Alexander Enk

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Dendritic cells in tolerance induction
    Alexander H Enk
    Department of Dermatol, Univ of Heidelberg, Vossstr 2, D 69115 Heidelberg, Germany
    Immunol Lett 99:8-11. 2005
  2. ncbi request reprint Different efficiency of heat shock proteins (HSP) to activate human monocytes and dendritic cells: superiority of HSP60
    Karen Bethke
    First Department of Internal Medicine and Department of Dermatology, Johannes Gutenberg Universitat, Mainz, Germany
    J Immunol 169:6141-8. 2002
  3. ncbi request reprint CD4+ CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue
    Sabine Ring
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Eur J Immunol 36:2981-92. 2006
  4. doi request reprint [Immunology of allergic contact dermatitis]
    A S Lonsdorf
    Universitäts Hautklinik, Vossstrasse 11, 69115, Heidelberg
    Hautarzt 60:32-41. 2009
  5. doi request reprint European Guidelines (S1) on the use of high-dose intravenous immunoglobulin in dermatology
    A H Enk
    Department of Dermatology, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    J Eur Acad Dermatol Venereol 30:1657-1669. 2016
  6. ncbi request reprint DCs and cytokines cooperate for the induction of tregs
    A H Enk
    Department of Dermatology, University of Heidelberg, Germany
    Ernst Schering Res Found Workshop . 2006
  7. doi request reprint Use of high-dose immunoglobulins in dermatology
    Alexander Enk
    J Dtsch Dermatol Ges 7:806-812. 2009
  8. doi request reprint Guidelines on the use of high-dose intravenous immunoglobulin in dermatology
    Alexander Enk
    Eur J Dermatol 19:90-8. 2009
  9. ncbi request reprint [Immunotherapy of malignant melanoma--basic principles and novel therapeutic approaches]
    Alexander H Enk
    Hautklinik der Ruprecht Karls Universität Heidelberg
    J Dtsch Dermatol Ges 4:635-45. 2006
  10. ncbi request reprint [On the 70th birthday of Professor Dr.med. Detlef Petzoldt]
    A H Enk
    Univ Hautklinik Heidelberg, Heidelberg
    J Dtsch Dermatol Ges 4:604. 2006

Detail Information

Publications52

  1. ncbi request reprint Dendritic cells in tolerance induction
    Alexander H Enk
    Department of Dermatol, Univ of Heidelberg, Vossstr 2, D 69115 Heidelberg, Germany
    Immunol Lett 99:8-11. 2005
    ..However, there are many overlapping features shared by the different subtypes of regulatory T cells and the common denominator is the production of regulatory cytokines such as IL-10 and TGF-beta...
  2. ncbi request reprint Different efficiency of heat shock proteins (HSP) to activate human monocytes and dendritic cells: superiority of HSP60
    Karen Bethke
    First Department of Internal Medicine and Department of Dermatology, Johannes Gutenberg Universitat, Mainz, Germany
    J Immunol 169:6141-8. 2002
    ..These findings show that HSP can differ considerably in the capacity to activate monocyte-derived APC under certain conditions and underline the potential of HSP60 and HSP72 as activation signals for the innate immune system...
  3. ncbi request reprint CD4+ CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue
    Sabine Ring
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Eur J Immunol 36:2981-92. 2006
    ..In conclusion, our data suggest that cytokine-dependent rather than cell-cell contact-dependent mechanisms play a pivotal role in the suppression of CHS reactions by Treg in vivo...
  4. doi request reprint [Immunology of allergic contact dermatitis]
    A S Lonsdorf
    Universitäts Hautklinik, Vossstrasse 11, 69115, Heidelberg
    Hautarzt 60:32-41. 2009
    ....
  5. doi request reprint European Guidelines (S1) on the use of high-dose intravenous immunoglobulin in dermatology
    A H Enk
    Department of Dermatology, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    J Eur Acad Dermatol Venereol 30:1657-1669. 2016
    ..Because the high costs of IVIg treatment also limit its first-line use, the first clinical guidelines on its use in dermatological conditions were established in 2008 and renewed in 2011...
  6. ncbi request reprint DCs and cytokines cooperate for the induction of tregs
    A H Enk
    Department of Dermatology, University of Heidelberg, Germany
    Ernst Schering Res Found Workshop . 2006
    ..However, there are many overlapping features shared by the different subtypes of regulatory T cell and the common denominator is the production of regulatory cytokines such as IL-10 and TGF-beta...
  7. doi request reprint Use of high-dose immunoglobulins in dermatology
    Alexander Enk
    J Dtsch Dermatol Ges 7:806-812. 2009
    ..of the Working Group on European Guidelines of the EDF (European Dermatology Forum) and the EADV (European Association of Dermato-Venereology) and should provide aid in decision making for the use of IVIg in treating dermatologic diseases..
  8. doi request reprint Guidelines on the use of high-dose intravenous immunoglobulin in dermatology
    Alexander Enk
    Eur J Dermatol 19:90-8. 2009
    ..Orientation towards the guideline recommendations laid down here should create a basis for this. The implementation of this EU guideline in general practice means that the use of IVIg in dermatology will be optimized throughout Europe...
  9. ncbi request reprint [Immunotherapy of malignant melanoma--basic principles and novel therapeutic approaches]
    Alexander H Enk
    Hautklinik der Ruprecht Karls Universität Heidelberg
    J Dtsch Dermatol Ges 4:635-45. 2006
    ..This overview summarizes the reasons for this lack of success and highlights future strategies for more successful therapy of malignant melanoma...
  10. ncbi request reprint [On the 70th birthday of Professor Dr.med. Detlef Petzoldt]
    A H Enk
    Univ Hautklinik Heidelberg, Heidelberg
    J Dtsch Dermatol Ges 4:604. 2006
  11. doi request reprint RASSF10 promoter hypermethylation is frequent in malignant melanoma of the skin but uncommon in nevus cell nevi
    Peter Helmbold
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    J Invest Dermatol 132:687-94. 2012
    ..In summary, RASSF10 proved to be a characteristically epigenetically silenced tumor suppressor in melanomagenesis, and analysis of RASSF10 methylation status represents a new candidate tool to assist in discrimination between MM and NCN...
  12. doi request reprint Treatment with 5-aminolaevulinic acid methylester is less painful than treatment with 5-aminolaevulinic acid nanoemulsion in topical photodynamic therapy for actinic keratosis
    Patrick Gholam
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Dermatology 222:358-62. 2011
    ..Topical photodynamic therapy (PDT) is an excellent treatment option for actinic keratosis (AK). Pain is one of the major adverse effects...
  13. pmc Automated universal BRAF state detection within the activation segment in skin metastases by pyrosequencing-based assay U-BRAF(V600)
    Alexander Skorokhod
    Department of Dermatology, Heidelberg University Hospital, Heidelberg, Germany
    PLoS ONE 8:e59221. 2013
    ..Therefore, we suggest U-BRAF(V600) assay as a most powerful sequencing-based diagnostic tool to automatically identify BRAF state as a prerequisite to targeted therapy...
  14. doi request reprint European Guidelines (S1) on the use of high-dose intravenous immunoglobulin in dermatology
    Alexander Enk
    Department of Dermatology, Ruprecht Karls University Heidelberg, Germany
    J Dtsch Dermatol Ges . 2016
    ..Because first-line use is limited by the high costs of IVIg, the first clinical guidelines on the use of IVIg in dermatological conditions were established in 2008 and renewed in 2011...
  15. doi request reprint Malignant syphilis with ocular involvement and organism-depleted lesions
    M Pleimes
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Clin Infect Dis 48:83-5. 2009
    ..We report a case of secondary pustular-ulcerative malignant syphilis with ocular involvement in a human immunodeficiency virus-infected patient. It was striking to find that ulcerative lesions can be highly organism depleted...
  16. ncbi request reprint Dendritic cells: key cells for the induction of regulatory T cells?
    K Mahnke
    Department of Dermatology, University of Heidelberg, Vossstrasse 2, 69115 Heidelberg, Germany
    Curr Top Microbiol Immunol 293:133-50. 2005
    ..In this review we focus on the interaction between DCs and T cells and highlight some mechanisms in the decision-making process of whether immunity or tolerance is induced...
  17. doi request reprint Pharmacodynamic immune monitoring of NFAT-regulated genes predicts skin cancer in elderly long-term renal transplant recipients
    Claudia Sommerer
    Department of Nephrology, University Hospital, University of Heidelberg, Germany
    Clin Transplant 22:549-54. 2008
    ..Among elderly allograft recipients non-melanoma skin cancer (NMSC) is the most common malignancy. We have previously shown that malignancies are associated with a higher intensity of ciclosporin A (CsA)-induced immunosuppression...
  18. doi request reprint Apoptotic signal molecules in skin biopsies of cutaneous lupus erythematosus: analysis using tissue microarray
    Ferdinand Toberer
    Division of Immunogenetics, Tumorimmunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Exp Dermatol 22:656-9. 2013
    ..These data suggest that the accumulation of apoptotic keratinocytes in CLE might be due to the increased epidermal expression of CD95, resulting in increased activity of the extrinsic apoptotic pathway in the disease. ..
  19. doi request reprint Merkel cell carcinoma induces lymphatic microvessel formation
    Siegfried Werchau
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    J Am Acad Dermatol 67:215-25. 2012
    ..Merkel cell carcinoma (MCC) is a rare, highly malignant neuroendocrine tumor of the skin characterized by frequent lymphatic metastasis...
  20. doi request reprint Management of cutaneous side effects of EGFR inhibitors: recommendations from a German expert panel for the primary treating physician
    Ralf Gutzmer
    Department of Dermatology, Allergy and Venereology, Skin Cancer Center, Hannover Medical School, Germany
    J Dtsch Dermatol Ges 9:195-203. 2011
    ..A panel of German dermatologists developed on the basis of personal experience and current literature consensus recommendations for the management of cutaneous side effects of EGFR inhibitors...
  21. pmc Pain reduction in patients after applying a nitrous oxide/oxygen mixture (Livopan) during photodynamic therapy: study protocol for an observational study (Livopan study)
    Patrick Gholam
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    BMJ Open 5:e006412. 2015
    ..Therefore, it remains unclear whether patients benefit from this inhalation analgesia. Within the Livopan study, this issue will be evaluated for the first time...
  22. ncbi request reprint Hyalinosis cutis et mucosae
    Bernadette Vago
    Department of Dermatology, University of Heidelberg, Germany
    J Dtsch Dermatol Ges 5:401-5. 2007
    ..A new mutation of the ECM1 gene was identified...
  23. pmc Phase II DeCOG-study of ipilimumab in pretreated and treatment-naïve patients with metastatic uveal melanoma
    Lisa Zimmer
    Department of Dermatology, University Hospital, University Duisburg Essen, Essen, Germany
    PLoS ONE 10:e0118564. 2015
    ..As patients with UM were excluded in these studies, the Dermatologic Cooperative Oncology Group (DeCOG) conducted a phase II to assess the efficacy and safety of ipilimumab in patients with metastatic UM...
  24. doi request reprint Skin cancer: follow-up, rehabilitation, palliative and supportive care
    Selma Ugurel
    Department of Dermatology, Venerology, and Allergology, University of Wurzburg, Germany
    J Dtsch Dermatol Ges 6:492-8; quiz 499. 2008
    ..Especially in follow-up and supportive care, the results of recent clinical trials have led to significant changes in the standard of care. These new insights and their consequences are the special focus of this article...
  25. doi request reprint Radiopharmaceutical therapy of patients with metastasized melanoma with the melanin-binding benzamide 131I-BA52
    Walter Mier
    Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
    J Nucl Med 55:9-14. 2014
    ..However, these responses are not persistent, and complementary targeted treatment strategies are required for malignant melanoma...
  26. doi request reprint FcγRIII (CD16) equips immature 6-sulfo LacNAc-expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens
    Thomas Döbel
    Department of Dermatology, Heidelberg University Hospital, Heidelberg, Germany
    Blood 121:3609-18. 2013
    ..In conclusion, these data provide strong evidence that slanDCs play an important role in IC-driven immune responses...
  27. ncbi request reprint Gnathostomiasis: import from Laos
    Felix Hennies
    Department of Dermatology, University of Heidelberg, Germany
    J Dtsch Dermatol Ges 4:414-6. 2006
    ..Because of the typical clinical findings, the history of a visit to Laos, and the presence of specific anti-Gnathostoma antibodies on Western blot, the diagnosis of cutaneous gnathostomiasis was made...
  28. ncbi request reprint [Ehlers-Danlos syndrome--20 years experience with diagnosis and classification at the university skin clinic of Heidelberg]
    Sylvia Proske
    Department of Dermatology, University of Heidelberg, Germany
    J Dtsch Dermatol Ges 4:308-18. 2006
    ..The main forms are classical, hypermobile, vascular, kyphoscoliotic A/B, arthrochalasis A/B and dermatosparaxis types...
  29. doi request reprint Factors influencing pain intensity during topical photodynamic therapy of complete cosmetic units for actinic keratoses
    Patrick Gholam
    Department of Dermatology, University Heidelberg, Heidelberg, Germany
    J Am Acad Dermatol 63:213-8. 2010
    ..Topical photodynamic therapy is a good treatment option for extensively photodamaged skin with multiple actinic keratoses. Pain is one of the major adverse effects during and after the treatment...
  30. doi request reprint Generalized interstitial granuloma annulare--response to adalimumab
    Siegfried Werchau
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Int J Dermatol 49:457-60. 2010
    ..A foreign-body granuloma formation induced by an unknown inciting antigen is suspected. Generalized forms often coincides with recalcitrant progression and frustrated experimental therapies...
  31. doi request reprint Frequent occurrence of RASSF1A promoter hypermethylation and Merkel cell polyomavirus in Merkel cell carcinoma
    Peter Helmbold
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Mol Carcinog 48:903-9. 2009
    ..No correlation between TSG hypermethylation and viral infection was found. Our results show frequent hypermethylation of RASSF1A and the presence of MCPyV in primary MCC, and that these events may contribute to the pathogenesis of MCC...
  32. doi request reprint Surgical intervention of pilonidal sinus: impact on patients' postoperative satisfaction and return to work time
    Maria Rita Gaiser
    Department of Dermatology, University of Heidelberg, Vossstr 2, 69115 Heidelberg, Germany
    Eur J Dermatol 23:487-90. 2013
    ..Pilonidal sinus (PS) is a chronic inflammatory process accompanied by psychological strain and a high rate of work incapacity...
  33. doi request reprint Herpes simplex vegetans: atypical genital herpes infection with prominent plasma cell infiltration in B-cell chronic lymphocytic leukemia
    Annette Römer
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    J Dtsch Dermatol Ges 6:865-7. 2008
    ..Herpes simplex vegetans often responds poorly to treatment in immunocom-promised patients...
  34. doi request reprint Photodynamic therapy--aspects of pain management
    Christine Fink
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    J Dtsch Dermatol Ges 13:15-22. 2015
    ..Therefore, this review puts the spotlight on predictors on pain intensity and aspects of pain management during photodynamic therapy. ..
  35. pmc Evaluating blood levels of neuron specific enolase, chromogranin A, and circulating tumor cells as Merkel cell carcinoma biomarkers
    Maria Rita Gaiser
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Oncotarget 6:26472-82. 2015
    ..EpCAM-positive circulating tumor cells (CTC) reflect disease status in several epithelial tumors. Here we investigate the use of NSE and ChrA blood levels and CTC counts as biomarkers for MCC disease behavior...
  36. doi request reprint Immunotherapy of Melanoma
    Carolin Bender
    Department of Dermatology and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany
    Oncol Res Treat 39:369-76. 2016
    ..This review provides a short overview of past, present, and future immunotherapeutic approaches and their limitations, with a focus on new combination agents in early clinical trials. ..
  37. ncbi request reprint Interleukin-10-treated dendritic cells modulate immune responses of naive and sensitized T cells in vivo
    Gabriele Müller
    Department of Dermatology, University of Mainz, Mainz, Germany
    J Invest Dermatol 119:836-41. 2002
    ..Thus, interleukin-10-treated dendritic cells inhibit ovalbumin-specific immune responses in naive and sensitized mice...
  38. pmc Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    Helmut Jonuleit
    Department of Dermatology, University of Mainz, 55101 Mainz, Germany
    J Exp Med 196:255-60. 2002
    ..This explains previously published conflicting data on the role of TGF-beta in CD25(+) Treg cell-induced immunosuppression...
  39. ncbi request reprint Immature, but not inactive: the tolerogenic function of immature dendritic cells
    Karsten Mahnke
    Department of Dermatology and Institute of Immunology, University of Mainz, Germany
    Immunol Cell Biol 80:477-83. 2002
    ..This review summarizes the current knowledge about the immunoregulatory role of immature DC that might act as guardians for the induction and maintenance of T cell tolerance in the periphery...
  40. ncbi request reprint Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells
    Karsten Mahnke
    Department of Dermatology, University of Mainz, Germany
    Blood 101:4862-9. 2003
    ..Thus, targeting of antigens to immature DCs through alphaDEC antibodies led to the induction of regulatory T cells, providing the basis for novel strategies to induce regulatory T cells in vivo...
  41. ncbi request reprint Induction of tolerogenic DCs: 'you are what you eat'
    Karsten Mahnke
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, D 55101, Mainz, Germany
    Trends Immunol 24:646-51. 2003
    ..Antigen receptors expressed by DCs might therefore have an important role in the induction and maintenance of peripheral tolerance...
  42. ncbi request reprint Early adenoviral gene expression mediates immunosuppression by transduced dendritic cell (DC): implications for immunotherapy using genetically modified DC
    Andrea Tuettenberg
    Department of Dermatology, J Gutenberg University, Mainz, Germany
    J Immunol 172:1524-30. 2004
    ..These results have important implications for the use of genetically modified DC for therapeutic application...
  43. ncbi request reprint CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity
    Kerstin Steinbrink
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, D 551312 Mainz, Germany
    Blood 99:2468-76. 2002
    ..Induction of anergic T cells might be exploited therapeutically for suppression of cellular immune responses in allergic or autoimmune diseases with identified (auto) antigens...
  44. doi request reprint Regulatory conversation between antigen presenting cells and regulatory T cells enhance immune suppression
    Karsten Mahnke
    Department of Dermatology, University Hospital Heidelberg, Vosstrasse 11, D 69115 Heidelberg, Germany
    Cell Immunol 250:1-13. 2007
    ..On the whole, the mutual interaction of Treg and APCs enables Treg to sustain their immunosuppressive functions which, in healthy individuals, may be crucial for the maintenance of peripheral tolerance...
  45. ncbi request reprint Expanded murine regulatory T cells: analysis of phenotype and function in contact hypersensitivity reactions
    Sabine Ring
    University Hospital Heidelberg, Department of Dermatology, Vossstrasse 11, D 69115 Heidelberg, Germany
    J Immunol Methods 326:10-21. 2007
    ..Thus, this protocol will facilitate the production of Treg as an "off-the-shelf reagent" and offers the possibility to explore the application of Treg as a cellular therapeutic in several allergic and autoimmune diseases...
  46. ncbi request reprint Induction of immunosuppressive functions of dendritic cells in vivo by CD4+CD25+ regulatory T cells: role of B7-H3 expression and antigen presentation
    Karsten Mahnke
    Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany
    Eur J Immunol 37:2117-26. 2007
    ..Accordingly, Treg may recruit DC for the amplification of immunosuppression by restraining their maturation in vivo and inducing an immunosuppressive phenotype of DC...
  47. ncbi request reprint Tolerogenic dendritic cells and regulatory T cells: a two-way relationship
    Karsten Mahnke
    University Hospital Heidelberg, Department of Dermatology, Vossstrasse 3, D 69115 Heidelberg, Germany
    J Dermatol Sci 46:159-67. 2007
    ..The possible means of cellular interactions as well as the consequences for tolerance and immunity are discussed in this review...
  48. ncbi request reprint Change in expression of MGMT during maturation of human monocytes into dendritic cells
    Manuela Briegert
    Institute of Toxicology, University of Mainz, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
    DNA Repair (Amst) 6:1255-63. 2007
    ..The data provide an example that high MGMT expression level does not necessarily implicate a higher level of resistance against O6-alkylating agents...
  49. ncbi request reprint Targeting of antigens to activated dendritic cells in vivo cures metastatic melanoma in mice
    Karsten Mahnke
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Cancer Res 65:7007-12. 2005
    ..Thus, these data show that targeting of dendritic cells in situ by the means of antibody-antigen conjugates may be a novel way to induce long-lasting antitumor immunity...
  50. ncbi request reprint Induction of strong and persistent MelanA/MART-1-specific immune responses by adjuvant dendritic cell-based vaccination of stage II melanoma patients
    Andrea Tuettenberg
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Int J Cancer 118:2617-27. 2006
    ....
  51. ncbi request reprint Dendritic cells, engineered to secrete a T-cell receptor mimic peptide, induce antigen-specific immunosuppression in vivo
    Karsten Mahnke
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Nat Biotechnol 21:903-8. 2003
    ..Thus these data show that DCs expressing the TCRpep are able to suppress T-cell activation and might be a useful tool for inducing antigen-specific immune suppression in vivo...
  52. ncbi request reprint Human CD25+ regulatory T cells: two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+ T helper cells
    Michael Stassen
    Institute of Immunology, Johannes Gutenberg University, Mainz, Germany
    Eur J Immunol 34:1303-11. 2004
    ....