Margarete Goppelt-Struebe

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells
    Alexander Weidemann
    Department of Nephrology and Hypertension, Universitatsklinikum Erlangen, Universitat Erlangen Nurnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Cell Commun Signal 11:80. 2013
  2. pmc Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells
    Jonathan Zuehlke
    Department of Nephrology and Hypertension, Friedrich Alexander Universitat Erlangen Nurnberg, Loschgestrasse 8, Erlangen 91054, Germany
    Cell Commun Signal 10:25. 2012
  3. pmc Cell type-specific regulation of CCN2 protein expression by PI3K-AKT-FoxO signaling
    Jana Samarin
    Department of Nephrology and Hypertension, Medical Clinic 4, University of Erlangen Nurnberg, University Hospital Erlangen, 91054, Erlangen, Germany
    J Cell Commun Signal 3:79-84. 2009
  4. ncbi request reprint Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton
    Christian Ott
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Loschgestrasse 8, D 91054 Erlangen, Germany
    J Biol Chem 278:44305-11. 2003
  5. doi request reprint Shear stress preconditioning modulates endothelial susceptibility to circulating TNF-alpha and monocytic cell recruitment in a simplified model of arterial bifurcations
    Iwona Cicha
    Laboratory of Molecular Cardiology, Medical Clinic 2, University of Erlangen Nuremberg, Schwabachanlage 10, 91054 Erlangen, Germany
    Atherosclerosis 207:93-102. 2009
  6. pmc Distinct mesenchymal alterations in N-cadherin and E-cadherin positive primary renal epithelial cells
    Christof Keller
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 7:e43584. 2012
  7. ncbi request reprint Actin-dependent regulation of connective tissue growth factor
    Susanne Muehlich
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Loschgestrasse 8, D 91054 Erlangen, Germany
    Am J Physiol Cell Physiol 292:C1732-8. 2007
  8. doi request reprint Matrix-independent stimulation of human tubular epithelial cell migration by Rho kinase inhibitors
    Sven Kroening
    Department of Nephrology and Hypertension, Medical Clinic 4, University Hospital of Erlangen, Erlangen, Germany
    J Cell Physiol 223:703-12. 2010
  9. ncbi request reprint Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro
    Iwona Cicha
    Medical Clinic II, University of Erlangen Nuremberg, Erlangen, Germany
    Arterioscler Thromb Vasc Biol 25:1008-13. 2005
  10. ncbi request reprint Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress
    Iwona Cicha
    Medical Clinic 2, University of Erlangen Nuremberg, Erlangen, Germany
    Atherosclerosis 196:136-45. 2008

Collaborators

Detail Information

Publications38

  1. pmc HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells
    Alexander Weidemann
    Department of Nephrology and Hypertension, Universitatsklinikum Erlangen, Universitat Erlangen Nurnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Cell Commun Signal 11:80. 2013
    ..To investigate this important aspect of PHD-inhibition, we used a spheroid-on-matrix cell culture model...
  2. pmc Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells
    Jonathan Zuehlke
    Department of Nephrology and Hypertension, Friedrich Alexander Universitat Erlangen Nurnberg, Loschgestrasse 8, Erlangen 91054, Germany
    Cell Commun Signal 10:25. 2012
    ..However, the role of different types of tubular epithelial cells in these processes so far has not been addressed in primary cultures of human cells...
  3. pmc Cell type-specific regulation of CCN2 protein expression by PI3K-AKT-FoxO signaling
    Jana Samarin
    Department of Nephrology and Hypertension, Medical Clinic 4, University of Erlangen Nurnberg, University Hospital Erlangen, 91054, Erlangen, Germany
    J Cell Commun Signal 3:79-84. 2009
    ..In endothelial cells activation of PI3K - AKT signaling was inversely related to CCN2 expression. FoxO transcription factors, which are negatively regulated by AKT, were identified as potent activators of CCN2 gene expression...
  4. ncbi request reprint Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton
    Christian Ott
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Loschgestrasse 8, D 91054 Erlangen, Germany
    J Biol Chem 278:44305-11. 2003
    ..These data link alterations in the microtubule and actin cytoskeleton to the expression of CTGF and provide a molecular basis for the observation that CTGF is up-regulated in cells exposed to mechanical stress...
  5. doi request reprint Shear stress preconditioning modulates endothelial susceptibility to circulating TNF-alpha and monocytic cell recruitment in a simplified model of arterial bifurcations
    Iwona Cicha
    Laboratory of Molecular Cardiology, Medical Clinic 2, University of Erlangen Nuremberg, Schwabachanlage 10, 91054 Erlangen, Germany
    Atherosclerosis 207:93-102. 2009
    ..This study investigated the endothelial response to shear stress in combination with the inflammatory cytokine TNF-alpha in a simplified model of arterial bifurcation...
  6. pmc Distinct mesenchymal alterations in N-cadherin and E-cadherin positive primary renal epithelial cells
    Christof Keller
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 7:e43584. 2012
    ..Renal tubular epithelial cells of proximal and distal origin differ markedly in their physiological functions. Therefore, we hypothesized that they also differ in their capacity to undergo epithelial to mesenchymal alterations...
  7. ncbi request reprint Actin-dependent regulation of connective tissue growth factor
    Susanne Muehlich
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Loschgestrasse 8, D 91054 Erlangen, Germany
    Am J Physiol Cell Physiol 292:C1732-8. 2007
    ..These findings provide novel evidence that monomeric actin is the connecting link between alterations in the cytoskeleton and CTGF gene expression and demonstrate the importance of SRF in regulating CTGF transcription...
  8. doi request reprint Matrix-independent stimulation of human tubular epithelial cell migration by Rho kinase inhibitors
    Sven Kroening
    Department of Nephrology and Hypertension, Medical Clinic 4, University Hospital of Erlangen, Erlangen, Germany
    J Cell Physiol 223:703-12. 2010
    ..Pharmacologic inhibition of ROCKs may thus favor repair processes in renal tubules by increasing the migratory capacity of tubular epithelial cells...
  9. ncbi request reprint Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro
    Iwona Cicha
    Medical Clinic II, University of Erlangen Nuremberg, Erlangen, Germany
    Arterioscler Thromb Vasc Biol 25:1008-13. 2005
    ..To assess the hypothesis that CTGF is involved in atherosclerotic plaque progression, we investigated CTGF protein expression and distribution in the different types of plaque morphology...
  10. ncbi request reprint Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress
    Iwona Cicha
    Medical Clinic 2, University of Erlangen Nuremberg, Erlangen, Germany
    Atherosclerosis 196:136-45. 2008
    ..Interference with shear stress-induced protein expression may inhibit endothelial dysfunction in atheroprone vessel regions...
  11. doi request reprint Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia
    Sven Kroening
    Department of Nephrology and Hypertension, University Hospital of Erlangen Nuremberg, Erlangen, Germany
    Am J Physiol Renal Physiol 298:F796-806. 2010
    ..Taken together, our data provide evidence that exposure to hypoxia decreased CTGF gene expression. Furthermore, hypoxia per se was not sufficient to induce a mesenchymal phenotype in primary tubular epithelial cells...
  12. ncbi request reprint Activated human platelets release connective tissue growth factor
    Iwona Cicha
    Medical Clinic IV, University of Erlangen Nuremberg, Loschgestr 8, D 91054 Erlangen, Germany
    Thromb Haemost 91:755-60. 2004
    ..In conclusion, CTGF is stored in normal human platelets, and can be released upon platelet activation. Aspirin treatment prevents CTGF release, suggesting that clinical benefits of this drug may involve the inhibition of CTGF secretion...
  13. ncbi request reprint Connective tissue growth factor is released from platelets under high shear stress and is differentially expressed in endothelium along atherosclerotic plaques
    Iwona Cicha
    Medical Clinic II, University of Erlangen Nuremberg, Germany
    Clin Hemorheol Microcirc 35:203-6. 2006
    ..Furthermore, disturbed flow along atherosclerotic vessels may induce endothelial CTGF expression and contribute to the progress of atherosclerotic lesions...
  14. ncbi request reprint Induction of cyclooxygenase-2 and enhanced release of prostaglandin E(2) and I(2) in human endothelial cells by engagement of CD40
    Christoph D Garlichs
    Medical Clinic II, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Atherosclerosis 163:9-16. 2002
    ..The hypothesis was tested that CD40-CD154 interaction is involved in the induction of cyclooxygenase-2 and the release of prostanoids in human endothelial cells...
  15. pmc Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression
    Angelika Hahn
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Loschgestr 8, D 91054 Erlangen, Germany
    Biochem J 362:33-40. 2002
    ..By exclusion of RhoA and non-specific cytoskeletal effects, the results in the present study indicate an important role for Rac and/or Cdc42 in pertussis toxin-sensitive LPA-mediated Cox-2 induction...
  16. doi request reprint Hic-5 as a regulator of endothelial cell morphology and connective tissue growth factor gene expression
    Claudiu Komorowsky
    Department of Nephrology and Hypertension, University Hospital Erlangen, Loschgestrasse 8, 91054, Erlangen, Germany
    J Mol Med (Berl) 88:623-31. 2010
    ..These data suggest that the reduced expression of Hic-5 may contribute to the anti-angiogenic effects of histone deacetylase inhibitors...
  17. doi request reprint Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in human proximal tubular cell lines
    Sven Kroening
    Department of Nephrology and Hypertension, Medical Clinic 4, University Hospital of Erlangen Nuremberg, 91054 Erlangen, Germany
    Nephrol Dial Transplant 24:3319-25. 2009
    ..Therefore, we hypothesized that the expression of CTGF might be modulated under hypoxic conditions...
  18. ncbi request reprint STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I
    Angela Graness
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Loschgestrasse 8, D 91054 Erlangen, Germany
    Biochem Pharmacol 72:32-41. 2006
    ....
  19. doi request reprint Inhibition of Rho kinases increases directional motility of microvascular endothelial cells
    Johannes Breyer
    Department of Nephrology and Hypertension, Universitat Erlangen Nurnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Biochem Pharmacol 83:616-26. 2012
    ..In summary, Rho kinase inhibition enhanced the migration and cytoskeletal restructuring preferentially in freshly attached endothelial cells. ROCK2 may be a potential target to manipulate endothelial cell migration after vessel injury...
  20. doi request reprint Carotid plaque vulnerability: a positive feedback between hemodynamic and biochemical mechanisms
    Iwona Cicha
    Laboratory of Molecular Cardiology, Department of Cardiology and Angiology, University of Erlangen Nuremberg, Schwabachanlage 10, 91054 Erlangen, Germany
    Stroke 42:3502-10. 2011
    ..The aim of this study was to investigate carotid plaque vulnerability markers in relation to blood flow direction and the mechanisms leading to plaque rupture at the upstream side of carotid stenoses...
  21. pmc A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy
    Bernward Hinkes
    Department of Pediatrics, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    BMC Nephrol 13:27. 2012
    ..Repeatedly she suffered from kidney transplant failure caused by consuming membranous nephropathy...
  22. pmc The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1
    Ruth Schietke
    Interdisciplinary Centre for Clinical Research, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 285:6658-69. 2010
    ..Lysyl oxidases could be an attractive molecular target for cancers of epithelial origin, in particular because they are partly extracellular...
  23. ncbi request reprint Resveratrol inhibits monocytic cell chemotaxis to MCP-1 and prevents spontaneous endothelial cell migration through Rho kinase-dependent mechanism
    Iwona Cicha
    Department of Cardiology and Angiology, University of Erlangen Nuremberg, Erlangen, Germany
    J Atheroscler Thromb 18:1031-42. 2011
    ..The anti-inflammatory red wine polyphenol, resveratrol, has been implicated in cardiovascular protection. In this study, we investigated the effects of resveratrol on endothelial and monocytic cell migration...
  24. doi request reprint Up-regulation of connective tissue growth factor in endothelial cells by the microtubule-destabilizing agent combretastatin A-4
    Jana Samarin
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, University Hospital Erlangen, Erlangen, Germany
    Mol Cancer Res 7:180-8. 2009
    ..Up-regulation of CTGF by low concentrations of CA-4P may thus occur in newly formed tumor vessels and contribute to the microvessel destabilization and antiangiogenic effects of CA-4P observed in vivo...
  25. ncbi request reprint Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor
    Stefan Gauer
    Department of Nephrology and Hypertension, Medical Clinic 4, University of Erlangen Nuremberg, Loschgestrasse 8, D 91054 Erlangen, Germany
    Nephrol Dial Transplant 22:3154-9. 2007
    ..The profibrotic protein connective tissue growth factor (CTGF) has been identified as one of the target proteins of aldosterone. However, the molecular mechanisms of aldosterone-mediated CTGF induction have not been characterized...
  26. pmc Lack of α8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells
    Ines Marek
    Hospital for Children and Adolescents, Universitat Erlangen Nurnberg, Loschgestrasse 15, 91054 Erlangen, Germany
    BMC Cell Biol 11:102. 2010
    ..For this reason we hypothesized that mesangial cells and vascular smooth muscle cells differ in their respective capacity to compensate for the lack of α8 integrin...
  27. ncbi request reprint Expression of cyclooxygenase-2 in biopsies obtained from human transplanted kidneys undergoing rejection
    Birgit Hausknecht
    1 Medizinische Klinik IV, Universitat Erlangen Nurnberg, Erlangen, Germany
    Transplantation 76:109-14. 2003
    ..This study investigates a potential involvement of COX-2 in transplant rejection. Therefore, we examined the expression of COX-2 in biopsies obtained for diagnostic purposes...
  28. doi request reprint Analysis of matrix-dependent cell migration with a barrier migration assay
    Sven Kroening
    Department of Nephrology and Hypertension, University Hospital Erlangen, 91054 Erlangen, Germany
    Sci Signal 3:pl1. 2010
    ..Thus, the barrier cell migration assay is a useful tool for exploring matrix-dependent migration of adherent cells...
  29. doi request reprint Inhibitors of oxygen sensing prolyl hydroxylases regulate nuclear localization of the transcription factors Smad2 and YAP/TAZ involved in CTGF synthesis
    Felix Preisser
    Department of Nephrology and Hypertension, Friedrich Alexander Universitat Erlangen Nurnberg, Loschgestr 8, 91054 Erlangen, Germany
    Biochim Biophys Acta 1863:2027-36. 2016
    ..This mechanism might be extended to other transcription factors and target genes, and may thus represent a novel mechanism of negative regulation of gene expression by PHD inhibition. ..
  30. pmc P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells
    Andre Kraus
    Department of Nephrology and Hypertension, Friedrich Alexander University of Erlangen Nurnberg, Ulmenweg 18, 91054, Erlangen, Germany
    Purinergic Signal 12:687-695. 2016
    ..In conclusion, P2Y2R mediates ATP-dependent cyst growth and is transcriptionally regulated by HIF-1α. These findings provide further mechanistic evidence on how hypoxia promotes cyst growth...
  31. ncbi request reprint Endothelial dysfunction and monocyte recruitment in cells exposed to non-uniform shear stress
    Iwona Cicha
    Medical Clinic 2, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Hemorheol Microcirc 39:113-9. 2008
    ....
  32. doi request reprint Connective tissue growth factor: context-dependent functions and mechanisms of regulation
    Iwona Cicha
    Department of Cardiology and Angiology, University Erlangen Nuremberg, Schwabachanlage 10, 91054 Erlangen, Germany
    Biofactors 35:200-8. 2009
    ..Finally, we will touch upon novel aspects of epigenetic regulation of CTGF gene expression. (c) 2009 International Union of Biochemistry and Molecular Biology, Inc...
  33. ncbi request reprint Differential involvement of the integrin-linked kinase (ILK) in RhoA-dependent rearrangement of F-actin fibers and induction of connective tissue growth factor (CTGF)
    Angela Graness
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Loschgestrasse 8, D 91054 Erlangen, Germany
    Cell Signal 18:433-40. 2006
    ..Taken together, ILK is involved in RhoA-dependent reorganization of the actin cytoskeleton, whereas activation of RhoA and RhoA-mediated gene expression is independent of ILK...
  34. doi request reprint Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells
    Sven Kroening
    Department of Nephrology and Hypertension, University Hospital of Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 24:755-62. 2009
    ..A major downstream mediator of TGF-beta is connective tissue growth factor (CTGF). However, the molecular mechanisms of CTGF regulation by HGF have not yet been investigated...
  35. ncbi request reprint Failure of cyclosporin A to induce transforming growth factor beta (TGF-beta) synthesis in activated peripheral blood lymphocytes
    Margarete Goppelt-Struebe
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Loschgestrasse 8, Germany
    Clin Transplant 17:20-5. 2003
    ..Furthermore, up-regulation of Cox-2 mRNA was inhibited by CsA. Taken together, there was no evidence for TGF-beta as a clinically relevant mediator being induced by CsA in activated peripheral blood T-lymphocytes...
  36. doi request reprint Dual inhibition of Src family kinases and Aurora kinases by SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner
    Iwona Cicha
    Department of Cardiology and Angiology, Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Schwabachanlage 10, 91054 Erlangen, Germany Electronic address
    Int J Biochem Cell Biol 46:39-48. 2014
    ..Taken together, in non-transformed epithelial cells, SU6656 modulates the expression of the pro-fibrotic factor CTGF in a time-dependent manner by inhibition of Src kinases and Aurora kinases. ..
  37. doi request reprint Differential regulation of connective tissue growth factor in renal cells by histone deacetylase inhibitors
    Claudiu Komorowsky
    Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany
    J Cell Mol Med 13:2353-64. 2009
    ..Different cell type-specific transcription factors seem to determine whether CTGF expression is reduced or increased in cells exposed to HDAC inhibitors...
  38. ncbi request reprint Role of macula densa cyclooxygenase-2 in renovascular hypertension
    Andrea Hartner
    Department of Medicine IV, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 284:F498-502. 2003
    ..Thus either COX-2 is not necessary for the macula densa mechanism or the macula densa is not important for maintaining high renin in renovascular hypertension...