future markers]
    A Haese
    Urologische Klinik und Poliklinik, Universitätskrankenhaus, Hamburg Eppendorf, Hamburg
    Urologe A 42:1172-87. 2003
    ..This overview summarizes established and potentially new forms of PSA and hK2 for early detection and staging of prostate cancer...
  22. ncbi request reprint [Type and extent of preoperative imaging before radical prostatectomy]
    H Isbarn
    Martini Klinik, Universitäres Prostatakarzinomzentrum Hamburg Eppendorf, Hamburg
    Urologe A 49:396-400. 2010
    ..We investigated the rate of computed tomography (CT), magnetic resonance imaging (MRI), and bone scintigraphy carried out before radical prostatectomy (RP) depending on the individual risk profile...
  23. ncbi request reprint The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer
    Alexander Haese
    Department of Urology, University Hospital Hamburg, Germany
    Prostate 54:181-6. 2003
    ..In this study we investigated whether hK2 adds independent information when considered together with traditionally used parameters to predict organ confined (pT2a/b) PCa...
  24. doi request reprint The novel nomogram of Gleason sum upgrade: possible application for the eligible criteria of low dose rate brachytherapy
    Lars Budaus
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Urol 17:862-8. 2010
    ....
  25. ncbi request reprint Validation of NF-kappaB p65 as a prostate cancer prognostic marker on a large cohort of European patients
    L Lessard
    Centre de Recherche du CHUM, Montreal, QC, Canada Hôpital du Sacré Coeur de Montréal, Montreal, QC, Canada University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Oncol 26:11055. 2008
    ..We and others have shown that the nuclear expression of p65 can predict biochemical recurrence and lymph node invasion in small cohorts (i.e. < 100 patients)...
  26. doi request reprint [F(18)]-fluoroethylcholine combined in-line PET-CT scan for detection of lymph-node metastasis in high risk prostate cancer patients prior to radical prostatectomy: Preliminary results from a prospective histology-based study
    T Steuber
    Martini Clinic, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur J Cancer 46:449-55. 2010
    ..To evaluate the diagnostic potential of PET/CT using ([F(18)]fluorethylcholine (FEC) for lymph node (LN) staging in high risk prostate cancer (PCa) patients prior to radical prostatectomy (RP)...
  27. ncbi request reprint Stage migration in clinically localized prostate cancer
    J Noldus
    Department of Urology, University Hospital, University of Hamburg, Germany
    Eur Urol 38:74-8. 2000
    ..To determine whether migration of pathological tumor stages in patients with clinically localized prostate cancer exists and whether this is due to an increasing frequency of treating patients with clinically insignificant cancer...
  28. doi request reprint [Role of lymph node dissection in prostate cancer]
    T Schlomm
    Martini Klinik, UKE Hamburg Eppendorf, Gebäude 046, Martinistrasse 52, 20246 Hamburg
    Urologe A 48:37-45. 2009
    ..Each patient should be individually counseled regarding his individual tumor features and the use of statistical prognostic tools such as nomograms...
  29. ncbi request reprint Prostate-specific antigen improves the ability of clinical stage and biopsy Gleason sum to predict the pathologic stage at radical prostatectomy in the new millennium
    Felix K H Chun
    Department of Urology, University Medical Centre, Eppendorf, Hamburg, Germany
    Eur Urol 52:1067-74. 2007
    ..The contemporary ability of prostate-specific antigen (PSA) to predict pathologic stage in men with localized prostate cancer was recently questioned...
  30. ncbi request reprint Contemporary prostate cancer prevalence among T1c biopsy-referred men with a prostate-specific antigen level < or = 4.0 ng per milliliter
    Sascha A Ahyai
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 53:750-7. 2008
    ..To investigate the prostate cancer (PCa) prevalence and risk factors of men with prostate-specific antigen (PSA) level< or =4.0 ng/ml and an unsuspicious digital rectal examination (DRE) in a large biopsy referral cohort...
  31. doi request reprint External validation of a preoperative nomogram for prediction of the risk of recurrence after radical prostatectomy
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 77:788-92. 2010
    ..To test the validity of an updated version of the preoperative Kattan nomogram for prediction of recurrence after radical prostatectomy (RP), published by Stephenson et al...
  32. ncbi request reprint High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series
    Jochen Walz
    Department of Urology, University Medical Centre Eppendorf, Hamburg, Germany
    Eur Urol 50:498-505. 2006
    ..We explored the yield of saturation biopsy and developed a nomogram predicting the probability of prostate cancer (PCa) on the basis of saturation biopsy...
  33. ncbi request reprint Discrimination of benign from malignant prostatic disease by selective measurements of single chain, intact free prostate specific antigen
    Thomas Steuber
    Department of Urology, University of Hamburg Eppendorf, Germany
    J Urol 168:1917-22. 2002
    ..We assessed the ability of serum intact PSA to discriminate between benign and malignant prostatic disease...
  34. doi request reprint Does HistoScanning™ predict positive results in prostate biopsy? A retrospective analysis of 1,188 sextants of the prostate
    J Schiffmann
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    World J Urol 32:925-30. 2014
    ..Existing literature is sparse and controversial. To provide more evidence according to that important clinical topic, we analyzed institutional data from the Martini-Clinic, Prostate Cancer Center, Hamburg...
  35. doi request reprint High Nr-CAM expression is associated with favorable phenotype and late PSA recurrence in prostate cancer treated by prostatectomy
    M C Tsourlakis
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prostate Cancer Prostatic Dis 16:159-64. 2013
    ..The aim of our study is to evaluate the prevalence of Nr-CAM expression in prostate cancer and to explore its association with phenotype and clinical disease course...
  36. ncbi request reprint [Functional results of various surgical techniques for radical prostatectomy]
    U Michl
    Urologische Universitätsklinik, Hamburg Eppendorf, Hamburg
    Urologe A 42:1196-202. 2003
    ..This paper shows the results of our own center and compares the data in the literature regarding functional results of radical prostatectomy with respect to various operative techniques...
  37. ncbi request reprint A multicenter clinical trial on the use of alpha1-antichymotrypsin-prostate-specific antigen in prostate cancer diagnosis
    M Lein
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    Prostate 47:77-84. 2001
    ..The aim was to evaluate the clinical performance of alpha(1)-antichymotrypsin prostate-specific antigen (PSA-ACT) for early diagnosis of prostate cancer (PCa) in a multicenter trial...
  38. ncbi request reprint Significance of high-grade prostatic intraepithelial neoplasia in needle biopsy specimens
    W Prange
    Institute of Pathology, University Hospital Eppendorf, University of Hamburg, Hamburg, Germany
    Urology 57:486-90. 2001
    ..Its value in predicting a significantly increased risk of concurrent prostate cancer needs to be further investigated in larger case studies...
  39. ncbi request reprint Circulating tumour-associated plasma DNA represents an independent and informative predictor of prostate cancer
    Felix K H Chun
    Department of Urology, University Hospital Hamburg Epppendorf, Hamburg, Germany
    BJU Int 98:544-8. 2006
    ..To investigate whether preoperative plasma levels of free DNA can discriminate between men with localized prostate cancer and benign prostatic hyperplasia (BPH)...
  40. ncbi request reprint Significant upgrading affects a third of men diagnosed with prostate cancer: predictive nomogram and internal validation
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    BJU Int 98:329-34. 2006
    ....
  41. doi request reprint Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer
    Sarah Minner
    Institute of Pathology, Department of Urology, Prostate Cancer Center University Medical Center, Hamburg Eppendorf, Germany
    Clin Cancer Res 16:1553-60. 2010
    ..The purpose of this study was to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in prostate cancer...
  42. ncbi request reprint Comparative assessment of the 1992 and 2002 pathologic T3 substages for the prediction of biochemical recurrence after radical prostatectomy
    Thomas Steuber
    Department of Urology, University Hospital Hamburg Eppendorf, Germany
    Cancer 106:775-82. 2006
    ....
  43. doi request reprint Differences in histopathological and biochemical outcomes in patients with low Gleason score prostate cancer
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 105:818-23. 2010
    ..Diagnosis (case series)...
  44. doi request reprint Critical assessment of tools to predict clinically insignificant prostate cancer at radical prostatectomy in contemporary men
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    Cancer 113:701-9. 2008
    ..Overtreatment of prostate cancer (PCa) is a concern, especially in patients who might qualify for the diagnosis of insignificant prostate cancer (IPCa). The ability to identify IPCa prior to definitive therapy was tested...
  45. ncbi request reprint Biochemical recurrence following radical prostatectomy: a comparison between prostate cancers located in different anatomical zones
    Herbert Augustin
    Department of Urology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Prostate 55:48-54. 2003
    ..To assess whether differences of biochemical recurrence after radical prostatectomy exist between prostate cancers located in the transition zone (TZ) and peripheral zone (PZ)...
  46. ncbi request reprint Prognostic significance of visible lesions on transrectal ultrasound in impalpable prostate cancers: implications for staging
    Herbert Augustin
    Department of Urology, University of Hamburg, Hamburg, Germany
    J Clin Oncol 21:2860-8. 2003
    ..The aim of this article is to provide a differentiated view of the significance of TRUS findings for staging purposes in impalpable prostate cancers...
  47. ncbi request reprint Development and internal validation of a nomogram predicting the probability of prostate cancer Gleason sum upgrading between biopsy and radical prostatectomy pathology
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 49:820-6. 2006
    ..We explored the rate of upgrading from biopsy to RP specimen in our contemporary cohort, and developed a model capable of predicting the probability of biopsy Gleason sum upgrading...
  48. doi request reprint [The value of real-time elastography in the diagnosis of prostate cancer]
    G Salomon
    Martini Klinik, Prostatakarzinom Zentrum am UKE, Universitätsklinik Hamburg Eppendorf, Martinistrasse 52, 20253, Hamburg, Deutschland
    Urologe A 48:628-36. 2009
    ..One of these new methods is sonoelastography. Its impact on prostate cancer diagnostics has not yet been fully investigated, but the number of publications on this new technique indicate increasing interest in it...
  49. doi request reprint Impact of annual surgical volume on length of stay in patients undergoing minimally invasive prostatectomy: a population-based study
    L Budaus
    Martiniclinic, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur J Surg Oncol 37:429-34. 2011
    ....
  50. ncbi request reprint Prospective validation of an algorithm with systematic sextant biopsy to predict pelvic lymph node metastasis in patients with clinically localized prostatic carcinoma
    Stefan Conrad
    Department of Urology, Institute of Mathematics and Computer Science in Medicine, University of Hamburg, Eppendorf University Hospital, Hamburg, Germany
    J Urol 167:521-5. 2002
    ..We prospectively validate an algorithm to predict pelvic lymph node metastasis in patients with clinically localized prostatic carcinoma...
  51. ncbi request reprint Development and internal validation of preoperative transition zone prostate cancer nomogram
    Thomas Steuber
    Department of Urology, University of Hamburg, Hamburg, Germany
    Urology 68:1295-300. 2006
    ..TZ PCa may be associated with more favorable RP pathologic findings than peripheral zone (PZ) PCa. To identify these men, we developed a model capable of predicting the probability of TZ PCa at RP...
  52. ncbi request reprint Percent free prostate specific antigen is not an independent predictor of organ confinement or prostate specific antigen recurrence in unscreened patients with localized prostate cancer treated with radical prostatectomy
    Markus Graefen
    Department of Urology, University Hospital Hamburg Eppendorf, Germany
    J Urol 167:1306-9. 2002
    ..We studied the controversial relationship of percent free prostate specific antigen (PSA) with organ confined prostate cancer and PSA failure after radical prostatectomy...
  53. doi request reprint [Psychosocial predictors of utilization of medical rehabilitation services among prostate cancer patients]
    C Lehmann
    Institut und Poliklinik für Medizinische Psychologie, Universitätsklinikum Hamburg Eppendorf UKE, Hamburg, Germany
    Rehabilitation (Stuttg) 51:160-70. 2012
    ..Therefore, this study exploratively aims at the identification of predictors of the use of rehabilitation services in a cohort of prostate cancer patients...
  54. doi request reprint [PSA--Quo vadis?]
    C Börgermann
    Klinik und Poliklinik fur Urologie, Uroonkologie und Kinderurologie, Universitatsklinik, Hufelandstrasse 55, 45122, Essen, Germany
    Urologe A 48:1008, 1010, 1012-4, passim. 2009
    ..A possible solution is to change the early detection paradigm from detection of all prostate cancers to identification of aggressive ones. In this article, early detection is discussed based on the recent literature...
  55. ncbi request reprint [Success rates of two-layer, microsurgical vasovasostomy. Results from a patient questionnaire and comparison with one-layer technique]
    M G Friedrich
    Klinik und Poliklinik fur Urologie, Universitat Hamburg, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Aktuelle Urol 37:58-63. 2006
    ..In our clinic the two-layer microsurgical technique (DL VVST) is considered to be the gold standard. We have examined the results of DL VVST by means of a questionnaire and compared them with those of the monolayer technique (ML VVST)...
  56. doi request reprint Depression, anxiety, post-traumatic stress disorder and health-related quality of life and its association with social support in ambulatory prostate cancer patients
    A Mehnert
    Department of Medical Psychology, University Medical Center Hamburg Eppendorf, Martinistr, Hamburg, Germany
    Eur J Cancer Care (Engl) 19:736-45. 2010
    ..001), whereas the impact of social support on physical health was rather weak. Findings emphasise the need for routine psychosocial screening...
  57. ncbi request reprint Advanced prostate cancer is associated with a decrease in serum luteinizing hormone
    H Hilz
    Institut fur Medizinische Biochemie und Molekularbiologie, Universitatskrankenhaus Eppendorf, Hamburg, Deutschland
    Eur Urol 38:243-9. 2000
    ..Depletion of serum LH by LHRH agonists is used as a therapeutic treatment in hormone-sensitive prostate cancer (PCa). However, little information on serum LH in different patient groups is available...
  58. ncbi request reprint A comparison of anaesthetic techniques for shock wave lithotripsy: the use of a remifentanil infusion alone compared to intermittent fentanyl boluses combined with a low dose propofol infusion
    M A Burmeister
    Department of Anaesthesia and Department of Urology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Anaesthesia 57:877-81. 2002
    ..We found that remifentanil used as the sole agent failed to demonstrate any advantage over the combination of fentanyl/propofol with regard to rapid recovery and discharge following anaesthesia for extracorporal shock wave lithotripsy...
  59. ncbi request reprint Pathological and clinical characteristics of large prostate cancers predominantly located in the transition zone
    A Erbersdobler
    Institute of Pathology, University of Hamburg, Germany
    Prostate Cancer Prostatic Dis 5:279-84. 2002
    ..8% of these patients suffered from postoperative PSA-recurrence. We conclude that the peculiar pathological and clinical characteristics of large prostate cancers in the transition zone might be important for prognostic considerations...
  60. ncbi request reprint Tumour grade, proliferation, apoptosis, microvessel density, p53, and bcl-2 in prostate cancers: differences between tumours located in the transition zone and in the peripheral zone
    Andreas Erbersdobler
    Institute of Pathology, University of Hamburg, Germany
    Eur Urol 41:40-6. 2002
    ..It is unclear, however, whether this can be put down to anatomical reasons alone, or if there are further differences between tumours of both zones...
  61. doi request reprint Importance of baseline potency rate assessment of men diagnosed with clinically localized prostate cancer prior to radical prostatectomy
    Georg Salomon
    Martini Clinic, Prostate Cancer Center, University of Hamburg, Hamburg, Germany
    J Sex Med 6:498-504. 2009
    ..Knowledge about baseline potency is highly important in men undergoing treatment for prostate cancer (PCa) as it might influence judgments about impact of treatment and thereby treatment decisions...
  62. ncbi request reprint Basic principles of anatomy for optimal surgical treatment of prostate cancer
    Jochen Walz
    Department of Urology, University Medical Centre Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    World J Urol 25:31-8. 2007
    ..Respecting and considering these anatomic principles during NSRP should result in good postoperative functional outcome, as well as in good outcome in cancer control...
  63. ncbi request reprint Role of nomograms for prostate cancer in 2007
    Felix K H Chun
    Department of Urology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    World J Urol 25:131-42. 2007
    ..In 2007 and the future, more specific and refined nomograms will be available which address relevant clinical end points. Moreover, novel markers in PCa outcomes will be quantified using the nomogram approach...
  64. doi request reprint Molecular cancer phenotype in normal prostate tissue
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Germany
    Eur Urol 55:885-90. 2009
    ..Insufficient sensitivity and specificity of prostate biopsies for cancer detection...
  65. ncbi request reprint Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, Department of Pathology and Urology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Clin Cancer Res 13:6579-84. 2007
    ..To determine its role in prostate cancer, we analyzed 2,497 prostate cancers on the DNA and protein level...
  66. doi request reprint Biochemical recurrence after radical prostatectomy: multiplicative interaction between surgical margin status and pathological stage
    Lars Budaus
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 184:1341-6. 2010
    ..We addressed the first degree of interaction between positive surgical margins and other established adverse predictors of biochemical recurrence after radical prostatectomy...
  67. ncbi request reprint Extraction and processing of high quality RNA from impalpable and macroscopically invisible prostate cancer for microarray gene expression analysis
    Thorsten Schlomm
    Department of Urology, University Clinic Hamburg Eppendorf, D 20246 Hamburg, Germany
    Int J Oncol 27:713-20. 2005
    ..Among these were several known prostate cancer relevant genes, such as AMACR, TARP, LIM, GPR160 (all up-regulated), CAV1, NTN1, MT1X; CLU, TRIM29, SPARCL1 and HSPB8 (all down-regulated)...
  68. ncbi request reprint Influence of nerve-sparing (NS) procedure during radical prostatectomy (RP) on margin status and biochemical failure
    Rein Jüri Palisaar
    Department of Urology, University Clinics of Bochum, Marienhospital Herne, 44627 Herne, Germany
    Eur Urol 47:176-84. 2005
    ..To evaluate whether nerve-sparing procedure itself is a risk factor for biochemical recurrence in carefully selected patients...
  69. ncbi request reprint Frozen section for the management of intraoperatively detected palpable tumor lesions during nerve-sparing scheduled radical prostatectomy
    Christian Eichelberg
    Department of Urology, University Hospital Hamburg Eppendorf, Germany
    Eur Urol 49:1011-6; discussion 1016-8. 2006
    ..We investigated the use of frozen section (FS) analysis to monitor the safety and efficiency of NS during RP in patients with intraoperatively identified subcapsular tumor lesions...
  70. ncbi request reprint Nerve distribution along the prostatic capsule
    Christian Eichelberg
    Department of Urology, University Hospital Eppendorf, Hamburg, Germany
    Eur Urol 51:105-10; discussion 110-1. 2007
    ..The objective of this study therefore was to determine the typical pattern of nerve distribution along the prostatic capsule...
  71. doi request reprint Prognostic significance of a positive surgical margin in pathologically organ-confined prostate cancer
    Sascha A Ahyai
    Department of Urology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 106:478-83. 2010
    ....
  72. ncbi request reprint Prediction of tumor heterogeneity in localized prostate cancer
    Hartwig Huland
    Department of Urology, University Clinics Hamburg Eppendorf, Martinistrasse 52, D 20246, Hamburg, Germany
    Urol Clin North Am 29:213-22. 2002
    ..Clinical T1 or T2 prostatic carcinoma is a heterogeneous but fairly predictable tumor...
  73. doi request reprint Clinical significance of p53 alterations in surgically treated prostate cancers
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Mod Pathol 21:1371-8. 2008
    ..The rate of p53 alterations increases with prostate cancer progression...
  74. ncbi request reprint Assessment of clinical and pathologic characteristics predisposing to disease recurrence following radical prostatectomy in men with pathologically organ-confined prostate cancer
    R Jüri Palisaar
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 41:155-61. 2002
    ..To identify risk factors for biochemical failure after radical prostatectomy (RP) in men with pathologically organ-confined (OC) prostate cancer (PCa)...
  75. doi request reprint Unilateral prostate cancer cannot be accurately predicted in low-risk patients
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 77:784-7. 2010
    ..We tested the accuracy of unilaterally unremarkable biopsy findings in cases of low-risk PCa patients who are potential candidates for HAT...
  76. ncbi request reprint Marked gene transcript level alterations occur early during radical prostatectomy
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Eur Urol 53:333-44. 2008
    ..However, transcript level patterns and RNA quality could rapidly change in response to ischemic and mechanical stress. Studies have shown that this occurs both perioperatively and after surgical removal of organs...
  77. doi request reprint Long-term data on the survival of patients with prostate cancer treated with radical prostatectomy in the prostate-specific antigen era
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 106:37-43. 2010
    ..Therapy (case series) Level of Evidence 4...
  78. doi request reprint The feasibility of prostate cancer detection by triple spectroscopy
    Georg Salomon
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 55:376-83. 2009
    ..We tested whether the combination of these techniques can differentiate malignant and benign prostate tissue ex vivo...
  79. doi request reprint A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer
    Olaf J C Hellwinkel
    Martini Klinik, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 101:1454-60. 2008
    ....
  80. doi request reprint Evaluation of prostate cancer detection with ultrasound real-time elastography: a comparison with step section pathological analysis after radical prostatectomy
    Georg Salomon
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 54:1354-62. 2008
    ..Conventional gray scale ultrasound has a low sensitivity and specificity for prostate cancer detection. Better imaging modalities are needed...
  81. doi request reprint Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Centre, Hamburg Eppendorf, Germany
    Eur Urol 55:394-401. 2009
    ..The presence of a tertiary Gleason grade (TGG) pattern in radical prostatectomy (RP) specimens has been described as associated with adverse pathology and a higher biochemical recurrence (BCR) rate after RP...
  82. ncbi request reprint Total and Gleason grade 4/5 cancer volumes are major contributors of human kallikrein 2, whereas free prostate specific antigen is largely contributed by benign gland volume in serum from patients with prostate cancer or benign prostatic biopsies
    Alexander Haese
    Department of Urology, University Clinic Eppendorf, Hamburg, Germany
    J Urol 170:2269-73. 2003
    ....
  83. ncbi request reprint Patient-reported sexual function after nerve-sparing radical retropubic prostatectomy
    Joachim Noldus
    Department of Urology, University of Hamburg, Martinistrasse 52, 20246, Hamburg, Germany
    Eur Urol 42:118-24. 2002
    ..Patient questionnaire based outcome analysis on post-operative erectile function after uni- or bilateral nerve-sparing RRP is described...
  84. doi request reprint Distinct subcellular expression patterns of neutral endopeptidase (CD10) in prostate cancer predict diverging clinical courses in surgically treated patients
    Achim Fleischmann
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 14:7838-42. 2008
    ..Neutral endopeptidase (CD10), an ectopeptidase bound to the cell surface, is thought to be a potential prognostic marker for prostate cancer...
  85. ncbi request reprint Anatomic radical retropubic prostatectomy-long-term recurrence-free survival rates for localized prostate cancer
    Felix K H Chun
    Department of Urology, University Medical Center Eppendorf, Hamburg, Germany
    World J Urol 24:273-80. 2006
    ..Our findings confirm excellent long-term biochemical cancer-control outcomes after RRP. High grade prostate cancer at final pathology and seminal vesicle invasion proved to be the strongest risk factors of BCR after surgery...
  86. ncbi request reprint Therapy of recurrent disease after radical prostatectomy in 2007
    Rudolf Schwarz
    Medical Center Hamburg Eppendorf, Section Radiation Oncology, Martinistr 52, 20246 Hamburg, Germany
    World J Urol 25:161-7. 2007
    ..In a patient with a high probability of local recurrence early radiotherapy for PSA relapse is suggested...
  87. ncbi request reprint Validation of a nomogram for prediction of side specific extracapsular extension at radical prostatectomy
    Thomas Steuber
    Department of Urology, Hamburg, Germany
    J Urol 175:939-44; discussion 944. 2006
    ..We developed a nomogram and compared the performance and discriminant properties of the tree regression and the nomogram in a contemporary cohort of European patients treated with radical retropubic prostatectomy...
  88. ncbi request reprint Association of free-prostate specific antigen subfractions and human glandular kallikrein 2 with volume of benign and malignant prostatic tissue
    Thomas Steuber
    Department of Urology, University of Hamburg Eppendorf, Hamburg, Germany
    Prostate 63:13-8. 2005
    ....
  89. doi request reprint [Current results on PSA-based prostate cancer detection]
    M Graefen
    Martini Klinik, Prostatakarzinomzentrum am UKE, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57:312-7. 2014
    ..Along with better risk stratification, the expansion of PSA screening should be discussed in order to reduce the still high numbers of palliative treatments, metastases, and prostate cancer-related deaths. ..
  90. doi request reprint Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer
    Alexander T El Gammal
    Departments of Gynecology, Institute of Pathology, Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg, Germany
    Clin Cancer Res 16:56-64. 2010
    ..Deletions of 8p and gains of 8q belong to the most frequent cytogenetic alterations in prostate cancer. The target genes of these alterations and their biological significance are unknown...
  91. doi request reprint The presence of prostate cancer on saturation biopsy can be accurately predicted
    Sascha A Ahyai
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 105:636-41. 2010
    ..To improve the ability of our previously reported saturation biopsy nomogram quantifying the risk of prostate cancer, as the use of office-based saturation biopsy has increased...
  92. ncbi request reprint Clinical use of urinary markers for the detection and prognosis of bladder carcinoma: a comparison of immunocytology with monoclonal antibodies against Lewis X and 486p3/12 with the BTA STAT and NMP22 tests
    Martin G Friedrich
    Department of Urology, University Hospital, University of Hamburg, Hamburg, Germany
    J Urol 168:470-4. 2002
    ..We compared the NMP22 (Matritech, Cambridge, Massachusetts) and BTA Stat (Bard Diagnostics, Redmond, Washington) tests with immunocytology using mAbs 486p3/12 and BG7 against Lewis X antigen...
  93. doi request reprint Effect of body mass index on histopathologic parameters: results of large European contemporary consecutive open radical prostatectomy series
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Urology 73:615-9. 2009
    ..Studies, predominantly derived from the United States, have suggested that an increased BMI is a significant predictor of adverse pathologic findings in patients treated with open RP...
  94. ncbi request reprint Zonal origin of localized prostate cancer does not affect the rate of biochemical recurrence after radical prostatectomy
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 51:949-55; discussion 955. 2007
    ..To investigate whether transition zone (TZ) prostate cancers demonstrate different rates of biochemical recurrence after radical prostatectomy compared to peripheral zone (PZ) cancers...
  95. ncbi request reprint Comparison of accuracy between the Partin tables of 1997 and 2001 to predict final pathological stage in clinically localized prostate cancer
    Herbert Augustin
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 171:177-81. 2004
    ..We validated externally the predictive accuracy of the 2001 Partin tables and compared the 1997 and 2001 versions...
  96. ncbi request reprint Prostate-specific antigen and related isoforms in the diagnosis and management of prostate cancer
    Alexander Haese
    Department of Urology, University Clinic Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Curr Urol Rep 5:231-40. 2004
    ..Newly discovered isoforms of free PSA also may impact early detection of prostate cancer with encouraging preliminary results that warrant further clinical investigation...
  97. ncbi request reprint Validation of NF-kappaB p65 as a prostate cancer prognostic marker on a large European cohort
    P O Gannon
    Research Center of the Universite de Montreal Hospital Center CRCHUM Institut du Cancer de Montreal, Montreal, QC, Canada Service of anatomopathology, Hôpital du Sacré Coeur, Montreal, QC, Canada Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany Martini Klinik Hamburg, Hamburg, Germany Research Center of the Universite de Montreal Hospital Center, Institut du Cancer de Montreal, Montreal, QC, Canada University of Montreal Hospital Center, Montreal, QC, Canada
    J Clin Oncol 29:4537. 2011
    ..In this study, we present validating results suggesting that NF-kB p65 can predict biochemical recurrence (BCR) in a large independent cohort...
  98. doi request reprint ["Expanded prostate cancer index composite" (EPIC-26): Results of functional treatment in patients with localized prostate cancer]
    B Beyer
    Martini Klinik, Prostatakrebszentrum Hamburg, Martinistrase 52, 20246, Hamburg, Deutschland
    Urologe A 54:1591-5. 2015
    ..Use of the ICHOM standard set and the EPIC-26 achieves a possibility for comparison of each form of therapy with respect to the curative success and the effect on health and quality of life of patients. ..
  99. pmc Clinical nodal staging scores for prostate cancer: a proposal for preoperative risk assessment
    L A Kluth
    1 Department of Urology, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA 2 Department of Urology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Br J Cancer 111:213-9. 2014
    ..The objective of this study was to develop a model that allows preoperative determination of the minimum number of lymph nodes needed to be removed at radical prostatectomy to ensure true nodal status...
  100. doi request reprint Comparison of prostate cancer volume measured by HistoScanning™ and final histopathological results
    J Schiffmann
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    World J Urol 32:939-44. 2014
    ..The aim of this study was to evaluate the accuracy of total tumor volume measured by HS (TVHS) in patients with PCa...
  101. pmc MR Imaging of Prostate Cancer: Diffusion Weighted Imaging and (3D) Hydrogen 1 (H) MR Spectroscopy in Comparison with Histology
    J Yamamura
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Radiol Res Pract 2011:616852. 2011
    ..9% and 98.3%, respectively. Conclusion. The results of our study showed that both DWI and MRS should be considered as an additional and complementary tool to the T2-weighted MRI for detecting prostate cancer...