Bjoern Buchholz

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. doi request reprint Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion
    Bjoern Buchholz
    Department of Nephrology and Hypertension, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    J Mol Med (Berl) 89:251-61. 2011
  2. doi request reprint The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis
    Bjoern Buchholz
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 26:3458-65. 2011
  3. doi request reprint Glucose promotes secretion-dependent renal cyst growth
    Andre Kraus
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Ulmenweg 18, 91054, Erlangen, Germany
    J Mol Med (Berl) 94:107-17. 2016
  4. pmc P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells
    Andre Kraus
    Department of Nephrology and Hypertension, Friedrich Alexander University of Erlangen Nurnberg, Ulmenweg 18, 91054, Erlangen, Germany
    Purinergic Signal 12:687-695. 2016
  5. doi request reprint The impact of hypoxia on nephrogenesis
    Bjoern Buchholz
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Curr Opin Nephrol Hypertens 25:180-6. 2016
  6. doi request reprint Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells
    Bjoern Buchholz
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 85:1058-67. 2014

Collaborators

Detail Information

Publications6

  1. doi request reprint Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion
    Bjoern Buchholz
    Department of Nephrology and Hypertension, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    J Mol Med (Berl) 89:251-61. 2011
    ..In conclusion, we provide in vitro evidence for the ability of principal rather than intercalated cells to form cysts, based on a synergism of cAMP and ATP signaling in enhancing apical fluid secretion...
  2. doi request reprint The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis
    Bjoern Buchholz
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 26:3458-65. 2011
    ..Moreover, although relative cyst volume was decreased, total kidney-to-body weight ratio was not significantly reduced by PLX5568. Further analyses revealed a 2-fold increase of renal and hepatic fibrosis in animals treated with PLX5568...
  3. doi request reprint Glucose promotes secretion-dependent renal cyst growth
    Andre Kraus
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Ulmenweg 18, 91054, Erlangen, Germany
    J Mol Med (Berl) 94:107-17. 2016
    ..These data suggest that glycemic control may help to reduce renal cyst growth in patients with polycystic kidney disease...
  4. pmc P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells
    Andre Kraus
    Department of Nephrology and Hypertension, Friedrich Alexander University of Erlangen Nurnberg, Ulmenweg 18, 91054, Erlangen, Germany
    Purinergic Signal 12:687-695. 2016
    ..In conclusion, P2Y2R mediates ATP-dependent cyst growth and is transcriptionally regulated by HIF-1α. These findings provide further mechanistic evidence on how hypoxia promotes cyst growth...
  5. doi request reprint The impact of hypoxia on nephrogenesis
    Bjoern Buchholz
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Curr Opin Nephrol Hypertens 25:180-6. 2016
    ..The purpose of this review is to highlight the influence of oxygen on nephrogenesis and to describe cellular mechanisms by which hypoxia can impair nephron formation...
  6. doi request reprint Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells
    Bjoern Buchholz
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 85:1058-67. 2014
    ..Knockdown of ANO1 by morpholino analogs also attenuated embryonic cyst growth. Thus, calcium-activated chloride secretion by anoctamin 1 appears to be a crucial component of renal cyst growth. ..