Philipp Diehl

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint Enhanced microparticles in ventricular assist device patients predict platelet, leukocyte and endothelial cell activation
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Interact Cardiovasc Thorac Surg 11:133-7. 2010
  2. ncbi request reprint [The role of microparticles in vascular diseases]
    P Diehl
    Abteilung für Innere Medizin III, Kardiologie und Angiologie, Medizinische Universitatsklinik, Hugstetter Strasse 55, Freiburg
    Hamostaseologie 28:203-6. 2008
  3. doi request reprint Discontinuation of long term clopidogrel therapy induces platelet rebound hyperaggregability between 2 and 6 weeks post cessation
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Clin Res Cardiol 100:765-71. 2011
  4. doi request reprint Increased platelet, leukocyte and endothelial microparticles predict enhanced coagulation and vascular inflammation in pulmonary hypertension
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Thromb Thrombolysis 31:173-9. 2011
  5. doi request reprint Increased levels of circulating microparticles in patients with severe aortic valve stenosis
    Philipp Diehl
    Dept for Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, D 79106 Freiburg, Germany
    Thromb Haemost 99:711-9. 2008
  6. doi request reprint Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, 79106 Freiburg, Germany
    Basic Res Cardiol 105:379-87. 2010
  7. pmc BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1
    Thomas Helbing
    Department for Cardiology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Arterioscler Thromb Vasc Biol 30:554-60. 2010
  8. doi request reprint A high ratio of ADP-TRAP induced platelet aggregation is associated more strongly with increased mortality after coronary stent implantation than high conventional ADP induced aggregation alone
    Christoph B Olivier
    Cardiology and Angiology I, Heart Center Freiburg University, Hugstetter Str 55, 79106, Freiburg, Germany
    Clin Res Cardiol 103:968-75. 2014
  9. doi request reprint High platelet reactivity after P2Y12-inhibition in patients with atrial fibrillation and coronary stenting
    Jonathan Rilinger
    Cardiology and Angiology I, Heart Center, Freiburg University, Hugstetter Str 55, 79106, Freiburg, Germany
    J Thromb Thrombolysis 42:558-65. 2016
  10. pmc Krüppel-like factor 15 regulates BMPER in endothelial cells
    Thomas Helbing
    Department of Cardiology, University of Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    Cardiovasc Res 85:551-9. 2010

Collaborators

  • Martin Moser
  • Katrin Fink
  • Stephan Sorichter
  • Andreas Zirlik
  • C Bode
  • T Grumann
  • Thomas Helbing
  • Christoph B Olivier
  • Qian Zhou
  • Patrick Weik
  • Katharina Schnabel
  • Cam Patterson
  • Jennifer S Esser
  • Jonathan Rilinger
  • Jennifer Heinke
  • Elena Z Brauers
  • Linus Arnold
  • Gwendoline Wiltgen
  • Melanie Meyer
  • Anne Charlet
  • Sebastian Grundmann
  • Alexandra Hornstein
  • Adrian Bauer
  • Manfred Olschewski
  • Christoph Brandt
  • René Rothweiler
  • Lena Goetz
  • Franziska Volkmar
  • Ulrich Goebel
  • Heike L Pahl

Detail Information

Publications13

  1. doi request reprint Enhanced microparticles in ventricular assist device patients predict platelet, leukocyte and endothelial cell activation
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Interact Cardiovasc Thorac Surg 11:133-7. 2010
    ....
  2. ncbi request reprint [The role of microparticles in vascular diseases]
    P Diehl
    Abteilung für Innere Medizin III, Kardiologie und Angiologie, Medizinische Universitatsklinik, Hugstetter Strasse 55, Freiburg
    Hamostaseologie 28:203-6. 2008
    ..They are detectable in many acute and chronic vascular diseases as a surrogate marker for disease activity but also play a role in the pathophysiology of vascular diseases...
  3. doi request reprint Discontinuation of long term clopidogrel therapy induces platelet rebound hyperaggregability between 2 and 6 weeks post cessation
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Clin Res Cardiol 100:765-71. 2011
    ..Stent thrombosis occurs frequently within the first weeks after cessation of longterm clopidogrel therapy. We investigated if rebound platelet hyperreactivity occurs to provide a mechanism for this clinical observation...
  4. doi request reprint Increased platelet, leukocyte and endothelial microparticles predict enhanced coagulation and vascular inflammation in pulmonary hypertension
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Thromb Thrombolysis 31:173-9. 2011
    ..02). PH patients have increased levels of platelet-, leukocyte- and endothelial MP indicating an increased vascular pro-coagulation and inflammation which might be related to thrombo-embolic complications as well as PH progression...
  5. doi request reprint Increased levels of circulating microparticles in patients with severe aortic valve stenosis
    Philipp Diehl
    Dept for Cardiology and Angiology, University Hospital Freiburg, Hugstetterstr 55, D 79106 Freiburg, Germany
    Thromb Haemost 99:711-9. 2008
    ....
  6. doi request reprint Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes
    Philipp Diehl
    Department of Cardiology and Angiology, University Hospital Freiburg, 79106 Freiburg, Germany
    Basic Res Cardiol 105:379-87. 2010
    ..This interaction is abolished by clopidogrel. Therefore, clopidogrel may act directly on leukocytes via the P2Y(12) receptor. (2) Clopidogrel may be under dosed in obese patients...
  7. pmc BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1
    Thomas Helbing
    Department for Cardiology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Arterioscler Thromb Vasc Biol 30:554-60. 2010
    ..We set out to investigate the effect of statins on BMP endothelial cell precursor-derived regulator (BMPER), a novel member of the BMP pathway...
  8. doi request reprint A high ratio of ADP-TRAP induced platelet aggregation is associated more strongly with increased mortality after coronary stent implantation than high conventional ADP induced aggregation alone
    Christoph B Olivier
    Cardiology and Angiology I, Heart Center Freiburg University, Hugstetter Str 55, 79106, Freiburg, Germany
    Clin Res Cardiol 103:968-75. 2014
    ..This study aimed to evaluate whether a high relative ADP induced aggregation (r-ADP-agg) is associated with an increased mortality in patients after coronary stent implantation...
  9. doi request reprint High platelet reactivity after P2Y12-inhibition in patients with atrial fibrillation and coronary stenting
    Jonathan Rilinger
    Cardiology and Angiology I, Heart Center, Freiburg University, Hugstetter Str 55, 79106, Freiburg, Germany
    J Thromb Thrombolysis 42:558-65. 2016
    ..Future studies will need to investigate if patients with AF receiving coronary stenting benefit from a reduction of antithrombotic therapy. ..
  10. pmc Krüppel-like factor 15 regulates BMPER in endothelial cells
    Thomas Helbing
    Department of Cardiology, University of Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    Cardiovasc Res 85:551-9. 2010
    ..BMPER is a key regulator of BMP4 activity and a prerequisite for BMP pathway activation by BMP4 in endothelial cells. Here, we characterize the BMPER promoter and elucidate mechanisms of BMPER regulation...
  11. ncbi request reprint [Is stent thrombosis the new Achilles heel of interventional cardiology? State of the Art clinical trials, causes and approaches for prevention]
    T Grumann
    Abteilung III für Kardiologie und Angiologie, Medizinische Universititäsklinik, Hugstetterstrasse 55, 79106 Freiburg
    Hamostaseologie 27:344-50. 2007
    ..Therefore, individual determination of platelet function in each patient undergoing stent implantation may help to avoid prothrombotic as well as bleeding complications...
  12. doi request reprint Third generation P2Y12 antagonists inhibit platelet aggregation more effectively than clopidogrel in a myocardial infarction registry
    Christoph B Olivier
    Christoph Olivier, MD, Cardiology and Angiology I, Heart Center, Freiburg University, Hugstetter Str 55, 79106 Freiburg, Germany, Tel 49 761 270 34410, E mail
    Thromb Haemost 111:266-72. 2014
    ..No significant difference in platelet inhibition was detected between prasugrel and ticagrelor. (registry for patients after Myocardial Infarction Treated with AntiPlatelet agents; DRKS00003146)...
  13. ncbi request reprint Bone Morphogenetic Protein-Modulator BMPER Regulates Endothelial Barrier Function
    Thomas Helbing
    Department of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany
    Inflammation . 2016
    ..Taken together, this data demonstrates that BMPER-modulated BMP pathway activity regulates VE-cadherin expression and vascular barrier function...