Uta Ceglarek

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Validation of the phenylalanine/tyrosine ratio determined by tandem mass spectrometry: sensitive newborn screening for phenylketonuria
    Uta Ceglarek
    University Hospital Leipzig, Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Germany
    Clin Chem Lab Med 40:693-7. 2002
  2. doi request reprint Rapid quantification of steroid patterns in human serum by on-line solid phase extraction combined with liquid chromatography-triple quadrupole linear ion trap mass spectrometry
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Clin Chim Acta 401:114-8. 2009
  3. ncbi request reprint Inclusion of MPA and in a rapid multi-drug LC-tandem mass spectrometric method for simultaneous determination of immunosuppressants
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Clin Chim Acta 373:168-71. 2006
  4. doi request reprint Challenges and developments in tandem mass spectrometry based clinical metabolomics
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, D 04103 Leipzig, Germany
    Mol Cell Endocrinol 301:266-71. 2009
  5. doi request reprint Effect of everolimus on pre-existing atherosclerosis in LDL-receptor deficient mice
    Frank Beutner
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Germany
    Atherosclerosis 222:337-43. 2012
  6. pmc Metabolomics of dietary fatty acid restriction in patients with phenylketonuria
    Ulrike Mütze
    Department of Women and Child Health, Hospital for Children and Adolescents, University Hospital, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e43021. 2012
  7. ncbi request reprint Rapid simultaneous quantification of immunosuppressants in transplant patients by turbulent flow chromatography combined with tandem mass spectrometry
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27 D 04103 Leipzig, Germany
    Clin Chim Acta 346:181-90. 2004
  8. doi request reprint Standardized peptidome profiling of human cerebrospinal fluid by magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Mathias Bruegel
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, Leipzig, Germany
    J Proteomics 72:608-15. 2009
  9. doi request reprint Evaluation of a novel commercial assay for the determination of cyclosporine A, tacrolimus, sirolimus, and everolimus by liquid chromatography-tandem mass spectrometric assay
    Susen Becker
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Ther Drug Monit 35:129-32. 2013
  10. doi request reprint Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice
    Ralph Burkhardt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Arterioscler Thromb Vasc Biol 31:775-84. 2011

Detail Information

Publications45

  1. ncbi request reprint Validation of the phenylalanine/tyrosine ratio determined by tandem mass spectrometry: sensitive newborn screening for phenylketonuria
    Uta Ceglarek
    University Hospital Leipzig, Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Germany
    Clin Chem Lab Med 40:693-7. 2002
    ..The phenylalanine/tyrosine ratio is crucial to improve the specificity and positive predictive value for the diagnosis of classical phenylketonuria...
  2. doi request reprint Rapid quantification of steroid patterns in human serum by on-line solid phase extraction combined with liquid chromatography-triple quadrupole linear ion trap mass spectrometry
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Clin Chim Acta 401:114-8. 2009
    ..We developed a rapid and reliable mass spectrometric method for the simultaneous quantification of steroid patterns in human serum...
  3. ncbi request reprint Inclusion of MPA and in a rapid multi-drug LC-tandem mass spectrometric method for simultaneous determination of immunosuppressants
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Clin Chim Acta 373:168-71. 2006
    ....
  4. doi request reprint Challenges and developments in tandem mass spectrometry based clinical metabolomics
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, D 04103 Leipzig, Germany
    Mol Cell Endocrinol 301:266-71. 2009
    ....
  5. doi request reprint Effect of everolimus on pre-existing atherosclerosis in LDL-receptor deficient mice
    Frank Beutner
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Germany
    Atherosclerosis 222:337-43. 2012
    ..Proliferation signal inhibitors/mTOR-inhibitors have been shown to reduce de novo development of hypercholesterolemic atherosclerosis in animal models. However, their effect on pre-existing atherosclerosis has not yet been studied...
  6. pmc Metabolomics of dietary fatty acid restriction in patients with phenylketonuria
    Ulrike Mütze
    Department of Women and Child Health, Hospital for Children and Adolescents, University Hospital, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e43021. 2012
    ..The influence of the long term PKU diet on fatty acid metabolism with a special focus on platelet eicosanoid metabolism has been investigated in the study presented here...
  7. ncbi request reprint Rapid simultaneous quantification of immunosuppressants in transplant patients by turbulent flow chromatography combined with tandem mass spectrometry
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27 D 04103 Leipzig, Germany
    Clin Chim Acta 346:181-90. 2004
    ....
  8. doi request reprint Standardized peptidome profiling of human cerebrospinal fluid by magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Mathias Bruegel
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, Leipzig, Germany
    J Proteomics 72:608-15. 2009
    ..Our reliable pretreatment protocol allows standardization of preanalytical modalities and thereby enables reproducible peptidome profiling of human CSF using MB separation followed by MALDI-TOF MS...
  9. doi request reprint Evaluation of a novel commercial assay for the determination of cyclosporine A, tacrolimus, sirolimus, and everolimus by liquid chromatography-tandem mass spectrometric assay
    Susen Becker
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Ther Drug Monit 35:129-32. 2013
    ....
  10. doi request reprint Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice
    Ralph Burkhardt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Arterioscler Thromb Vasc Biol 31:775-84. 2011
    ..We sought to identify novel atherosclerosis-modifying loci and their potential functional links in a genome-wide approach using cosegregation analysis of atherosclerosis and related intermediate phenotypes in mice...
  11. ncbi request reprint Mechanisms of Involvement of Eicosanoids and their Precursors in the Pathophysiology and Treatment of Schizophrenia
    Luise Schmidt
    Department of Psychiatry, University of Leipzig Semmelweisstr 10, 04103 Leipzig, Germany
    Med Chem 9:763-73. 2013
    ..COX-2 inhibitors may exert this therapeutic action through their effects in reducing PGE2, type-2 cytokine and kynurenic acid production and strengthening glutamatergic neurotransmission. ..
  12. doi request reprint LC-MS-based metabolomics in the clinical laboratory
    Susen Becker
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 883:68-75. 2012
    ..In this context an overview on recent LC-MS/MS based metabolome studies for cancer, diabetes and coronary heart disease is presented...
  13. ncbi request reprint Standardized peptidome profiling of human urine by magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Georg Martin Fiedler
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig, Germany
    Clin Chem 53:421-8. 2007
    ....
  14. doi request reprint Serum peptidome profiling revealed platelet factor 4 as a potential discriminating Peptide associated with pancreatic cancer
    Georg Martin Fiedler
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Clin Cancer Res 15:3812-9. 2009
    ....
  15. doi request reprint Preclinical challenges in steroid analysis of human samples
    Uta Ceglarek
    Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Paul List Str 13 15, Germany
    J Steroid Biochem Mol Biol 121:505-12. 2010
    ....
  16. ncbi request reprint Standardized approach to proteome profiling of human serum based on magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Sven Baumann
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig, Germany
    Clin Chem 51:973-80. 2005
    ..The aims of our study were to establish a proteome fractionation technique and to validate a standardized blood sampling, processing, and storage procedure for proteomic pattern analysis...
  17. ncbi request reprint Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS/MS
    Jan Lembcke
    Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany
    J Lipid Res 46:21-6. 2005
    ..4% and 9.9%. The analytical sensitivity was at least 150-fold higher compared with GC-MS. Our new method allows a rapid and simultaneous determination of free and esterified phytosterols in serum...
  18. doi request reprint Standardized preprocessing of urine for proteome analysis
    Georg Martin Fiedler
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Medical Faculty, University Leipzig, Leipzig, Germany
    Methods Mol Biol 641:47-63. 2010
    ..Such a procedure is necessary for generating consistent and reliable data from which meaningful results may be obtained for biomarker discovery and general proteomic experiments...
  19. doi request reprint Liquid chromatography quadrupole linear ion trap mass spectrometry for quantitative steroid hormone analysis in plasma, urine, saliva and hair
    Alexander Gaudl
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig University, Liebigstraße 27, 04103 Leipzig, Germany Electronic address
    J Chromatogr A 1464:64-71. 2016
    ..Concludingly, simple protein precipitation combined with rapid online SPE LC-MS/MS/MS allows us to quantify over broad, essential concentration ranges in human serum, saliva, urine and hair. ..
  20. doi request reprint Preanalytical Investigation of Polyunsaturated Fatty Acids and Eicosanoids in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry
    Juliane Dorow
    1 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Biopreserv Biobank 14:107-13. 2016
    ..The arachidonic acid metabolism is useful as a quality marker since eicosanoids are easily subjected to in vitro oxidation processes...
  21. doi request reprint Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque
    Christin Helmschrodt
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Germany LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Germany Electronic address
    Clin Chim Acta 425:3-8. 2013
    ....
  22. pmc Circulating sterols as predictors of early allograft dysfunction and clinical outcome in patients undergoing liver transplantation
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, University of Leipzig, 04103 Leipzig, Germany LIFE Leipzig Research Center for Civilization Diseases, University Leipzig, Philipp Rosenthal Strasse 27, 04103 Leipzig, Germany
    Metabolomics 12:182. 2016
    ..Sensitive and specific assessment of the hepatic graft metabolism after liver transplantation (LTX) is essential for early detection of postoperative dysfunction implying the need for consecutive therapeutic interventions...
  23. pmc Plasma Amino Acid Concentrations Predict Mortality in Patients with End-Stage Liver Disease
    Benedict Kinny-Köster
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    PLoS ONE 11:e0159205. 2016
    ..Encephalopathy and sarcopenia are known to dramatically worsen the prognosis. Aim of this study was to investigate a complex panel of plasma amino acids in the context of mortality in patients with end-stage liver disease...
  24. doi request reprint Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography-tandem mass spectrometry
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany LIFE Leipzig Research Center for Civilization Diseases, University Leipzig, Philipp Rosenthal Strasse 27, 04103 Leipzig, Germany
    Clin Chim Acta 435:1-6. 2014
    ..Preanalytical standardization is required for a reliable quantification of the signaling molecules sphingosine-1-phosphate (S1P), sphinganine-1-phosphate (SA1P) and sphingosine (SPH)...
  25. doi request reprint Quantification of seven apolipoproteins in human plasma by proteotypic peptides using fast LC-MS/MS
    Uta Ceglarek
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
    Proteomics Clin Appl 7:794-801. 2013
    ....
  26. doi request reprint Fast liquid chromatography-quadrupole linear ion trap-mass spectrometry analysis of polyunsaturated fatty acids and eicosanoids in human plasma
    Linda Kortz
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 927:209-13. 2013
    ..The lower limit of quantitation ranged between 200 and 1000ng/mL for the PUFAs and 10-1000pg/mL for the metabolites. The method was applied to a study on plasma samples from 50 healthy subjects...
  27. doi request reprint Sepsis-associated changes of the arachidonic acid metabolism and their diagnostic potential in septic patients
    Mathias Bruegel
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Department of Internal Medicine, Intensive Care Unit, University Hospital Leipzig, Leipzig, Germany
    Crit Care Med 40:1478-86. 2012
    ..Therefore, the primary objective of our study was to screen for differentially regulated arachidonic acid metabolites in septic patients using a lipopolysaccharide whole-blood model and to investigate their diagnostic potential...
  28. pmc Potential of dried blood self-sampling for cyclosporine c(2) monitoring in transplant outpatients
    Alexander Benedikt Leichtle
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany
    J Transplant 2010:201918. 2010
    ..Conclusions. C(2) self-obtained dried blood sampling can easily be performed by transplant outpatients and is therefore suitable and cost-effective for close therapeutic drug monitoring...
  29. pmc Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood
    Ralph Burkhardt
    LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    PLoS Genet 11:e1005510. 2015
    ..At several loci, we provide evidence for metabolite regulation via gene-expression and observed overlaps with GWAS loci for common diseases. These results form a strong rationale for subsequent functional and disease-related studies. ..
  30. pmc Ten years of specialized adult care for phenylketonuria - a single-centre experience
    Ulrike Mütze
    Department of Women and Child Health, Hospital for Children and Adolescents, Centre for Paediatric Research Leipzig CPL, University Hospitals, University of Leipzig, Liebigstr 20 a, 04103, Leipzig, Germany
    Orphanet J Rare Dis 11:27. 2016
    ....
  31. doi request reprint Sample preparation strategies for targeted proteomics via proteotypic peptides in human blood using liquid chromatography tandem mass spectrometry
    Julia Dittrich
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany LIFE Leipzig Research Center for Civilization Diseases, University Leipzig, Leipzig, Germany
    Proteomics Clin Appl 9:5-16. 2015
    ..The main focus is on the tryptic digestion as a bottleneck of protein quantification via proteotypic peptides. Conclusively, requirements for a high-throughput application are discussed. ..
  32. doi request reprint Genetic regulation of serum phytosterol levels and risk of coronary artery disease
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig, Germany
    Circ Cardiovasc Genet 3:331-9. 2010
    ..Serum levels are under tight genetic control. We used a genomic approach to study the molecular regulation of serum phytosterol levels and potential links to coronary artery disease (CAD)...
  33. ncbi request reprint Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/- mice despite severe hypercholesterolemia
    Marc A Mueller
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Atherosclerosis 198:39-48. 2008
    ..The significant reduction of atherosclerotic lesions was associated with a delayed transition from early macrophages enriched lesions to advanced atherosclerotic plaques...
  34. doi request reprint Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans
    Frank W Albert
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Horm Behav 53:413-21. 2008
    ..Our findings reinforce the notion that tameness is correlated with differences in stress response and will facilitate future efforts to uncover the genetic basis for animal tameness...
  35. pmc Lineage-Specific Changes in Biomarkers in Great Apes and Humans
    Claudius Ronke
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    PLoS ONE 10:e0134548. 2015
    ....
  36. doi request reprint Nicotinamide: a vitamin able to shift macrophage differentiation toward macrophages with restricted inflammatory features
    Ronald Weiss
    University of Leipzig, Translational Centre for Regenerative Medicine TRM Leipzig, Leipzig, Germany University Hospital Leipzig, Institute for Clinical Immunology, Leipzig, Germany University of Leipzig, Institute of Biology, Leipzig, Germany
    Innate Immun 21:813-26. 2015
    ..In conclusion, our data show that vitamin B3, when present during the differentiation of monocytes into GM-MØ, interferes with biochemical pathways resulting in strongly reduced pro-inflammatory features...
  37. doi request reprint The hyporeactivity of salivary cortisol at stress test (TSST-C) in children with internalizing or externalizing disorders is contrastively associated with α-amylase
    Yoon Ju Bae
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany Electronic address
    J Psychiatr Res 71:78-88. 2015
    ....
  38. pmc The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany
    Markus Loeffler
    LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany
    BMC Public Health 15:691. 2015
    ....
  39. doi request reprint Association between IgE-mediated allergies and diabetes mellitus type 1 in children and adolescents
    Sabine Klamt
    LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
    Pediatr Diabetes 16:493-503. 2015
    ..According to the Th1/Th2-hypothesis, the immune system is said to either develop into the direction of Th1 or Th2 cells. This would mean that a child developing T1DM is unlikely to develop an IgE-mediated allergy and vice versa...
  40. doi request reprint Liquid chromatography-tandem mass spectrometry for the analysis of eicosanoids and related lipids in human biological matrices: a review
    Linda Kortz
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, 04103 Leipzig, Germany LIFE Leipzig Research Center for Civilization Diseases, Universitat Leipzig, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 964:1-11. 2014
    ....
  41. ncbi request reprint Impact of clozapine, N-desmethylclozapine and chlorpromazine on thromboxane production in vitro
    Hubertus Himmerich
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Med Chem 8:1032-8. 2012
    ..Additionally, known side effects of APs such as orthostatic hypotension may be a result of changes in the concentrations of TxA2 or TxB2...
  42. pmc Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets
    Yan Zheng
    Department of Nutrition Y Z, F M S, L Q, Harvard T H Chan School of Public Health, Boston, Massachusetts 02115 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics U C, J T, University Hospital Leipzig, 04103 Leipzig, Germany Department of Epidemiology, School of Public Health and Tropical Medicine T H, T W, Y H, L Q, Tulane University, New Orleans, Louisiana 70118 Department of Epidemiology, Saw Swee Hock School of Public Health T H, National University of Singapore, Singapore 119077 Department of Epidemiology W M, Harvard T H Chan School of Public Health, Boston, Massachusetts 02115 Pennington Biomedical Research Center G A B, Louisiana State University, Baton Rouge, Louisiana 70808 and Channing Division of Network Medicine, Department of Medicine L Q, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115
    J Clin Endocrinol Metab 101:3820-3826. 2016
    ..Previous evidence suggested that the preventative effects of taurine on diabetes might be through regulating the expression levels of diabetes-related genes...
  43. doi request reprint Impact of myeloperoxidase-derived oxidants on the product profile of human 5-lipoxygenase
    Josefin Zschaler
    Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany Translational Center for Regenerative Medicine Leipzig, Leipzig University, Leipzig, Germany Electronic address
    Free Radic Biol Med 85:148-56. 2015
    ....
  44. doi request reprint Fast liquid chromatography combined with mass spectrometry for the analysis of metabolites and proteins in human body fluids
    Linda Kortz
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Germany
    Anal Bioanal Chem 399:2635-44. 2011
    ..Practical aspects of, recent developments in, and the present status of high-throughput analysis of human body fluids for therapeutic drug monitoring, toxicology, clinical metabolomics, and proteomics are presented...
  45. doi request reprint Cyclosporin A in the ocular fluids of uveitis patients following long-term systemic administration
    Paolo Mora
    Institute of Ophthalmology, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    Graefes Arch Clin Exp Ophthalmol 246:1047-52. 2008
    ..To determine the levels of cyclosporin A (CsA) in tears and the anterior segment of the eye following long-term oral intake for autoimmune diseases...