- The function of complexes between the outer mitochondrial membrane pore (VDAC) and the adenine nucleotide translocase in regulation of energy metabolism and apoptosisMikhail Y Vyssokikh
A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
Acta Biochim Pol 50:389-404. 2003..However, when, for example, free radicals cause dissociation of the octamer, VDAC interacts with the ANT with the same results as described above: Bax-dependent cytochrome c release and risk of permeability transition pore opening...
- The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transitionD Brdiczka
Faculty of Biology, University of Konstanz, Germany
Biofactors 8:235-42. 1998..Indeed, reconstituted pure ANT showed PT-pore-like properties concerning Ca2+ sensitivity. However, as cyclophilin was missing, sensitivity against cyclosporin was not observed...
- Mitochondrial contact sites: their role in energy metabolism and apoptosisDieter G Brdiczka
Department of Pharmacology and Physiology, Box 711, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
Biochim Biophys Acta 1762:148-63. 2006..Furthermore, we describe experiments involving the complex-stabilizing conditions in vitro and in intact cells. At the end, we discuss unsolved problems and opportunities for clinical application of the complex-stabilizing factors...