Jürgen Durner

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. doi request reprint Determination of homologous distributions of bisEMA dimethacrylates in bulk-fill resin-composites by GC-MS
    Jürgen Durner
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestr 70, 80336 Munich, Germany Electronic address
    Dent Mater 31:473-80. 2015
  2. doi request reprint Investigation of different bleaching conditions on the amount of elutable substances from nano-hybrid composites
    Jürgen Durner
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestr 70, 80336 Munich, Germany Walther Straub Institute of Pharmacology und Toxicology, Nussbaumstr 26, 80336 Munich, Germany Electronic address
    Dent Mater 30:192-9. 2014
  3. doi request reprint Correlation of the degree of conversion with the amount of elutable substances in nano-hybrid dental composites
    Jürgen Durner
    Walther Straub Institute of Pharmacology and Toxicology, Nussbaumstr 26, 80336 Munich, Germany
    Dent Mater 28:1146-53. 2012
  4. doi request reprint Synergistic interaction caused to human gingival fibroblasts from dental monomers
    J Durner
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestr 70, 80336 Munich, Germany
    Dent Mater 28:818-23. 2012
  5. doi request reprint Effect of hydrogen peroxide on the three-dimensional polymer network in composites
    Jürgen Durner
    Walther Straub Institute of Pharmacology and Toxicology, Nussbaumstrasse 26, Munich, Germany
    Dent Mater 27:573-80. 2011
  6. doi request reprint Influence of silver nano-particles on monomer elution from light-cured composites
    Jürgen Durner
    Walther Straub Institute of Pharmacology und Toxicology, Nussbaumstr 26, 80336 Munich, Germany
    Dent Mater 27:631-6. 2011
  7. doi request reprint Induction of DNA strand breaks by dental composite components compared to X-ray exposure in human gingival fibroblasts
    Jürgen Durner
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestrasse 70, 80336 Munich, Germany
    Arch Toxicol 85:143-8. 2011
  8. doi request reprint Release of TEGDMA from composite during the chewing situation
    J Durner
    Institute of Clinical Chemistry, Campus Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Dent Mater 26:e197-204. 2010
  9. doi request reprint Clinical chemistry: challenges for analytical chemistry and the nanosciences from medicine
    Jürgen Durner
    Universitätsklinikum München, Institut fur Klinische Chemie, Ludwig Maximilians Universitat Munchen, Marchioninistrasse 15, 81377 Munchen
    Angew Chem Int Ed Engl 49:1026-51. 2010
  10. doi request reprint Metabolism of TEGDMA and HEMA in human cells
    Jürgen Durner
    Institute of Clinical Chemistry, Ludwig Maximilians University of Munich, Germany
    Biomaterials 31:818-23. 2010

Collaborators

Detail Information

Publications33

  1. doi request reprint Determination of homologous distributions of bisEMA dimethacrylates in bulk-fill resin-composites by GC-MS
    Jürgen Durner
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestr 70, 80336 Munich, Germany Electronic address
    Dent Mater 31:473-80. 2015
    ..It was the aim of the present study to develop a method allowing detection of bisEMA and its different degrees of ethoxylation eluted from polymerized resin composites...
  2. doi request reprint Investigation of different bleaching conditions on the amount of elutable substances from nano-hybrid composites
    Jürgen Durner
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestr 70, 80336 Munich, Germany Walther Straub Institute of Pharmacology und Toxicology, Nussbaumstr 26, 80336 Munich, Germany Electronic address
    Dent Mater 30:192-9. 2014
    ..To analyse the influence of irradiation time, aging before bleaching, and bleaching technique (home bleaching vs. in-office bleaching) on the amount of elutable substances from modern nano-hybrid resin-based composites (RBCs)...
  3. doi request reprint Correlation of the degree of conversion with the amount of elutable substances in nano-hybrid dental composites
    Jürgen Durner
    Walther Straub Institute of Pharmacology and Toxicology, Nussbaumstr 26, 80336 Munich, Germany
    Dent Mater 28:1146-53. 2012
    ..One nano-hybrid RBC based on tricyclodecane-(TCD)-urethane (Venus(®) Diamond) and two conventionally formulated RBCs (TetricEvo Ceram(®), Filtek™ Supreme XTE) were considered...
  4. doi request reprint Synergistic interaction caused to human gingival fibroblasts from dental monomers
    J Durner
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestr 70, 80336 Munich, Germany
    Dent Mater 28:818-23. 2012
    ..We dissolved the basic monomers in the comonomers and incubated human gingival fibroblasts (HGFs) with these binary mixtures in different concentrations...
  5. doi request reprint Effect of hydrogen peroxide on the three-dimensional polymer network in composites
    Jürgen Durner
    Walther Straub Institute of Pharmacology and Toxicology, Nussbaumstrasse 26, Munich, Germany
    Dent Mater 27:573-80. 2011
    ..Therefore the study was performed to test the effects of hydrogen peroxide on the three-dimensional polymer network in composites...
  6. doi request reprint Influence of silver nano-particles on monomer elution from light-cured composites
    Jürgen Durner
    Walther Straub Institute of Pharmacology und Toxicology, Nussbaumstr 26, 80336 Munich, Germany
    Dent Mater 27:631-6. 2011
    ..Silver particles were also added to experimental dental composites to reduce caries. The aim of our study was to show whether silver nanoparticles can lead to higher amounts of elutable substances...
  7. doi request reprint Induction of DNA strand breaks by dental composite components compared to X-ray exposure in human gingival fibroblasts
    Jürgen Durner
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestrasse 70, 80336 Munich, Germany
    Arch Toxicol 85:143-8. 2011
    ..But 0.25 mM BisGMA is more than 100-fold higher than that concentration found in worst case calculations. Therefore, our data did not support our hypothesis...
  8. doi request reprint Release of TEGDMA from composite during the chewing situation
    J Durner
    Institute of Clinical Chemistry, Campus Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Dent Mater 26:e197-204. 2010
    ..It could be shown that chewing simulation has no significant (p<0.05) effect on the release of 14C-TEGDMA (and/or 14C-degradation products) from polymerized composites...
  9. doi request reprint Clinical chemistry: challenges for analytical chemistry and the nanosciences from medicine
    Jürgen Durner
    Universitätsklinikum München, Institut fur Klinische Chemie, Ludwig Maximilians Universitat Munchen, Marchioninistrasse 15, 81377 Munchen
    Angew Chem Int Ed Engl 49:1026-51. 2010
    ..The introduction of new methods and trends into medicinal analysis is explored, along with opportunities and problems associated with personalized medicine...
  10. doi request reprint Metabolism of TEGDMA and HEMA in human cells
    Jürgen Durner
    Institute of Clinical Chemistry, Ludwig Maximilians University of Munich, Germany
    Biomaterials 31:818-23. 2010
    ..Therefore the epoxide pathway with formation of the epoxy-intermediate 2,3-epoxymethacrylic acid is the main route of metabolisation of HEMA and TEGDMA...
  11. doi request reprint The toxicokinetics and distribution of 2-hydroxyethyl methacrylate in mice
    J Durner
    Institute of Clinical Chemistry, Faculty of Medicine, Campus Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    Biomaterials 30:2066-71. 2009
    ..Two metabolic pathways of 14C-HEMA can be described. The peak HEMA levels in all tissues examined after 24h were lower than known toxic levels. Therefore the study did not support the hypothesis...
  12. doi request reprint Eluted substances from unpolymerized and polymerized dental restorative materials and their Nernst partition coefficient
    Jürgen Durner
    Institute of Clinical Chemistry, Faculty of Medicine, Campus Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Dent Mater 26:91-9. 2010
    ..The study was performed to investigate the elution of substances from unpolymerized and polymerized composites (Tetric=TET; Arabesk=ARA), ormoceres (Admira)=ADM; Definite=DEF) and the compomere (Hytac=HYT)...
  13. ncbi request reprint Toxicokinetic of HEMA in guinea pigs
    F X Reichl
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstr 26, 80336 Munich, Germany
    J Dent 30:353-8. 2002
    ..In the present study the uptake, distribution and excretion of 14C-HEMA applied via different routes were examined in vivo in guinea pigs...
  14. doi request reprint Elution of TEGDMA and HEMA from polymerized resin-based bonding systems
    Franz Xaver Reichl
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, 80336 Munich, Germany
    Dent Mater 28:1120-5. 2012
    ..In this study the amount of TEGDMA and HEMA eluted from several adhesive systems was quantified...
  15. doi request reprint No evidence for DNA double-strand breaks caused by endodontic sealers
    Kirsten L Van Landuyt
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Munich, Germany
    J Endod 38:636-41. 2012
    ..The objective of this study was to test possible mutagenicity of resin-based endodontic sealers by evaluating their potential to induce DNA double-strand breaks (DSBs)...
  16. doi request reprint Prognostic relevance of oncological serum biomarkers in liver cancer patients undergoing transarterial chemoembolization therapy
    Nikolaus Kohles
    Institute of Clinical Chemistry, University Hospital Munich Grosshadern, Munich, Germany
    Tumour Biol 33:33-40. 2012
    ..3 vs. 92.7). The combination of AFP, CHE, and LDH enables efficient pretherapeutic stratification of HCC patients in advanced tumor stage for TACE therapy...
  17. doi request reprint Expression of CYP450-2E1 and formation of 2,3-epoxymethacrylic acid (2,3-EMA) in human oral cells exposed to dental materials
    Franz Xaver Reichl
    Department of Operative Dentistry and Periodontology, Ludwig Maximilians University, 80336 Munich, Germany
    Dent Mater 26:1151-6. 2010
    ..Oral cells are highly exposed to (co)monomers released from composites. Therefore in this study the, expression of CYP450-2E1 in human oral (and other) cells was investigated as well as the formation of 2,3-EMA in cells exposed to MA...
  18. ncbi request reprint Uptake, clearance and metabolism of TEGDMA in guinea pigs
    Franz Xaver Reichl
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstr 26, 80336, Munich, Germany
    Dent Mater 18:581-9. 2002
    ..The resin monomer triethyleneglycoldimethacrylate (TEGDMA) is used as a diluent in many resin-based bonding, cementing and direct tooth filling materials...
  19. ncbi request reprint Measurement of late-night salivary cortisol with an automated immunoassay system
    Michael Vogeser
    Institute of Clinical Chemistry, Hospital of the University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Clin Chem Lab Med 44:1441-5. 2006
    ..Therefore, the aim of our study was to assess the analytical performance of the first automated cortisol immunoassay specified for salivary measurements and to establish late-night sampling reference-range data for this test...
  20. ncbi request reprint HLA association is different in children and adults with severe acquired aplastic anemia
    Monika Fuhrer
    Department of Onkology and Hematology, Dr v Haunersche Kinderklinik of the Ludwig Maximilians University of Munich, Munich, Germany
    Pediatr Blood Cancer 48:186-91. 2007
    ..In SAA, few large studies based on data mainly from adults describe a positive HLA correlation with HLA-DR2 (DRB1*15) and HLA-B14...
  21. ncbi request reprint Cytotoxicity of dental composite components and mercury compounds in lung cells
    F X Reichl
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstr 26, 80336, Munich, Germany
    Dent Mater 17:95-101. 2001
    ....
  22. ncbi request reprint Cytotoxicity of dental composite components and mercury compounds in pulmonary cells
    K Kehe
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Germany
    Biomaterials 22:317-22. 2001
    ..TEGDMA was about 5-fold (A549 cells) and about 2-fold (L2 cells) more toxic compared to HEMA. It is to be assumed that the risk of lung cell damage by dental composite components is even more unlikely...
  23. ncbi request reprint Biological clearance of TEGDMA in guinea pigs
    F X Reichl
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstr 26, 80336 Munich, Germany
    Arch Toxicol 75:22-7. 2001
    ..9 +/- 4.6% of the 14C (means +/- SEM; n = 4) was exhaled as 14C-carbon dioxide. The results indicate a rapid clearance of 14C-TEGDMA and/or 14C-TEGDMA metabolite(s) from the organism and exhalation is the major route of elimination...
  24. ncbi request reprint Biological clearance of HEMA in guinea pigs
    F X Reichl
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Germany
    Biomaterials 23:2135-41. 2002
    ..6 +/- 2.11% of the administered 14C-HEMA dose (mean +/- sem; n = 4) as 14C-carbondioxide. The results indicate a rapid clearance of 14C-HEMA and/or 14C-HEMA metabolite(s) from the organism, exhalation being the major route of elimination...
  25. ncbi request reprint Effect of dental materials on gluconeogenesis in rat kidney tubules
    F X Reichl
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstrasse 26, D 80336 Munich, Germany
    Arch Toxicol 73:381-6. 1999
    ..7 +/- 2.9; TEGDMA, 1.8 +/- 0.2; MeHgCl, 0.018 +/- 0.0005; and HgCl(2), 0. 0016 +/- 0.0005. The toxic effect of HgCl(2) was approximately 1000 or 10 000 higher than that of the dental composite components TEGDMA or HEMA, respectively...
  26. doi request reprint The elution and breakdown behavior of constituents from various light-cured composites
    Marija Sevkusic
    Walther Straub Institute of Pharmacology and Toxicology, Nussbaumstr 26, D 80336 Munich, Germany Electronic address
    Dent Mater 30:619-31. 2014
    ..The aim of this study was to examine the time-related elution and breakdown of separable constituents of polymerized composites using deuterated solvents...
  27. doi request reprint Effects of antioxidants on DNA-double strand breaks in human gingival fibroblasts exposed to methacrylate based monomers
    Susanne Lottner
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestr 70, 80336 Munich, Germany
    Dent Mater 29:991-8. 2013
    ..In this study the effects of the antioxidants N-acetylcysteine (ACC) and ascorbic acid (Asc) on the number of DNA double-strand breaks (DSBs) in human gingiva fibroblasts (HGFs) were tested...
  28. doi request reprint Effect of modulated irradiation time on the degree of conversion and the amount of elutable substances from nano-hybrid resin-based composites
    Nicoleta Ilie
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestr 70, 80336, Munich, Germany
    Clin Oral Investig 18:97-106. 2014
    ..The aim of our study was to analyse whether the irradiation time and/or the modulation of irradiation time influence the degree of conversion (DC) and the amount of elutable substances from modern nano-hybrid resin-based composites (RBCs)...
  29. doi request reprint Effect of radical amplified photopolymerization (RAP) in resin-based composites
    Nicoleta Ilie
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestr 70, 80336, Munich, Germany
    Clin Oral Investig 18:1081-8. 2014
    ....
  30. doi request reprint Polymerization kinetic calculations in dental composites: a method comparison analysis
    Nicoleta Ilie
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians Universitat Munchen, Goethestr 70, 80336, Munich, Germany
    Clin Oral Investig 18:1587-96. 2014
    ....
  31. doi request reprint Cytotoxicity and induction of DNA double-strand breaks by components leached from dental composites in primary human gingival fibroblasts
    Mohamed Shehata
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Goethestr 70, 80336 Munich, Germany
    Dent Mater 29:971-9. 2013
    ..The public interest steadily increases in the biological adverse effects caused by components released from resin-based dental restorations...
  32. doi request reprint Influence of various irradiation processes on the mechanical properties and polymerisation kinetics of bulk-fill resin based composites
    Nicoleta Ilie
    Department of Operative Restorative Dentistry, Periodontology and Pedodontics, Ludwig Maximilians University of Munich, Germany
    J Dent 41:695-702. 2013
    ..To assess the effect of irradiation time and distance of the light tip on the micro-mechanical properties and polymerisation kinetics of two bulk-fill resin-based composites at simulated clinically relevant filling depth...
  33. pmc Relevance of circulating nucleosomes and oncological biomarkers for predicting response to transarterial chemoembolization therapy in liver cancer patients
    Nikolaus Kohles
    Institute of Clinical Chemistry, University Hospital Munich Grosshadern, Germany
    BMC Cancer 11:202. 2011
    ..Transarterial chemoembolization (TACE) therapy is an effective locoregional treatment in hepatocellular cancer (HCC) patients. For early modification of therapy, markers predicting therapy response are urgently required...