Andreas Dietz

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Exposure to cement dust, related occupational groups and laryngeal cancer risk: results of a population based case-control study
    Andreas Dietz
    Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Int J Cancer 108:907-11. 2004
  2. ncbi request reprint Prognostic relevance of serum levels of the angiogenic peptide bFGF in advanced carcinoma of the head and neck treated by primary radiochemotherapy
    A Dietz
    Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Head Neck 22:666-73. 2000
  3. ncbi request reprint [Diagnosis with (18)F-FDG PET scan after larynx preservation by primary radiochemotherapy]
    A Dietz
    Hals Nasen Ohren Universitätsklinik Heidelberg, Heidelberg
    HNO 52:38-44. 2004
  4. ncbi request reprint [Gene therapy with p53 tumor suppressors]
    A Dietz
    Hals Nasen Ohren Universitätsklinik Heidelberg
    HNO 51:365-8. 2003
  5. ncbi request reprint Prognostic impact of reoxygenation in advanced cancer of the head and neck during the initial course of chemoradiation or radiotherapy alone
    Andreas Dietz
    Department of Otolaryngology, Head and Neck Surgery, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Head Neck 25:50-8. 2003
  6. ncbi request reprint [Laryngeal carcinoma--a question of personal susceptibility]
    A Dietz
    Universitäts Hals Nasen Ohrenklinik Im Neuenheimer Feld 400, 69120 Heidelberg
    HNO 50:105-8. 2002
  7. ncbi request reprint Effectiveness of a new perforated 0.15 mm poly-p-dioxanon-foil versus titanium-dynamic mesh in reconstruction of the orbital floor
    A Dietz
    Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Germany
    J Craniomaxillofac Surg 29:82-8. 2001
  8. ncbi request reprint [Prognostic value of hemoglobin level for primary radiochemotherapy of head-neck carcinomas]
    A Dietz
    Hals Nasen Ohren Universitätsklinik Heidelberg
    HNO 48:655-64. 2000
  9. doi request reprint Heterogeneity of epithelial and stromal cells of head and neck squamous cell carcinomas in ex vivo chemoresponse
    Iris Susanne Horn
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Leipzig, Liebigstrasse 10 14, 04103, Leipzig, Germany
    Cancer Chemother Pharmacol 65:1153-63. 2010
  10. doi request reprint Assay-based response evaluation in head and neck oncology: requirements for better decision making
    Andreas Dietz
    Department of Otolaryngology, Head and Neck Surgery, University Clinic of Leipzig, Leipzig, Germany
    Eur Arch Otorhinolaryngol 267:483-94. 2010

Detail Information

Publications61

  1. ncbi request reprint Exposure to cement dust, related occupational groups and laryngeal cancer risk: results of a population based case-control study
    Andreas Dietz
    Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Int J Cancer 108:907-11. 2004
    ..We conclude that there is good evidence for cement dust exposure acting as a tobacco, alcohol and asbestos independent risk factor for laryngeal carcinoma. Our study gives a base for further toxicologic investigations on this topic...
  2. ncbi request reprint Prognostic relevance of serum levels of the angiogenic peptide bFGF in advanced carcinoma of the head and neck treated by primary radiochemotherapy
    A Dietz
    Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Head Neck 22:666-73. 2000
    ....
  3. ncbi request reprint [Diagnosis with (18)F-FDG PET scan after larynx preservation by primary radiochemotherapy]
    A Dietz
    Hals Nasen Ohren Universitätsklinik Heidelberg, Heidelberg
    HNO 52:38-44. 2004
    ..i.) following iterative reconstruction. Additional (18)F-FDG-PET investigations were done and correlated with the clinical outcome in 16/20 patients at 3 months and in 14/20 patients at 6 months after the end of therapy...
  4. ncbi request reprint [Gene therapy with p53 tumor suppressors]
    A Dietz
    Hals Nasen Ohren Universitätsklinik Heidelberg
    HNO 51:365-8. 2003
  5. ncbi request reprint Prognostic impact of reoxygenation in advanced cancer of the head and neck during the initial course of chemoradiation or radiotherapy alone
    Andreas Dietz
    Department of Otolaryngology, Head and Neck Surgery, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Head Neck 25:50-8. 2003
    ....
  6. ncbi request reprint [Laryngeal carcinoma--a question of personal susceptibility]
    A Dietz
    Universitäts Hals Nasen Ohrenklinik Im Neuenheimer Feld 400, 69120 Heidelberg
    HNO 50:105-8. 2002
  7. ncbi request reprint Effectiveness of a new perforated 0.15 mm poly-p-dioxanon-foil versus titanium-dynamic mesh in reconstruction of the orbital floor
    A Dietz
    Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Germany
    J Craniomaxillofac Surg 29:82-8. 2001
    ..The main aim of this clinical trial is to compare this new PDS foil with titanium dynamic mesh (0.3 mm) (TD), which is well established in reconstruction of the orbital floor...
  8. ncbi request reprint [Prognostic value of hemoglobin level for primary radiochemotherapy of head-neck carcinomas]
    A Dietz
    Hals Nasen Ohren Universitätsklinik Heidelberg
    HNO 48:655-64. 2000
    ..We propose to test this in randomized clinical trials...
  9. doi request reprint Heterogeneity of epithelial and stromal cells of head and neck squamous cell carcinomas in ex vivo chemoresponse
    Iris Susanne Horn
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Leipzig, Liebigstrasse 10 14, 04103, Leipzig, Germany
    Cancer Chemother Pharmacol 65:1153-63. 2010
    ..Valid prediction of the effectiveness of chemotherapeutic agents in individual head and neck squamous cell carcinoma (HNSCC) is desirable and might be achieved using ex vivo assays...
  10. doi request reprint Assay-based response evaluation in head and neck oncology: requirements for better decision making
    Andreas Dietz
    Department of Otolaryngology, Head and Neck Surgery, University Clinic of Leipzig, Leipzig, Germany
    Eur Arch Otorhinolaryngol 267:483-94. 2010
    ..To this end, essential needs and hints are addressed and discussed...
  11. ncbi request reprint Hedgehog targeting by cyclopamine suppresses head and neck squamous cell carcinoma and enhances chemotherapeutic effects
    Christian Mozet
    Department of Otolaryngology, University of Leipzig, Leipzig, Germany
    Anticancer Res 33:2415-24. 2013
    ..In head and neck squamous cell carcinomas (HNSCC), Hh overexpression was associated with poor prognosis. Therefore, we analyzed the effect of Hh signaling blockade with cyclopamine on colony formation of cells from HNSCC samples...
  12. ncbi request reprint Occupation, exposure to polycyclic aromatic hydrocarbons and laryngeal cancer risk
    Heiko Becher
    Department of Tropical Hygiene and Public Health, University of Heidelberg, Germany
    Int J Cancer 116:451-7. 2005
    ..Our study contributes to classifying polycyclic aromatic hydrocarbons as a risk factor for laryngeal cancer...
  13. doi request reprint Simvastatin suppresses head and neck squamous cell carcinoma ex vivo and enhances the cytostatic effects of chemotherapeutics
    Matthaeus Stoehr
    Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Liebigstrasse 10 14, 04103, Leipzig, Germany
    Cancer Chemother Pharmacol 73:827-37. 2014
    ..Possible additive or synergistic effects of Sim combinations with established chemotherapeutics are determined as well...
  14. doi request reprint Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes
    Rashda Abbasi
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:1431-9. 2009
    ..1-fold. SNPs in the other genes did not show a significant association with laryngeal cancer risk. We conclude that common genetic variations in NER genes can significantly modify laryngeal cancer risk...
  15. ncbi request reprint Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1
    Angela Risch
    Division of Toxicology and Cancer Risk Factors German Cancer Research Center DKFZ, Heidelberg, Germany
    Pharmacogenetics 13:225-30. 2003
    ..As part of the Rhein-Neckar Larynx-case-control study, this study investigated the potential risk-modifying effect of genetic polymorphisms in enzymes involved in ethanol and tobacco carcinogen metabolism for laryngeal cancer in Germany...
  16. doi request reprint Long-term results of a prospective multicenter phase II study to preserve the larynx function using concomitant boost radiochemotherapy with Carboplatin
    Volker Rudat
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Radiother Oncol 89:33-7. 2008
    ..This prospective phase II study was undertaken to assess the feasibility of a larynx preservation protocol with simultaneous radiochemotherapy...
  17. doi request reprint Proteomic analysis of field cancerization in pharynx and oesophagus: a prospective pilot study
    Mariana Roesch-Ely
    Molecular Biology Laboratory, Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, INF 400, Heidelberg, Germany
    J Pathol 221:462-70. 2010
    ..007, log-rank test). Protein profiles of small diagnostic biopsies hold great promise to improve personalized risk assessment in HNSCC. Larger studies are needed to further substantiate these findings...
  18. doi request reprint Occupational wood dust exposure and the risk of laryngeal cancer: a population based case-control study in Germany
    Heribert Ramroth
    Department of Tropical Hygiene and Public Health, University of Heidelberg, Heidelberg, Germany
    Am J Ind Med 51:648-55. 2008
    ..To investigate the effect of exposure to wood dust on the risk of laryngeal cancer...
  19. ncbi request reprint Head and neck tumor sites differ in prevalence and spectrum of p53 alterations but these have limited prognostic value
    Franz X Bosch
    Molekularbiologisches Labor, Universitäts HNO Klinik, Heidelberg, Germany
    Int J Cancer 111:530-8. 2004
    ..The large patient cohort of this study showed that p53 is differentially affected in the different tumor sites of the head and neck, but its mode of inactivation does not play a major role in tumor progression...
  20. pmc Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients
    Efterpi Kostareli
    a Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Epigenetics 11:61-73. 2016
    ..15, 95% CI [1.36-3.41], P = 0.001). In summary, the MS and the MMSS exhibit an excellent performance as prognosticators for survival, which is not limited by the anatomical site, and both could be implemented in future clinical trials. ..
  21. pmc HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas
    Efterpi Kostareli
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, Germany
    J Clin Invest 123:2488-501. 2013
    ..In summary, our study highlights specific alterations in global gene promoter methylation in HPV-driven OPSCCs and identifies a signature that predicts the clinical outcome in OPSCCs...
  22. pmc Occupation and educational inequalities in laryngeal cancer: the use of a job index
    Irene Santi
    Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    BMC Public Health 13:1080. 2013
    ..The aim of this study was to evaluate the role of occupation using different occupational indices, differentiating between physical, psycho-social and toxic exposures and trying to summarize the occupational burden into one variable...
  23. doi request reprint Occupational asbestos exposure as a risk factor for laryngeal carcinoma in a population-based case-control study from Germany
    Heribert Ramroth
    Institute of Public Health, University of Heidelberg, Germany
    Am J Ind Med 54:510-4. 2011
    ..As several studies have identified asbestos exposure as an independent occupational risk factor for laryngeal cancer, the aim of our study was to confirm this association...
  24. doi request reprint Current aspects of targeted therapy in head and neck tumors
    Andreas Dietz
    Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany
    Eur Arch Otorhinolaryngol 265:S3-12. 2008
    ....
  25. doi request reprint Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced laryngeal and hypopharyngeal cancer offers moderate late toxicity outcome (DeLOS-I-trial)
    Andreas Dietz
    Department of Otolaryngology, University of Leipzig, Germany
    Eur Arch Otorhinolaryngol 266:1291-300. 2009
    ..Due to a slight increase of relevant late dysphagia, functional outcome regarding swallowing and tracheotomy free breathing should be more focused in future larynx organ preservation trials...
  26. ncbi request reprint Combined effects of lapatinib and cisplatin on colony formation of head and neck squamous cell carcinoma
    Christoph Schrader
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Leipzig, Germany
    Anticancer Res 32:3191-9. 2012
    ..We studied combined effects of lapatinib and cisplatin on colony formation (CF) of epithelial cells of individual HNSCC in short term ex vivo assays...
  27. pmc Intensity and inhalation of smoking in the aetiology of laryngeal cancer
    Heribert Ramroth
    Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Int J Environ Res Public Health 8:976-84. 2011
    ..Changing inhalation habits might be considered as a first step to reducing the risk of developing laryngeal cancer. However, the best way to effectively reduce laryngeal cancer risk is to quit smoking...
  28. doi request reprint Nitric oxide synthase (NOS2/3) expression in head and neck squamous cell carcinomas in correlation with clinical patterns
    Christian Mozet
    Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Germany
    Onkologie 32:655-60. 2009
    ....
  29. ncbi request reprint Reduced poly(ADP-ribosyl)ation in lymphocytes of laryngeal cancer patients: results of a case-control study
    Nahid Rajaee-Behbahani
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 98:780-4. 2002
    ..Our results suggest that a reduced capacity of somatic cells to synthesize poly(ADP-ribose) might be associated with an increased risk for laryngeal cancer. The underlying mechanism remains to be investigated...
  30. ncbi request reprint Pretreatment evaluation of carcinomas of the hypopharynx and larynx with 18F-fluorodeoxyglucose, 123I-alpha-methyl-L-tyrosine and 99mTc-hexakis-2-methoxyisobutylisonitrile
    Marcus Henze
    Department of Nuclear Medicine, University of Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 29:324-30. 2002
    ..IMT SPET was clearly superior to MIBI SPET in this population. A further evaluation of the specificity of IMT in a larger number of patients appears justified...
  31. doi request reprint Single tissue samples from head and neck squamous cell carcinomas are representative regarding the entire tumor's chemosensitivity to cisplatin and docetaxel
    Gunnar Wichmann
    Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Liebigstrasse 26, Leipzig, Germany
    Onkologie 32:264-72. 2009
    ..Questionable so far was whether tissue samples of about 100 mg correctly reflect the chemoresponse of a whole HNSCC. This was proven using an ex-vivo colony-forming assay...
  32. ncbi request reprint Transcript and proteome analysis reveals reduced expression of calgranulins in head and neck squamous cell carcinoma
    Mariana Roesch Ely
    Molecular Biology Laboratory, Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, INF 400, Heidelberg D 69120, Germany
    Eur J Cell Biol 84:431-44. 2005
    ..These observations suggest that the normal function of the calgranulins A and B in mucosa might be different from that in skin...
  33. doi request reprint Reduced proliferation and colony formation of head and neck squamous cell carcinoma (HNSCC) after dual targeting of EGFR and hedgehog pathways
    Hannes Liebig
    ENT Research Laboratory, Clinic for Otorhinolaryngology, Head and Neck Surgery, University Hospital Leipzig, Liebigstraße 21, Liebigstr 10 14, 04103, Leipzig, Germany
    Cancer Chemother Pharmacol . 2017
    ..Overexpressed Hh associates with poor prognosis. The Hh inhibitor vismodegib targets smoothened, and based on molecular data, may prevent resistance to EGFR targeting...
  34. doi request reprint To what degree is the association between educational inequality and laryngeal cancer explained by smoking, alcohol consumption, and occupational exposure?
    Irene Santi
    Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Scand J Work Environ Health 40:315-22. 2014
    ..The aim of this study was to measure the extent to which the association between socioeconomic status and laryngeal cancer among males is mediated by smoking, alcohol consumption, and occupational exposure...
  35. doi request reprint Overexpression of the Hedgehog signalling pathway in head and neck squamous cell carcinoma
    Kamelia Dimitrova
    Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Germany
    Onkologie 36:279-86. 2013
    ..HH signalling blockade reduces tumour growth in vitro and in vivo. We aimed to determine whether head and neck squamous cell carcinomas (HNSCCs) express HH proteins in comparison to healthy mucosa...
  36. doi request reprint Factors predicting survival after diagnosis of laryngeal cancer
    Heribert Ramroth
    Institute of Public Health, University of Heidelberg, Germany
    Oral Oncol 47:1154-8. 2011
    ..For future research it would be desirable to study the effect of treatment on quality of life in multivariate analysis as well as other modifiable risk factors as smoking and drinking reduction or cessation after diagnosis...
  37. doi request reprint Different immunomodulatory effects associated with sub-micrometer particles in ambient air from rural, urban and industrial areas
    Gunnar Wichmann
    Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Liebigstrasse 26, D 04103 Leipzig, Germany
    Toxicology 257:127-36. 2009
    ..5)-adsorbed chemicals provoke different effects on immune responses and shifts in the regulatory balance that might have implications for allergy and cancer development...
  38. doi request reprint Environmental tobacco smoke and laryngeal cancer: results from a population-based case-control study
    Heribert Ramroth
    Department of Tropical Hygiene and Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Eur Arch Otorhinolaryngol 265:1367-71. 2008
    ..Our findings are in line with the hypothesis that ETS increases the risk of laryngeal cancer. Meta-analyses based on subgroups of nonsmokers from earlier studies are warranted to confirm our findings...
  39. doi request reprint Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis
    Elisabeth Rudolph
    Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany
    Eur Arch Otorhinolaryngol 268:165-79. 2011
    ..7-64.7%). Different study aims and patient selection criteria prohibit general conclusions. However, this review may provide an actual picture of the complexity of factors influencing the survival of laryngeal cancer patients...
  40. doi request reprint Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: Outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry
    Gunnar Wichmann
    Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Germany Electronic address
    Eur J Cancer 72:144-155. 2016
    ..A score facilitating decision-making after 1 cycle induction chemotherapy (IC-1) may improve LFS and TSS...
  41. doi request reprint Association of history of allergies and influenza-like infections with laryngeal cancer in a case-control study
    Filippos T Filippidis
    Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany
    Eur Arch Otorhinolaryngol 272:2063-9. 2015
    ....
  42. ncbi request reprint Stimulation by Monocyte Chemoattractant Protein-1 Modulates the Ex-vivo Colony Formation by Head and Neck Squamous Cell Carcinoma Cells
    Gunnar Wichmann
    Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany
    Anticancer Res 35:3917-24. 2015
    ....
  43. ncbi request reprint The impact of stromal cell contamination on chemosensitivity testing of head and neck carcinoma
    Ralph Dollner
    Department of Otorhinolaryngology, Head and Neck Surgery, Institute of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
    Anticancer Res 24:325-31. 2004
    ....
  44. ncbi request reprint p53-positive tumor-distant squamous epithelia of the head and neck reveal selective loss of chromosome 17
    Christina Wolf
    Molecular Biology Laboratory, Department of Otorhinolaryngology, University Hospital, School of Medicine, Heidelberg, Germany
    Laryngoscope 114:698-704. 2004
    ..The objective was to investigate whether chromosomal aberrations can be detected in tumor-distant mucosa and whether they can help predict the risk of second primary malignancy...
  45. doi request reprint Pharmacotherapy for squamous-cell carcinoma of the head and neck
    Giorgos Papaspyrou
    Philipp University Marburg, Department of Otolaryngology, Head and Neck Surgery, Deutschhausstrasse 3, 35037 Marburg, Germany
    Expert Opin Pharmacother 12:397-409. 2011
    ..squamous-cell carcinoma of the head and neck (HNSCC) is one of the most common malignancies, the treatment of which constitutes a therapeutic challenge...
  46. pmc Integrated Multipoint-Laser Endoscopic Airway Measurements by Transoral Approach
    Marie Neitsch
    Clinic of Otolaryngology, Head and Neck Surgery, Department of Head Medicine and Oral Health, University Hospital Leipzig, Liebigstrasse 12, 04103 Leipzig, Germany
    Biomed Res Int 2016:6838697. 2016
    ..So far no standardized method for endoscopic distance measurement is available. The aim of this study was to evaluate the feasibility and accuracy of transoral airway measurements with a multipoint-laser endoscope...
  47. ncbi request reprint SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition
    Anette Weber
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Leipzig, Germany
    Oncogene 24:6699-708. 2005
    ..During its involvement in tumor growth, restoration of SOCS-3 may hold treatment potential for HNSCC...
  48. pmc Head and neck cancer: effective prevention in youth and predictive diagnostics for personalised treatment strategies according to biological differences
    Andreas Dietz
    Department of Otolaryngology, Head and Neck Surgery, University Clinic of Leipzig, Leipzig, Germany Klinik und Poliklinik für Hals, Nasen, Ohrenheilkunde Plastische Operationen, Universitat Leipzig, Liebigstrasse 10 14, Leipzig, 04103 Germany
    EPMA J 2:241-9. 2011
    ..Vaccination against HPV infection in children plays an increasing role in prevention strategies and probably also reduces the oncogenic risk for HNSCC...
  49. doi request reprint Use of Floseal and effects on wound healing and pain in adults undergoing tonsillectomy: randomised comparison versus electrocautery
    Christian Mozet
    Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Liebigstrasse 10 14, 04103 Leipzig, Germany
    Eur Arch Otorhinolaryngol 269:2247-54. 2012
    ..Furthermore, FS is associated with a significantly shortened duration of pain-medication use and overall reduction in consumption/demand...
  50. pmc Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors
    Volker Rudat
    Department of Radiation Oncology, University of Heidelberg, Heidelberg 69120, Germany
    J Oncol 2012:391917. 2012
    ..19). Conclusions. The TTV was the predominant prognostic factor for both, patients treated with definitive or postoperative radiotherapy...
  51. ncbi request reprint Efficacy of intensified hyperfractionated and accelerated radiotherapy and concurrent chemotherapy with carboplatin and 5-fluorouracil: updated results of a randomized multicentric trial in advanced head-and-neck cancer
    Robert Semrau
    Department of Radiation Oncology, University of Cologne, Cologne, Germany
    Int J Radiat Oncol Biol Phys 64:1308-16. 2006
    ..In a subgroup analysis the influence of pretherapeutical hemoglobin level (p-Hb) on survival under locoregional control (SLC) was tested...
  52. ncbi request reprint Ex vivo responsiveness of head and neck squamous cell carcinoma to glufosfamide, a novel alkylating agent
    Ralph Dollner
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Gernany
    Anticancer Res 24:2947-51. 2004
    ..The present study investigates the ex vivo responsiveness of Head and Neck Squamous Cell Carcinoma (HNSCC) specimens to glufosfamide...
  53. ncbi request reprint Ex vivo chemosensitivity of head and neck carcinoma to cytostatic drug combinations
    Ralph Dollner
    Klinik und Poliklinik Fur Hals, Nasen, Ohrenheilkunde Plastische Operationen der Universität Leipzig, Leipzig, Germany
    Anticancer Res 26:1651-5. 2006
    ....
  54. ncbi request reprint Quality of life correlates after surgery for laryngeal carcinoma
    Julian Bindewald
    Department of Social Medicine, University of Leipzig, Leipzig, Germany
    Laryngoscope 117:1770-6. 2007
    ..To assess the correlation of operation mode, postoperative radiotherapy, and disease stage factors with the health-related quality of life (HRQL) measures after surgery for laryngeal carcinoma...
  55. ncbi request reprint Ex vivo responsiveness of head and neck squamous cell carcinoma to vinorelbine
    Ralph Dollner
    Klinik und Poliklinik Fur Hals, Nasen, Ohrenheilkunde Plastische Operationen der Universität Leipzig, Leipzig, Germany
    Anticancer Res 26:2361-5. 2006
    ..To predict the individual chemoresponse, the application of an ex vivo assay to quantify the response of HNSCC to vinorelbine is presented...
  56. ncbi request reprint Psychosocial determinants of successful voice rehabilitation after laryngectomy
    Susanne Singer
    Department of Social Medicine, University of Leipzig, Leipzig, Germany
    J Chin Med Assoc 70:407-23. 2007
    ..Clinicians should be careful about considering their patients to be "unmotivated" if the rehabilitation fails; instead, they should encourage them to communicate actively and take part in social activities...
  57. ncbi request reprint Protein microarrays for the detection of biomarkers in head and neck squamous cell carcinomas
    Anette Weber
    Department of ENT, University of Leipzig, 04103 Leipzig, Germany
    Hum Pathol 38:228-38. 2007
    ..These data indicate that our protein arrays provide protein information in a systematic, reproducible, and also high-throughput fashion...
  58. ncbi request reprint Requirement specification for surgical simulation systems with surgical workflows
    Oliver Burgert
    Innovation Center Computer Assisted Surgery ICCAS, Universitat Leipzig, Germany
    Stud Health Technol Inform 125:58-63. 2007
    ..We are currently using this method for the design of a new simulator for transnasal neurosurgery with good success...
  59. ncbi request reprint Screening for mental disorders in laryngeal cancer patients: a comparison of 6 methods
    Susanne Singer
    Department of Social Medicine, University of Leipzig, Germany
    Psychooncology 17:280-6. 2008
    ..The aim of this study was to determine how accurate mental distress screening instruments are in identifying psychological sequelae in ambulatory laryngeal cancer patients who have undergone surgery...
  60. ncbi request reprint [ElePhant: an anatomic-electronic simulation system for the evaluation of computer assisted interventions and surgical education]
    Hendrik Möckel
    Innovation Center Computer Assisted Surgery ICCAS, Universitat Leipzig, Leipzig, Deutschland
    Biomed Tech (Berl) 52:375-82. 2007
    ..Techniques are necessary for an objective detection of injuries to the structures at risk. The aim of this study was the technical realization of a simulation system for the ENT intervention, mastoidectomy...
  61. ncbi request reprint Surgical PACS for the digital operating room. Systems engineering and specification of user requirements
    Werner Korb
    Innovation Center Computer Assisted Surgery, Leipzig, Germany
    Stud Health Technol Inform 119:267-72. 2006
    ..The properties of QFD for the underlying problem and first results are discussed. Finally, this leads to a first definition of an S-PACS system...