Manuel A Friese

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. doi request reprint Pathogenic CD8(+) T cells in multiple sclerosis
    Manuel A Friese
    Institut für Neuroimmunologie und Klinische Multiple Sklerose Forschung, Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Ann Neurol 66:132-41. 2009
  2. doi request reprint Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function
    Melanie Piédavent-Salomon
    Institut für Neuroimmunologie und Multiple Sklerose, Zentrum fur Molekulare Neurobiologie Hamburg, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Brain 138:3263-74. 2015
  3. doi request reprint [Autoimmune synaptic encephalopathies]
    M A Friese
    Institut für Neuroimmunologie und Klinische MS Forschung, Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Falkenried 94, 20251 Hamburg, Deutschland
    Nervenarzt 82:1239-49. 2011
  4. doi request reprint CD8⁺ MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis
    Anne Willing
    Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Eur J Immunol 44:3119-28. 2014
  5. doi request reprint Neutrophils amplify autoimmune central nervous system infiltrates by maturing local APCs
    Karin Steinbach
    Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, D 20251 Hamburg, Germany
    J Immunol 191:4531-9. 2013
  6. doi request reprint Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis
    Caren Ramien
    Institute of Neuroimmunology and Multiple Sclerosis INIMS, Center for Molecular Neurobiology Hamburg ZMNH, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neurosci Biobehav Rev 67:137-46. 2016
  7. pmc Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy
    Jan Broder Engler
    Institut für Neuroimmunologie und Multiple Sklerose, Zentrum fur Molekulare Neurobiologie Hamburg, Universitatsklinikum Hamburg Eppendorf, 20251 Hamburg, Germany
    Proc Natl Acad Sci U S A . 2017
  8. doi request reprint Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis
    Manuel A Friese
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitatsklinikum Hamburg Eppendorf, Falkenried 94, D 20251 Hamburg, Germany
    Nat Rev Neurol 10:225-38. 2014
  9. doi request reprint Acquired channelopathies as contributors to development and progression of multiple sclerosis
    Benjamin Schattling
    Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Falkenried 94, D 20251 Hamburg, Germany
    Exp Neurol 262:28-36. 2014
  10. doi request reprint TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis
    Benjamin Schattling
    Forschergruppe Neuroimmunologie, Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Nat Med 18:1805-11. 2012

Collaborators

Detail Information

Publications14

  1. doi request reprint Pathogenic CD8(+) T cells in multiple sclerosis
    Manuel A Friese
    Institut für Neuroimmunologie und Klinische Multiple Sklerose Forschung, Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Ann Neurol 66:132-41. 2009
    ..Here, we review the evidence that CD8(+) T cells play a role in MS pathogenesis...
  2. doi request reprint Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function
    Melanie Piédavent-Salomon
    Institut für Neuroimmunologie und Multiple Sklerose, Zentrum fur Molekulare Neurobiologie Hamburg, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Brain 138:3263-74. 2015
    ..Therefore, by combining human and mouse analyses we show that CD226 exhibits an important role in the activation of regulatory T cells, with its genetically imposed dysregulation impairing regulatory T cell function. ..
  3. doi request reprint [Autoimmune synaptic encephalopathies]
    M A Friese
    Institut für Neuroimmunologie und Klinische MS Forschung, Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Falkenried 94, 20251 Hamburg, Deutschland
    Nervenarzt 82:1239-49. 2011
    ..Tests which differentiate these antibodies are now available in specialized laboratories...
  4. doi request reprint CD8⁺ MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis
    Anne Willing
    Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Eur J Immunol 44:3119-28. 2014
    ..Therefore, CD8(+) MAIT cells seem to play a role in the innate arm of immunopathology in MS. ..
  5. doi request reprint Neutrophils amplify autoimmune central nervous system infiltrates by maturing local APCs
    Karin Steinbach
    Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, D 20251 Hamburg, Germany
    J Immunol 191:4531-9. 2013
    ....
  6. doi request reprint Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis
    Caren Ramien
    Institute of Neuroimmunology and Multiple Sclerosis INIMS, Center for Molecular Neurobiology Hamburg ZMNH, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neurosci Biobehav Rev 67:137-46. 2016
    ..A better understanding of the molecular underpinnings may ultimately help to devise sex-specific treatment strategies as well as highlight novel avenues for therapy in both sexes. ..
  7. pmc Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy
    Jan Broder Engler
    Institut für Neuroimmunologie und Multiple Sklerose, Zentrum fur Molekulare Neurobiologie Hamburg, Universitatsklinikum Hamburg Eppendorf, 20251 Hamburg, Germany
    Proc Natl Acad Sci U S A . 2017
    ..This newly defined mechanism confers protection from autoimmunity during pregnancy and represents a potential target for future therapy...
  8. doi request reprint Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis
    Manuel A Friese
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitatsklinikum Hamburg Eppendorf, Falkenried 94, D 20251 Hamburg, Germany
    Nat Rev Neurol 10:225-38. 2014
    ....
  9. doi request reprint Acquired channelopathies as contributors to development and progression of multiple sclerosis
    Benjamin Schattling
    Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Falkenried 94, D 20251 Hamburg, Germany
    Exp Neurol 262:28-36. 2014
    ..Together, we describe which ion channels in the immune and nervous system commend as attractive future drugable targets in MS treatment. ..
  10. doi request reprint TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis
    Benjamin Schattling
    Forschergruppe Neuroimmunologie, Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Nat Med 18:1805-11. 2012
    ..Electrophysiological recordings revealed TRPM4-dependent neuronal ion influx and oncotic cell swelling upon excitotoxic stimulation. Therefore, interference with TRPM4 could translate into a new neuroprotective treatment strategy...
  11. pmc Multiple sclerosis: Molecular mimicry of an antimyelin HLA class I restricted T-cell receptor
    Geraldine Rühl
    Institute of Clinical Neuroimmunology G R, A G N, K S, R H, K D and Munich Cluster for Systems Neurology SyNergy R H, K D, Ludwig Maximilian University, Munich Department of Life Sciences A P, M K, i A, Technical University Munich, Freising Max Planck Institute of Biochemistry S P, Martinsried Institute of Neuroimmunology and Multiple Sclerosis M A F, University Medical Centre, Hamburg Eppendorf, Hamburg, Germany MRC Human Immunology Unit K E A, Radcliffe Department of Medicine, Weatherall, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK and Center for Integrated Protein Science Munich CIPSM I A, Germany
    Neurol Neuroimmunol Neuroinflamm 3:e241. 2016
    ....
  12. doi request reprint Plasticity of Th17 Cells in Autoimmune Kidney Diseases
    Christian F Krebs
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    J Immunol 197:449-57. 2016
    ....
  13. pmc Activity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis
    Benjamin Schattling
    Institut für Neuroimmunologie und Multiple Sklerose, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    JCI Insight 1:e89810. 2016
    ..2 activity exacerbates inflammation-induced neurodegeneration irrespective of immune cell alterations and identifies NaV1.2 as a promising neuroprotective drug target in multiple sclerosis...
  14. doi request reprint Pregnancy and multiple sclerosis: feto-maternal immune cross talk and its implications for disease activity
    Konstantinos Patas
    Center for Molecular Neurobiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Reprod Immunol 97:140-6. 2013
    ..Reproductive immunology therefore has great potential to provide insights into MS immunopathogenesis and highlight novel avenues for treatment of MS and other autoimmune diseases...