Affiliation: University of Mainz
- Pain in chemotherapy-induced neuropathy--more than neuropathic?Christian Geber
Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Germany Electronic address
Pain 154:2877-87. 2013..Patients stratified for musculoskeletal or neuropathic pain, however, differed in psychological and somatosensory parameters. This stratification might allow for the application of a more specific therapy...
- Severe tremor after cotrimoxazole-induced elevation of venlafaxine serum concentrations in a patient with major depressive disorderChristian Geber
Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
Ther Drug Monit 35:279-82. 2013..The observed overall pharmacokinetic effect was most probably the result of decreased N-demethylation of venlafaxine by (1) reduced expression of CYP2C19 due to a genetic deficit and (2) inhibition of CYP2C9 by cotrimoxazole...
- Comparison of LEP and QST and their contribution to standard sensory diagnostic assessment of spinal lesions: a pilot studyChristian Geber
Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Langenbeckstrasse 1, 55131 Mainz, Germany
Neurol Sci 32:401-10. 2011..LEP detected more deficits than any single QST parameter or their combination but additional QST allows the detection of positive sensory signs. The diagnostic gain of SEP was limited...
- Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre studyChristian Geber
Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Germany
Pain 152:548-56. 2011....
- Numbness in clinical and experimental pain--a cross-sectional study exploring the mechanisms of reduced tactile functionChristian Geber
Neurologische Universitatsklinik, Johannes Gutenberg Universitat, Mainz, Germany
Pain 139:73-81. 2008..Hypaesthesia (numbness) often encountered in clinical pain can be reproduced by experimental nociceptive stimulation. The time course of effects suggests a mechanism involving central plasticity...
- Psychophysics, flare, and neurosecretory function in human pain models: capsaicin versus electrically evoked painChristian Geber
Klinik und Poliklinik für Neurologie der Universität Mainz, Germany
J Pain 8:503-14. 2007..The different time courses of pain stimulation (CAP: rapidly decaying pain versus ES: pain plateau) led to different peripheral neurosecretory effects but induced similar central plasticity and hyperalgesia...
- Revised definition of neuropathic pain and its grading system: an open case series illustrating its use in clinical practiceChristian Geber
Department of Neurology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
Am J Med 122:S3-12. 2009..Its clinical use should be further validated in prospective studies...
- Do intensity ratings and skin conductance responses reliably discriminate between different stimulus intensities in experimentally induced pain?Markus Breimhorst
Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, Mainz, Germany
J Pain 12:61-70. 2011..Further studies are needed to reveal the reason for this lack of accuracy for SCRs when applying electrical pain stimuli...
- Anosognosia for obvious visual field defects in stroke patientsBernhard Baier
Department of Neurology, University of Mainz, Langenbeckstr 1, 55131, Mainz, Germany
Brain Struct Funct 220:1855-60. 2015..Damage to these regions appears to induce unawareness of visual field defects and thus may play a significant role for conscious visual perception. ..
- Anosognosia for hemiparesis after left-sided strokeBernhard Baier
Department of Neurology, Edith Stein Fachklinik, Bad Bergzabern, Germany Department of Neurology, University of Mainz, Mainz, Germany Electronic address
Cortex 61:120-6. 2014..The present single case observation thus argues against an original role of the left hemisphere in self-awareness about limb function. We discuss the data in the context of previous observations in the literature. ..
- A pathway in the brainstem for roll-tilt of the subjective visual vertical: evidence from a lesion-behavior mapping studyBernhard Baier
Department of Neurology, University of Mainz, 55131 Mainz, Germany
J Neurosci 32:14854-8. 2012..Present data indicate that graviceptive otolith signals present a predominant role in the multisensory system of verticality perception...
- Evolving understandings about complex regional pain syndrome and its treatmentMarcel Fechir
Klinik und Poliklinik fur Neurologie, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, Mainz, Germany
Curr Pain Headache Rep 12:186-91. 2008..The common therapeutic aim is to maintain or restore normal function of the affected extremity. Beyond highlighting pathophysiologic concepts, this article describes recent therapeutic approaches...
- Interaction of calcitonin gene related peptide (CGRP) and substance P (SP) in human skinTanja Schlereth
Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr 1, D 55131 Mainz, Germany Electronic address
Neuropeptides 59:57-62. 2016..CGRP10-6M prevented SP-induced early vasodilation but augmented SP-induced PPE. These interactions might explain why vascular symptoms in chronic pain can differ strikingly between individuals...
- Facilitation and inhibition by capsaicin of cholinergic neurotransmission in the guinea-pig small intestineChristian Geber
Institut fur Pharmakologie, Universitat Mainz, 55131, Mainz, Germany
Naunyn Schmiedebergs Arch Pharmacol 372:277-83. 2006..The facilitatory effect is indirect and involves tachykinin release and excitation of NK1 and NK3 receptors on cholinergic neurons. The inhibition of acetylcholine release may be due to a decrease of Ca2+ influx into cholinergic neurons...