Rolf E Brenner

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. ncbi request reprint Mesenchymal progenitor cells communicate via alpha and beta integrins with a three-dimensional collagen type I matrix
    Leslie Heckmann
    Department of Orthopedics, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
    Cells Tissues Organs 182:143-54. 2006
  2. ncbi request reprint Influence of p38MAPK inhibition on IL-1beta-stimulated human chondrocytes: a microarray approach
    Helga Joos
    Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany
    Int J Mol Med 23:685-93. 2009
  3. pmc Recessive multiple epiphyseal dysplasia (rMED) with homozygosity for C653S mutation in the DTDST gene--phenotype, molecular diagnosis and surgical treatment of habitual dislocation of multilayered patella: case report
    Timo Hinrichs
    Department of Sports Medicine and Sports Nutrition, University of Bochum, Bochum, Germany
    BMC Musculoskelet Disord 11:110. 2010
  4. pmc CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells
    Norbert Schutze
    Orthopedic Department, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    BMC Cell Biol 8:45. 2007
  5. doi request reprint Ultrathin sP(EO-stat-PO) hydrogel coatings are biocompatible and preserve functionality of surface bound growth factors in vivo
    Carl Neuerburg
    Department of Orthopaedics, University of Ulm, Ulm, Germany
    J Mater Sci Mater Med 24:2417-27. 2013
  6. pmc The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro
    Anita Ignatius
    Institute of Orthopaedic Research and Biomechanics, Department of Traumatology, Hand, Plastic, and Reconstructive Surgery, Center of Surgery, University of Ulm, Ulm, Germany
    J Trauma 71:952-60. 2011
  7. doi request reprint Does complement play a role in bone development and regeneration?
    Philipp Schoengraf
    Institute of Orthopaedic Research and Biomechanics, Centre of Muskuloskelettal Research, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    Immunobiology 218:1-9. 2013
  8. ncbi request reprint Interactive effects of growth factors and three-dimensional scaffolds on multipotent mesenchymal stromal cells
    Leslie Heckmann
    Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Federal Republic of Germany
    Biotechnol Appl Biochem 49:185-94. 2008
  9. doi request reprint Effects of mechanical strain on human mesenchymal stem cells and ligament fibroblasts in a textured poly(L-lactide) scaffold for ligament tissue engineering
    Ludwika Kreja
    Institute of Orthopaedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Mater Sci Mater Med 23:2575-82. 2012
  10. doi request reprint Single impact trauma in human early-stage osteoarthritic cartilage: implication of prostaglandin D2 but no additive effect of IL-1β on cell survival
    Helga Joos
    Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany
    Int J Mol Med 28:271-7. 2011

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Mesenchymal progenitor cells communicate via alpha and beta integrins with a three-dimensional collagen type I matrix
    Leslie Heckmann
    Department of Orthopedics, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
    Cells Tissues Organs 182:143-54. 2006
    ..The aim of our study was to investigate interactions of mesenchymal progenitor cells (MPCs) with collagen matrices...
  2. ncbi request reprint Influence of p38MAPK inhibition on IL-1beta-stimulated human chondrocytes: a microarray approach
    Helga Joos
    Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany
    Int J Mol Med 23:685-93. 2009
    ..Our results do not predict a pro-apoptotic or cancer promoting effect and markedly extend the knowledge on p38MAPK inhibition in chondrocytes beyond primary target genes...
  3. pmc Recessive multiple epiphyseal dysplasia (rMED) with homozygosity for C653S mutation in the DTDST gene--phenotype, molecular diagnosis and surgical treatment of habitual dislocation of multilayered patella: case report
    Timo Hinrichs
    Department of Sports Medicine and Sports Nutrition, University of Bochum, Bochum, Germany
    BMC Musculoskelet Disord 11:110. 2010
    ..Due to its clinical heterogeneity diagnosis may be difficult. Mutations of at least six separate genes can cause MED. Joint deformities, joint pain and gait disorders are common symptoms...
  4. pmc CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells
    Norbert Schutze
    Orthopedic Department, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    BMC Cell Biol 8:45. 2007
    ....
  5. doi request reprint Ultrathin sP(EO-stat-PO) hydrogel coatings are biocompatible and preserve functionality of surface bound growth factors in vivo
    Carl Neuerburg
    Department of Orthopaedics, University of Ulm, Ulm, Germany
    J Mater Sci Mater Med 24:2417-27. 2013
    ..Hence, NCO-sP(EO-stat-PO)-coatings could offer an attractive platform to improve integration of orthopedic implants. ..
  6. pmc The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro
    Anita Ignatius
    Institute of Orthopaedic Research and Biomechanics, Department of Traumatology, Hand, Plastic, and Reconstructive Surgery, Center of Surgery, University of Ulm, Ulm, Germany
    J Trauma 71:952-60. 2011
    ..We proved the hypothesis that complement might be involved in bone healing after fracture...
  7. doi request reprint Does complement play a role in bone development and regeneration?
    Philipp Schoengraf
    Institute of Orthopaedic Research and Biomechanics, Centre of Muskuloskelettal Research, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    Immunobiology 218:1-9. 2013
    ..This review describes the complex mutual regulation of the two systems, and indicates some of the negative side effects as a result of inappropriate or excessive complement activation...
  8. ncbi request reprint Interactive effects of growth factors and three-dimensional scaffolds on multipotent mesenchymal stromal cells
    Leslie Heckmann
    Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Federal Republic of Germany
    Biotechnol Appl Biochem 49:185-94. 2008
    ..It is important to take these complex interactions, which partly differ from differentiated cells, into account in further tissue-engineering approaches...
  9. doi request reprint Effects of mechanical strain on human mesenchymal stem cells and ligament fibroblasts in a textured poly(L-lactide) scaffold for ligament tissue engineering
    Ludwika Kreja
    Institute of Orthopaedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Mater Sci Mater Med 23:2575-82. 2012
    ..The results indicated that the new textured PLA scaffold could transfer the mechanical load to the ACL-fibroblasts and improved their ligament phenotype. This scaffold might be suitable as a cell-carrying component of ACL prostheses...
  10. doi request reprint Single impact trauma in human early-stage osteoarthritic cartilage: implication of prostaglandin D2 but no additive effect of IL-1β on cell survival
    Helga Joos
    Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany
    Int J Mol Med 28:271-7. 2011
    ..The up-regulation of mediators was time-dependent, with a more early increase of PGD2 compared to prostaglandin E2 (PGE2) and a late induction of NO by co-stimulation with IL-1β between 6 and 24 h...
  11. pmc IL-1β inhibits human osteoblast migration
    Nina Emily Hengartner
    Orthopedic Department, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Germany
    Mol Med 19:36-42. 2013
    ....
  12. doi request reprint Single impact cartilage trauma and TNF-α: interactive effects do not increase early cell death and indicate the need for bi-/multidirectional therapeutic approaches
    Cathrin Hogrefe
    Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany
    Int J Mol Med 30:1225-32. 2012
    ..As TNF-α does not contribute to the loss of chondrocytes in the initial post-traumatic phase, a combination with pharmaco-therapeutic strategies reducing early cell death could be reasonable...
  13. doi request reprint Differential Interactive Effects of Cartilage Traumatization and Blood Exposure In Vitro and In Vivo
    Helga Joos
    Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany
    Am J Sports Med 43:2822-32. 2015
    ..Both blood exposure and trauma are known to induce cell death and inflammation and to enhance proteoglycan release in cartilage...
  14. doi request reprint The effect of substrate surface nanotopography on the behavior of multipotnent mesenchymal stromal cells and osteoblasts
    Jörg Fiedler
    Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedic Surgery, University of Ulm, Germany
    Biomaterials 34:8851-9. 2013
    ..The present experimental data also allow the important conclusion that cell proliferation and differentiation can be optimized simultaneously by fine-tuning nanoscaled topographical parameters...
  15. doi request reprint Development of a new biomechanically defined single impact rabbit cartilage trauma model for in vivo-studies
    Frank Leucht
    Department of Orthopaedic Surgery, University of Ulm, Ulm, Germany
    J Invest Surg 25:235-41. 2012
    ..Clinically oriented and easy to handle animal models are urgently needed to test pharmacologic treatment of cartilage trauma to reduce the resulting tissue damage by chondrocyte apoptosis and induction of matrix-degrading enzymes...
  16. pmc IL-1beta regulates FHL2 and other cytoskeleton-related genes in human chondrocytes
    Helga Joos
    Department of Orthopedics, University of Ulm, Ulm, Germany
    Mol Med 14:150-9. 2008
    ..We conclude that L-1beta is involved in the regulation of various cytoskeletal components in human chondrocytes including the multifunctional protein FHL2. This might be relevant for the pathogenesis of OA...
  17. ncbi request reprint Phenotypic instability of Saos-2 cells in long-term culture
    Heinz Juergen Hausser
    Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Germany
    Biochem Biophys Res Commun 333:216-22. 2005
    ..Our observations indicate that special care is required when results obtained with Saos-2 cells with different culture history are to be compared...
  18. ncbi request reprint Agrin is highly expressed by chondrocytes and is required for normal growth
    Heinz Juergen Hausser
    Department of Orthopedics, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, RKU, Oberer Eselsberg 45, 89081, Ulm, Germany
    Histochem Cell Biol 127:363-74. 2007
    ..Our data show that agrin is expressed in cartilage and that it plays a critical role in normal skeletal growth...
  19. ncbi request reprint X-linked spondyloepiphyseal dysplasia tarda: molecular cause of a heritable disorder associated with early degenerative joint disease
    Jörg Fiedler
    University of Ulm, Department of Orthopedics, Division for Biochemistry of Joint and Connective Tissue Disorders, RKU, Oberer Eselsberg 45, DE 89081 Ulm, Germany
    Acta Orthop Scand 74:737-41. 2003
    ..SEDT should be kept in mind as a differential diagnosis in men with early "primary" bilateral osteoarthrosis...
  20. ncbi request reprint To go or not to go: Migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF
    Jörg Fiedler
    Department of Orthopaedics, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
    J Cell Biochem 93:990-8. 2004
    ..Moreover, these observations may be useful for novel approaches towards guided tissue regeneration or tissue engineering of bone...
  21. doi request reprint Copper and silver ion implantation of aluminium oxide-blasted titanium surfaces: proliferative response of osteoblasts and antibacterial effects
    Jörg Fiedler
    Department of Orthopedics, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
    Int J Artif Organs 34:882-8. 2011
    ..These results indicate that Ag-ion implantation may be a promising methodological approach for antibacterial functionalization of titanium implants...
  22. pmc Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β
    Anita Ignatius
    Institute of Orthopaedic Research and Biomechanics, Center of Musculoskeletal Research Ulm, University of Ulm, Ulm, Germany
    J Cell Biochem 112:2594-605. 2011
    ....
  23. pmc Dysplasia epiphysealis hemimelica: a case report with novel pathophysiologic aspects
    Mario Perl
    Department of Orthopaedics, University of Ulm Medical School, Ulm, Germany
    Clin Orthop Relat Res 467:2472-8. 2009
    ..Immunohistochemical analysis of the lesion provided a more accurate diagnosis and may contribute to unraveling potential novel mechanisms involved in its pathogenesis...
  24. doi request reprint NCO-sP(EO-stat-PO) surface coatings preserve biochemical properties of RGD peptides
    Jörg Fiedler
    Orthopaedic Clinic, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Oberer Eselsberg 45, D 89081 Ulm, Germany
    Int J Mol Med 27:139-45. 2011
    ..Our results indicate specific effects of these adhesion peptides on MSC biology and show that this coating system is useful for selective testing of cellular interactions with adhesive ligands...
  25. ncbi request reprint IGF-I and IGF-II stimulate directed cell migration of bone-marrow-derived human mesenchymal progenitor cells
    Jörg Fiedler
    Orthopaedic Department, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
    Biochem Biophys Res Commun 345:1177-83. 2006
    ..In conclusion, our results show that IGF-I and -II are chemotactic factors for MPC and indicate that IGFBP-5 both modulates the IGF-I effect and directly stimulates migration of human mesenchymal progenitor cells...
  26. pmc Improved anchorage of Ti6Al4V orthopaedic bone implants through oligonucleotide mediated immobilization of BMP-2 in osteoporotic rats
    Julia V Wölfle
    Department of Orthopaedic Surgery, Centre of Musculoskeletal Research, University of Ulm, Ulm, Germany
    PLoS ONE 9:e86151. 2014
    ..Thus, we could show the biocompatibility and in vivo functionality of this modular, self-organizing system for immobilization and subsequent release of BMP-2 in vivo. ..
  27. ncbi request reprint X-linked spondyloepiphyseal dysplasia tarda: Novel and recurrent mutations in 13 European families
    Jörg Fiedler
    University of Ulm, Department of Orthopedics, Division for Biochemistry of Joint and Connective Tissue Diseases, Germany
    Hum Mutat 24:103. 2004
    ..All sequence variations identified are either deletions of complete exons or predicted to result in a premature stop codon or to lead into splicing defects and are associated with a loss of considerable parts of the sedlin protein...
  28. ncbi request reprint VEGF-A and PlGF-1 stimulate chemotactic migration of human mesenchymal progenitor cells
    Jörg Fiedler
    Orthopaedic Department, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
    Biochem Biophys Res Commun 334:561-8. 2005
    ....
  29. pmc Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers
    Stefan Fickert
    Department of Orthopaedics, University of Ulm, Ulm, Germany
    Arthritis Res Ther 6:R422-32. 2004
    ....
  30. pmc Crucial role of IL1beta and C3a in the in vitro-response of multipotent mesenchymal stromal cells to inflammatory mediators of polytrauma
    Nina Emily Hengartner
    Orthopedic Department, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
    PLoS ONE 10:e0116772. 2015
    ....
  31. ncbi request reprint Testican-1, an inhibitor of pro-MMP-2 activation, is expressed in cartilage
    Heinz J Hausser
    University of Ulm, Division for Biochemistry of Joint and Connective Tissue Diseases, Ulm, Germany
    Osteoarthritis Cartilage 12:870-7. 2004
    ..As MT1-MMP mediated pro-MMP-2 activation is of significance for cartilage destruction in osteoarthritis, we studied the expression and localization of testican-1 in human articular cartilage...
  32. doi request reprint Role of Complement on Broken Surfaces After Trauma
    Markus Huber-Lang
    Department of Orthopedic Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Adv Exp Med Biol 865:43-55. 2015
    ..In conclusion, the complement system may be activated by trauma-altered surfaces and is crucially involved in connective tissue healing and posttraumatic systemic inflammatory response. ..
  33. ncbi request reprint BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells
    Jörg Fiedler
    Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Germany
    J Cell Biochem 87:305-12. 2002
    ....
  34. pmc Mesenchymal Stem Cells after Polytrauma: Actor and Target
    Markus Huber-Lang
    Department of Orthopaedic Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital of Ulm, 89081 Ulm, Germany
    Stem Cells Int 2016:6289825. 2016
    ..We summarize relevant cellular and signaling mechanisms and provide an up-to-date overview about promising future therapeutic MSC strategies in the context of severe tissue trauma. ..
  35. ncbi request reprint X-linked spondyloepiphyseal dysplasia tarda: molecular cause of a heritable platyspondyly
    Jörg Fiedler
    University of Ulm, Department of Orthopedics, Ulm, Germany
    Spine (Phila Pa 1976) 28:E478-82. 2003
    ..Report of a family affected with X-linked spondyloepiphyseal dysplasia tarda with special respect to radiologic alterations of the spine from puberty to the forth decade and to molecular analysis of the underlying genetic defect...
  36. ncbi request reprint Biocompatibility and osseointegration of beta-TCP: histomorphological and biomechanical studies in a weight-bearing sheep model
    Holger E Koepp
    Department of Orthopaedic Surgery, University of Ulm, Oberer Eselsberg 45, D 89081 Ulm, Germany
    J Biomed Mater Res B Appl Biomater 70:209-17. 2004
    ..In conclusion, in a weight bearing implantation model beta-TCP showed good biocompatibility, osseointegration and beginning degradation, even though it was not further degraded between 6 and 12 months...
  37. ncbi request reprint Low doses and high doses of heparin have different effects on osteoblast-like Saos-2 cells in vitro
    Heinz Juergen Hausser
    University of Ulm, Division for Biochemistry of Joint and Connective Tissue Diseases, Ulm, Germany
    J Cell Biochem 91:1062-73. 2004
    ..These results imply that heparin at concentrations well below those used for antithrombotic therapy might eventually turn out to be beneficial for bone formation...
  38. doi request reprint The (-765 G→C) promoter variant of the COX-2/PTGS2 gene is associated with a lower risk for end-stage hip and knee osteoarthritis
    E M Schneider
    Division for Experimental Anaesthesiology, Department of Anaesthesiology, University Hospital Ulm, Ulm, Germany
    Ann Rheum Dis 70:1458-60. 2011
    ..Functional polymorphisms in genes of proinflammatory signalling cascades may contribute to the genetic risk of osteoarthritis (OA)...
  39. ncbi request reprint A novel star PEG-derived surface coating for specific cell adhesion
    Juergen Groll
    Department of Textile and Macromolecular Chemistry, RWTH Aachen, Pauwelsstrasse 8, 52074 Aachen, Germany
    J Biomed Mater Res A 74:607-17. 2005
    ..Thus, the Star PEG/RGD film did not negatively influence the differentiation process. The high flexibility of the system considering the incorporation of biologically active compounds opens a broad field of future experiments...