Jörg Ellinger

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. doi request reprint Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    BJU Int 104:48-52. 2009
  2. ncbi request reprint Evaluation of Global Histone Acetylation Levels in Bladder Cancer Patients
    Jörg Ellinger
    University Hospital Bonn, Department of Urology, Bonn, Germany
    Anticancer Res 36:3961-4. 2016
  3. doi request reprint Systematic Expression Analysis of Mitochondrial Complex I Identifies NDUFS1 as a Biomarker in Clear-Cell Renal-Cell Carcinoma
    Jörg Ellinger
    Department of Urology, University Hospital Bonn, Bonn, Germany Electronic address
    Clin Genitourin Cancer . 2016
  4. ncbi request reprint MicroRNAs: a novel non-invasive biomarker for patients with urological malignancies
    Jörg Ellinger
    Universitatsklinikum Bonn, Klinik und Poliklinik für Urologie und Kinderurologie, Sigmund Freud Strabe 25, 53105 Bonn, Germany
    Curr Pharm Biotechnol 15:486-91. 2014
  5. ncbi request reprint Serum microRNAs as biomarkers in patients undergoing prostate biopsy: results from a prospective multi-center study
    Anna M Westermann
    Universitatsklinikum Bonn, Klinik und Poliklinik für Urologie und Kinderurologie, Bonn, Germany Sigmund Freud Straße 25, 53105 Bonn
    Anticancer Res 34:665-9. 2014
  6. doi request reprint Circulating mitochondrial DNA in serum: a universal diagnostic biomarker for patients with urological malignancies
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    Urol Oncol 30:509-15. 2012
  7. doi request reprint Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    Cancer Invest 30:92-7. 2012
  8. doi request reprint CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer
    Jörg Ellinger
    Klinik und Poliklinik für Urologie and Institut für Pathologie, Universitatsklinikum Bonn, Bonn, Germany
    J Urol 182:324-9. 2009
  9. doi request reprint Global levels of histone modifications predict prostate cancer recurrence
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    Prostate 70:61-9. 2010
  10. doi request reprint The role of cell-free circulating DNA in the diagnosis and prognosis of prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urol Oncol 29:124-9. 2011

Detail Information

Publications80

  1. doi request reprint Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    BJU Int 104:48-52. 2009
    ..To analyse the diagnostic and prognostic value of cell-free mitochondrial (mt)DNA in patients with testicular cancer, as increased levels of cell-free circulating mtDNA have been reported in patients with cancer...
  2. ncbi request reprint Evaluation of Global Histone Acetylation Levels in Bladder Cancer Patients
    Jörg Ellinger
    University Hospital Bonn, Department of Urology, Bonn, Germany
    Anticancer Res 36:3961-4. 2016
    ..Our study was designed to investigate the value of global histone acetylation levels as diagnostic and prognostic biomarker for BCA patients...
  3. doi request reprint Systematic Expression Analysis of Mitochondrial Complex I Identifies NDUFS1 as a Biomarker in Clear-Cell Renal-Cell Carcinoma
    Jörg Ellinger
    Department of Urology, University Hospital Bonn, Bonn, Germany Electronic address
    Clin Genitourin Cancer . 2016
    ..So far, little is known about the expression of the mitochondrial complex I (NADH:ubiquinone oxidoreductase) subunits in clear-cell renal-cell carcinoma (ccRCC)...
  4. ncbi request reprint MicroRNAs: a novel non-invasive biomarker for patients with urological malignancies
    Jörg Ellinger
    Universitatsklinikum Bonn, Klinik und Poliklinik für Urologie und Kinderurologie, Sigmund Freud Strabe 25, 53105 Bonn, Germany
    Curr Pharm Biotechnol 15:486-91. 2014
    ....
  5. ncbi request reprint Serum microRNAs as biomarkers in patients undergoing prostate biopsy: results from a prospective multi-center study
    Anna M Westermann
    Universitatsklinikum Bonn, Klinik und Poliklinik für Urologie und Kinderurologie, Bonn, Germany Sigmund Freud Straße 25, 53105 Bonn
    Anticancer Res 34:665-9. 2014
    ..We aimed to investigate serum levels of miR-26a-1 and miR-141 in patients undergoing prostate biopsy clinical suspicious for prostate cancer (PCA) in a prospective multi-center study...
  6. doi request reprint Circulating mitochondrial DNA in serum: a universal diagnostic biomarker for patients with urological malignancies
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    Urol Oncol 30:509-15. 2012
    ..Cell-free circulating mitochondrial DNA (mtDNA) has been proposed as universal diagnostic and prognostic biomarker in cancer patients...
  7. doi request reprint Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    Cancer Invest 30:92-7. 2012
    ..H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis...
  8. doi request reprint CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer
    Jörg Ellinger
    Klinik und Poliklinik für Urologie and Institut für Pathologie, Universitatsklinikum Bonn, Bonn, Germany
    J Urol 182:324-9. 2009
    ..DNA hypermethylation is a common cancer associated alteration. We analyzed methylation patterns of cell-free serum DNA in patients with testicular cancer...
  9. doi request reprint Global levels of histone modifications predict prostate cancer recurrence
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    Prostate 70:61-9. 2010
    ..Our study was performed to evaluate histone lysine (H(x)K(y)) and histone acetyl (H(x)Ac) modifications in prostate tissue...
  10. doi request reprint The role of cell-free circulating DNA in the diagnosis and prognosis of prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urol Oncol 29:124-9. 2011
    ..The detection of increased DNA levels and tumor-specific DNA sequences may provide diagnostic and prognostic information. The recent findings in the emerging field of cell-free DNA will be discussed...
  11. doi request reprint DNA hypermethylation in papillary renal cell carcinoma
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    BJU Int 107:664-9. 2011
    ..To investigate the pattern of DNA CpG island hypermethylation in papillary renal cell carcinoma (pRCC)...
  12. doi request reprint [Circulating cell-free serum DNA: significance as a new biomarker for urological malignancies]
    J Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Deutschland
    Urologe A 49:1131-2, 1134. 2010
    ..Measurement of cell-free DNA allowed sensitive and specific discrimination between cancer patients and those with non-malignant diseases...
  13. doi request reprint Apoptotic DNA fragments in serum of patients with muscle invasive bladder cancer: a prognostic entity
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Cancer Lett 264:274-80. 2008
    ..011) indicating that the AI is an independent prognostic factor. Thus, cell-free DNA seems to be a useful prognostic marker in patients with BCA...
  14. doi request reprint Mitochondrial DNA in serum of patients with prostate cancer: a predictor of biochemical recurrence after prostatectomy
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    BJU Int 102:628-32. 2008
    ..To investigate the role of circulating mitochondrial DNA (mtDNA) in patients with localized prostate cancer, as recent reports show that patients with advanced cancer have increased levels of mtDNA...
  15. ncbi request reprint Prostate cancer tissue is masked by bicalutamide: a case report
    J Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Med Res 12:212-5. 2007
    ..Despite of detailed histological work-up and immunohistochemistry cancer suspicious lesions were not found. We think that bicalutamide may be capable of masking prostate cancer cells...
  16. ncbi request reprint Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Int J Cancer 122:138-43. 2008
    ..We suggest that cancer-induced apoptosis of peripheral noncancerous tissues is relevant in many malignancies...
  17. ncbi request reprint CpG island hypermethylation in cell-free serum DNA identifies patients with localized prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Prostate 68:42-9. 2008
    ..Our aim was to analyze the diagnostic and prognostic possibilities of multigene methylation analysis in cell-free serum DNA of prostate cancer (PCA) patients...
  18. ncbi request reprint Hypermethylation of cell-free serum DNA indicates worse outcome in patients with bladder cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    J Urol 179:346-52. 2008
    ..CpG island hypermethylation is a frequent event in bladder carcinogenesis and progression. We investigated the diagnostic and prognostic value of hypermethylation in cell-free serum DNA of patients with bladder cancer...
  19. doi request reprint CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urology 71:161-7. 2008
    ..CpG island hypermethylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. We investigated its role at multiple gene sites during prostate carcinogenesis...
  20. doi request reprint Gender-specific differences in cancer-specific survival after radical cystectomy for patients with urothelial carcinoma of the urinary bladder in pathologic tumor stage T4a
    Matthias May
    Department of Urology, St Elisabeth Klinikum, Straubing, Germany
    Urol Oncol 31:1141-7. 2013
    ..Bladder cancer (UCB) staged pT4a show heterogeneous outcome after radical cystectomy (RC). No risk model has been established to date. Despite gender-specific differences, no comparative studies exist for this tumor stage...
  21. doi request reprint Analysis of sex differences in cancer-specific survival and perioperative mortality following radical cystectomy: results of a large German multicenter study of nearly 2500 patients with urothelial carcinoma of the bladder
    Wolfgang Otto
    Department of Urology, Caritas St Josef Medical Centre, University of Regensburg, Landshuterstrasse 65, Regensburg, Germany
    Gend Med 9:481-9. 2012
    ..Although overall incidence is higher in men, cancer-specific survival (CSS) has been suggested to be lower in women. Although the former effect is attributed to greater exposure to carcinogens in men, the latter has not been elucidated...
  22. ncbi request reprint Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci
    Patrick J Bastian
    Klinik und Poliklinik für Urologie and Institut für Pathologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Clin Cancer Res 11:4097-106. 2005
    ..Our study was designed to evaluate promoter CpG island hypermethylation in the diagnosis and prognosis of prostate cancer...
  23. doi request reprint Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinoma
    Sebastian Rogenhofer
    Department of Urology, University of Bonn, Germany
    BJU Int 109:459-65. 2012
    ..To evaluate if histone H3 lysine 27 (H3K27) methylation plays a role in renal cell carcinoma (RCC) tissue and whether its expression is a predictor of cancer recurrence in RCC...
  24. doi request reprint Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Int J Cancer 127:2360-6. 2010
    ..Our study on H3K4 methylation supports the concept of global histone modifications as potential cancer prognosis markers...
  25. ncbi request reprint Cell-free circulating DNA: Diagnostic value in patients with renal cell cancer
    Stefan Hauser
    Department of Urology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anticancer Res 30:2785-9. 2010
    ..To analyse the diagnostic and prognostic value of cell-free DNA in patients with renal cell carcinoma (RCC)...
  26. doi request reprint Global histone H4K20 trimethylation predicts cancer-specific survival in patients with muscle-invasive bladder cancer
    Ann Christin Schneider
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    BJU Int 108:E290-6. 2011
    ..To determine the role of global histone methylation as a prognostic parameter in patients with bladder cancer...
  27. doi request reprint Pathological upstaging detected in radical cystectomy procedures is associated with a significantly worse tumour-specific survival rate for patients with clinical T1 urothelial carcinoma of the urinary bladder
    Matthias May
    Department of Urology, St Elisabeth Klinikum Straubing, Straubing, Germany
    Scand J Urol Nephrol 45:251-7. 2011
    ..This study aimed to evaluate the frequency and prognosis of upstaging in patients undergoing RC due to UCB...
  28. doi request reprint Analysis of serum microRNAs (miR-26a-2*, miR-191, miR-337-3p and miR-378) as potential biomarkers in renal cell carcinoma
    Stefan Hauser
    Universitatsklinikum Bonn, Klinik und Poliklinik für Urologie und Kinderurologie, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Cancer Epidemiol 36:391-4. 2012
    ..Emerging evidence suggest that microRNAs could serve as non-invasive biomarker for cancer patients. Our study was designed to analyze circulating serum microRNAs in patients with renal cell carcinoma (RCC)...
  29. doi request reprint Multicenter evaluation of the prognostic value of pT0 stage after radical cystectomy due to urothelial carcinoma of the bladder
    Matthias May
    Department of Urology, St Elisabeth Klinikum, Straubing LMU München, Munchen, Germany
    BJU Int 108:E278-83. 2011
    ..To evaluate the characteristics and long-term outcome of patients with pT0 stage after radical cystectomy (RC) for urothelial carcinoma of the urinary bladder (UCB)...
  30. doi request reprint Prognostic significance of venous tumour thrombus consistency in patients with renal cell carcinoma (RCC)
    Valerie L Weiss
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    BJU Int 113:209-17. 2014
    ..To identify the prognostic impact of venous tumour thrombus (VTT) in locally advanced renal cell carcinomas (RCCs). To further differentiate the clinical course of patients with VTT who have similar clinicopathological characteristics...
  31. pmc Alterations of global histone H4K20 methylation during prostate carcinogenesis
    Turang E Behbahani
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    BMC Urol 12:5. 2012
    ..Our study was designed to assess global methylation levels of histone 4 lysine 20 (H4K20me1-3) at different stages of prostate cancer (PCA) carcinogenesis...
  32. doi request reprint Systematic expression analysis of the mitochondrial complex III subunits identifies UQCRC1 as biomarker in clear cell renal cell carcinoma
    Jörg Ellinger
    University Hospital Bonn, Department of Urology, 53105 Bonn, Germany
    Oncotarget . 2016
    ..Taken together, our data implicate that dysregulated UQCRC1 and UQCRFS1 are involved in impaired mitochondrial electron transport chain function...
  33. doi request reprint PITX2 DNA Methylation as Biomarker for Individualized Risk Assessment of Prostate Cancer in Core Biopsies
    Barbara Uhl
    Institute of Pathology, University Hospital Bonn, Bonn, Germany
    J Mol Diagn . 2016
    ..This study indicates that the PITX2 methylation assay is feasible in prostate biopsies and might add valuable prognostic information for risk assessment in a presurgical diagnostic setting...
  34. doi request reprint External validation of a risk model to predict recurrence-free survival after radical cystectomy in patients with pathological tumor stage T3N0 urothelial carcinoma of the bladder
    Matthias May
    Department of Urology, St Elisabeth Klinikum, Straubing, Germany
    J Urol 187:1210-4. 2012
    ..We present what is to our knowledge the first external validation of this risk model...
  35. pmc PITX3 promoter methylation is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients after radical prostatectomy
    Emily Eva Holmes
    Institute of Pathology, University Hospital Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Clin Epigenetics 8:104. 2016
    ..Furthermore, mPITX3 was analyzed in combination with the established PCa methylation biomarker PITX2 (mPITX2)...
  36. doi request reprint The peripheral zone of the prostate is more prone to tumor development than the transitional zone: is the ETS family the key?
    Zaki Shaikhibrahim
    Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany
    Mol Med Rep 5:313-6. 2012
    ..Furthermore, ETS members up-regulated in PCA are already overexpressed in the normal PZ, suggesting that these members play a role in the development and progression of PCA...
  37. ncbi request reprint Serum DNA hypermethylation in patients with kidney cancer: results of a prospective study
    Stefan Hauser
    Department of Urology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anticancer Res 33:4651-6. 2013
    ..No reliable biomarker for renal cell carcinoma (RCC) exists. The purpose of this study was to analyze the value of CpG island hypermethylation of cell-free (cf) circulating serum DNA in patients with RCC as a potential biomarker...
  38. doi request reprint Histone methylation defines an epigenetic entity in penile squamous cell carcinoma
    Sebastian Rogenhofer
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    J Urol 189:1117-22. 2013
    ..Histone methylation patterns are frequently altered during carcinogenesis. Therefore, we investigated the methylation pattern of the histones H3K4, H3K9 and H3K27 in penile carcinoma and normal tissue...
  39. ncbi request reprint Serum DNA hypermethylation in patients with bladder cancer: results of a prospective multicenter study
    Stefan Hauser
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Anticancer Res 33:779-84. 2013
    ..A few reports indicated that methylated serum DNA in patients with bladder cancer (BCA) is a useful non-invasive biomarker. The purpose of this prospective multicenter study was to validate earlier studies...
  40. doi request reprint Global histone acetylation levels: prognostic relevance in patients with renal cell carcinoma
    Davit Mosashvilli
    Department of Urology, University Hospital Bonn, Bonn, Germany
    Cancer Sci 101:2664-9. 2010
    ..In conclusion, our study supports the concept of global histone modification levels as a universal cancer prognosis marker, and provides evidence for the use of histone deacetylases inhibitors as future drugs in the therapy of RCC...
  41. ncbi request reprint Enhanced expression of peroxisome proliferate-activated receptor gamma (PPAR-γ) in advanced prostate cancer
    Sebastian Rogenhofer
    Department of Urology, University of Erlangen, 91054 Erlangen, Germany
    Anticancer Res 32:3479-83. 2012
    ..Recent studies have underlined the role of nuclear receptors in the involvement of prostate cancer signalling pathways...
  42. pmc CDO1 promoter methylation is associated with gene silencing and is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients
    Sebastian Meller
    a University Hospital Bonn, Institute of Pathology, Bonn, Germany
    Epigenetics . 2016
    ..Further studies are needed to validate CDO1 methylation assays and to evaluate the clinical utility of CDO1 methylation for the management of PCa...
  43. pmc CXCL12 promoter methylation and PD-L1 expression as prognostic biomarkers in prostate cancer patients
    Diane Goltz
    Institute of Pathology, University Hospital Bonn, Bonn, Germany
    Oncotarget . 2016
    ..Recent data suggest that the CXCR4/CXCL12 axis is functionally linked to the PD-1/PD-L1 immune checkpoint. We evaluated the prognostic value of aberrant CXCL12 DNA methylation with respect to PD-L1 expression in primary PCa...
  44. ncbi request reprint DNA hypermethylation as a predictor of PSA recurrence in patients with low- and intermediate-grade prostate cancer
    Rudolf Moritz
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Munster, Albert Schweitzer Campus 1, GB A1, 48149 Munster, Germany
    Anticancer Res 33:5249-54. 2013
    ..DNA CpG island hypermethylation causes gene silencing and is a common event in prostate carcinogenesis and progression. We investigated its role as a possible prognostic marker in patients with PCA Gleason score ≤7...
  45. doi request reprint Evaluation of reference genes for the analysis of serum miRNA in patients with prostate cancer, bladder cancer and renal cell carcinoma
    Imke Sanders
    Department of Urology, University Hospital Bonn, Bonn, Germany
    Int J Urol 19:1017-25. 2012
    ..To identify an appropriate reference gene for the analysis of circulating micro-ribonucleic acid in patients with urological malignancies...
  46. doi request reprint Tyrosine kinase expression profile in clear cell renal cell carcinoma
    Turang E Behbahani
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    World J Urol 30:559-65. 2012
    ..To profile different tyrosine kinase (TK) expression patterns in clear cell renal carcinoma (ccRCC)...
  47. ncbi request reprint Decreased levels of histone H3K9me1 indicate poor prognosis in patients with renal cell carcinoma
    Sebastian Rogenhofer
    Department of Urology, University Hospital Bonn, Bonn, Germany
    Anticancer Res 32:879-86. 2012
    ..To determine the role of global histone H3K9 and H4K20 methylation levels as prognostic parameters in patients with renal cell cancer (RCC)...
  48. ncbi request reprint Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Eur Urol 51:665-74; discussion 674. 2007
    ....
  49. doi request reprint Alterations of global histone H3K9 and H3K27 methylation levels in bladder cancer
    Jörg Ellinger
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    Urol Int 93:113-8. 2014
    ..Epigenetic alterations, including histone modifications, play an important role during carcinogenesis. This study was designed to systematically investigate histone H3K9 and H3K27 methylation levels in bladder cancer (BCa) tissue...
  50. pmc Identification of prostaglandin receptors in human ureters
    Matthias Oll
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    BMC Urol 12:35. 2012
    ..Prostaglandins play an important role in ureteral obstruction, but the detailed expression profiles of the prostaglandin receptors (PTGER1, PTGER2, PTGER3, PTGER4, PTGFR) remain unknown in the different parts of the human ureter...
  51. doi request reprint Genes differentially expressed in the peripheral zone compared to the transitional zone of the normal human prostate and their potential regulation by ETS factors
    Zaki Shaikhibrahim
    Institute of Pathology, University Hospital Bonn, D 53127 Bonn, Germany
    Mol Med Rep 5:32-6. 2012
    ..These findings may explain the lower susceptibility for PCa of the TZ compared to the PZ. According to bioinformatic analysis, 8/9 of these genes may be potentially regulated by ETS transcription factors...
  52. doi request reprint Saturation biopsy improves preoperative Gleason scoring of prostate cancer
    Philip Kahl
    Department of Pathology, University Hospital Bonn Medical School, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
    Pathol Res Pract 205:259-64. 2009
    ..Both techniques fail to detect insignificant prostate cancer...
  53. doi request reprint Circulating microRNAs (miRNA) in serum of patients with prostate cancer
    Robert Mahn
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Germany
    Urology 77:1265.e9-16. 2011
    ..To analyze circulating microRNAs (miRNA) in serum as non-invasive biomarker in patients with localized prostate cancer (PCA), benign prostate hyperplasia (BPH) and healthy individuals (HI)...
  54. doi request reprint Epigenetic regulation of microRNA expression in renal cell carcinoma
    Miriam Schiffgen
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Biochem Biophys Res Commun 436:79-84. 2013
    ..Our experiments show that the treatment with the epigenetic drugs causes re-expression of silenced microRNAs with putative tumor suppressive function in ccRCC cell lines...
  55. doi request reprint Thulium laser (Revolix) vapoenucleation of the prostate is a safe procedure in patients with an increased risk of hemorrhage
    Stefan Hauser
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    Urol Int 88:390-4. 2012
    ..To evaluate the feasibility and safety of thulium:yttrium-aluminium-garnet laser vapoenucleation of the prostate (ThuVEP) in patients with chronic anticoagulation and bleeding disorders...
  56. ncbi request reprint Cell-free serum DNA in patients with bladder cancer: results of a prospective multicenter study
    Stefan Hauser
    Department of Urology and Paediatric Urology, University Hospital Bonn, Bonn, Germany
    Anticancer Res 32:3119-24. 2012
    ..Cell-free DNA may serve as a biomarker for patients with cancer; we designed our study to determine its potential in patients with bladder cancer (BCA)...
  57. doi request reprint Cell-free circulating DNA: diagnostic value in patients with testicular germ cell cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    J Urol 181:363-71. 2009
    ..Increased levels of cell-free circulating DNA have been described in various malignancies as a diagnostic and prognostic biomarker. We analyzed the significance of cell-free DNA in patients with testicular cancer...
  58. pmc MicroRNAs in renal cell carcinoma: diagnostic implications of serum miR-1233 levels
    Lena M Wulfken
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    PLoS ONE 6:e25787. 2011
    ..MicroRNA expression is altered in cancer cells, and microRNAs could serve as diagnostic/prognostic biomarker for cancer patients. Our study was designed to analyze circulating serum microRNAs in patients with renal cell carcinoma (RCC)...
  59. ncbi request reprint Primary Urethral Plasmacytoma Treated with High-Dose-Rate Brachytherapy: A Case Report
    Johannes Stein
    Department of Urology, University Clinic Bonn, Bonn, Germany
    Urol Int 97:369-372. 2016
    ..Besides an uncomplicated urinary tract infection and hyperpigmentation of the penis, the patient tolerated the radiotherapy well and is still free of disease after 15 months follow-up...
  60. pmc Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma
    Sarah Schrödter
    Department of Urology, University Hospital Bonn, Bonn, Germany
    Mol Cancer 15:10. 2016
    ..Clear cell renal cell carcinoma (ccRCC) is among the most common human malignancies...
  61. pmc Analysis of tissue and serum microRNA expression in patients with upper urinary tract urothelial cancer
    Stephanie Kriebel
    Universitatsklinikum Bonn, Klinik und Poliklinik für Urologie und Kinderurologie, Bonn, Germany
    PLoS ONE 10:e0117284. 2015
    ..MicroRNAs play an important role in many human malignancies; so far, their expression remains to be studied in upper urinary tract urothelial cancer (UUTUC)...
  62. doi request reprint Glutathione-S-transferase pi 1(GSTP1) gene silencing in prostate cancer cells is reversed by the histone deacetylase inhibitor depsipeptide
    Vera Hauptstock
    Department of Pathology, University Hospital Bonn, Bonn, Germany
    Biochem Biophys Res Commun 412:606-11. 2011
    ..Successful therapy requires both, DNA demethylation and activating histone modifications, to induce complete gene expression of epigenetically silenced genes and depsipeptide fulfils both criteria...
  63. ncbi request reprint Primitive neuroectodermal tumor: rare, highly aggressive differential diagnosis in urologic malignancies
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urology 68:257-62. 2006
    ..It is characterized by the expression of MIC2 and neural markers (eg, neuron-specific enolase, synaptophysin, S-100, vimentin, Leu-7), and the presence of the EWS-FLI1 translocation...
  64. doi request reprint Stem cell marker expression in small cell lung carcinoma and developing lung tissue
    Lin Kristin Koch
    Institut of Pathology, University of Bonn, Bonn, Germany
    Hum Pathol 39:1597-605. 2008
    ..Taken together, we show that small cell lung cancers and clustered epithelial cells in developing proximal bronchi share the expression of stem cell markers, suggesting a possible histogenetic link...
  65. doi request reprint Diagnostic meaning of urodynamic studies in pouch incontinence: results of a small series
    Stefan Latz
    Department of Urology, Bonn University, Bonn, Germany
    Urol Int 92:237-41. 2014
    ..To evaluate the meaning of urodynamic parameters in patients with pouch incontinence...
  66. doi request reprint Pathological outcomes of men eligible for active surveillance after undergoing radical prostatectomy: are results predictable?
    Turang Ed Behbahani
    Department of Urology, University of Bonn, Bonn, Germany
    Clin Genitourin Cancer 10:32-6. 2012
    ..To analyze pathological results in patients with prostate cancer eligible for active surveillance (AS) after radical prostatectomy and available prediction systems...
  67. doi request reprint Spindle cell rhabdomyosarcoma of the prostate
    Stefan Latz
    Department of Urology, University of Bonn, Bonn, Germany
    Int J Urol 20:935-7. 2013
    ..4 Gy). The tumor initially shrank, but an early local recurrence arose. Second-line chemotherapy was applied, followed by a salvage radical cytoprostatectomy. The patient died of disseminated disease 14 months after diagnosis. ..
  68. doi request reprint Circulating microRNAs in serum: novel biomarkers for patients with bladder cancer?
    Anna Regina Scheffer
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    World J Urol 32:353-8. 2014
    ..So far, circulating microRNAs have not been analyzed in patients with bladder cancer...
  69. doi request reprint Expression of programmed cell death protein 4 (PDCD4) and miR-21 in urothelial carcinoma
    Nicolas Fischer
    Department of Urology, University of Bonn, Bonn, Germany
    Biochem Biophys Res Commun 417:29-34. 2012
    ..We investigated the role of the programmed cell death 4 (PDCD4) tumor suppressor gene in specimens of transitional cell carcinoma and of healthy individuals...
  70. doi request reprint Identification of immunity-related genes in prostate cancer and potential role of the ETS family of transcription factors in their regulation
    Zaki Shaikhibrahim
    Institute of Pathology, University Hospital Bonn, Bonn, Germany
    Int J Mol Med 28:799-807. 2011
    ..Unraveling the dynamics of the ETS-immunity-related genes will provide an invaluable insight into understanding prostate cancer immunology...
  71. ncbi request reprint Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies?
    Sabine Ellinger
    Department of Food and Nutrition Sciences Nutrition Physiology, University of Bonn, Endenicher Allee 11 13, 53115 Bonn, Germany
    Curr Opin Clin Nutr Metab Care 9:722-7. 2006
    ....
  72. ncbi request reprint Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence
    Philip Kahl
    Institute of Pathology, University Hospital Bonn Medical School, Germany
    Cancer Res 66:11341-7. 2006
    ..Our present study suggests that LSD1 and nuclear FHL2 may serve as novel biomarkers predictive for prostate cancer with aggressive biology and point to a role of LSD1 and FHL2 in constitutive activation of AR-mediated growth signals...
  73. doi request reprint Cytoplasmatic and Nuclear YAP1 and pYAP1 Staining in Urothelial Bladder Cancer
    Stefan Latz
    Department of Urology, University Hospital Bonn, Bonn, Germany
    Urol Int 96:39-45. 2016
    ..We evaluated staining and clinical significance of YAP1 and phosphorylated YAP1 (pYAP1) in urothelial bladder cancer (BCA)...
  74. pmc Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors
    Niklas Klümper
    Section for Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne Bonn, University Hospital of Bonn, Bonn, Germany
    Diagn Pathol 10:165. 2015
    ..Aim of the study was to investigate the implication of MED15 in TGCT development and its stratification into histological subtypes...
  75. doi request reprint Circulating serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as biomarkers in patients with testicular germ cell cancer
    Isabella Syring
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany Electronic address
    J Urol 193:331-7. 2015
    ..miRNAs are deregulated in cancer and could serve as noninvasive serum biomarkers. We explored the role of serum miRNAs as a novel biomarker in patients with testicular germ cell tumor...
  76. doi request reprint First report of an unexpected blind-ending duplication of the ureter as a rare pitfall in kidney transplantation
    Stefan Hauser
    Department of Urology, University of Bonn, Bonn, Germany
    Transpl Int 21:696-7. 2008
    ..Accuracy should be ensured when exploring the exact anatomy of the donor organ...
  77. doi request reprint Epigenetic biomarkers in the blood of patients with urological malignancies
    Jörg Ellinger
    Department of Urology, University Hospital Bonn, Bonn, Germany
    Expert Rev Mol Diagn 15:505-16. 2015
    ....
  78. doi request reprint KDM5C is overexpressed in prostate cancer and is a prognostic marker for prostate-specific antigen-relapse following radical prostatectomy
    Johannes Stein
    Institute of Pathology, University of Bonn, Bonn, Germany
    Am J Pathol 184:2430-7. 2014
    ..Moreover, overexpression of KDM5C is an independent new predictive marker for therapy failure as determined by biochemical recurrence in patients after prostatectomy. ..
  79. ncbi request reprint Impact of the menstrual cycle on circulating cell-free DNA
    Martin Pölcher
    Department of Gynecology and Obstetrics, Center for Integrated Oncology, Bonn University Medical Center, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Anticancer Res 30:2235-40. 2010
    ..To determine serum levels of circulating cell-free DNA (cfDNA) throughout the stages of endometrial proliferation and apoptosis during the menstrual cycle...
  80. doi request reprint Nucleic acid-based tissue biomarkers of urologic malignancies
    Dimo Dietrich
    Institute of Pathology, University Hospital Bonn UKB, Bonn, Germany
    Crit Rev Clin Lab Sci 51:173-99. 2014
    ..Furthermore, specific challenges regarding the development and clinical implementation of nucleic acid-based biomarkers are discussed...