Dirk Drasdo

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint A single-cell-based model of tumor growth in vitro: monolayers and spheroids
    Dirk Drasdo
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Phys Biol 2:133-47. 2005
  2. ncbi request reprint Mathematical modelling of liver regeneration after intoxication with CCl(4)
    Stefan Höhme
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Chem Biol Interact 168:74-93. 2007
  3. pmc Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
    Stefan Hoehme
    Interdisciplinary Centre for Bioinformatics IZBI, University of Leipzig, Härtelstrasse 16 18, D 04107 Leipzig, Germany
    Proc Natl Acad Sci U S A 107:10371-6. 2010
  4. pmc A cell-based simulation software for multi-cellular systems
    Stefan Hoehme
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Germany
    Bioinformatics 26:2641-2. 2010
  5. pmc Individual fates of mesenchymal stem cells in vitro
    Axel Krinner
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Haertelstr, 16 18, 04107 Leipzig, Germany
    BMC Syst Biol 4:73. 2010
  6. doi request reprint TiQuant: software for tissue analysis, quantification and surface reconstruction
    Adrian Friebel
    Interdisciplinary Centre for Bioinformatics IZBI, University of Leipzig, Germany
    Bioinformatics 31:3234-6. 2015
  7. ncbi request reprint Shape characterization of extracted and simulated tumor samples using topological and geometric measures
    Markus Rohrschneider
    Image and Signal Processing Group, University of Leipzig, Germany
    Conf Proc IEEE Eng Med Biol Soc 2007:6272-8. 2007
  8. pmc Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations in vitro
    Jörg Galle
    Interdisciplinary Centre for Bioinformatics, Leipzig, Germany
    Biophys J 88:62-75. 2005
  9. ncbi request reprint Gene network inference from incomplete expression data: transcriptional control of hematopoietic commitment
    Kristin Missal
    Bioinformatics Group, Department of Computer Science, University of Leipzig Härtelstrasse 16 18, D 04107 Leipzig, Germany
    Bioinformatics 22:731-8. 2006
  10. pmc Modeling the influence of the E-cadherin-beta-catenin pathway in cancer cell invasion: a multiscale approach
    Ignacio Ramis-Conde
    French National Institute for Research in Computer Science and Control INRIA, Domaine de Voluceau Rocquencourt, Le Chesnay, France
    Biophys J 95:155-65. 2008

Detail Information

Publications10

  1. ncbi request reprint A single-cell-based model of tumor growth in vitro: monolayers and spheroids
    Dirk Drasdo
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Phys Biol 2:133-47. 2005
    ..Based on our findings we propose a phenomenological growth law in early expansion phases in which specific biological small-scale processes are subsumed in a small number of effective parameters...
  2. ncbi request reprint Mathematical modelling of liver regeneration after intoxication with CCl(4)
    Stefan Höhme
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Chem Biol Interact 168:74-93. 2007
    ....
  3. pmc Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
    Stefan Hoehme
    Interdisciplinary Centre for Bioinformatics IZBI, University of Leipzig, Härtelstrasse 16 18, D 04107 Leipzig, Germany
    Proc Natl Acad Sci U S A 107:10371-6. 2010
    ..The results of this analysis clearly confirmed the model prediction. We believe our procedure is widely applicable in the systems biology of tissues...
  4. pmc A cell-based simulation software for multi-cellular systems
    Stefan Hoehme
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Germany
    Bioinformatics 26:2641-2. 2010
    ..0 support. All cell and environment parameters can be independently varied which facilitates species specific simulations and allows for detailed analyses of growth dynamics and links between cellular and multi-cellular phenotypes...
  5. pmc Individual fates of mesenchymal stem cells in vitro
    Axel Krinner
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Haertelstr, 16 18, 04107 Leipzig, Germany
    BMC Syst Biol 4:73. 2010
    ..Here, we study MSC plasticity on the level of individual cells applying a multi-scale computer model that is based on the concept of noise-driven stem cell differentiation...
  6. doi request reprint TiQuant: software for tissue analysis, quantification and surface reconstruction
    Adrian Friebel
    Interdisciplinary Centre for Bioinformatics IZBI, University of Leipzig, Germany
    Bioinformatics 31:3234-6. 2015
    ..TiQuant implements a novel method for the reconstruction of three-dimensional surfaces of biological systems, data that often cannot be obtained experimentally but which is of utmost importance for tissue modelling in systems biology...
  7. ncbi request reprint Shape characterization of extracted and simulated tumor samples using topological and geometric measures
    Markus Rohrschneider
    Image and Signal Processing Group, University of Leipzig, Germany
    Conf Proc IEEE Eng Med Biol Soc 2007:6272-8. 2007
    ..We further illustrate how these geometric and topological properties can be used for a quantitative comparison of histological material and single-cell-based tumor growth simulations...
  8. pmc Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations in vitro
    Jörg Galle
    Interdisciplinary Centre for Bioinformatics, Leipzig, Germany
    Biophys J 88:62-75. 2005
    ..We compare our simulation results with experimental findings on a number of epithelial and tumor cell populations and suggest in vitro experiments to test our model predictions...
  9. ncbi request reprint Gene network inference from incomplete expression data: transcriptional control of hematopoietic commitment
    Kristin Missal
    Bioinformatics Group, Department of Computer Science, University of Leipzig Härtelstrasse 16 18, D 04107 Leipzig, Germany
    Bioinformatics 22:731-8. 2006
    ..However, owing to experimental limitations a complete determination of the precursor state is not possible...
  10. pmc Modeling the influence of the E-cadherin-beta-catenin pathway in cancer cell invasion: a multiscale approach
    Ignacio Ramis-Conde
    French National Institute for Research in Computer Science and Control INRIA, Domaine de Voluceau Rocquencourt, Le Chesnay, France
    Biophys J 95:155-65. 2008
    ..Implications for cell migration and cancer invasion are also discussed...