Chi Un Choe

Summary

Affiliation: University Medical Center Hamburg-Eppendorf
Country: Germany

Publications

  1. doi request reprint Differential regulation of AMPK activation in leptin- and creatine-deficient mice
    Malte Stockebrand
    1Experimental Neuropediatrics, Center for Molecular Neurobiology and Department of Pediatrics, University Medical Center Hamburg Eppendorf, Falkenried 94, 20251 Hamburg, Germany
    FASEB J 27:4147-56. 2013
  2. doi request reprint A clinical and neurobiological case of IgM NMDA receptor antibody associated encephalitis mimicking bipolar disorder
    Chi Un Choe
    Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20253 Hamburg, Germany
    Psychiatry Res 208:194-6. 2013
  3. pmc CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia
    Chi Un Choe
    Department of Neurology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e19046. 2011
  4. doi request reprint Temporal and spatial dynamics of cerebral immune cell accumulation in stroke
    Mathias Gelderblom
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Stroke 40:1849-57. 2009
  5. doi request reprint Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies
    Chi Un Choe
    Departments of Neurology C C, O S, C G, T M, Experimental Neuropediatrics C C, M S, D I, Department of Clinical Pharmacology and Toxicology D A, R H B, N L, R A B, E S, and German Center for Cardiovascular Research D A, P S W, R H B, S B, T Z, E S, Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany F O, C M, S Baldus, S Blankenberg, T Z Department of Clinical Chemistry, University Medical Center Hamburg Eppendorf, Hamburg, Germany T S Department of Cardiology and Angiology P S W, Gutenberg Health Study P S W, and Department of Clinical Chemistry K L, Johannes Gutenberg University, Mainz, National University of Singapore
    Circulation 128:1451-61. 2013
  6. pmc Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke
    Frank Leypoldt
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 4:e7337. 2009
  7. doi request reprint Nitroxyl in the central nervous system
    Chi Un Choe
    Department of Neurology, University Hospital Hamburg Eppendorf, Germany
    Antioxid Redox Signal 14:1699-711. 2011
  8. doi request reprint L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome
    Chi Un Choe
    Experimental Neuropediatrics, Center for Molecular Neurobiology and Department of Pediatrics, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Hum Mol Genet 22:110-23. 2013
  9. doi request reprint Measurement of homoarginine in human and mouse plasma by LC-MS/MS and ELISA: a comparison and a biological application
    Kathrin Cordts
    Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Amino Acids 47:2015-22. 2015
  10. doi request reprint Homoarginine and cardiovascular outcome in the population-based Dallas Heart Study
    Dorothee Atzler
    From the Departments of Clinical Pharmacology and Toxicology D A, R H B, E S and Neurology, Experimental Neuropediatrics C U C, University Medical Center Hamburg Eppendorf, Hamburg, Germany DZHK Deutsches Zentrum für Herz Kreislauf Forschung e V, partner site Hamburg Kiel Lübeck, Germany D A, R H B, E S and Division of Cardiology, Department of Internal Medicine M O G, J A d L, D K M and Department of Clinical Sciences C R A, D K M, University of Texas Southwestern Medical Center, Dallas
    Arterioscler Thromb Vasc Biol 34:2501-7. 2014

Collaborators

Detail Information

Publications13

  1. doi request reprint Differential regulation of AMPK activation in leptin- and creatine-deficient mice
    Malte Stockebrand
    1Experimental Neuropediatrics, Center for Molecular Neurobiology and Department of Pediatrics, University Medical Center Hamburg Eppendorf, Falkenried 94, 20251 Hamburg, Germany
    FASEB J 27:4147-56. 2013
    ....
  2. doi request reprint A clinical and neurobiological case of IgM NMDA receptor antibody associated encephalitis mimicking bipolar disorder
    Chi Un Choe
    Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20253 Hamburg, Germany
    Psychiatry Res 208:194-6. 2013
    ..Further clinical and neurobiological studies are needed to study the pathophysiological relevance of IgM NMDAR antibodies. ..
  3. pmc CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia
    Chi Un Choe
    Department of Neurology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e19046. 2011
    ..Therefore, we investigated the dynamics of CD38 in stroke and the impact of CD38-deficiency on cytokine production, inflammation and cerebral damage in a mouse model of cerebral ischemia-reperfusion...
  4. doi request reprint Temporal and spatial dynamics of cerebral immune cell accumulation in stroke
    Mathias Gelderblom
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Stroke 40:1849-57. 2009
    ..The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model...
  5. doi request reprint Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies
    Chi Un Choe
    Departments of Neurology C C, O S, C G, T M, Experimental Neuropediatrics C C, M S, D I, Department of Clinical Pharmacology and Toxicology D A, R H B, N L, R A B, E S, and German Center for Cardiovascular Research D A, P S W, R H B, S B, T Z, E S, Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany F O, C M, S Baldus, S Blankenberg, T Z Department of Clinical Chemistry, University Medical Center Hamburg Eppendorf, Hamburg, Germany T S Department of Cardiology and Angiology P S W, Gutenberg Health Study P S W, and Department of Clinical Chemistry K L, Johannes Gutenberg University, Mainz, National University of Singapore
    Circulation 128:1451-61. 2013
    ..Our studies of human cohorts and a confirmatory murine model associated the arginine homologue homoarginine and its metabolism with stroke pathology and outcome...
  6. pmc Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke
    Frank Leypoldt
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 4:e7337. 2009
    ..ADMA is a predictor of cardiovascular events and mortality in humans. It is eliminated primarily by enzymatic activity of dimethylarginine dimethylaminohydrolase (DDAH)...
  7. doi request reprint Nitroxyl in the central nervous system
    Chi Un Choe
    Department of Neurology, University Hospital Hamburg Eppendorf, Germany
    Antioxid Redox Signal 14:1699-711. 2011
    ....
  8. doi request reprint L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome
    Chi Un Choe
    Experimental Neuropediatrics, Center for Molecular Neurobiology and Department of Pediatrics, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Hum Mol Genet 22:110-23. 2013
    ..In addition to insights into metabolic changes in Cr deficiency syndromes, our genetic model reveals a novel mechanism as a potential treatment option for obesity and type 2 diabetes mellitus...
  9. doi request reprint Measurement of homoarginine in human and mouse plasma by LC-MS/MS and ELISA: a comparison and a biological application
    Kathrin Cordts
    Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Amino Acids 47:2015-22. 2015
    ..Our LC-MS/MS and the commercially available ELISA assay are suitable for hArg measurement in human and mouse plasma, but different reference values for each method need to be considered...
  10. doi request reprint Homoarginine and cardiovascular outcome in the population-based Dallas Heart Study
    Dorothee Atzler
    From the Departments of Clinical Pharmacology and Toxicology D A, R H B, E S and Neurology, Experimental Neuropediatrics C U C, University Medical Center Hamburg Eppendorf, Hamburg, Germany DZHK Deutsches Zentrum für Herz Kreislauf Forschung e V, partner site Hamburg Kiel Lübeck, Germany D A, R H B, E S and Division of Cardiology, Department of Internal Medicine M O G, J A d L, D K M and Department of Clinical Sciences C R A, D K M, University of Texas Southwestern Medical Center, Dallas
    Arterioscler Thromb Vasc Biol 34:2501-7. 2014
    ..This investigation in the population-based Dallas Heart Study (DHS) aimed to evaluate the association of homoarginine with clinical and subclinical cardiovascular outcomes...
  11. doi request reprint L-homoarginine and cardiovascular disease
    Dorothee Atzler
    aInstitute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf bDZHK Deutsches Zentrum für Herz Kreislauf Forschung e V, partner site Hamburg Kiel Lübeck cDepartment of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Curr Opin Clin Nutr Metab Care 18:83-8. 2015
    ..In this article, we review the current findings regarding L-homoarginine metabolism and (patho-)physiology with a focus on its clinical impact...
  12. ncbi request reprint C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon
    Chi Un Choe
    Institute for Neural Signal Transduction, ZMNH, Department of Pediatrics, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Hum Mol Genet 15:2888-902. 2006
    ..In summary, the attenuated functional effects of 14-3-3epsilon on C-terminally truncated HERG channels demonstrate the physiological importance of coupling beta-adrenergic stimulation and HERG channel activity...
  13. doi request reprint Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity
    Chi Un Choe
    Department of Neurology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Neurochem 110:1766-73. 2009
    ..Taken together, our data indicate that HNO might worsen cerebral ischemia-reperfusion injury by increasing oxidative stress and decreasing brain perfusion at concentrations shown to be cardioprotective in vivo...