Philipp Ehlermann

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint [Dilated cardiomyopathy]
    Philipp Ehlermann
    Innere Medizin III Kardiologie, Angiologie und Pneumologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Herzschrittmacherther Elektrophysiol 23:196-200. 2012
  2. pmc Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene
    Philipp Ehlermann
    Medizinische Klinik, Abt Innere Medizin III, Universitatsklinikum Heidelberg, Germany
    BMC Med Genet 9:95. 2008
  3. pmc Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products
    Philipp Ehlermann
    Universitat Heidelberg, Abteilung Innere Medizin III, Heidelberg, Germany
    Cardiovasc Diabetol 5:6. 2006
  4. ncbi request reprint [Papillary muscle rupture due to cardiac contusion]
    P Ehlermann
    Innere Medizin III Kardiologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Z Kardiol 93:763-4. 2004
  5. pmc Heart rate reduction for 36 months with ivabradine reduces left ventricular mass in cardiac allograft recipients: a long-term follow-up study
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1323-8. 2013
  6. pmc Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1253-8. 2013
  7. doi request reprint Is there an additional benefit of serial NT-proBNP measurements in patients with stable chronic heart failure receiving individually optimized therapy?
    Jennifer Franke
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 100:1059-67. 2011
  8. ncbi request reprint S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts
    Andrew Remppis
    Medizinische Klinik III, Universitat Heidelberg, 69115 Heidelberg, Germany
    J Gene Med 6:387-94. 2004
  9. doi request reprint Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation
    Mark Luedde
    Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany
    Cardiovasc Res 86:452-60. 2010
  10. doi request reprint A decade of developments in chronic heart failure treatment: a comparison of therapy and outcome in a secondary and tertiary hospital setting
    Jennifer Franke
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Res Cardiol 101:1-10. 2012

Detail Information

Publications40

  1. doi request reprint [Dilated cardiomyopathy]
    Philipp Ehlermann
    Innere Medizin III Kardiologie, Angiologie und Pneumologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Herzschrittmacherther Elektrophysiol 23:196-200. 2012
    ..This applies with some restrictions for asymptomatic patients in NYHA class I. Patients should receive optimal drug therapy for 3-12 months before ICD implantation...
  2. pmc Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene
    Philipp Ehlermann
    Medizinische Klinik, Abt Innere Medizin III, Universitatsklinikum Heidelberg, Germany
    BMC Med Genet 9:95. 2008
    ..MYBPC3 mutations initially were considered to cause a benign form of HCM. The aim of this study was to examine the clinical outcome of patients and their relatives with 18 different MYBPC3 mutations...
  3. pmc Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products
    Philipp Ehlermann
    Universitat Heidelberg, Abteilung Innere Medizin III, Heidelberg, Germany
    Cardiovasc Diabetol 5:6. 2006
    ..As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression...
  4. ncbi request reprint [Papillary muscle rupture due to cardiac contusion]
    P Ehlermann
    Innere Medizin III Kardiologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Z Kardiol 93:763-4. 2004
  5. pmc Heart rate reduction for 36 months with ivabradine reduces left ventricular mass in cardiac allograft recipients: a long-term follow-up study
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1323-8. 2013
    ..However, long-term data regarding the effects of ivabradine, a novel If channel antagonist, are limited in patients after heart transplantation...
  6. pmc Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1253-8. 2013
    ....
  7. doi request reprint Is there an additional benefit of serial NT-proBNP measurements in patients with stable chronic heart failure receiving individually optimized therapy?
    Jennifer Franke
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 100:1059-67. 2011
    ..The role of serial NT-proBNP measurements in patients suffering from chronic systolic heart failure (CHF) who already receive individually optimized pharmacotherapy is still unresolved...
  8. ncbi request reprint S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts
    Andrew Remppis
    Medizinische Klinik III, Universitat Heidelberg, 69115 Heidelberg, Germany
    J Gene Med 6:387-94. 2004
    ..Here, we explore a strategy to improve contractile properties of engineered heart tissue (EHT) by S100A1 gene transfer...
  9. doi request reprint Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation
    Mark Luedde
    Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany
    Cardiovasc Res 86:452-60. 2010
    ..Here, we describe a family with LVNC due to a novel missense mutation, pE96K, in the cardiac troponin T gene (TNNT2)...
  10. doi request reprint A decade of developments in chronic heart failure treatment: a comparison of therapy and outcome in a secondary and tertiary hospital setting
    Jennifer Franke
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Res Cardiol 101:1-10. 2012
    ..To investigate determinants and temporal developments of treatment strategies, 5-year survival and heart transplantation rates between patients treated at secondary and tertiary hospitals...
  11. pmc Long-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation
    Rasmus Rivinius
    Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
    Drug Des Devel Ther 10:677-86. 2016
    ..Given its long half-life, pre-transplant use of amiodarone has been controversially discussed, with divergent results regarding morbidity and mortality after heart transplantation (HTX)...
  12. pmc Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation
    Matthias Helmschrott
    Department of Cardiology, Angiology, Pneumology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 9:1217-24. 2015
    ..Nephrotoxicity is a serious adverse effect of calcineurin inhibitor therapy in patients after heart transplantation (HTX)...
  13. ncbi request reprint Large-scale mutation screening in patients with dilated or hypertrophic cardiomyopathy: a pilot study using DGGE
    Raphael Zeller
    Innere Medizin III, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Mol Med (Berl) 84:682-91. 2006
    ..The platform proved a valuable contribution to elucidating the genetic causes of DCM and HCM as demonstrated by the identification of 17 different known and novel mutations and 98 different polymorphisms in our setting...
  14. doi request reprint Gender aspects in clinical presentation and prognostication of chronic heart failure according to NT-proBNP and the Heart Failure Survival Score
    Jennifer Franke
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 104:334-41. 2015
    ..We performed a prospective multi-center study to assess gender-specific differences in the predictive value of the measured level of NT-proBNP and the calculated Heart Failure Survival Score (HFSS)...
  15. pmc Conversion to generic cyclosporine A in stable chronic patients after heart transplantation
    Maximilian Kraeuter
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:1421-6. 2013
    ..Available CSA products differ in the constitution of their emulsion. To compare intra-individual differences after a conversion to a generic CSA, a retrospective single-center study was initiated...
  16. doi request reprint Immunosuppression with tacrolimus early after orthotopic heart transplantation: a comparison of prograf and advagraf
    Ali Ghodsizad
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Heart Surg Forum 15:E307-9. 2012
    ..We compared trough levels and clinical outcomes in patients who received Prograf or Advagraf (tacrolimus) de novo following heart transplantation surgery...
  17. pmc Green tea halts progression of cardiac transthyretin amyloidosis: an observational report
    Arnt V Kristen
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Res Cardiol 101:805-13. 2012
    ..Thus, it might also halt progression of TTR amyloidosis. This is a single-center observational report on the effects of GT consumption in patients with ATTR cardiomopathy...
  18. ncbi request reprint Heart rate reduction after heart transplantation with beta-blocker versus the selective If channel antagonist ivabradine
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transplantation 84:988-96. 2007
    ....
  19. ncbi request reprint Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2)
    Patrick Most
    Innere Medizin III, Universitat Heidelberg, 69115 Heidelberg, Germany
    J Biol Chem 278:48404-12. 2003
    ..These findings warrant speculation that injury-dependent release of the S100A1 protein from cardiomyocytes may serve as an intrinsic mechanism to promote survival of the myocardium in vivo...
  20. pmc Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen
    Matthias Helmschrott
    Department of Cardiology, Angiology, Pneumology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 8:1307-14. 2014
    ..The use of tacrolimus (TAC) in patients after heart transplantation (HTX) has increased over the last few years...
  21. pmc Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy
    Rasmus Rivinius
    Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 9:93-102. 2015
    ..Special emphasis was placed on the effects of a mammalian target of rapamycin (mTOR) containing immunosuppressive regimen...
  22. pmc Alterations in cardiac DNA methylation in human dilated cardiomyopathy
    Jan Haas
    Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany
    EMBO Mol Med 5:413-29. 2013
    ..In vivo studies of orthologous ly75 and adora2a in zebrafish demonstrate a functional role of these genes in adaptive or maladaptive pathways in heart failure...
  23. doi request reprint Use of cardiovascular magnetic resonance for risk stratification in chronic heart failure: prognostic value of late gadolinium enhancement in patients with non-ischaemic dilated cardiomyopathy
    Stephanie Lehrke
    Abteilung Innere Medizin III, Medizinische Klinik, Universitatsklinikum Heidelberg, Heidelberg, Germany
    Heart 97:727-32. 2011
    ..The goal of this study was to investigate the long-term prognostic significance of late gadolinium enhancement (LGE) as detected by contrast-enhanced cardiovascular magnetic resonance (CE-CMR) in patients with DCM...
  24. ncbi request reprint Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia
    Stephanie K Geiger
    Division of Molecular Genetics, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    J Mol Med (Berl) 86:281-9. 2008
    ....
  25. pmc Adjuvant Use of Ivabradine in Acute Heart Failure due to Myocarditis
    Jennifer Franke
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Case Report Med 2011:203690. 2011
    ....
  26. pmc Effects of vildagliptin (Galvus®) therapy in patients with type 2 diabetes mellitus after heart transplantation
    Ibrahim Gueler
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Drug Des Devel Ther 7:297-303. 2013
    ..Type 2 Diabetes mellitus (T2DM) is a common comorbidity in patients after heart transplantation (HTx) and is associated with adverse long-term outcomes...
  27. ncbi request reprint A comparison of measured trough levels and abbreviated AUC estimation by limited sampling strategies for monitoring mycophenolic acid exposure in stable heart transplant patients receiving cyclosporin A-containing and cyclosporin A-free immunosuppressive
    Andreas O Dösch
    Department of Cardiology, University Hospital, University of Heidelberg, Heidelberg, Germany
    Clin Ther 28:893-905. 2006
    ..A reliable method of achieving effective and well-tolerated levels of NIMF-based immunosuppression would be of eminent interest...
  28. ncbi request reprint Immediate and chronic effects of AV-delay optimization in patients with cardiac resynchronization therapy
    Stefan E Hardt
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Int J Cardiol 115:318-25. 2007
    ..However, the chronic functional effects of AV-delay optimization have not been systematically examined despite of their potential role for chronic functional improvement...
  29. ncbi request reprint Transthyretin valine-94-alanine, a novel variant associated with late-onset systemic amyloidosis with cardiac involvement
    Arnt V Kristen
    Department of Cardiology, Medical University of Heidelberg, Heidelberg, Germany
    Amyloid 14:283-7. 2007
    ..Final clinical assessment of severity of cardiac involvement in the present patient is rendered complex by possible concomitant or preceding idiopathic dilated cardiomyopathy...
  30. doi request reprint Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy
    David Hassel
    Department of Medicine III, University of Heidelberg, Heidelberg, Germany
    Nat Med 15:1281-8. 2009
    ..Increasing mechanical strain aggravated Z-disk damage in nexilin-deficient skeletal muscle, implying a unique role of nexilin in protecting Z-disks from mechanical trauma...
  31. doi request reprint Effects of β-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction
    Jin Li
    Department of Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Clin Res Cardiol 104:241-9. 2015
    ..In conclusion, this study reveals reduction of LV mass among LVNC patients during β-blocker therapy. Effects of β-blocker treatment in LVNC require validation in prospective controlled studies. ..
  32. ncbi request reprint The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes
    Andrew Remppis
    Basic Res Cardiol 97:I56-62. 2002
    ....
  33. doi request reprint A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy
    Benjamin Meder
    Department of Internal Medicine III, University Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Eur Heart J 35:1069-77. 2014
    ..By a large-scale case-control genome-wide association study we aimed here to identify novel genetic risk loci for DCM...
  34. pmc Left ventricular long axis strain: a new prognosticator in non-ischemic dilated cardiomyopathy?
    Johannes H Riffel
    Department of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    J Cardiovasc Magn Reson 18:36. 2016
    ..However, the prognostic value of LAS in cardiomyopathies with reduced left ventricular ejection fraction (LVEF) has not been evaluated yet...
  35. ncbi request reprint Predictive value of inflammatory and hemostatic parameters, atherosclerotic risk factors, and chest x-ray for aortic arch atheromatosis
    Philipp Ehlermann
    Medizinische Klinik, Abt Innere Medizin III Kardiologie, Universitat Heidelberg, Heidelberg, Germany
    Stroke 35:34-9. 2004
    ..In most cases AAA is only detected after the embolic event. This study was therefore designed to identify predictive factors for AAA...
  36. ncbi request reprint The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers
    Patrick Most
    Abteilung Innere Medizin III Kardiologie, Universitat Heidelberg, 69115 Heidelberg, Germany
    J Biol Chem 278:26356-64. 2003
    ..Thus, our data suggest that S100A1 may serve as an endogenous enhancer of SR Ca2+ release and might therefore be of physiological relevance in the process of excitation-contraction coupling in skeletal muscle...
  37. doi request reprint The "Wagshurst study": p.Val40Ile transthyretin gene variant causes late-onset cardiomyopathy
    Ralf Bauer
    Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Amyloid 21:267-75. 2014
    ..This study aims to characterize a cohort of patients with the rare transthyretin (TTR) Val20Ile (p.TTRVal40Ile) variant...
  38. ncbi request reprint Role of erythropoietin in anemia after heart transplantation
    Christian A Gleissner
    Department of Cardiology, Angiology and Pneumonology, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Int J Cardiol 112:341-7. 2006
    ..Anemia after heart transplantation is common; however, there are scant data on etiology and treatment. This study evaluates type of anemia and the effects of erythropoietin therapy...
  39. ncbi request reprint Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance
    Patrick Most
    Medizinische Universitätsklinik und Poliklinik III, Universität zu Heidelberg, 69115 Heidelberg
    J Biol Chem 278:33809-17. 2003
    ..Because S100A1 protein expression is down-regulated in heart failure, increasing S100A1 expression in the heart may represent a novel means to augment contractility...
  40. ncbi request reprint Images in cardiovascular medicine. Hereditary hypertrophic nonobstructive cardiomyopathy seen on delayed hyperenhancement magnetic resonance imaging
    Henning Steen
    Division of Cardiology, Pneumology, and Angiology, Department of Internal Medicine III, University of Heidelberg, Germany
    Circulation 113:e458-9. 2006