Nicole Fischer

Summary

Affiliation: University Medical Center Hamburg-Eppendorf
Country: Germany

Publications

  1. pmc Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples
    Nicole Fischer
    Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf UKE, Hamburg, Germany German Center for Infection research DZIF, partner site Hamburg Borstel Lübeck, Germany
    J Clin Microbiol 53:2238-50. 2015
  2. doi request reprint Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer
    Nicole Fischer
    Institute for Medical Microbiology and Virology, University Medical Center Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Clin Virol 43:277-83. 2008
  3. doi request reprint Detection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: cell morphology and growth phenotype do not reflect presence of the virus
    Nicole Fischer
    Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 126:2133-42. 2010
  4. pmc Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract
    Nicole Fischer
    Institute for Medical Microbiology and Virology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Emerg Infect Dis 16:1000-2. 2010
  5. pmc No detection of XMRV in blood samples and tissue sections from prostate cancer patients in Northern Europe
    Kristin Stieler
    Institute for Medical Microbiology and Virology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e25592. 2011
  6. doi request reprint Host range and cellular tropism of the human exogenous gammaretrovirus XMRV
    Kristin Stieler
    Institute for Medical Microbiology and Virology, University Medical Center Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Virology 399:23-30. 2010
  7. pmc High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens
    Sophie Borchert
    Institute for Medical Microbiology and Virology, University Medical Center Eppendorf, Hamburg, Germany
    J Virol 88:3144-60. 2014
  8. doi request reprint Replication of Merkel cell polyomavirus induces reorganization of promyelocytic leukemia nuclear bodies
    Friederike Neumann
    1 Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Gen Virol 97:2926-2938. 2016
  9. pmc A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence
    Juliane Marie Theiss
    Research Group Virus Genomics, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS Pathog 11:e1004974. 2015
  10. doi request reprint In Vitro Replication Assay for Merkel Cell Polyomavirus (MCPyV)
    Friederike Neumann
    Institute for Medical Microbiology, Virology and Hygiene University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Curr Protoc Microbiol 38:14F.2.1-19. 2015

Collaborators

Detail Information

Publications15

  1. pmc Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples
    Nicole Fischer
    Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf UKE, Hamburg, Germany German Center for Infection research DZIF, partner site Hamburg Borstel Lübeck, Germany
    J Clin Microbiol 53:2238-50. 2015
    ..Thus, analysis of respiratory samples from known or suspected influenza patients by UMERS provides valuable information that is relevant for clinical investigation. ..
  2. doi request reprint Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer
    Nicole Fischer
    Institute for Medical Microbiology and Virology, University Medical Center Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Clin Virol 43:277-83. 2008
    ....
  3. doi request reprint Detection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: cell morphology and growth phenotype do not reflect presence of the virus
    Nicole Fischer
    Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 126:2133-42. 2010
    ..The cell lines described here extend the repertoire of available MCPyV-positive MCC-lines and should aid in the elucidation of the role of MCPyV in the pathogenesis of MCC...
  4. pmc Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract
    Nicole Fischer
    Institute for Medical Microbiology and Virology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Emerg Infect Dis 16:1000-2. 2010
    ..XMRV-specific sequences were detected in 2%-3% of samples from 168 immunocompetent carriers and approximately 10% of samples from 161 immunocompromised patients...
  5. pmc No detection of XMRV in blood samples and tissue sections from prostate cancer patients in Northern Europe
    Kristin Stieler
    Institute for Medical Microbiology and Virology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e25592. 2011
    ....
  6. doi request reprint Host range and cellular tropism of the human exogenous gammaretrovirus XMRV
    Kristin Stieler
    Institute for Medical Microbiology and Virology, University Medical Center Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Virology 399:23-30. 2010
    ..XMRV-LTR activity is significantly higher in the prostate cancer cell line LNCaP and in prostate stromal fibroblasts, compared to other cell types tested and could be one factor contributing to efficient viral spread in prostate tissue...
  7. pmc High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens
    Sophie Borchert
    Institute for Medical Microbiology and Virology, University Medical Center Eppendorf, Hamburg, Germany
    J Virol 88:3144-60. 2014
    ....
  8. doi request reprint Replication of Merkel cell polyomavirus induces reorganization of promyelocytic leukemia nuclear bodies
    Friederike Neumann
    1 Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Gen Virol 97:2926-2938. 2016
    ..While PML and Daxx had no effect on MCPyV DNA replication, MCPyV replication was increased in cells depleted for Sp100, strongly suggesting that Sp100 is a negative regulator of MCPyV DNA replication...
  9. pmc A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence
    Juliane Marie Theiss
    Research Group Virus Genomics, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS Pathog 11:e1004974. 2015
    ..Our data suggest that MCPyV may have evolved strategies to enter a non- or low level vegetative stage of infection which could aid the virus in establishing and maintaining a lifelong persistence. ..
  10. doi request reprint In Vitro Replication Assay for Merkel Cell Polyomavirus (MCPyV)
    Friederike Neumann
    Institute for Medical Microbiology, Virology and Hygiene University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Curr Protoc Microbiol 38:14F.2.1-19. 2015
    ..However, serial transmission of infectious virus is still restricted in these cells...
  11. pmc Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV
    Kristin Stieler
    Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Eppendorf, Hamburg, Germany
    PLoS ONE 5:e11738. 2010
    ..The Apobec3 (A3) proteins, a family of cytidine deaminases, are one important group of host proteins that control primary infection and efficient viral spread...
  12. pmc Replication, gene expression and particle production by a consensus Merkel Cell Polyomavirus (MCPyV) genome
    Friederike Neumann
    Institute for Microbiology and Virology, University Medical Center Eppendorf, Hamburg, Germany
    PLoS ONE 6:e29112. 2011
    ..However, serial transmission of infectious virus was not observed. This in vitro culturing system allows the study of viral replication and will facilitate the molecular dissection of important aspects of the MCPyV lifecycle...
  13. pmc XMRV induces cell migration, cytokine expression and tumor angiogenesis: are 22Rv1 cells a suitable prostate cancer model?
    Kristin Stieler
    Institute for Microbiology and Virology, University Medical Center Eppendorf, Hamburg, Germany
    PLoS ONE 7:e42321. 2012
    ..We propose that data received with 22Rv1 cells or equivalent cells carrying xenotropic gammaretroviruses should be carefully controlled including other prostate cancer cell lines tested for viral sequences...
  14. doi request reprint Merkel cell polyomavirus detection in Merkel cell cancer tumors in Northern Germany using PCR and protein expression
    Miriam Leitz
    Institute for Microbiology and Virology, University Medical Center Eppendorf, Hamburg, Germany
    J Med Virol 86:1813-9. 2014
    ..These data are in accord with published studies describing heterogeneity in MCPyV viral loads and suggest that detection of MCPyV in Merkel cell carcinoma by PCR should be undertaken using multiple primer pairs...
  15. doi request reprint Investigation of Viral and Host Chromatin by ChIP-PCR or ChIP-Seq Analysis
    Thomas Gunther
    Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
    Curr Protoc Microbiol 40:1E.10.1-21. 2016
    ..Here, we provide protocols that are suitable for performing ChIP-PCR and ChIP-Seq studies on chromatin of large and small viral genomes...