Peter A Fasching

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. doi request reprint HER2 and TOP2A amplification in a hospital-based cohort of breast cancer patients: associations with patient and tumor characteristics
    Peter A Fasching
    Division of Hematology Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Breast Cancer Res Treat 145:193-203. 2014
  2. pmc FemZone trial: a randomized phase II trial comparing neoadjuvant letrozole and zoledronic acid with letrozole in primary breast cancer patients
    Peter A Fasching
    University Breast Center, Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen Comprehensive Cancer Center Erlangen EMN, Erlangen, Germany
    BMC Cancer 14:66. 2014
  3. pmc Overexpression of SERBP1 (Plasminogen activator inhibitor 1 RNA binding protein) in human breast cancer is correlated with favourable prognosis
    Nuran Bektas Serce
    Department of Pathology, University Hospital Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    BMC Cancer 12:597. 2012
  4. pmc The role of genetic breast cancer susceptibility variants as prognostic factors
    Peter A Fasching
    University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen Nuremberg, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Hum Mol Genet 21:3926-39. 2012
  5. doi request reprint Genetic variants in the tryptophan hydroxylase 2 gene (TPH2) and depression during and after pregnancy
    Peter A Fasching
    Erlangen University Perinatal Center, Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    J Psychiatr Res 46:1109-17. 2012
  6. pmc Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer
    Volkmar Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20241 Hamburg, Germany
    Breast Cancer Res 13:R71. 2011
  7. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  8. pmc The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer
    Nuran Bektas
    Department of Pathology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Breast Cancer Res 10:R58. 2008
  9. doi request reprint Role of genetic polymorphisms and ovarian cancer susceptibility
    Peter A Fasching
    University of California at Los Angeles, David Geffen School of Medicine, Division of Hematology and Oncology, Los Angeles, CA, USA
    Mol Oncol 3:171-81. 2009
  10. pmc Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment
    Peter A Fasching
    Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, California, USA
    BMC Cancer 11:486. 2011

Detail Information

Publications81

  1. doi request reprint HER2 and TOP2A amplification in a hospital-based cohort of breast cancer patients: associations with patient and tumor characteristics
    Peter A Fasching
    Division of Hematology Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Breast Cancer Res Treat 145:193-203. 2014
    ....
  2. pmc FemZone trial: a randomized phase II trial comparing neoadjuvant letrozole and zoledronic acid with letrozole in primary breast cancer patients
    Peter A Fasching
    University Breast Center, Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen Comprehensive Cancer Center Erlangen EMN, Erlangen, Germany
    BMC Cancer 14:66. 2014
    ....
  3. pmc Overexpression of SERBP1 (Plasminogen activator inhibitor 1 RNA binding protein) in human breast cancer is correlated with favourable prognosis
    Nuran Bektas Serce
    Department of Pathology, University Hospital Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    BMC Cancer 12:597. 2012
    ..This is the first study to present a systematic characterisation of SERBP1 expression in human breast cancer and normal breast tissue at both the mRNA and the protein level...
  4. pmc The role of genetic breast cancer susceptibility variants as prognostic factors
    Peter A Fasching
    University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen Nuremberg, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Hum Mol Genet 21:3926-39. 2012
    ..Survival may be influenced by a distinct set of germline variants from those influencing susceptibility...
  5. doi request reprint Genetic variants in the tryptophan hydroxylase 2 gene (TPH2) and depression during and after pregnancy
    Peter A Fasching
    Erlangen University Perinatal Center, Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    J Psychiatr Res 46:1109-17. 2012
    ....
  6. pmc Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer
    Volkmar Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20241 Hamburg, Germany
    Breast Cancer Res 13:R71. 2011
    ..The aim of the study was to investigate whether serum concentrations of TIMP-1 and CAIX are associated with the detection of CTC in metastatic breast cancer...
  7. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  8. pmc The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer
    Nuran Bektas
    Department of Pathology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Breast Cancer Res 10:R58. 2008
    ..To the best of our knowledge, in the current study we present for the first time a systematic characterisation of ISG15 expression in human breast cancer and normal breast tissue both at the mRNA and protein level...
  9. doi request reprint Role of genetic polymorphisms and ovarian cancer susceptibility
    Peter A Fasching
    University of California at Los Angeles, David Geffen School of Medicine, Division of Hematology and Oncology, Los Angeles, CA, USA
    Mol Oncol 3:171-81. 2009
    ..This review describes the efforts that have been made in this field by individual case-control studies and through multi-center collaborations as part of international consortia such as the Ovarian Cancer Association Consortium (OCAC)...
  10. pmc Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment
    Peter A Fasching
    Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, California, USA
    BMC Cancer 11:486. 2011
    ..This study investigated the predictive and prognostic value of Ki67 in patients with invasive breast cancer receiving neoadjuvant treatment for breast cancer...
  11. doi request reprint Comprehensive visualization of paresthesia in breast cancer survivors
    Sebastian M Jud
    Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Universitaetsstrasse 21 23, 91054, Erlangen, Germany
    Arch Gynecol Obstet 290:135-41. 2014
    ..This article presents a new method of assessing the spatial distribution of paresthesia in breast cancer survivors after different locoregional treatments...
  12. doi request reprint Neurokinin 1 receptor gene polymorphism might be correlated with recurrence rates in endometriosis
    Stefan P Renner
    Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany
    Gynecol Endocrinol 25:726-33. 2009
    ..Aim of this study was, therefore, to examine the effect of a single nucleotide polymorphism (SNP) of the NK1R gene on the susceptibility for endometriosis and the disease free survival (DFS) after surgery for endometriosis...
  13. doi request reprint Hormone replacement therapy and prognosis in ovarian cancer patients
    Alexander Hein
    Department of Gynecology and Obstetrics, Comprehensive Cancer Center, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Cancer Prev 22:52-8. 2013
    ..Sex hormone exposure through HRT may influence the behavior of ovarian cancers after the onset of the disease. This study supports the hypothesis that ovarian cancer is a hormonally influenced tumor...
  14. doi request reprint Shared decision-making in metastatic breast cancer: discrepancy between the expected prolongation of life and treatment efficacy between patients and physicians, and influencing factors
    Michael P Lux
    University Breast Center Franconia, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen EMN, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Universitätsstrasse 21 23, 91054, Erlangen, Germany
    Breast Cancer Res Treat 139:429-40. 2013
    ..There appear to be some indicators that might help address the problem, such as the physicians' level of training and experience and the patients' specific social circumstances...
  15. pmc Characterizing mammographic images by using generic texture features
    Lothar Haberle
    University Breast Center for Franconia, Erlangen Nuremberg Comprehensive Cancer Center, Erlangen University Hospital, Department of Gynecology and Obstetrics, Universitaetsstrasse 21 23, 91054 Erlangen, Germany
    Breast Cancer Res 14:R59. 2012
    ..The aims of this study were to evaluate a variety of automated texture features in mammograms as risk factors for breast cancer and to compare them with the percentage mammographic density (PMD) by using a case-control study design...
  16. doi request reprint Prognostic molecular markers and neoadjuvant therapy response in anthracycline-treated breast cancer patients
    David L Wachter
    Institute of Pathology, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arch Gynecol Obstet 287:337-44. 2013
    ..This study analyzed the value of immunohistochemical biomarkers for predicting pathological complete response (pCR) and prognosis in a group of BC patients receiving standardized treatment...
  17. doi request reprint Single nucleotide polymorphisms in the progesterone receptor gene and association with uterine leiomyoma tumor characteristics and disease risk
    Stefan P Renner
    Department of Gynaecology and Obstetrics, University Clinic Erlangen, Laboratory for Molecular Medicine, Erlangen, Germany
    Am J Obstet Gynecol 199:648.e1-9. 2008
    ..This investigation analyzed the +331G/A and the V600L single nucleotide polymorphisms in the progesterone receptor, and correlated their incidence with clinical and tumor parameters as well as disease risk...
  18. doi request reprint Early aberrant insulin-like growth factor signaling in the progression to endometrial carcinoma is augmented by tamoxifen
    Pamela L Strissel
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Erlangen, Germany
    Int J Cancer 123:2871-9. 2008
    ....
  19. doi request reprint Prognostic relevance of Ki-67 in the primary tumor for survival after a diagnosis of distant metastasis
    Christian R Loehberg
    Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Universitätsstrasse 21 23, 91054 Erlangen, Bavaria, Germany
    Breast Cancer Res Treat 138:899-908. 2013
    ..Ki-67 is useful in addition to known prognostic factors for breast cancer. It is able to indicate a group of women with a poorer prognosis, specifically in the group of patients with PR-positive breast cancer...
  20. pmc Circulating micro-RNAs as potential blood-based markers for early stage breast cancer detection
    Michael G Schrauder
    Department of Obstetrics and Gynaecology, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 7:e29770. 2012
    ..We investigated whether microarray-based miRNA profiling on whole blood could discriminate between early stage breast cancer patients and healthy controls...
  21. doi request reprint Mammographic density as a risk factor for breast cancer in a German case-control study
    Katharina Heusinger
    University Breast Center Franconia, Germany
    Eur J Cancer Prev 20:1-8. 2011
    ..7; P<0.001). This study provides further evidence that MD is an important risk factor for breast cancer. These results indicate strong associations between MD and the risk of breast cancer in a matched case-control study in Germany...
  22. doi request reprint Factors influencing breast changes after pregnancy
    Claudia Rauh
    Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Cancer Prev 22:259-61. 2013
    ..Further studies are needed to clarify whether these individual responses interact with the effect of pregnancy on the BC risk...
  23. doi request reprint Association of mammographic density with hormone receptors in invasive breast cancers: results from a case-only study
    Katharina Heusinger
    Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen Nuremberg, Germany
    Int J Cancer 131:2643-9. 2012
    ..These effects were independent of other risk factors such as age, BMI, parity, and hormone replacement therapy, possibly suggesting other pathways that mediate this effect...
  24. doi request reprint Correlation of high-risk human papilloma viruses but not of herpes viruses or Chlamydia trachomatis with endometriosis lesions
    Peter Oppelt
    Department of Gynaecology and Obstetrics, University Clinic Erlangen, Erlangen, Germany
    Fertil Steril 93:1778-86. 2010
    ..To investigate whether sexually transmitted viruses or prokaryotes, like human papilloma viruses (HPV), herpes viruses, and Chlamydia trachomatis, are associated with endometriosis lesions...
  25. doi request reprint Diabetes and prognosis in a breast cancer cohort
    Michael G Schrauder
    Department of Obstetrics and Gynaecology, University Hospital Erlangen, Erlangen, Germany
    J Cancer Res Clin Oncol 137:975-83. 2011
    ..The aim of this retrospective cohort study was to examine the effect of diabetes on the clinical course and the prognosis of early stage breast cancer in relation to tumour and patient characteristics...
  26. doi request reprint Assessment of mammographic density before and after first full-term pregnancy
    Christian R Loehberg
    Department of Obstetrics and Gynecology, University Breast Center Franconia, Erlangen, Germany
    Eur J Cancer Prev 19:405-12. 2010
    ..It may be hypothesized that breast cancer risk reduction associated with pregnancy is mediated through a direct reduction of MD, and MD assessment might be incorporated in individualizing risk assessment and prevention...
  27. doi request reprint Association of mammographic density with the proliferation marker Ki-67 in a cohort of patients with invasive breast cancer
    Katharina Heusinger
    Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Breast Cancer Res Treat 135:885-92. 2012
    ..MD correlates inversely with Ki-67 proliferation in BC tumors only in some subgroups of BC patients, defined by commonly known BC risk factors that are usually associated with MD as well...
  28. doi request reprint Breast cancer risk assessment in a mammography screening program and participation in the IBIS-II chemoprevention trial
    Christian R Loehberg
    Department of Ob Gyn, University Breast Center Franconia, Univeristy Hospital Erlangen, Erlangen, Germany
    Breast Cancer Res Treat 121:101-10. 2010
    ..More individualized approaches and communication of breast cancer risk at the time of the risk assessment might be helpful to increase the participation and the understanding of chemopreventive approaches...
  29. doi request reprint Breast volumetry using a three-dimensional surface assessment technique
    Martin C Koch
    University Breast Center Franconia, Department of Ob Gyn, University Hospital Erlangen, Universitaetsstrasse 21 23, 91054, Erlangen, Germany
    Aesthetic Plast Surg 35:847-55. 2011
    ..This study evaluated a new technique to determine breast volume and compared measures using a three-dimensional (3D) body surface scanner and magnetic resonance imaging (MRI) scans, with the latter used as the standard method...
  30. doi request reprint Socioeconomic status and depression during and after pregnancy in the Franconian Maternal Health Evaluation Studies (FRAMES)
    Alexander Hein
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Universitaetsstrasse 21 23, 91054, Erlangen, Germany
    Arch Gynecol Obstet 289:755-63. 2014
    ..The aim of this study was to investigate the value of socioeconomic factors in predicting depressive symptoms during and after pregnancy...
  31. ncbi request reprint Health utilities in gynecological oncology and mastology in Germany
    Thomas Hildebrandt
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Universitätsstrasse 21 23, 91054 Erlangen, Germany
    Anticancer Res 34:829-35. 2014
    ..However, these may widely deviate from the values for a woman actually living in Germany. It is, therefore, necessary to collect and analyze health utilities in Germany...
  32. doi request reprint Pain perception and detailed visual pain mapping in breast cancer survivors
    Sebastian M Jud
    Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Erlangen, Germany
    Breast Cancer Res Treat 119:105-10. 2010
    ..This study presents a method of visualizing pain areas and assigning them to a pictogram of the body in a sample of breast cancer patients. The method is easy to use and could help generate pain maps in several types of disease...
  33. doi request reprint Mammographic density is the main correlate of tumors detected on ultrasound but not on mammography
    Lothar Haberle
    Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Germany, Friedrich Alexander University of Erlangen Nuremberg, Comprehensive Cancer Center Erlangen EMN, Erlangen, Germany
    Int J Cancer 139:1967-74. 2016
    ..Risk probabilities ranged from 1% for a defined low-risk group up to 40% for a high-risk group. These findings might help identify women who should be offered ultrasound examinations in addition to mammography. ..
  34. pmc Endometriosis as a risk factor for ovarian or endometrial cancer - results of a hospital-based case-control study
    Stefanie Burghaus
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Comprehensive Cancer Center Erlangen EMN, Erlangen, Germany
    BMC Cancer 15:751. 2015
    ..The aim of this study was to investigate the extent to which a medical history of endometriosis can serve as a risk factor for ovarian or endometrial cancer...
  35. ncbi request reprint Mitomycin C and Capecitabine (MiX Trial) for Therapy of Patients with Metastasized, Breast Cancer Pretreated with Anthracycline
    Katrin Almstedt
    Department of Obstetrics and Gynaecology, University of Erlangen, Erlangen, Germany
    Anticancer Res 36:419-25. 2016
    ....
  36. pmc Knowledge and attitudes regarding medical research studies among patients with breast cancer and gynecological diseases
    Michael P Lux
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen EMN, Friedrich Alexander University, Universitätsstrasse 21 23, 91054, Erlangen, Germany
    BMC Cancer 15:587. 2015
    ....
  37. pmc Polymorphisms in the RANK/RANKL genes and their effect on bone specific prognosis in breast cancer patients
    Alexander Hein
    Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Comprehensive Cancer Center Erlangen EMN, Erlangen, Germany
    Biomed Res Int 2014:842452. 2014
    ..The effect of rs1054016(RANKL) adds to the evidence that the RANK pathway plays a role in BC pathogenesis and progression with respect to BMFS, emphasizing the connection between BC and bone health. ..
  38. doi request reprint Assessment of breast cancer tumour size using six different methods
    Martina Meier-Meitinger
    Institute of Diagnostic Radiology, Erlangen University Hospital, Erlangen, Germany
    Eur Radiol 21:1180-7. 2011
    ..Tumour size estimates using mammography (MG), conventional ultrasound (US), compound imaging (CI) and real-time elastography (RTE) were compared with histopathological specimen sizes...
  39. ncbi request reprint Evaluation of mathematical models for breast cancer risk assessment in routine clinical use
    Peter A Fasching
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany
    Eur J Cancer Prev 16:216-24. 2007
    ..Estimations of p(life) and p(mut) based on a mathematical model should use algorithms and penetrance/frequency data appropriate to the population counseled. Reproductive/hormonal data, should be incorporated as Tyrer-Cuzick does...
  40. doi request reprint Quality assured health care in certified breast centers and improvement of the prognosis of breast cancer patients
    Matthias W Beckmann
    University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Universitätsstrasse 21 23, Erlangen Nuremberg, Germany
    Onkologie 34:362-7. 2011
    ..The aim of this analysis was to investigate whether patients treated in certified breast centers (CBC) have a favorable prognosis as compared to patients treated outside of certified breast treatment units...
  41. doi request reprint Correlates of mammographic density in B-mode ultrasound and real time elastography
    Sebastian Michael Jud
    Department of Gynecolgoy and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Eur J Cancer Prev 21:343-9. 2012
    ..Furthermore, the application of ultrasound for breast tissue characterization could enable comprehensive research concerning breast cancer risk and breast density in young and pregnant women...
  42. doi request reprint Delivery mode and the course of pre- and postpartum depression
    Claudia Rauh
    Department of Obstetrics and Gynecology, University Perinatal Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Universitätsstrasse 21 23, 91054, Erlangen, Germany
    Arch Gynecol Obstet 286:1407-12. 2012
    ..To compare depressiveness scores, both during and after pregnancy, with the delivery mode (DM)...
  43. doi request reprint Association of molecular subtypes with breast cancer risk factors: a case-only analysis
    Claudia Rauh
    aDepartment of Gynecology and Obstetrics bInstitute of Pathology cInstitute of Diagnostic Radiology, Comprehensive Cancer Center Erlangen EMN, Erlangen University Hospital dDepartment of Medical Informatics, Biometry and Epidemiology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen ePrivate Practice, Dr Med Poehls and Colleagues, Wuerzburg, Germany
    Eur J Cancer Prev 24:484-90. 2015
    ....
  44. pmc Meconium indicators of maternal alcohol abuse during pregnancy and association with patient characteristics
    Tamme W Goecke
    Department of Obstetrics and Gynecology, Friedrich Alexander University of Erlangen Nuremberg, Universitaetsstraß 21 23, 91054 Erlangen, Germany Department of Obstetrics and Gynecology, University of RWTH Aachen, Pauwelsstrß 30, 52074 Aachen, Germany
    Biomed Res Int 2014:702848. 2014
    ..Identification of women with moderate alcohol abuse during pregnancy is difficult. We correlated self-reported alcohol consumption during pregnancy and patient characteristics with objective alcohol indicators measured in fetal meconium...
  45. doi request reprint Akt and p53 are potential mediators of reduced mammary tumor growth by cloroquine and the mTOR inhibitor RAD001
    Christian R Loehberg
    Department of Obstetrics and Gynecology, University Hospital Erlangen, Universitaetsstr 21 23, 91054 Erlangen, Germany
    Biochem Pharmacol 83:480-8. 2012
    ....
  46. ncbi request reprint Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome
    Helge Binder
    Department of Obstetrics and Gynaecology, Erlangen University Hospital, Universitaetsstrasse 21 23, 91054 Erlangen, Germany
    Reproduction 135:107-16. 2008
    ..The other FSHR coding gene variations and CYP19A1 rs10046 investigated are most likely not involved in the aetiology of iatrogenic OHSS or sterility...
  47. doi request reprint Financing of certified centers: a willingness-to-pay analysis
    Falk C Thiel
    Department of Gynecology, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arch Gynecol Obstet 287:495-509. 2013
    ..A hypothetical maximum willingness to pay can be calculated using a willingness-to-pay analysis, making it possible to identify deficiencies in the arbitrary setting of health budgets at the macro-level...
  48. doi request reprint Shared decision-making in breast cancer: discrepancy between the treatment efficacy required by patients and by physicians
    Falk C Thiel
    University Breast Center for Franconia, Department of Gynaecology and Obstetrics, Friedrich Alexander University of Erlangen Nuremberg, Universitätsstrasse 21 23, Erlangen Nuremberg 91054, Germany
    Breast Cancer Res Treat 135:811-20. 2012
    ..Individual factors were also identified in both groups that significantly influence thresholds for accepting adjuvant treatment, independently of risk estimates and therapy guidelines...
  49. ncbi request reprint Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue
    Juergen Kindla
    Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Cancer Biol Ther 11:584-91. 2011
    ....
  50. doi request reprint Ki-67 as a prognostic molecular marker in routine clinical use in breast cancer patients
    Folkward G Wiesner
    University Breast Center for Franconia, Erlangen University Hospital, Erlangen, Germany
    Breast 18:135-41. 2009
    ..The aims of the present study were to examine interactions between Ki-67 and other biomarkers in breast cancer patients and to assess the relationship of Ki-67 to histological grading...
  51. pmc CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer
    Deborah J Thompson
    Department of Public Health and Primary CareCentre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UKDepartment of Genetics and Computational BiologyQIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, AustraliaWellcome Trust Centre for Human GeneticsUniversity of Oxford, Oxford OX3 7BN, UKAcademic Department of BiochemistryRoyal Marsden Hospital, London SW3 6JJ, UKDepartment of Clinical GeneticsSt George s Hospital Medical School, London SW17 0RE, UKDepartment of OncologyCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UKDepartment of Medical Epidemiology and BiostatisticsKarolinska Institutet, Stockholm SE 171 77, SwedenDepartment of MedicineDivision of Hematology Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USADepartment of Gynecology and ObstetricsUniversity Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Erlangen 91054, GermanyInstitute of Human GeneticsUniversity Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Erlangen 91054, GermanyGynaecology Research UnitHannover Medical School, Hannover 30625, GermanyClinics of Gynaecology and ObstetricsHannover Medical School, Hannover 30625, GermanyDepartment of GynaecologyJena University Hospital Friedrich Schiller University, Jena 07743, GermanyVesalius Research CenterLeuven 3000
    Endocr Relat Cancer 23:77-91. 2016
    ..For both phenotypes, the associations with rs727479 were stronger among women with a higher BMI (Pinteraction=0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction. ..
  52. pmc Genetic variants in the genes of the stress hormone signalling pathway and depressive symptoms during and after pregnancy
    Michael Schneider
    Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Biomed Res Int 2014:469278. 2014
    ....
  53. doi request reprint Polymorphisms in estrogen metabolism and estrogen pathway genes and the risk of miscarriage
    S Cupisti
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Bavaria, Germany
    Arch Gynecol Obstet 280:395-400. 2009
    ..This study investigated genetic variations in the estrogen pathway and their association with miscarriages...
  54. ncbi request reprint Lymphedema in breast cancer survivors: assessment and information provision in a specialized breast unit
    Hiba A Bani
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Universitaetsstrasse 21 23, D 91054 Erlangen, Germany
    Patient Educ Couns 66:311-8. 2007
    ....
  55. doi request reprint Major histocompatibility complex class II polymorphisms are associated with the development of anti-resorptive agent-induced osteonecrosis of the jaw
    Philipp Stockmann
    Department of Oral and Maxillofacial Surgery, University Hospital Erlangen, Erlangen, Germany
    J Craniomaxillofac Surg 41:71-5. 2013
    ..This result supports recent findings that inflammation and infection might play an important role in the pathogenesis of ARONJ...
  56. doi request reprint Visual pain mapping in endometriosis
    Stefan P Renner
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Universitätsstrasse 21 23, 91054, Erlangen, Germany
    Arch Gynecol Obstet 286:687-93. 2012
    ..To construct pain maps in order to describe the distribution of pelvic pain in a group of endometriosis patients and endometriosis-free patients, to assess the feasibility of this method...
  57. doi request reprint Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy
    Tamme W Goecke
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany
    Acta Obstet Gynecol Scand 89:7-14. 2010
    ..To assess the association between pregnancy-associated symptoms and common single nucleotide polymorphisms (SNPs) in genes known to be involved in the pathogenesis of nausea and vomiting...
  58. pmc Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
    Kate Lawrenson
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA
    Nat Commun 7:12675. 2016
    ..Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk. ..
  59. doi request reprint Semi-automated delineation of breast cancer tumors and subsequent materialization using three-dimensional printing (rapid prototyping)
    Rudiger Schulz-Wendtland
    Institute of Diagnostic Radiology, Erlangen University Hospital, Erlangen, Germany
    J Surg Oncol . 2016
    ..The aim of this study was to explore facilities for the semi-automated delineation of breast cancer tumors and to assess the feasibility of 3D printing of breast cancer tumors...
  60. pmc Inhibition of adhesion, proliferation, and invasion of primary endometriosis and endometrial stromal and ovarian carcinoma cells by a nonhyaluronan adhesion barrier gel
    Stefan P Renner
    University Clinic Erlangen, Department of Gynaecology and Obstetrics, University Endometriosis Centre Franconia, Laboratory for Molecular Medicine, Friedrich Alexander University Erlangen Nuremberg FAU, 91054 Erlangen, Germany
    Biomed Res Int 2015:450468. 2015
    ..Our findings could help to prevent local cell growth/invasion and possible consequent recurrences. ..
  61. doi request reprint Correlates of the desire for improved cosmetic results after breast-conserving therapy and mastectomy in breast cancer patients
    Mayada R Bani
    University Breast Center for Franconia, Erlangen University Hospital, Universitaetsstrasse 21 23, D 91054 Erlangen, Germany
    Breast 17:640-5. 2008
    ..Breast reconstruction after mastectomy can be discussed with the patients even after a long follow-up, especially when the appearance seems to influence partnership issues...
  62. doi request reprint Did you drink alcohol during pregnancy? Inaccuracy and discontinuity of women's self-reports: On the way to establish meconium ethyl glucuronide (EtG) as a biomarker for alcohol consumption during pregnancy
    Anna Eichler
    Division of Child and Adolescent Mental Health, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Schwabachanlage 6 und 10, 91054 Erlangen, Germany Electronic address
    Alcohol 54:39-44. 2016
    ..The next step to establish EtG as a biomarker for intrauterine alcohol exposure is to correlate EtG values in meconium with child developmental impairments. ..
  63. pmc Circulating tumor cells predict survival in early average-to-high risk breast cancer patients
    Brigitte Rack
    Affiliations of authors Department of Gynecology and Obstetrics, Ludwig Maximilians University Munich, Munich, Germany BR, JJ, UA, KF Department of Gynecology and Obstetrics, Clinical Center Traunstein, Traunstein, Germany CS Department of Gynecology and Obstetrics, Heinrich Heine University Duesseldorf, Duesseldorf, Germany PH, TF Augsburg, Germany TZ Braunschweig, Germany RL Frankfurt, Germany HT National Center for Tumor Diseases, University Hospital, Heidelberg, Germany AS Charité University Hospital Campus Virchow, Berlin, Germany WL Department of Obstetrics and Gynecology, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Erlangen, Germany PAF, MWB Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany KP Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany TWPF, WJ
    J Natl Cancer Inst 106:. 2014
    ..Circulating tumor cells (CTCs) have been shown to predict reduced survival outcomes in metastatic breast cancer...
  64. pmc Population distribution of lifetime risk of ovarian cancer in the United States
    Celeste Leigh Pearce
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
    Cancer Epidemiol Biomarkers Prev 24:671-6. 2015
    ..In U.S. women, lifetime risk of ovarian cancer is 1.37%, but some women are at a substantially lower or higher risk than this average...
  65. ncbi request reprint Influence of mammographic density on the diagnostic accuracy of tumor size assessment and association with breast cancer tumor characteristics
    Peter A Fasching
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Universitaetsstrasse 21 23, D 91054 Erlangen, Germany
    Eur J Radiol 60:398-404. 2006
    ..We investigated the accuracy of tumor size estimation and the association between tumor characteristics and breast density (BD)...
  66. ncbi request reprint Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta
    Reiner Strick
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Universitaetsstr 21 23, 91054, Erlangen, Germany
    J Mol Med (Berl) 85:23-38. 2007
    ..Interactions between Syncytin-1 and TGF-beta may contribute to the etiology of EnCa progression and also help to clarify the regulation of cell-cell fusions occurring in development and in other syncytial cell tumors...
  67. doi request reprint Assessment of breast volume changes during human pregnancy using a three-dimensional surface assessment technique in the prospective CGATE study
    Christian M Bayer
    aDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen EMN bInstitute of Diagnostic Radiology, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen cDepartment of Gynecology and Obstetrics, University of Schleswig Holstein, Lübeck Campus, Lubeck, Germany
    Eur J Cancer Prev 23:151-7. 2014
    ..Breast volume changes during pregnancy are an interesting phenotype that can be easily assessed in further studies to examine breast cancer risk. ..
  68. doi request reprint Mitomycin C in patients with gynecological malignancies
    Laura Kahmann
    University Breast Center for Franconia, Department of Gynecology, Erlangen University Hospital, Erlangen, Erlangen, Germany
    Onkologie 33:547-57. 2010
    ....
  69. doi request reprint Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer
    M Schrauder
    University Breast Center for Franconia, Erlangen University Hospital, Universitaetsstrasse 21 23, 91054, Erlangen, Bavaria, Germany
    J Cancer Res Clin Oncol 134:873-82. 2008
    ..Recent studies have produced contradictory results regarding the association between ATM genetic variants and breast cancer risk...
  70. doi request reprint Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase III GeparQuinto study
    Alexander Hein
    Department of Gynecology and Obstetrics, University Breast Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen EMN Comprehensive Cancer Center, Erlangen, Germany
    Int J Cancer 137:2981-8. 2015
    ..Although none of the observed effects survived correction for multiple testing, our observations are consistent with previous studies on BEV efficacy in BC. Further research is warranted to clarify the predictive value of these markers. ..
  71. pmc A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, USA
    Nat Genet 43:1210-4. 2011
    ..25, P = 1.1 × 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations...
  72. ncbi request reprint Hereditary breast and ovarian cancer: review and future perspectives
    Michael P Lux
    Department of Obstetrics and Gynecology, University Clinic Erlangen, Universitätsstrasse 21 23, 91054 Erlangen, Germany
    J Mol Med (Berl) 84:16-28. 2006
    ..Without adjuvant hormone therapy or chemotherapy, the overall survival in BRCA mutation carriers is reduced. Chemotherapy regimens involving platinum are particularly beneficial in the treatment of hereditary BC...
  73. pmc Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies
    Celeste Leigh Pearce
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Lancet Oncol 13:385-94. 2012
    ..We undertook an international collaborative study to assess the association between endometriosis and histological subtypes of ovarian cancer...
  74. pmc Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk
    Luis G Carvajal-Carmona
    Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, 95616, USA
    Hum Genet 134:231-45. 2015
    ..Our study thus reports a novel endometrial cancer risk locus and expands the spectrum of cancer types associated with genetic variation at 5p15, further highlighting the importance of this region for cancer susceptibility. ..
  75. pmc Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study
    Alice W Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    Gynecol Oncol 136:542-8. 2015
    ..Given the hypothesized etiologic role of gonadotropins, an assessment of how variability in genes involved in the gonadotropin signaling pathway impacts disease risk is warranted...
  76. doi request reprint Pooled analysis of the prognostic relevance of progesterone receptor status in five German cohort studies
    Jessica Salmen
    Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
    Breast Cancer Res Treat 148:143-51. 2014
    ..The significantly greater prognostic value in node-positive and high-grade tumors suggests a greater role in the progression of advanced and aggressive tumors. ..
  77. pmc Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer
    Hui Shen
    USC Epigenome Center, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA
    Nat Commun 4:1628. 2013
    ..These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes...
  78. ncbi request reprint Chlamydia trachomatis infection as a risk factor for infertility among women in Ghana, West Africa
    Jorn Siemer
    University Hospital, Department of Obstetrics and Gynaecology, Erlangen, Germany
    Am J Trop Med Hyg 78:323-7. 2008
    ..The adjusted odds ratios were 2.1 and 2.8, respectively. Our data suggest that previous C. trachomatis infections may contribute to infertility in Ghanaian women...
  79. pmc Genome-wide association study identifies a possible susceptibility locus for endometrial cancer
    Jirong Long
    Department of Medicine, Vanderbilt University Schoolof Medicine, Nashville, TN, USA
    Cancer Epidemiol Biomarkers Prev 21:980-7. 2012
    ..Genome-wide association studies (GWAS) have identified more than 100 genetic loci for various cancers. However, only one is for endometrial cancer...
  80. ncbi request reprint The impact of breast cancer awareness and socioeconomic status on willingness to receive breast cancer prevention drugs
    Peter A Fasching
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Universitaetsstrasse 21 23, D 91054, Erlangen, Germany
    Breast Cancer Res Treat 101:95-104. 2007
    ..To find associations between knowledge about risk factors for breast cancer and the socioeconomic status of healthy women, as well as their attitude toward taking chemopreventive drugs...
  81. ncbi request reprint Effects of the antiestrogens tamoxifen and raloxifene on the estrogen receptor transactivation machinery
    Michael Glaeser
    Department of Gynecology and Obstetrics, Heinrich Heine University, Duesseldorf, Germany
    Anticancer Res 26:735-44. 2006
    ..In comparison, the expressions of ERbeta and progesterone receptor were strongly influenced by antiE, while the expression of SRCs was only slightly affected...