Helmut Friess

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Pancreatic resection for M1 pancreatic ductal adenocarcinoma
    Shailesh V Shrikhande
    Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai, 400012, India
    Ann Surg Oncol 14:118-27. 2007
  2. pmc Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells
    Jamael El Fitori
    Department of General Surgery, University of Heidelberg, Germany
    Cancer Cell Int 5:3. 2005
  3. pmc Invasion and metastasis in pancreatic cancer
    Shereen Keleg
    University of Heidelberg, Department of Surgery, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Mol Cancer 2:14. 2003
  4. pmc Effects of STI571 (gleevec) on pancreatic cancer cell growth
    Junsheng Li
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Mol Cancer 2:32. 2003
  5. pmc Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer
    Junsheng Li
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Mol Cancer 4:14. 2005
  6. pmc Cancer cachexia
    Marcus E Martignoni
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110 Germany
    Mol Cancer 2:36. 2003
  7. pmc The presence of the proteolysis-inducing factor in urine does not predict the malignancy of a pancreatic tumour
    Niels Teich
    Universitat Leipzig, Medizinische Klinik und Poliklinik II, Leipzig, Germany
    BMC Gastroenterol 5:20. 2005
  8. pmc Randomized phase II--study evaluating EGFR targeting therapy with cetuximab in combination with radiotherapy and chemotherapy for patients with locally advanced pancreatic cancer--PARC: study protocol [ISRCTN56652283]
    R Krempien
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 5:131. 2005
  9. ncbi request reprint [Pancreatic cancer screening: mission impossible?]
    M Bartel
    Abteilung für Allgemein, Viszeral und Unfallchirurgie, Universitatsklinikum Heidelberg
    Z Gastroenterol 44:1181-2. 2006
  10. ncbi request reprint Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer
    H Friess
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Cell Mol Life Sci 60:1180-99. 2003

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Pancreatic resection for M1 pancreatic ductal adenocarcinoma
    Shailesh V Shrikhande
    Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai, 400012, India
    Ann Surg Oncol 14:118-27. 2007
    ..Improved safety of pancreatic surgery has led to consideration of more aggressive approaches, such as resection for primary pancreatic ductal adenocarcinoma (PDAC) with metastatic disease (M1)...
  2. pmc Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells
    Jamael El Fitori
    Department of General Surgery, University of Heidelberg, Germany
    Cancer Cell Int 5:3. 2005
    ..CONCLUSION: MIA is over-expressed in pancreatic cancer and has the potential of promoting the invasiveness of pancreatic cancer cells...
  3. pmc Invasion and metastasis in pancreatic cancer
    Shereen Keleg
    University of Heidelberg, Department of Surgery, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Mol Cancer 2:14. 2003
    ..In this review we highlight the most important genetic alterations involved in tumor invasion and metastasis and further outline the role of tumor angiogenesis and lymphangiogenesis in systemic tumor dissemination...
  4. pmc Effects of STI571 (gleevec) on pancreatic cancer cell growth
    Junsheng Li
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Mol Cancer 2:32. 2003
    ..STI571 has specific activity in inhibiting c-kit, PDGF and Abl receptor tyrosine kinases and has proven successful in the treatment of CML and GIST patients. Here, we investigated the potential role of STI571 in pancreatic cancer...
  5. pmc Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer
    Junsheng Li
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Mol Cancer 4:14. 2005
    ..Since pancreatic cancers over-express a number of heparin-binding growth factors and their receptors, the expression and function of this enzyme in pancreatic cancer was analyzed...
  6. pmc Cancer cachexia
    Marcus E Martignoni
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110 Germany
    Mol Cancer 2:36. 2003
    ..In the present editorial we will focus cachexia related on cancer and provide some insight into this prognosis-limiting syndrome...
  7. pmc The presence of the proteolysis-inducing factor in urine does not predict the malignancy of a pancreatic tumour
    Niels Teich
    Universitat Leipzig, Medizinische Klinik und Poliklinik II, Leipzig, Germany
    BMC Gastroenterol 5:20. 2005
    ..We hypothesized that PIF could be a useful marker to exclude benign pancreatic tumors, as chronic pancreatitis with a pancreatic mass...
  8. pmc Randomized phase II--study evaluating EGFR targeting therapy with cetuximab in combination with radiotherapy and chemotherapy for patients with locally advanced pancreatic cancer--PARC: study protocol [ISRCTN56652283]
    R Krempien
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 5:131. 2005
    ....
  9. ncbi request reprint [Pancreatic cancer screening: mission impossible?]
    M Bartel
    Abteilung für Allgemein, Viszeral und Unfallchirurgie, Universitatsklinikum Heidelberg
    Z Gastroenterol 44:1181-2. 2006
  10. ncbi request reprint Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer
    H Friess
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Cell Mol Life Sci 60:1180-99. 2003
    ..The identification of a large panel of altered genes in PDAC will stimulate additional studies that will lead to improved understanding of the molecular mechanisms underlying pancreatic malignant growth...
  11. ncbi request reprint [Central case management in surgery]
    H Friess
    Chirurgische Klinik, Universitat Heidelberg, Germany
    Anaesthesist 52:830-6. 2003
    ..In this article, we will present our basic concept of a central patient management in a surgical university department...
  12. ncbi request reprint Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer
    Helmut Friess
    Department of General Surgery, University of Heidelberg, Germany
    Lab Invest 83:731-42. 2003
    ..These findings illustrate that the NK-1R pathway is activated in human pancreatic cancer and has the potential to contribute to cancer cell growth, thus suggesting the existence of a neuro-cancer cell interaction in vivo...
  13. pmc Identification of disease-specific genes in chronic pancreatitis using DNA array technology
    H Friess
    Department of Visceral and Transplantation Surgery, Inselspital, University of Bern, Bern, Switzerland
    Ann Surg 234:769-78; discussion 778-9. 2001
    ..To use DNA arrays to analyze the differential gene expression patterns in the normal pancreas and in pancreatic diseases...
  14. pmc A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer
    Helmut Friess
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    BMC Cancer 6:285. 2006
    ..In this study, the treatment effects of the angiogenesis inhibitor Cilengitide and gemcitabine were compared with gemcitabine alone in patients with advanced unresectable pancreatic cancer...
  15. pmc Neural alterations in surgical stage chronic pancreatitis are independent of the underlying aetiology
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Gut 50:682-6. 2002
    ....
  16. ncbi request reprint [Central patient management in surgery]
    H Friess
    Abteilung für Allgemeine, Viszerale, Unfallchirurgie und Poliklinik, Chirurgische Klinik, Universitat Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg
    Chirurg 73:111-7. 2002
    ..In this article, we will present our basic concept of a central patient management in a surgical university department...
  17. ncbi request reprint Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Gastroenterology 132:1447-64. 2007
    ..The aim of this study was to analyze the impact of the PSC-specific matrix protein periostin on tumor responses to radiochemotherapy...
  18. ncbi request reprint PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer
    Jamael El Fitori
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer 110:1457-68. 2007
    ..The aim of this study was to analyze the role of FLT3 in pancreatic cancer and to study the biological activity of combined inhibition of neovascularization and mitogenesis in this disease...
  19. ncbi request reprint Silencing of X-linked inhibitor of apoptosis (XIAP) decreases gemcitabine resistance of pancreatic cancer cells
    Shailesh V Shrikhande
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Anticancer Res 26:3265-73. 2006
    ..It confers resistance to apoptosis induction by chemotherapeutic agents. The aim of this study was to evaluate the influence of XIAP in pancreatic cancer...
  20. ncbi request reprint Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer
    Michael W Müller
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 121:2421-33. 2007
    ..Furthermore, negative clinicopathological correlations suggest that SEMA3A might represent a novel intervention target but not a treatment option for pancreatic cancer patients...
  21. ncbi request reprint FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth
    Hany Kayed
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 118:43-54. 2006
    ..In conclusion, overexpression of FXYD3 in pancreatic cancer may contribute to the proliferative activity of this malignancy...
  22. ncbi request reprint Desmoplastic reaction influences pancreatic cancer growth behavior
    Mark Hartel
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    World J Surg 28:818-25. 2004
    ..Because patients with high CTGF mRNA expression levels have a better prognosis, our findings indicate that the desmoplastic reaction provides a growth disadvantage for pancreatic cancer cells...
  23. pmc Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Neoplasia 11:497-508. 2009
    ..Although both cancer and stellate cells (PSCs) secrete proangiogenic factors, pancreatic cancer is a scirrhous and hypoxic tumor. The impact of cancer-PSCs interactions on angiogenesis was analyzed...
  24. pmc Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer
    Ivane Abiatari
    Department of General Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    J Cell Mol Med 14:1166-79. 2010
    ..Analysis of human and different transgenic mouse pancreatic cancers demonstrated that moesin is a phenotypic marker for anaplastic carcinoma, suggesting that this ERM protein plays a specific role in pancreatic carcinogenesis...
  25. ncbi request reprint Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway
    Yun Su
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    J Gastrointest Surg 10:1230-41; discussion 1242. 2006
    ..These findings suggest a possible role of the Notch pathway during pancreatic regeneration since Jagged-1 inhibits inducible collagen-1 production, suggesting a new mechanism of tissue repair in this disease...
  26. pmc The neurotrophic factor artemin promotes pancreatic cancer invasion
    Güralp O Ceyhan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg 244:274-81. 2006
    ..To analyze the role of Artemin in pancreatic ductal adenocarcinoma (PDAC) in terms of expression, influence on cancer cell behavior, and pain correlation...
  27. ncbi request reprint Factors influencing survival after bypass procedures in patients with advanced pancreatic adenocarcinomas
    Michael W Müller
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Am J Surg 195:221-8. 2008
    ..We sought to define markers in these patients that could predict survival and thus aid decision making for selection of the most appropriate therapeutic palliative option...
  28. pmc Cannabinoids in pancreatic cancer: correlation with survival and pain
    Christoph W Michalski
    Department of General Surgery, Technische Universität Munich, Munich, Germany
    Int J Cancer 122:742-50. 2008
    ..Therefore, changes in the levels of endocannabinoid metabolizing enzymes and cannabinoid receptors on pancreatic cancer cells may affect prognosis and pain status of PDAC patients...
  29. ncbi request reprint Expression and differential signaling of heregulins in pancreatic cancer cells
    Armin Kolb
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 120:514-23. 2007
    ..High HRG-beta levels but not HRG-alpha levels were associated with decreased patient survival. In conclusion, HRG is expressed by pancreatic cancer cells and influences pancreatic cancer cell growth and patient survival...
  30. doi request reprint R2 resection in pancreatic cancer--does it make sense?
    Jörg Köninger
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Langenbecks Arch Surg 393:929-34. 2008
    ..Extensive surgical exploration for definitive clear resectability may lead to R2 resections in single cases...
  31. pmc BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion
    Hany Kayed
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Mol Cancer 6:83. 2007
    ..Gene silencing was carried out using specific siRNA molecules...
  32. ncbi request reprint Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer
    Hany Kayed
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 110:668-76. 2004
    ....
  33. ncbi request reprint Effects of bone sialoprotein on pancreatic cancer cell growth, invasion and metastasis
    Hany Kayed
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Cancer Lett 245:171-83. 2007
    ....
  34. ncbi request reprint Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy
    Arianeb Mehrabi
    Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer 107:2108-21. 2006
    ..Highly selected patients may be able to undergo living-donor LTx, preserving the donor pool. The role of different adjuvant therapies for patients with HEH remains to be determined...
  35. doi request reprint Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors?
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Am J Gastroenterol 104:171-81. 2009
    ....
  36. ncbi request reprint Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma
    Moritz N Wente
    Department of General Surgery, University of Heidelberg, D 69120 Heidelberg, Germany
    Int J Oncol 33:297-308. 2008
    ....
  37. ncbi request reprint Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma
    Junchao Guo
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Mol Med 17:761-7. 2006
    ..Together with the known function of YAP65 in different growth and differentiation regulating pathways, it is suggested that this gene plays a role in the normal and diseased pancreas...
  38. ncbi request reprint Enhanced expression of 14-3-3sigma in pancreatic cancer and its role in cell cycle regulation and apoptosis
    Ahmed Guweidhi
    Department of General Surgery, University of Heidelberg, Germany
    Carcinogenesis 25:1575-85. 2004
    ....
  39. ncbi request reprint Pancreatic tumor cells influence the composition of the extracellular matrix
    Jörg Köninger
    Department of General Surgery, University of Heidelberg, Germany
    Biochem Biophys Res Commun 322:943-9. 2004
    ..These findings indicate that malignant cells can actively influence the composition of the ECM through TGFbeta1 and other soluble factors, altering their microenvironment in a tumor-favorable way...
  40. ncbi request reprint Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion
    Shereen Keleg
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 121:21-32. 2007
    ..Furthermore, ADM increases invasiveness of some pancreatic cancer cells and might influence angiogenesis, suggesting that blocking this pathway might have a therapeutic potential...
  41. doi request reprint Consensus transcriptome signature of perineural invasion in pancreatic carcinoma
    Ivane Abiatari
    Department of General Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, Munich, Germany
    Mol Cancer Ther 8:1494-504. 2009
    ..The established nerve invasion model and the consensus signature of perineural invasion could be instrumental in the identification of novel therapeutic targets of pancreatic cancer as exemplified by KIF14 and ARHGDIbeta...
  42. ncbi request reprint Combination therapy for advanced pancreatic cancer using Herceptin plus chemotherapy
    Peter Buchler
    Department of General Surgery, Ruprecht Karls University of Heidelberg, D 69120 Heidelberg, Germany
    Int J Oncol 27:1125-30. 2005
    ..We conclude that, as with breast cancer, the anti-tumor activity of Herceptin may be improved by combination with taxanes or gemcitabine...
  43. ncbi request reprint CXCL14 expression and potential function in pancreatic cancer
    Moritz N Wente
    Department of Surgery, University of Heidelberg, D 69120 Heidelberg, Germany
    Cancer Lett 259:209-17. 2008
    ..In conclusion, CXCL14 might play a pivotal role in the pathobiology of pancreatic cancer, probably by regulating cancer invasion...
  44. ncbi request reprint Role of mononuclear cells and inflammatory cytokines in pancreatic cancer-related cachexia
    Marc E Martignoni
    Department of General Surgery, University of Heidelberg, Germany
    Clin Cancer Res 11:5802-8. 2005
    ..In this study, we investigated which factors are associated with the cachectic status of the patients and evaluated cachexia-promoting capacity of cancer and inflammatory cells...
  45. pmc Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer
    Irene Esposito
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Clin Pathol 60:885-95. 2007
    ..To determine the role of two antiapoptotic proteins of the inhibitor of apoptosis protein family, cellular inhibitor of apoptosis protein 1 (cIAP1) and cellular inhibitor of apoptosis protein 2 (cIAP2), in human pancreatic carcinogenesis...
  46. ncbi request reprint Transforming growth factor-beta pathway is activated in cholecystolithiasis
    Jörg Köninger
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Langenbecks Arch Surg 390:21-8. 2005
    ..In the present study we analyzed the role of TGF-beta and its downstream target CTGF in patients with cholecystolithiasis...
  47. pmc The Notch signaling pathway is related to neurovascular progression of pancreatic cancer
    Peter Buchler
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Ann Surg 242:791-800, discussion 800-1. 2005
    ..To analyze the potential role of the Notch signaling pathway in pancreatic cancer angiogenesis and invasion...
  48. pmc Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Mol Cancer 9:88. 2010
    ..To identify organ- and disease-specific stellate cell transcriptional fingerprints, we employed genome-wide transcriptional analysis of primary human PSC and HSC isolated from patients with chronic inflammation or cancer...
  49. ncbi request reprint Aberrant gata-3 expression in human pancreatic cancer
    Antanas Gulbinas
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110 69120, Heidelberg, Germany
    J Histochem Cytochem 54:161-9. 2006
    ..Furthermore, strong specific upregulation of Gata-3 impaired nuclear translocation and its cooperative action with the TGF-beta pathway, suggesting that Gata-3 plays a central role in human pancreatic cancer...
  50. pmc Osteonectin influences growth and invasion of pancreatic cancer cells
    Ahmed Guweidhi
    Department of General Surgery, University of Heidelberg, Germany
    Ann Surg 242:224-34. 2005
    ..We sought to examine the expression and functional role of osteonectin in primary and metastatic pancreatic ductal adenocarcinoma (PDAC)...
  51. doi request reprint Fundamental differences in the neural invasion behavior of pancreatic endocrine tumors: relevance for local recurrence rates?
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, D 69120 Heidelberg, Germany
    Hum Pathol 40:50-7. 2009
    ..This phenomenon may explain the low rate of local relapses after tumor resection in pancreatic endocrine tumors despite the high frequency of neural invasion...
  52. ncbi request reprint Preoperative acute pancreatitis in periampullary tumors: implications for surgical management
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Digestion 75:165-71. 2007
    ..Currently there is no information about the impact of preoperative pancreatitis on the surgical management of periampullary tumors...
  53. ncbi request reprint Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas
    Hany Kayed
    Department of General Surgery, The University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Mol Carcinog 42:183-92. 2005
    ....
  54. ncbi request reprint Protein expression profiling reveals distinctive changes in serum proteins associated with chronic pancreatitis
    Daniel Hartmann
    Research Laboratory, European Center for Pancreas Research, Section for Pancreas Surgery and Molecular Research, Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Pancreas 35:334-42. 2007
    ..Testing of serum for protein patterns to monitor progression of suspected to definite chronic pancreatitis (CP)...
  55. ncbi request reprint Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells
    Grace Kusumawidjaja
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer Biol Ther 6:367-76. 2007
    ..In conclusion, BTF3 is overexpressed in PDAC, where it acts as a transcriptional regulator rather than a direct modulator of apoptosis...
  56. pmc Second-look operation for unresectable pancreatic ductal adenocarcinoma at a high-volume center
    Christoph W Michalski
    Department of General Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, 81675, Munich, Germany
    Ann Surg Oncol 15:186-92. 2008
    ..The value of re-exploration for pancreatic ductal adenocarcinoma after the initial diagnosis of unresectability is unclear...
  57. ncbi request reprint Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer
    Moritz N Wente
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Pancreas 31:119-25. 2005
    ..Furthermore, the therapeutic efficacy of a monoclonal anti-PSCA antibody in an in vivo pancreatic cancer model was determined...
  58. ncbi request reprint Stapler hepatectomy is a safe dissection technique: analysis of 300 patients
    Peter Schemmer
    Department of General Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, Heidelberg, 69120, Germany
    World J Surg 30:419-30. 2006
    ..Thus, the feasibility of stapler hepatectomy and a risk analysis of surgical morbidity based on intraoperative data have been prospectively assessed on a routine clinical basis...
  59. ncbi request reprint Pancreatic cancer: from bench to 5-year survival
    Jorg Kleeff
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Pancreas 33:111-8. 2006
    ..Translational research combined with clinical trials will hopefully lead to improved survival and better quality of life for pancreatic cancer patients in the future...
  60. pmc The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis
    Güralp O Ceyhan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Gut 56:534-44. 2007
    ..Artemin was recently shown to eliminate neuropathic pain and reverse neurochemical damage after nerve injury. The role of artemin and its receptor GFRalpha3 was investigated in patients with chronic pancreatitis...
  61. ncbi request reprint Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment
    Pascal O Berberat
    Division of Pancreatic Surgery and Molecular Pancreatic Research, Department of General Surgery, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 11:3790-8. 2005
    ..Therefore, specific inhibition of HO-1 expression may be a new option in pancreatic cancer therapy and may be used as sensitizer to chemotherapy and radiotherapy...
  62. ncbi request reprint Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    Oncogene 24:4421-32. 2005
    ..In conclusion, loss of BNIP3 expression occurs late in pancreatic cancer, contributes to resistance to chemotherapy, and correlates with a worsened prognosis...
  63. ncbi request reprint Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in pancreatic neoplasm and pancreatic stellate cells
    Weiwei Zhang
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    Cancer Biol Ther 6:218-27. 2007
    ....
  64. pmc Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer
    Irene Esposito
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Neoplasia 9:8-17. 2007
    ..In conclusion, SPARCL1 expression in pancreatic tissues is highly correlated with level of vascularity. Its anti-invasive effects and reduced expression in metastasis indicate tumor-suppressor function...
  65. ncbi request reprint Increase in substance P precursor mRNA in noninflamed small-bowel sections in patients with Crohn's disease
    Christoph W Michalski
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Am J Surg 193:476-81. 2007
    ....
  66. ncbi request reprint Is there still a role for total pancreatectomy?
    Michael W Müller
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg 246:966-74; discussion 974-5. 2007
    ....
  67. pmc Distal pancreatectomy: risk factors for surgical failure in 302 consecutive cases
    Jorg Kleeff
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg 245:573-82. 2007
    ..The objective of this study was to identify potential risk factors for mortality and morbidity after distal pancreatectomy, with special focus on the formation of pancreatic fistula...
  68. ncbi request reprint Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis
    Hany Kayed
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Histol Histopathol 23:819-26. 2008
    ..The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies...
  69. doi request reprint Pigment epithelium-derived factor associates with neuropathy and fibrosis in pancreatic cancer
    Tamar Samkharadze
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am J Gastroenterol 106:968-80. 2011
    ..Its role in pancreatic fibrosis and neuropathy is unknown...
  70. doi request reprint Identification of malignancy factors by analyzing cystic tumors of the pancreas
    Andrea Bauer
    Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Pancreatology 9:34-44. 2009
    ....
  71. ncbi request reprint Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma
    Matthias M Gaida
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Int J Mol Med 26:281-8. 2010
    ..ADAM10 silencing or rhADAM10 had no effect on cell viability. ADAM10 silencing markedly reduced invasiveness and migration of cancer cells. These findings establish ADAM10 as a contributing factor in PDAC invasion and metastasis...
  72. ncbi request reprint Differentially expressed genes in postperfusion biopsies predict early graft dysfunction after liver transplantation
    Pascal O Berberat
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Transplantation 82:699-704. 2006
    ..We hypothesized that changes in gene expression represent the earliest indicator of ischemia/reperfusion-related injuries measurable in the graft and could be used as prognostic marker for the occurrence of graft-related complications...
  73. ncbi request reprint Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature
    Martin Loos
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Virchows Arch 450:719-26. 2007
    ..Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma. We suggest that this tumor be called solid type clear cell carcinoma of the pancreas...
  74. ncbi request reprint Correlation of glypican-1 expression with TGF-beta, BMP, and activin receptors in pancreatic ductal adenocarcinoma
    Hany Kayed
    Department of General Surgery, University of Heidelberg, D 69120 Heidelberg, Germany
    Int J Oncol 29:1139-48. 2006
    ..GPC1 down-regulation suppresses pancreatic cancer cell growth and slightly modifies signaling of members of the TGF-beta family of growth factors...
  75. ncbi request reprint The microtubule-associated protein MAPRE2 is involved in perineural invasion of pancreatic cancer cells
    Ivane Abiatari
    Department of General Surgery, Technische Universitat Munchen, D 81675 Munich, Germany
    Int J Oncol 35:1111-6. 2009
    ..Therefore, targeting this microtubule-associated protein might be a promising approach in the therapy of pancreatic cancer...
  76. ncbi request reprint Nerve growth factor and enhancement of proliferation, invasion, and tumorigenicity of pancreatic cancer cells
    Zhaowen Zhu
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Mol Carcinog 35:138-47. 2002
    ....
  77. ncbi request reprint Overexpressed decorin in pancreatic cancer: potential tumor growth inhibition and attenuation of chemotherapeutic action
    Jörg Köninger
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 10:4776-83. 2004
    ..The aim of this study was to investigate the expression and significance of decorin in pancreatic cancer...
  78. doi request reprint Uroguanylin inhibits proliferation of pancreatic cancer cells
    Oliver Kloeters
    Department of General Surgery, University of Heidelberg, Germany
    Scand J Gastroenterol 43:447-55. 2008
    ..In colon cancer, guanylin peptides are shown to exert strong anti-tumor activity through the GC-C pathway. The objective of this study was to analyze the role of guanylin and uroguanylin in human pancreatic cancer...
  79. ncbi request reprint Influences of the lysosomal associated membrane proteins (Lamp-1, Lamp-2) and Mac-2 binding protein (Mac-2-BP) on the prognosis of pancreatic carcinoma
    Beat M Künzli
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Cancer 94:228-39. 2002
    ..The authors studied the expression of Lamp-1, Lamp-2, and Mac-2-BP in pancreatic carcinoma and evaluated their influence on patient prognosis...
  80. pmc Corticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer
    Chengwen Zhang
    Research Group Molecular Urooncology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    BMC Cancer 6:61. 2006
    ..While the potent pro-apoptotic properties and the supportive effects of GCs to tumour therapy in lymphoid cells are well studied, the impact of GCs to cytotoxic treatment of pancreatic carcinoma is unknown...
  81. ncbi request reprint Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer
    Alexander Koliopanos
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Oncogene 21:6059-70. 2002
    ..In addition, almost all human pancreatic cancer tissues expressed this receptor at high levels, suggesting that these or related compounds may play a role in the therapy of pancreatic cancer in the future...
  82. ncbi request reprint Down-regulation of DOC-2 in colorectal cancer points to its role as a tumor suppressor in this malignancy
    Jorg Kleeff
    Department of General Surgery, University of Heidelberg, Germany
    Dis Colon Rectum 45:1242-8. 2002
    ..In these tumors it negatively influences mitogenic signal transduction of growth factors and blocks ras activity. In the present study we sought to determine the role of DOC-2 in colorectal cancer...
  83. ncbi request reprint Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells
    Zheng Pan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Int J Oncol 35:823-8. 2009
    ..18 months, respectively, p=0.006). Down-regulation of GRP94 decreases apoptosis resistance in pancreatic cancer cells. Clinically, patients with high GRP94 expression show a tendency for a worsened survival...
  84. ncbi request reprint Induction and expression of betaig-h3 in pancreatic cancer cells
    Dominik Schneider
    Department of Visceral and Transplantation Surgery, University of Bern, Bern, Switzerland
    Biochim Biophys Acta 1588:1-6. 2002
    ....
  85. pmc Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer
    Peter Buchler
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Neoplasia 11:196-206. 2009
    ..Taken together, we show for the first time that uPAR is under transcriptional control of HIF and that this is important for hypoxia-induced metastasis...
  86. ncbi request reprint Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma
    Jorg Konig
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 115:359-67. 2005
    ..These data suggest that MRP3 and MRP5 are involved in drug resistance of pancreatic tumors and that quantitative analysis of their expression may contribute to predict the benefit of chemotherapy in patients with pancreatic cancer...
  87. ncbi request reprint A new tool for experimental tumour research
    Chengwen Zhang
    Molecular Urooncology, German Cancer Research Center, Heidelberg, Germany
    Oncol Rep 15:1153-5. 2006
    ..Thus, storing freshly resected tumours in OES may save time for tumour transfer and initiation of experiments...
  88. ncbi request reprint Expression analysis of PMP22/Gas3 in premalignant and malignant pancreatic lesions
    Junsheng Li
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Histochem Cytochem 53:885-93. 2005
    ..Its expression in PanIN lesions and some pancreatic cancer cells in vitro and in vivo suggests a role of PMP22 in the neoplastic transformation process from the normal pancreas to pre-malignant lesions to pancreatic cancer...
  89. ncbi request reprint Acquired resistance of pancreatic cancer cells towards 5-Fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes
    Xin Shi
    Department of Visceral and Transplantation Surgery, Inselspital, University of Bern, Switzerland
    Oncology 62:354-62. 2002
    ....
  90. ncbi request reprint Hepaticojejunostomy--analysis of risk factors for postoperative bile leaks and surgical complications
    Dalibor Antolovic
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Gastrointest Surg 11:555-61. 2007
    ..Our results demonstrate that hepaticojejunostomy is a safe procedure if performed in a standardized fashion. The above found factors may help to better predict the risk for complications after hepaticojejunostomy...
  91. ncbi request reprint Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells
    Quan Liao
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Gastroenterology 124:1830-45. 2003
    ..In view of the important role of MAPK kinase phosphatase (MKP)-1 in the regulation of MAPK activation, the expression and functional role of MKP-1 was analyzed...
  92. ncbi request reprint Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus
    Armin Kolb
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer Biol Ther 8:1527-33. 2009
    ..Therefore, this analysis might help to identify PDAC in patients with new-onset DM in the age group at risk. Larger clinical trials have to confirm these findings...
  93. ncbi request reprint Gefitinib ('Iressa', ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation
    Junsheng Li
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Oncol 25:203-10. 2004
    ..Gefitinib also inhibits anchorage-independent growth and invasiveness, suggesting that gefitinib may offer a new approach for the treatment of pancreatic cancer...
  94. ncbi request reprint Bile duct infarction following intraarterial hepatic chemotherapy mimicking multiple liver metastasis: report of a case and review of the literature
    Shailesh Shrikhande
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Dig Dis Sci 47:338-44. 2002
  95. ncbi request reprint Inflammatory response after abdominal surgery
    Bernd Sido
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Best Pract Res Clin Anaesthesiol 18:439-54. 2004
    ..As concluded from animal studies, the gas used for the pneumoperitoneum may possess substantial immunomodulatory activity...
  96. doi request reprint Cachexia worsens prognosis in patients with resectable pancreatic cancer
    Jeannine Bachmann
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    J Gastrointest Surg 12:1193-201. 2008
    ..Remarkably, there are only a few data available on the impact of cachexia in patients with pancreatic cancer scheduled for tumor resection...
  97. ncbi request reprint Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease
    Beat M Künzli
    Liver and Transplantation Centers, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, 02215, USA
    Am J Physiol Gastrointest Liver Physiol 292:G223-30. 2007
    ..Our data suggest distinct roles for CD39 and P2-purinergic signaling in both tissue remodeling and fibrogenesis with respect to human pancreatic diseases...
  98. pmc Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia
    Meike Korner
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology of the University of Bern, Murtenstrasse 31, PO Box 62, CH 3010 Bern, Switzerland
    Am J Pathol 167:959-68. 2005
    ..Reduced secretin binding in pancreatic ductal tumors may relate to (alternatively spliced) secretin receptor isoforms. Thus, secretin receptors in pancreatic tumors may represent potential clinical targets...
  99. ncbi request reprint Thioredoxin is downstream of Smad7 in a pathway that promotes growth and suppresses cisplatin-induced apoptosis in pancreatic cancer
    Nichole Boyer Arnold
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Res 64:3599-606. 2004
    ..These findings suggest that TRX is downstream of Smad7 in a pathway that confers a growth advantage to pancreatic cancer cells and that increases their resistance to CDDP-mediated apoptosis, implying novel regulatory functions for Smad7...
  100. ncbi request reprint Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer
    Julia Mayerle
    Department of Medicine B, Westfalische Wilhelms Universitat Munster, Germany
    Gastroenterology 124:949-60. 2003
    ..We have studied the role of p120(ctn), a recently discovered member of the cadherin/catenin family, in human pancreatic cancer...
  101. ncbi request reprint Connective tissue growth factor gene expression alters tumor progression in esophageal cancer
    Alexander Koliopanos
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    World J Surg 26:420-7. 2002
    ....