B Goke

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint [A therapeutic option for type-2 diabetes. The incretion hormone GLP-1]
    Burkhard Goke
    Medizinische Klinik II, Klinikum Grosshadern Ludwig Maximilians Universität Marchioninistr 15, 81377 Munchen
    Pharm Unserer Zeit 31:294-9. 2002
  2. ncbi request reprint Coefficient of beta-cell failure in patients with type 2 diabetes treated with pioglitazone or acarbose
    B Goke
    Department of Internal Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany
    Exp Clin Endocrinol Diabetes 112:115-7. 2004
  3. ncbi request reprint Dexamethasone stimulation of retinoic Acid-induced sodium iodide symporter expression and cytotoxicity of 131-I in breast cancer cells
    S Unterholzner
    Department of Internal Medicine II, Ludwig Maximilians University, 81377 Munich, Germany
    J Clin Endocrinol Metab 91:69-78. 2006
  4. ncbi request reprint Radioiodine therapy of colon cancer following tissue-specific sodium iodide symporter gene transfer
    I V Scholz
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians University Munich, Germany
    Gene Ther 12:272-80. 2005
  5. doi request reprint The role of fatty acid hydrolase gene variants in inflammatory bowel disease
    M Storr
    Department of Medicine II Grosshadern, University of Munich, Munich, Germany
    Aliment Pharmacol Ther 29:542-51. 2009
  6. ncbi request reprint Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex
    B Yuece
    Department of Internal Medicine II and Institute of Surgical Research, Ludwig Maximilians University Munich, Munich, Germany
    Neurogastroenterol Motil 19:744-53. 2007
  7. doi request reprint GLP-1 regulates gastroduodenal motility involving cholinergic pathways
    J Schirra
    Department of Internal Medicine II, Ludwig Maximilians University, Munich, Germany
    Neurogastroenterol Motil 21:609-18, e21-2. 2009
  8. ncbi request reprint STW 5 (Iberogast) and its individual herbal components modulate intestinal electrophysiology of mice
    A Sibaev
    Department of Internal Medicine II, Ludwig Maximilians University of Munich, Germany
    Phytomedicine 13:80-9. 2006
  9. ncbi request reprint An unusual cause of azathioprine inefficacy
    M Storr
    Department of Medicine II, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    Endoscopy 38:E61. 2006
  10. pmc Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells
    P Dames
    Medizinische Klinik II, Ludwig Maximilians Universitat, München 80336, Germany
    Exp Diabetes Res 2012:460869. 2012

Detail Information

Publications46

  1. ncbi request reprint [A therapeutic option for type-2 diabetes. The incretion hormone GLP-1]
    Burkhard Goke
    Medizinische Klinik II, Klinikum Grosshadern Ludwig Maximilians Universität Marchioninistr 15, 81377 Munchen
    Pharm Unserer Zeit 31:294-9. 2002
  2. ncbi request reprint Coefficient of beta-cell failure in patients with type 2 diabetes treated with pioglitazone or acarbose
    B Goke
    Department of Internal Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany
    Exp Clin Endocrinol Diabetes 112:115-7. 2004
    ..This method of analysis has been used to assess data on HbA1c and fasting glucose concentrations from a randomised study comparing pioglitazone with acarbose...
  3. ncbi request reprint Dexamethasone stimulation of retinoic Acid-induced sodium iodide symporter expression and cytotoxicity of 131-I in breast cancer cells
    S Unterholzner
    Department of Internal Medicine II, Ludwig Maximilians University, 81377 Munich, Germany
    J Clin Endocrinol Metab 91:69-78. 2006
    ....
  4. ncbi request reprint Radioiodine therapy of colon cancer following tissue-specific sodium iodide symporter gene transfer
    I V Scholz
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians University Munich, Germany
    Gene Ther 12:272-80. 2005
    ..This study demonstrates the potential of NIS as a therapeutic gene allowing radioiodine therapy of colon cancer following tumor-specific NIS gene transfer...
  5. doi request reprint The role of fatty acid hydrolase gene variants in inflammatory bowel disease
    M Storr
    Department of Medicine II Grosshadern, University of Munich, Munich, Germany
    Aliment Pharmacol Ther 29:542-51. 2009
    ..Recent studies suggest a role for the endocannabinoid system, including fatty acid amide hydrolase (FAAH), in intestinal inflammation...
  6. ncbi request reprint Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex
    B Yuece
    Department of Internal Medicine II and Institute of Surgical Research, Ludwig Maximilians University Munich, Munich, Germany
    Neurogastroenterol Motil 19:744-53. 2007
    ..Our data strongly suggest a physiological involvement of the CB-1 receptor in the regulation of small intestinal motility. Therefore, CB1 receptors are a promising target for the treatment of motility disorders...
  7. doi request reprint GLP-1 regulates gastroduodenal motility involving cholinergic pathways
    J Schirra
    Department of Internal Medicine II, Ludwig Maximilians University, Munich, Germany
    Neurogastroenterol Motil 21:609-18, e21-2. 2009
    ..Cholinergic mechanisms mediate the effects of GLP-1 on postprandial gastric accommodation but not on antro-pyloro-duodenal motility. GLP-1 reduces fasting and postprandial glycaemia, in part by reducing glucagon secretion...
  8. ncbi request reprint STW 5 (Iberogast) and its individual herbal components modulate intestinal electrophysiology of mice
    A Sibaev
    Department of Internal Medicine II, Ludwig Maximilians University of Munich, Germany
    Phytomedicine 13:80-9. 2006
    ..These effects represent a summation effect of different constituents of this phytotherapeuticum and prove that STW 5 has characteristic effects on intestinal electrophysiology...
  9. ncbi request reprint An unusual cause of azathioprine inefficacy
    M Storr
    Department of Medicine II, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    Endoscopy 38:E61. 2006
  10. pmc Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells
    P Dames
    Medizinische Klinik II, Ludwig Maximilians Universitat, München 80336, Germany
    Exp Diabetes Res 2012:460869. 2012
    ..Whether these findings extend to other experimental conditions or to in vivo physiology needs to be determined in further studies...
  11. ncbi request reprint Adalimumab in patients with Crohn's disease--safety and efficacy in an open-label single centre study
    J Seiderer
    Department of Internal Medicine II, University Hospital Munich Grosshadern, Munich, Germany
    Aliment Pharmacol Ther 25:787-96. 2007
    ....
  12. ncbi request reprint The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation
    J Seiderer
    Department of Internal Medicine II Grosshadern, University of Munich, Marchioninistrasse 15, D 81377 Munich, Germany
    Tissue Antigens 70:238-46. 2007
    ....
  13. ncbi request reprint Dexamethasone enhances the cytotoxic effect of radioiodine therapy in prostate cancer cells expressing the sodium iodide symporter
    I V Scholz
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians University 81377 Munich, Germany
    J Clin Endocrinol Metab 89:1108-16. 2004
    ....
  14. pmc Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
    J Schirra
    Department of Internal Medicine II, Clinical Research Unit, Ludwig Maximilians University, Marchioninistr 15, Munich 81377, Germany
    Gut 55:243-51. 2006
    ..Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying...
  15. ncbi request reprint [21-year-old patient with recurrent diarrhea, weight loss, leg edema and iron deficiency. Gluten sensitive sprue]
    C Schafer
    Medizinische Klinik II, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistrasse 15, 81377 Munchen
    Internist (Berl) 43:1459-63. 2002
  16. doi request reprint Saxagliptin is non-inferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: a 52-week randomised controlled trial
    B Goke
    Hospital of the Ludwig Maximilian, University of Munich, Munich, Germany
    Int J Clin Pract 64:1619-31. 2010
    ..To assess the efficacy and safety of saxagliptin vs. glipizide as add-on therapy to metformin in patients with type 2 diabetes mellitus and inadequate glycaemic control on metformin alone...
  17. doi request reprint The role of the novel Th17 cytokine IL-26 in intestinal inflammation
    J Dambacher
    University Hospital Munich Grosshadern, Department of Medicine II, Ludwig Maximilians University, Munich, Germany
    Gut 58:1207-17. 2009
    ..Currently, its function in human disease is completely unknown. The aim of this study was to analyse its role in intestinal inflammation...
  18. doi request reprint Efficacy and safety of vildagliptin monotherapy during 2-year treatment of drug-naïve patients with type 2 diabetes: comparison with metformin
    B Goke
    Department of Internal Medicine II, University of Munich Grosshadern, Munich, Germany
    Horm Metab Res 40:892-5. 2008
    ..Vildagliptin was weight neutral, while weight loss was observed with metformin; however, metformin was associated with significantly worse gastrointestinal tolerability...
  19. doi request reprint Reduced proliferation and a high apoptotic frequency of pancreatic beta cells contribute to genetically-determined diabetes susceptibility of db/db BKS mice
    R Puff
    Ludwig Maximilians Universitat, Klinikum Grosshadern, Medizinische Klinik, Munchen, Germany
    Horm Metab Res 43:306-11. 2011
    ..These factors could also play a role in the genetic predisposition for type 2 diabetes in humans...
  20. ncbi request reprint Importance of changes in gastric emptying for postprandial plasma glucose fluxes in healthy humans
    H J Woerle
    Dept of Internal Medicine II, Clinical Research Unit, Univ of Munich, LMU, Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Am J Physiol Endocrinol Metab 294:E103-9. 2008
    ..Theoretically, gastric emptying (GE) should be another important factor. However, its impact on pp glucose homeostasis is unknown...
  21. doi request reprint Oesophageal ulceration after selective internal radiation therapy in a patient with carcinoma of unknown primary
    C H Kubisch
    Gastroenterology, University of Munich
    Z Gastroenterol 48:546-50. 2010
    ..Patients with solely liver metastases from adenocarinomas represent the most frequent subgroup with an unfavourable prognosis. The medium survival averages 6 to 9 months. No chemotherapheutic standard has been established...
  22. doi request reprint [Diabetes mellitus - perioperative management]
    P Rittler
    Chirurgische Klinik und Poliklinik, Campus Klinikum Grosshadern, LMU Munchen, Marchioninistrasse 15, 81377 Munchen, Deutschland
    Chirurg 80:410, 412-5. 2009
    ..According to guidelines of the German Society of Nutrition, the approximation of normoglycemia is reasonable as long as hypoglycemia is avoided (suggested range for plasma glucose 80-145 mg/dL)...
  23. doi request reprint [Incidentaloma of the pancreas]
    C H Kubisch
    Internal Medicine, University of Munich, Marchioninistrasse 15, 81377 Munich
    Z Gastroenterol 46:292-6. 2008
    ..The surgical resection of pancreatic incidentalomas offers a significant advantage in survival when the total collective of affected individuals is taken into account...
  24. ncbi request reprint [Perspectives of cannabinoids in gastroenterology]
    M Storr
    Medizinische Klinik und Poliklinik II der Ludwig Maximilians Universität München
    Z Gastroenterol 44:185-91. 2006
    ..Additionally, this review will discuss potential indications within gastroenterology, where results from basic research or individual observations suggest that a future use of cannabinoids in gastroenterology seems possible...
  25. ncbi request reprint [Primary hyperparathyroidism, adrenal tumors and neuroendocrine tumors of the pancreas--clinical diagnosis and imaging requirements]
    C J Auernhammer
    Medizinische Klinik II, Klinikum der Ludwig Maximilians Universität München, Standort Grosshadern
    Radiologe 43:265-74. 2003
    ..The requirements concerning various imaging techniques and their relative importance in localization strategies of the different tumors are complex...
  26. ncbi request reprint Herbal extracts modulate the amplitude and frequency of slow waves in circular smooth muscle of mouse small intestine
    M Storr
    Department of Internal Medicine II and Institute for Surgical Research, Ludwig Maximilian University of Munich, Germany
    Digestion 70:257-64. 2004
    ..STW 5 is a phytotherapeutic agent consisting of a fixed mixture of 9 individual plant extracts. The electrophysiological mechanisms of action of STW 5 remain obscure...
  27. ncbi request reprint [Injection of botulinum toxin for diffuse esophageal spasm]
    M Storr
    Medizinische Klinik und Poliklinik II
    Dtsch Med Wochenschr 130:266-9. 2005
    ..A 67-year-old man complained of recurrent retrosternal pain for 3 - 5 minutes as the only symptom for 3 - 4 years. Only when dysphagia occurred in the course of the disease was a gastroenterologist consulted...
  28. ncbi request reprint [Therapy of hyperlipoproteinemia in the elderly]
    K G Parhofer
    Medizinische Klinik II, Grosshadern, Klinikum der Ludwig Maximilians Universität München
    Internist (Berl) 44:968-76. 2003
    ..e. a LDL-cholesterol below 100 mg/dl should be achieved. In hyper- or dyslipoproteinemic patients without evidence of clinical or subclinical atherosclerosis cholesterol lowering drugs should be used restrictively...
  29. ncbi request reprint [MRI in Crohn's disease after transduodenal contrast administration using negative oral MRI contrast media]
    N Holzknecht
    Institut fur Klinische Radiologie, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munich
    Radiologe 43:43-50. 2003
    ..To compare the efficacy and quality of conventional and MR enteroclysis with different filling methods regarding the assessment of extension and extraluminal manifestations in Crohn's disease...
  30. ncbi request reprint [Inflammatory bowel diseases (IBD) -- critical discussion of etiology, pathogenesis, diagnostics, and therapy]
    T Ochsenkuhn
    Medizinische Klinik II, Klinikum der Universitat Munchen Grosshadern, Munich
    Radiologe 43:1-8. 2003
    ..The basic understanding of IBD,which is necessary for efficient diagnostic and therapeutic concepts is reviewed...
  31. ncbi request reprint Increase in adiponectin levels during pioglitazone therapy in relation to glucose control, insulin resistance as well as ghrelin and resistin levels
    C Otto
    Medical Department 2, Grosshadern, University Hospital of Munich, Marchioninistrasse 15, D 81377 Munich, Germany
    J Endocrinol Invest 29:231-6. 2006
    ....
  32. ncbi request reprint [Pathogenesis and epidemiology of sigmoid diverticulosis]
    T Ochsenkuhn
    Medizinische Klinik II, Klinikum Grosshadern, LMU Munchen, Marchioninistrasse 15, 81375 München
    Chirurg 73:665-9. 2002
    ..Intestinal disturbances of innervation and motility also contribute to the formation of diverticula. The term "hypersegmentation" is an attempt to combine these factors into a single pathogenetic model...
  33. ncbi request reprint Crohn disease of the small bowel proximal to the terminal ileum: detection by MR-enteroclysis
    T Ochsenkuhn
    Department of Medicine II, Institute of Clinical Radiology, Klinikum Grosshadern, University of Munich, Germany
    Scand J Gastroenterol 39:953-60. 2004
    ..Hence, we applied MR-enteroclysis to assess the percentage of patients with small-bowel inflammation proximal to the terminal ileum among patients with CD and abdominal pain...
  34. doi request reprint JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand
    S R Mucha
    University of Munich, University Hospital Grosshadern, Department of Medicine II, Research Lab B 5 E01 308, Marchioninistrasse 15, D 81377 Munich, Germany
    Gut 58:688-98. 2009
    ..In this study we investigated whether JNK activity in HCC could contribute to the resistance to apoptosis in these tumours...
  35. ncbi request reprint ANP preconditioning does not increase protection against experimental pancreatitis, observed after general anesthesia and jugular vein catheterization
    I Ploessl
    Department of Medicine II, Grosshadern Hospital, University of Munich, Institute of Pathology, University of Munich, Germany
    Pancreas 28:166-73. 2004
    ..This indicates that stress caused by general anesthesia and jugular vein catheterization can be sufficient for preconditioning while ANP, in contrast to models of ischemic liver reperfusion injury, does not confer additional protection...
  36. ncbi request reprint An unusual cause of intractable vomiting after cisplatin chemotherapy
    M Storr
    Department of Medicine II, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    Endoscopy 38:E54. 2006
  37. ncbi request reprint B-cell lymphoma with bowel-to-bowel penetration diagnosed by double-balloon endoscopy
    C Schafer
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilian University Munich, Germany
    Endoscopy 39:E204. 2007
  38. ncbi request reprint Effect of pioglitazone on lipids in well controlled patients with diabetes mellitus type 2 -- results of a pilot study
    K G Parhofer
    Department of Internal Medicine II, Grosshadern, Ludwig Maximilians University, Munich, Germany
    Exp Clin Endocrinol Diabetes 113:49-52. 2005
    ..It is unclear whether different antidiabetic strategies differ in their effects on the lipid profile. Particularly, it is unknown whether glitazones improve lipid values independently of their effects on glucose metabolism...
  39. doi request reprint Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini
    A Malo
    Dept of Internal Medicine, University of Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 299:G877-86. 2010
    ..These data hint new perspectives for an employment of chemical chaperones in the therapy of acute pancreatitis...
  40. doi request reprint Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population
    A Graser
    Department of Clinical Radiology, University of Munich, Klinikum Grosshadern, Munich, Germany
    Gut 58:241-8. 2009
    ....
  41. doi request reprint Sodium iodide symporter (NIS)-mediated radiovirotherapy of hepatocellular cancer using a conditionally replicating adenovirus
    G K Grunwald
    Department of Internal Medicine II Campus Grosshadern, University Hospital of Munich, Munich, Germany
    Gene Ther 20:625-33. 2013
    ..In conclusion, local in vivo NIS gene transfer using a replication-selective oncolytic adenovirus is able to induce a significant therapeutic effect, which can be enhanced by additional (131)I application...
  42. ncbi request reprint CB1 and TRPV1 receptors mediate protective effects on colonic electrophysiological properties in mice
    A Sibaev
    Department of Internal Medicine II and Institute of Surgical Research, Ludwig Maximilians University Munich, Marchioninistr 15, 81377, Munich, Germany
    J Mol Med (Berl) 84:513-20. 2006
    ..In mutants, these electrophysiological changes display different patterns, suggesting the lack of protective properties for neuromuscular interactions and membrane stability...
  43. ncbi request reprint Low frequency of colorectal dysplasia in patients with long-standing inflammatory bowel disease colitis: detection by fluorescence endoscopy
    T Ochsenkuhn
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    Endoscopy 38:477-82. 2006
    ..We combined this technique with random biopsies to prospectively evaluate the occurrence of dysplasias in patients with long-standing IBD...
  44. ncbi request reprint The +1059G/C polymorphism in the C-reactive protein (CRP) gene is associated with involvement of the terminal ileum and decreased serum CRP levels in patients with Crohn's disease
    D Thalmaier
    Department of Medicine II Grosshadern, University of Munich, Munich, Germany
    Aliment Pharmacol Ther 24:1105-15. 2006
    ..Serum C-reactive protein (CRP) levels influence the response to anti-tumour necrosis factor (TNF) therapies...
  45. ncbi request reprint Retinoic acid-induced stimulation of sodium iodide symporter expression and cytotoxicity of radioiodine in prostate cancer cells
    C Spitzweg
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians University, Munich 81377, Germany
    Endocrinology 144:3423-32. 2003
    ..Therefore atRA may be used to enhance the therapeutic response to radioiodine in prostate cancer cells following PSA promoter-directed NIS gene delivery...
  46. ncbi request reprint Alpha-fetoprotein promoter-targeted sodium iodide symporter gene therapy of hepatocellular carcinoma
    M J Willhauck
    Department of Internal Medicine II, Ludwig Maximilians University, Munich, Germany
    Gene Ther 15:214-23. 2008
    ..This study demonstrates the potential of tumor-specific NIS gene therapy as an innovative treatment strategy for HCC...