B L Fiebich

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint Substance P induces expression of the corticotropin-releasing factor receptor 1 by activation of the neurokinin-1 receptor
    Maike Hamke
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Brain Res 1102:135-44. 2006
  2. pmc Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Neuroinflammation 4:25. 2007
  3. doi request reprint Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2
    Antonio Carlos Pinheiro de Oliveira
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 56:844-55. 2008
  4. pmc Detrimental effects of tropisetron on permanent ischemic stroke in the rat
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstr, 5, D 79104 Freiburg, Germany
    BMC Neurosci 9:19. 2008
  5. pmc The effects of tea extracts on proinflammatory signaling
    Frank Pajonk
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1714, USA
    BMC Med 4:28. 2006
  6. ncbi request reprint Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine
    Bernd L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Pharmacol Res 53:391-6. 2006
  7. ncbi request reprint IL-6 expression induced by adenosine A2b receptor stimulation in U373 MG cells depends on p38 mitogen activated kinase and protein kinase C
    Bernd L Fiebich
    University of Freiburg Medical School, Department of Psychiatry and Psychotherapy, Neurochemistry Research Group, Hauptstrasse 5, D 79104 Freiburg, Germany
    Neurochem Int 46:501-12. 2005
  8. ncbi request reprint Antiinflammatory effects of 5-HT3 receptor antagonists in lipopolysaccharide-stimulated primary human monocytes
    B L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Scand J Rheumatol Suppl 119:28-32. 2004
  9. ncbi request reprint Expression of 5-HT3A receptors in cells of the immune system
    B L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Scand J Rheumatol Suppl 119:9-11. 2004
  10. ncbi request reprint Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 75:2020-8. 2000

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Substance P induces expression of the corticotropin-releasing factor receptor 1 by activation of the neurokinin-1 receptor
    Maike Hamke
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Brain Res 1102:135-44. 2006
    ..Further studies are needed to substantiate this link in vivo...
  2. pmc Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Neuroinflammation 4:25. 2007
    ..The aim of this study was to examine whether resveratrol is able to reduce prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2alpha (8-iso-PGF2 alpha) production by lipopolysaccharide (LPS)-activated primary rat microglia...
  3. doi request reprint Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2
    Antonio Carlos Pinheiro de Oliveira
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 56:844-55. 2008
    ....
  4. pmc Detrimental effects of tropisetron on permanent ischemic stroke in the rat
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstr, 5, D 79104 Freiburg, Germany
    BMC Neurosci 9:19. 2008
    ....
  5. pmc The effects of tea extracts on proinflammatory signaling
    Frank Pajonk
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1714, USA
    BMC Med 4:28. 2006
    ..We investigated the underlying molecular mechanisms and compared effects of tea extracts with the effects of epigallocatechin-gallate, the proposed most-active moiety of green tea...
  6. ncbi request reprint Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine
    Bernd L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Pharmacol Res 53:391-6. 2006
    ....
  7. ncbi request reprint IL-6 expression induced by adenosine A2b receptor stimulation in U373 MG cells depends on p38 mitogen activated kinase and protein kinase C
    Bernd L Fiebich
    University of Freiburg Medical School, Department of Psychiatry and Psychotherapy, Neurochemistry Research Group, Hauptstrasse 5, D 79104 Freiburg, Germany
    Neurochem Int 46:501-12. 2005
    ..This is supported by the fact that NECA induced the activation of PKC delta and epsilon in U373 MG cells...
  8. ncbi request reprint Antiinflammatory effects of 5-HT3 receptor antagonists in lipopolysaccharide-stimulated primary human monocytes
    B L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Scand J Rheumatol Suppl 119:28-32. 2004
    ..In conclusion, our data show that the binding of tropisetron to 5-HT3 receptors results in antiinflammatory effects through inhibition of TNF-alpha/IL-1beta, which might explain the antiphlogistic effects of 5-HT3 antagonists...
  9. ncbi request reprint Expression of 5-HT3A receptors in cells of the immune system
    B L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Scand J Rheumatol Suppl 119:9-11. 2004
    ..Our data show that 5-HT3A receptors are widely expressed in cells of the immune system and that they might play an important role in inflammatory events and in the observed antiphlogistic effects of 5-HT3 receptor antagonists...
  10. ncbi request reprint Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 75:2020-8. 2000
    ..The ability of p38 MAPK to augment COX-2 expression in human neuroblastoma cells, as shown here, suggests that p38 MAPK may be involved in neuronal expression of COX-2 in AD...
  11. ncbi request reprint Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin E(2) synthesis in rat microglial cells
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Neuropharmacology 39:2205-13. 2000
    ..Furthermore, these results may help explain the clinical experience of an adjuvant analgesic effect of caffeine and paracetamol when combined with acetylsalicylic acid...
  12. ncbi request reprint The neuropeptide substance P activates p38 mitogen-activated protein kinase resulting in IL-6 expression independently from NF-kappa B
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Immunol 165:5606-11. 2000
    ..Drugs targeting this MAPK may therefore interfere with SP-correlated neuropsychiatric disorders and may represent a therapeutic approach in these disorders...
  13. ncbi request reprint The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha
    B L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Neuropharmacology 38:1325-33. 1999
    ....
  14. ncbi request reprint Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB
    Anne Waschbisch
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 96:680-93. 2006
    ....
  15. ncbi request reprint Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 51:199-208. 2005
    ..This detailed view of the intracellular signaling pathway in microglial activation and COX-2 expression opens a new therapeutic window in the search for new and more effective central anti-inflammatory agents...
  16. ncbi request reprint Cytokine-induced transcription of protein-tyrosine-phosphatases in human astrocytoma cells
    G Schumann
    Department of Psychiatry, Albert Ludwigs Universitat, Hauptstrasse 5, 79104, Freiburg, Germany
    Brain Res Mol Brain Res 62:56-64. 1998
    ....
  17. ncbi request reprint Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 79:950-8. 2001
    ....
  18. ncbi request reprint Anti-inflammatory drugs: a hope for Alzheimer's disease?
    M Hull
    Department of Psychiatry, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Expert Opin Investig Drugs 9:671-83. 2000
    ....
  19. ncbi request reprint Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Neuroimmunol 174:39-51. 2006
    ....
  20. ncbi request reprint Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 93:549-59. 2005
    ..This study shows, for the first time, a central role of 5-HT7 receptor linked to p38 MAPK and PKC epsilon for the induction of cytokine synthesis in astrocytic cells...
  21. ncbi request reprint Inhibition of substance P-induced cytokine synthesis by St. John's wort extracts
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Germany
    Pharmacopsychiatry 34:S26-8. 2001
    ..John's wort, but also lend support to the hypothesis that the antidepressant effect of St. John's wort is, at least in part, a result of its inhibitory effects on SP-induced protein synthesis...
  22. ncbi request reprint Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons
    M Hull
    Department of Psychiatry and Psychotherapy, University of Freiburg, Medical School, Germany
    Neurosci Lett 261:33-6. 1999
    ..Glutamate but not IL-6 induced a dephosphorylation of tau. Furthermore IL-6 did not influence the glutamate-induced dephoshorylation of tau. We conclude that the role of IL-6 in AD is not related to the phosphorylation of tau...
  23. pmc Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia
    Johannes C M Schlachetzki
    Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Freiburg, Germany
    J Neuroinflammation 7:2. 2010
    ..In the present study, we investigate the role of norepinephrine on cyclooxygenase- (COX-)2 expression/synthesis and prostaglandin (PG)E2 production in rat primary microglia...
  24. ncbi request reprint Inhibition of TNF-alpha synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69
    B L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Phytomedicine 8:28-30. 2001
    ..Our data provides evidence that the Harpagophytum extract SteiHap 69 has anti-inflammatory properties. Further studies are required in order to elucidate the molecular mechanism of Devil's claw anti-inflammatory effects...
  25. ncbi request reprint Cloning of rat HIV-1-chemokine coreceptor CKR5 from microglia and upregulation of its mRNA in ischemic and endotoxinemic rat brain
    O Spleiss
    Department of Psychiatry, University of Freiburg, Germany
    J Neurosci Res 53:16-28. 1998
    ..In summary, upregulation of CC-chemokines and CKR5 in the CNS upon bacterial infection or in ischemia may impact on microglial activation stage and result in increased risk of HIV-1 infection...
  26. ncbi request reprint Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs
    M Hull
    Department of Psychiatry, Neurochemistry Research, University of Freiburg, Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Curr Med Chem 9:83-8. 2002
    ..Inhibitors of p38MAPK and PPAR gamma agonists may be suitable agents to suppress inflammatory activation in AD...
  27. ncbi request reprint [Substance P-antagonists as a new class of antidepressant drugs]
    K Lieb
    Abteilung Psychiatrie und Psychotherapie, Universitatsklinikum Freiburg, Germany
    Dtsch Med Wochenschr 127:2563-5. 2002
  28. ncbi request reprint [Substance P receptor antagonists--a new antidepressive and anxiolytic mechanism?]
    K Lieb
    Abt Psychiatrie und Psychotherapie, Universitatsklinik Freiburg
    Nervenarzt 71:758-61. 2000
    ..Although these findings are promising, further studies are necessary to prove the hypothesis that substance P receptor antagonists represent a new class of antidepressants or anxiolytics. Respective studies are currently underway...
  29. ncbi request reprint Substance P and affective disorders: new treatment opportunities by neurokinin 1 receptor antagonists?
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg, Medical School, Germany
    Neuropsychobiology 45:2-6. 2002
    ..It also reviews current treatment approaches with neurokinin 1 receptor antagonists which appear to be promising drugs for the future treatment of affective disorders...
  30. ncbi request reprint Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells
    Bernd L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, D 79104 Freiburg, Germany
    J Neuroimmunol 132:18-24. 2002
    ..The data suggest that parthenolide might have a potential in the treatment of CNS diseases where NO is part of the pathophysiology...
  31. ncbi request reprint Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes
    Michael Hull
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Neurochem Int 48:663-72. 2006
    ..The potential role of astroglial cells in the phagocytosis of amyloid and the involvement of PGs in this process suggests that a modulation of PGs synthesis may be a putative target in the prevention of amyloid deposition...
  32. ncbi request reprint Prostaglandin E2 synthesis in human monocyte-derived dendritic cells
    Johannes Norgauer
    Department of Experimental Dermatology, University of Freiburg, D 79104 Freiburg, Germany
    Int J Mol Med 12:83-6. 2003
    ..Our data indicate that during lps-induced maturation p38 regulates COX-2 expression and PGE2 synthesis in DC...
  33. ncbi request reprint Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells
    Klaus Lieb
    Department of Psychiatry, University of Freiburg Medical School, D 79104, Freiburg, Germany
    Neurochem Int 42:131-7. 2003
    ....
  34. ncbi request reprint No modulatory effect of neurokinin-1 receptor antagonists on serotonin uptake in human and rat brain synaptosomes
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Eur Neuropsychopharmacol 15:641-6. 2005
    ..These results show that in humans, as in rodents, inhibition of the 5-HT transporter is probably not the underlying mechanism of the assumed antidepressant activity of NK-1-RA...
  35. doi request reprint Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells
    Harsharan S Bhatia
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Arch Biochem Biophys 477:253-8. 2008
    ..These data suggest that modulation of microglial activation might contribute to the mechanism of cerebral protection by mangiferin...
  36. ncbi request reprint Valproic acid inhibits substance P-induced activation of protein kinase C epsilon and expression of the substance P receptor
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    J Neurochem 86:69-76. 2003
    ..Whether both mechanisms contribute to the mood-stabilizing properties of VPA has to be evaluated in further studies...
  37. ncbi request reprint Effects of substance P and its antagonist L-733060 on long term potentiation in guinea pig hippocampal slices
    Jens M Langosch
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstr 5, D 79104 Freiburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:315-9. 2005
    ..In conclusion, SP has excitatory effects in the hippocampus and is able to facilitate LTP via activation of the NK-1 receptor...
  38. ncbi request reprint Synergistic inhibitory effect of ascorbic acid and acetylsalicylic acid on prostaglandin E2 release in primary rat microglia
    Bernd L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Germany
    J Neurochem 86:173-8. 2003
    ..Our results show that ascorbic acid and acetylsalicylic acid act synergistically in inhibiting PGE2 synthesis, which may help to explain a possible protective effect of ascorbic acid in various brain diseases...
  39. ncbi request reprint Effects of coffees before and after special treatment procedure on cell membrane potentials in stomach cells
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Methods Find Exp Clin Pharmacol 28:369-72. 2006
    ..These results are in good accordance with clinical pharmacological results from potential difference measurements in healthy volunteers we found in the literature...
  40. ncbi request reprint Petasites hybridus extracts in vitro inhibit COX-2 and PGE2 release by direct interaction with the enzyme and by preventing p42/44 MAP kinase activation in rat primary microglial cells
    B L Fiebich
    University of Freiburg Medical School, Dept of Psychiatry and Psychotherapy, Freiburg, Germany
    Planta Med 71:12-9. 2005
    ..Therefore, these Petasites hybridus extracts can be regarded as natural selective inhibitors of COX-2 and its expression, an effect which is independent from the petasin content...
  41. ncbi request reprint Early-onset Alzheimer's disease due to mutations of the presenilin-1 gene on chromosome 14: a 7-year follow-up of a patient with a mutation at codon 139
    M Hull
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Eur Arch Psychiatry Clin Neurosci 248:123-9. 1998
    ..Although the majority of EOAD patients belong to the sporadic (non-genetic) type of AD, early-onset dementia, early myocloni and a familial history of AD should direct attention to the possibility of a genetic form of AD...
  42. doi request reprint Micro-array profiling exhibits remarkable intra-individual stability of human platelet micro-RNA
    C Stratz
    Bernd L Fiebich, Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79014 Freiburg, Germany
    Thromb Haemost 107:634-41. 2012
    ..Single-point analysis of platelet miRNA profile is reasonable when inter-individual differences are studied. The functional annotation network points toward extra-platelet effects of platelet miRNAs...
  43. ncbi request reprint Effects of an ethanolic salix extract on the release of selected inflammatory mediators in vitro
    B L Fiebich
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    Phytomedicine 11:135-8. 2004
    ..Our data further suggest that the proprietary Salix extract is a weak inhibitor of proinflammatory cytokines...
  44. ncbi request reprint 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline-induced apoptosis in the human neuroblastoma cell line SK-N-SH
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 91:263-73. 2004
    ....
  45. pmc Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells
    Lena Wendeburg
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Neuroinflammation 6:26. 2009
    ....
  46. ncbi request reprint Effects of substance P on memory and mood in healthy male subjects
    Inga Herpfer
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
    Hum Psychopharmacol 22:567-73. 2007
    ..The results may be interpreted as evidence for an anxiogenic and memory-disturbing effect of SP. Further studies will focus on the effects of SP in patients with depression, anxiety and cognitive disorders...
  47. ncbi request reprint Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 100:1108-20. 2007
    ....
  48. ncbi request reprint 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, Freiburg 79104, Germany
    Ann N Y Acad Sci 1010:304-6. 2003
    ..In this study, we report that TaClo is a highly cytotoxic agent that leads to apoptosis in human neuroblastoma cells involving caspase-3 activation...
  49. ncbi request reprint Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum
    Giovanni Appendino
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy
    J Nat Prod 70:608-12. 2007
    ..Arzanol inhibited HIV-1 replication in T cells and the release of pro-inflammatory cytokines in LPS-stimulated primary monocytes, qualifying as a novel plant-derived anti-inflammatory and antiviral chemotype worth further investigation...
  50. ncbi request reprint Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways
    Rocio Sancho
    Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de Cordoba, Facultad de Medicina, Cordoba, Spain
    J Immunol 172:2341-51. 2004
    ..These findings provide new mechanistic insights into the anti-inflammatory activities of NADA and highlight their potential to design novel therapeutic strategies to manage inflammatory diseases...
  51. doi request reprint Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii
    Arieh Moussaieff
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel
    J Cereb Blood Flow Metab 28:1341-52. 2008
    ..This study attributes the anti-inflammatory activity of Boswellia resin to IA and related cembranoid diterpenes and suggests that they may serve as novel neuroprotective agents...
  52. doi request reprint Denbinobin, a naturally occurring 1,4-phenanthrenequinone, inhibits HIV-1 replication through an NF-kappaB-dependent pathway
    Gonzalo Sanchez-Duffhues
    Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de Cordoba, Facultad de Medicina, Cordoba, Spain
    Biochem Pharmacol 76:1240-50. 2008
    ....
  53. ncbi request reprint The acetaminophen-derived bioactive N-acylphenolamine AM404 inhibits NFAT by targeting nuclear regulatory events
    Francisco J Caballero
    Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de Cordoba, Facultad de Medicina, Avda de Menendez Pidal s n, 14004 Cordoba, Spain
    Biochem Pharmacol 73:1013-23. 2007
    ..These findings provide new mechanistic insights into the immunological effects of AM404 which in part could explain some of the activities ascribed to the widely used acetaminophen...
  54. doi request reprint Identification of 5-HT3 receptors on human platelets: increased surface immunoreactivity after activation with adenosine diphosphate (ADP) and thrombin receptor-activating peptide (TRAP)
    Christian Stratz
    Thromb Haemost 99:784-6. 2008
  55. ncbi request reprint 5-HT3 receptor antagonist for the treatment of tendinopathy
    Kazem Mousavizadeh
    Nat Clin Pract Rheumatol 4:E4. 2008
  56. ncbi request reprint COX-1/COX-2 inhibitors based on the methanone moiety
    Gerd Dannhardt
    Institute of Pharmacy, Fachbereich Chemie und Pharmazie, Johannes Gutenberg University of Mainz, Staudingerweg 5, D 55099 Mainz, Germany
    Eur J Med Chem 37:147-61. 2002
    ..The potency and the enzyme selectivity were varied by structural modifications of the lead...
  57. ncbi request reprint Cyclooxygenase inhibition in ischemic brain injury
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    Curr Pharm Des 14:1401-18. 2008
    ..Finally, we will provide a critical evaluation of the therapeutic potential of COX inhibitors in cerebral ischemia and discuss new targets downstream of COX with potential neuroprotective ability...
  58. ncbi request reprint Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation
    Arieh Moussaieff
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Mol Pharmacol 72:1657-64. 2007
    ..Cembrenoid diterpenoids, specifically IA and its derivatives, may thus constitute a potential novel group of NF-kappaB inhibitors, originating from an ancient anti-inflammatory herbal remedy...
  59. ncbi request reprint Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors
    Nieves Marquez
    Departamento de Biologia Celular, Fisiología e Inmunología Facultad de Medicina, Cordoba, Spain
    J Pharmacol Exp Ther 308:993-1001. 2004
    ..These findings provide new insights into the molecular mechanisms involved in the immunomodulatory and anti-inflammatory activities of this natural compound...
  60. ncbi request reprint Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway
    Nieves Marquez
    Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de Cordoba, Facultad de Medicina, Avda de Menendez Pidal s n, 14004 Cordoba, Spain
    Antiviral Res 66:137-45. 2005
    ....
  61. ncbi request reprint Substance P in serum and cerebrospinal fluid of depressed patients: no effect of antidepressant treatment
    Michael Deuschle
    Central Institute of Mental Health Mannheim, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Psychiatry Res 136:1-6. 2005
    ..Serum SP concentrations were not related to treatment response or the class of antidepressant administered. Our data do not support the hypothesis that changes in SP levels in serum or CSF are related to antidepressant response...
  62. ncbi request reprint Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 1007:98-108. 2004
    ....
  63. ncbi request reprint The growth inhibitory activity of the Cimicifuga racemosa extract Ze 450 is mediated through estrogen and progesterone receptors-independent pathways
    Marcela Garita-Hernandez
    Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de Cordoba, Cordoba, Spain
    Planta Med 72:317-23. 2006
    ....
  64. ncbi request reprint Nonsteroidal drugs and Alzheimer's disease
    Michael Hull
    N Engl J Med 346:1171-3. 2002
  65. ncbi request reprint Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca(2+) from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappaB, and activator prot
    Carmen Navarrete
    Departamento de Biologia Celular, Fisiologia e Inmunologia, Facultad de Medicina, Avda de Menendez Pidal s n, Universidad de Cordoba, 14004 Cordoba, Spain
    J Pharmacol Exp Ther 319:422-30. 2006
    ..In contrast, basiliolide C, where the 15-carbon is oxidized to an acetoxymethine, was much less active. These findings qualify these compounds as new probes to investigate intracellular calcium homeostasis...
  66. ncbi request reprint No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress
    Nicolas Rohleder
    Department of Psychology, Dresden University of Technology, Zellescher Weg 17, D 01069 Dresden, Germany
    Life Sci 78:3082-9. 2006
    ..Further studies have to reveal the mechanisms involved in the stress-induced up regulation of IL-1ra...
  67. pmc Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    J Pharmacol Exp Ther 323:488-98. 2007
    ..Modulation of COX in brain injury by COX inhibitors or agents modulating prostaglandin E(2) formation/signaling may be useful in clinical settings associated with BBB disruption...
  68. ncbi request reprint Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line
    Antonio Macho
    Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de Cordoba, Facultad de Medicina, Avda de Menendez Pidal s n, E 14004 Cordoba, Spain
    Biochem Pharmacol 68:875-83. 2004
    ..The evaluation of ferutinin analogs in calcium mobilization and apoptosis assays showed strict structure-activity relationships, with p-hydroxylation of the benzoyl moiety being requested for activity...